EA200100798A1 - Пиперидиновые, тетрагидропиридиновые и пиперазиновые производные, их получение и использование - Google Patents
Пиперидиновые, тетрагидропиридиновые и пиперазиновые производные, их получение и использованиеInfo
- Publication number
- EA200100798A1 EA200100798A1 EA200100798A EA200100798A EA200100798A1 EA 200100798 A1 EA200100798 A1 EA 200100798A1 EA 200100798 A EA200100798 A EA 200100798A EA 200100798 A EA200100798 A EA 200100798A EA 200100798 A1 EA200100798 A1 EA 200100798A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- crr
- disorders
- tetrahydropyridine
- piperidine
- piperazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Пиперидиновые, тетрагидропиридиновые или пиперазиновые производные, имеющие формулу (I), любые из их энантиомеров, или любая их смесь, или их кислотно-аддитивные соли, в которых B представляет Cалкилен, Cалкенилен или Cалкинилен; X представляет -O-, -S- или -CRR-; и Y представляет -CRR-, -CRR-CRR- или -CR=CR-; либо X и Y вместе образуют группу -CR=CR- или -CR=CR-CRR-; Z представляет -O- или -S-; W представляет N, C или CH, а пунктирная линия обозначает необязательную связь; A представляет бициклическое кольцо, выбранное из формул (Ia) и (Ib), в которых E, Eи Eвыбраны из O, S, N, NR, C, CRи CHR, а пунктирная линия обозначает необязательную связь, при условии, что Eи Eи/или Eне могут одновременно представлять O или S. Соединения изобретения считаются полезными для лечения аффективных расстройств, таких как депрессия, психоз, тревожные состояния, включая общее тревожное состояние, панические расстройства, обсессивно-компульсивные расстройства и расстройства аппетита.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA199900084 | 1999-01-22 | ||
PCT/DK2000/000026 WO2000043382A1 (en) | 1999-01-22 | 2000-01-21 | Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200100798A1 true EA200100798A1 (ru) | 2001-12-24 |
Family
ID=8089560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100798A EA200100798A1 (ru) | 1999-01-22 | 2000-01-21 | Пиперидиновые, тетрагидропиридиновые и пиперазиновые производные, их получение и использование |
Country Status (26)
Country | Link |
---|---|
US (2) | US6596722B2 (ru) |
EP (1) | EP1149087B1 (ru) |
JP (1) | JP2002535322A (ru) |
KR (1) | KR20010101606A (ru) |
CN (1) | CN1344265A (ru) |
AR (1) | AR022303A1 (ru) |
AT (1) | ATE263763T1 (ru) |
AU (1) | AU767377B2 (ru) |
BG (1) | BG105781A (ru) |
BR (1) | BR0009007A (ru) |
CA (1) | CA2361059A1 (ru) |
CZ (1) | CZ20012657A3 (ru) |
DE (1) | DE60009663T2 (ru) |
EA (1) | EA200100798A1 (ru) |
HK (1) | HK1045505A1 (ru) |
HU (1) | HUP0105065A3 (ru) |
IL (1) | IL144113A0 (ru) |
IS (1) | IS5983A (ru) |
MX (1) | MXPA01007226A (ru) |
NO (1) | NO20013538L (ru) |
NZ (1) | NZ512732A (ru) |
PL (1) | PL349909A1 (ru) |
SK (1) | SK10302001A3 (ru) |
TR (1) | TR200102089T2 (ru) |
WO (1) | WO2000043382A1 (ru) |
ZA (1) | ZA200105548B (ru) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU736596B2 (en) * | 1997-07-25 | 2001-08-02 | H. Lundbeck A/S | Indole and 2,3-dihydroindole derivatives, their preparation and use |
PL201178B1 (pl) * | 1999-08-23 | 2009-03-31 | Solvay Pharm Bv | Nowe pochodne fenylopiperazyny, sposób ich wytwarzania, kompozycja farmaceutyczna oraz zastosowanie |
AR027133A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de heteroarilo, su preparacion y uso. |
CA2453837C (en) * | 2001-07-20 | 2011-10-04 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder using eltoprazine and related compounds |
US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
WO2003013571A1 (en) * | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
US7507568B2 (en) * | 2002-09-25 | 2009-03-24 | The Proctor & Gamble Company | Three dimensional coordinates of HPTPbeta |
US7226755B1 (en) * | 2002-09-25 | 2007-06-05 | The Procter & Gamble Company | HPTPbeta as a target in treatment of angiogenesis mediated disorders |
US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
US7235569B2 (en) | 2003-05-02 | 2007-06-26 | Wyeth | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use |
US7276603B2 (en) | 2003-05-02 | 2007-10-02 | Wyeth | Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use |
US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
US20060122175A1 (en) * | 2004-12-07 | 2006-06-08 | Solvay Pharmaceuticals B.V. | Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
US20070072870A2 (en) | 2004-12-08 | 2007-03-29 | Solvay Pharmeceuticals B.V. | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition |
JP2008537725A (ja) * | 2004-12-08 | 2008-09-25 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | 部分的ドーパミン−d2受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体 |
DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
KR100589877B1 (ko) * | 2005-12-20 | 2006-06-19 | 주식회사 픽슨이앤씨 | 파형강판 구조물의 보강라이너 설치용 거푸집 |
RU2494108C2 (ru) | 2006-04-07 | 2013-09-27 | Аерпио Терапетикс, Инк. | Антитела, которые связывают человеческий белок бета-тирозин фосфатазу (нртрвета), и их использование |
US8846685B2 (en) | 2006-06-27 | 2014-09-30 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
US7589212B2 (en) * | 2006-06-27 | 2009-09-15 | Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
US7795444B2 (en) * | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
US9096555B2 (en) | 2009-01-12 | 2015-08-04 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome |
US8367676B2 (en) | 2009-06-30 | 2013-02-05 | Astrazeneca Ab | 2-carboxamide-7-piperazinyl-benzofuran derivatives 774 |
MX2011007420A (es) | 2009-07-06 | 2011-12-14 | Akebia Therapeutics Inc | Compuestos, composiciones y metodos para prevenir la metastasis de las celulas cancerigenas. |
EP2655365B1 (en) | 2010-12-20 | 2015-12-16 | Acturum Life Science AB | 2-carboxamide-4-piperazinyl-benzofuran derivative |
CN104337812B (zh) | 2013-07-29 | 2018-09-14 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其使用方法和用途 |
CN104725363B (zh) * | 2013-12-20 | 2019-03-01 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
CN106243088B (zh) * | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
TWI707683B (zh) | 2018-06-13 | 2020-10-21 | 美商輝瑞股份有限公司 | Glp-1受體促效劑及其用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
FR2670491B1 (fr) * | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
RU2118322C1 (ru) * | 1993-07-05 | 1998-08-27 | Дюфар Интернэшнл Рисерч Б.В. | 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли |
-
2000
- 2000-01-17 AR ARP000100197A patent/AR022303A1/es not_active Application Discontinuation
- 2000-01-21 MX MXPA01007226A patent/MXPA01007226A/es not_active Application Discontinuation
- 2000-01-21 KR KR1020017009122A patent/KR20010101606A/ko not_active Application Discontinuation
- 2000-01-21 AU AU22781/00A patent/AU767377B2/en not_active Ceased
- 2000-01-21 CA CA002361059A patent/CA2361059A1/en not_active Abandoned
- 2000-01-21 SK SK1030-2001A patent/SK10302001A3/sk unknown
- 2000-01-21 CN CN00805148A patent/CN1344265A/zh active Pending
- 2000-01-21 NZ NZ512732A patent/NZ512732A/en unknown
- 2000-01-21 TR TR2001/02089T patent/TR200102089T2/xx unknown
- 2000-01-21 AT AT00901481T patent/ATE263763T1/de not_active IP Right Cessation
- 2000-01-21 EA EA200100798A patent/EA200100798A1/ru unknown
- 2000-01-21 EP EP00901481A patent/EP1149087B1/en not_active Expired - Lifetime
- 2000-01-21 IL IL14411300A patent/IL144113A0/xx unknown
- 2000-01-21 WO PCT/DK2000/000026 patent/WO2000043382A1/en not_active Application Discontinuation
- 2000-01-21 JP JP2000594798A patent/JP2002535322A/ja not_active Withdrawn
- 2000-01-21 HU HU0105065A patent/HUP0105065A3/hu unknown
- 2000-01-21 PL PL00349909A patent/PL349909A1/xx not_active Application Discontinuation
- 2000-01-21 BR BR0009007-7A patent/BR0009007A/pt not_active IP Right Cessation
- 2000-01-21 DE DE60009663T patent/DE60009663T2/de not_active Expired - Fee Related
- 2000-01-21 CZ CZ20012657A patent/CZ20012657A3/cs unknown
-
2001
- 2001-06-28 IS IS5983A patent/IS5983A/is unknown
- 2001-07-05 ZA ZA200105548A patent/ZA200105548B/en unknown
- 2001-07-09 US US09/901,585 patent/US6596722B2/en not_active Expired - Fee Related
- 2001-07-17 NO NO20013538A patent/NO20013538L/no not_active Application Discontinuation
- 2001-08-03 BG BG105781A patent/BG105781A/xx unknown
-
2002
- 2002-05-16 US US10/147,950 patent/US20020173512A1/en not_active Abandoned
- 2002-09-20 HK HK02106884.4A patent/HK1045505A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
SK10302001A3 (sk) | 2002-01-07 |
KR20010101606A (ko) | 2001-11-14 |
NO20013538L (no) | 2001-09-17 |
ZA200105548B (en) | 2002-07-05 |
DE60009663D1 (de) | 2004-05-13 |
CN1344265A (zh) | 2002-04-10 |
JP2002535322A (ja) | 2002-10-22 |
HUP0105065A3 (en) | 2003-06-30 |
NO20013538D0 (no) | 2001-07-17 |
NZ512732A (en) | 2003-10-31 |
BG105781A (en) | 2002-05-31 |
EP1149087B1 (en) | 2004-04-07 |
MXPA01007226A (es) | 2002-04-24 |
BR0009007A (pt) | 2001-11-27 |
AR022303A1 (es) | 2002-09-04 |
EP1149087A1 (en) | 2001-10-31 |
CA2361059A1 (en) | 2000-07-27 |
TR200102089T2 (tr) | 2002-07-22 |
US6596722B2 (en) | 2003-07-22 |
US20020035113A1 (en) | 2002-03-21 |
DE60009663T2 (de) | 2005-04-14 |
PL349909A1 (en) | 2002-10-07 |
AU2278100A (en) | 2000-08-07 |
WO2000043382A1 (en) | 2000-07-27 |
IS5983A (is) | 2001-06-28 |
HUP0105065A2 (hu) | 2002-07-29 |
AU767377B2 (en) | 2003-11-06 |
IL144113A0 (en) | 2002-05-23 |
US20020173512A1 (en) | 2002-11-21 |
CZ20012657A3 (cs) | 2002-02-13 |
ATE263763T1 (de) | 2004-04-15 |
HK1045505A1 (zh) | 2002-11-29 |
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