CY1111363T1 - Τρικυκλικος ανταγωνιστης υποδοχεων θρομβινης - Google Patents

Τρικυκλικος ανταγωνιστης υποδοχεων θρομβινης

Info

Publication number
CY1111363T1
CY1111363T1 CY20111100338T CY111100338T CY1111363T1 CY 1111363 T1 CY1111363 T1 CY 1111363T1 CY 20111100338 T CY20111100338 T CY 20111100338T CY 111100338 T CY111100338 T CY 111100338T CY 1111363 T1 CY1111363 T1 CY 1111363T1
Authority
CY
Cyprus
Prior art keywords
thromvin
tricycle
competitor
receptors
thrombosis
Prior art date
Application number
CY20111100338T
Other languages
English (en)
Inventor
Samuel Chackalamannil
William J Greenlee
Yuguang Wang
Yan Xia
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29250954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111363(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of CY1111363T1 publication Critical patent/CY1111363T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Το όξινο θειικό άλας της ένωσης: και η χρήση του για τη θεραπεία της θρόμβωσης, της αθηροσκλήρωσης, της επαναστένωσης, της υπέρτασης, της στηθάγχης, της αρρυθμίας, της καρδιακής ανεπάρκειας, του μυοκαρδιακού εμφράγματος, της σπειραματονεφρίτιδας, του θρομβωτικού εγκεφαλικού επεισοδίου, του θρομβοεμβολικού εγκεφαλικού επεισοδίου, των περιφερικών αγγειακών ασθενειών, των φλεγμονωδών διαταραχών, της εγκεφαλικής ισχαιμίας ή του καρκίνου.
CY20111100338T 2002-04-16 2011-03-30 Τρικυκλικος ανταγωνιστης υποδοχεων θρομβινης CY1111363T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37307202P 2002-04-16 2002-04-16
EP09150995A EP2065384B1 (en) 2002-04-16 2003-04-14 Tricyclic thrombin receptor antagonist

Publications (1)

Publication Number Publication Date
CY1111363T1 true CY1111363T1 (el) 2015-08-05

Family

ID=29250954

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20081100152T CY1107184T1 (el) 2002-04-16 2008-02-07 Τρικυκλικοι ανταγωνιστες υποδοχεα θρομβινης
CY20111100338T CY1111363T1 (el) 2002-04-16 2011-03-30 Τρικυκλικος ανταγωνιστης υποδοχεων θρομβινης
CY2015029C CY2015029I1 (el) 2002-04-16 2015-07-10 Τρικυκλικοι ανταγωνιστες υποδοχεα θρομβινης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20081100152T CY1107184T1 (el) 2002-04-16 2008-02-07 Τρικυκλικοι ανταγωνιστες υποδοχεα θρομβινης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2015029C CY2015029I1 (el) 2002-04-16 2015-07-10 Τρικυκλικοι ανταγωνιστες υποδοχεα θρομβινης

Country Status (34)

Country Link
US (3) US7304078B2 (el)
EP (5) EP1860106B1 (el)
JP (2) JP4558331B2 (el)
KR (1) KR101026929B1 (el)
CN (1) CN1659162B (el)
AR (1) AR039570A1 (el)
AT (3) ATE378330T1 (el)
AU (1) AU2003221932B2 (el)
BR (1) BRPI0309309B8 (el)
CA (1) CA2482858C (el)
CY (3) CY1107184T1 (el)
DE (3) DE60331114D1 (el)
DK (2) DK1495018T3 (el)
EC (1) ECSP045368A (el)
ES (3) ES2357876T3 (el)
FR (1) FR15C0047I2 (el)
HK (3) HK1070887A1 (el)
IL (1) IL164585A (el)
LT (1) LTC1495018I2 (el)
LU (1) LU92759I2 (el)
MX (1) MXPA04010308A (el)
MY (1) MY144040A (el)
NL (1) NL300746I2 (el)
NO (2) NO330500B1 (el)
NZ (2) NZ535880A (el)
PE (1) PE20040412A1 (el)
PL (1) PL214718B1 (el)
PT (2) PT1495018E (el)
RU (2) RU2329264C9 (el)
SG (1) SG164279A1 (el)
SI (2) SI1495018T1 (el)
TW (1) TWI343919B (el)
WO (1) WO2003089428A1 (el)
ZA (1) ZA200408342B (el)

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Also Published As

Publication number Publication date
PL214718B1 (pl) 2013-09-30
LU92759I2 (en) 2015-08-31
CY2015029I2 (el) 2016-04-13
EP1495018B3 (en) 2011-03-16
KR20040099441A (ko) 2004-11-26
EP1982984A3 (en) 2008-10-29
NO2015016I1 (no) 2015-07-20
CA2482858A1 (en) 2003-10-30
EP1982984B1 (en) 2013-02-13
TW200404068A (en) 2004-03-16
ATE378330T1 (de) 2007-11-15
JP2010132710A (ja) 2010-06-17
NO2015016I2 (no) 2015-07-09
BRPI0309309B1 (pt) 2018-09-04
ZA200408342B (en) 2006-05-31
NL300746I1 (el) 2016-01-21
EP2065384A1 (en) 2009-06-03
ES2357876T3 (es) 2011-05-03
CY1107184T1 (el) 2012-10-24
EP2062890B1 (en) 2011-01-05
RU2004133375A (ru) 2005-07-10
NZ535880A (en) 2007-11-30
DE60331114D1 (de) 2010-03-11
IL164585A0 (en) 2005-12-18
IL164585A (en) 2010-11-30
CA2482858C (en) 2010-11-30
NZ575139A (en) 2010-08-27
CN1659162A (zh) 2005-08-24
EP1860106A1 (en) 2007-11-28
DK2065384T3 (da) 2011-05-02
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