PL178314B1 - Benzamidy podstawione grupą fluoroalkoksylową, hamujące fosfodiesterazę cyklicznych nukleotydów, sposób ich otrzymywania i lek zawierający podstawione benzamidy - Google Patents
Benzamidy podstawione grupą fluoroalkoksylową, hamujące fosfodiesterazę cyklicznych nukleotydów, sposób ich otrzymywania i lek zawierający podstawione benzamidyInfo
- Publication number
- PL178314B1 PL178314B1 PL94311820A PL31182094A PL178314B1 PL 178314 B1 PL178314 B1 PL 178314B1 PL 94311820 A PL94311820 A PL 94311820A PL 31182094 A PL31182094 A PL 31182094A PL 178314 B1 PL178314 B1 PL 178314B1
- Authority
- PL
- Poland
- Prior art keywords
- salts
- halogen atom
- hydrogen atom
- alkyl group
- halogen
- Prior art date
Links
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- 150000003936 benzamides Chemical class 0.000 title claims abstract description 10
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 30
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims abstract description 13
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 13
- 150000002367 halogens Chemical class 0.000 claims abstract description 13
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims abstract description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 9
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 8
- 239000001257 hydrogen Substances 0.000 claims abstract description 5
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH199693 | 1993-07-02 | ||
PCT/EP1994/002169 WO1995001338A1 (de) | 1993-07-02 | 1994-07-02 | Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren |
Publications (2)
Publication Number | Publication Date |
---|---|
PL311820A1 PL311820A1 (en) | 1996-03-18 |
PL178314B1 true PL178314B1 (pl) | 2000-04-28 |
Family
ID=4223466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL94311820A PL178314B1 (pl) | 1993-07-02 | 1994-07-02 | Benzamidy podstawione grupą fluoroalkoksylową, hamujące fosfodiesterazę cyklicznych nukleotydów, sposób ich otrzymywania i lek zawierający podstawione benzamidy |
Country Status (28)
Cited By (3)
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US8431154B2 (en) | 2002-02-20 | 2013-04-30 | Takeda Gmbh | Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidone as excipient |
US8536206B2 (en) | 2003-03-08 | 2013-09-17 | Takeda Gmbh | Process for the preparation of roflumilast |
US8663694B2 (en) | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
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US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
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AU3284000A (en) | 1999-03-10 | 2000-09-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid- 4-yl)benzamide in the treatment of multiple sclerosis |
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SI1212089T1 (sl) * | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Sinergisticna kombinacija roflumilasta in salmeterola |
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- 1994-07-02 US US08/564,322 patent/US5712298A/en not_active Expired - Lifetime
- 1994-07-02 DE DE59410119T patent/DE59410119D1/de not_active Expired - Lifetime
- 1994-07-02 SK SK1617-95A patent/SK283263B6/sk not_active IP Right Cessation
- 1994-07-02 AT AT94924713T patent/ATE217612T1/de active
- 1994-07-02 CN CN94192659A patent/CN1046939C/zh not_active Expired - Lifetime
- 1994-07-02 WO PCT/EP1994/002169 patent/WO1995001338A1/de active IP Right Grant
- 1994-07-02 JP JP07503287A patent/JP3093271B2/ja not_active Expired - Lifetime
- 1994-07-02 CZ CZ19961A patent/CZ290266B6/cs not_active IP Right Cessation
- 1994-07-02 SI SI9430420T patent/SI0706513T1/xx unknown
- 1994-07-02 RU RU96102569A patent/RU2137754C1/ru active Protection Beyond IP Right Term
- 1994-07-02 DK DK94924713T patent/DK0706513T3/da active
- 1994-07-02 KR KR1019950705937A patent/KR100331255B1/ko not_active IP Right Cessation
- 1994-07-02 EP EP94924713A patent/EP0706513B1/de not_active Expired - Lifetime
- 1994-07-02 PT PT94924713T patent/PT706513E/pt unknown
- 1994-07-02 HU HU9503541A patent/HU220041B/hu active Protection Beyond IP Right Term
- 1994-07-02 SG SG9605206-3A patent/SG143011A1/en unknown
- 1994-07-02 AU AU74907/94A patent/AU687087B2/en not_active Expired
- 1994-07-02 ES ES94924713T patent/ES2176252T3/es not_active Expired - Lifetime
- 1994-07-02 PL PL94311820A patent/PL178314B1/pl unknown
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- 1994-07-02 NZ NZ271316A patent/NZ271316A/en not_active IP Right Cessation
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1995
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- 1995-12-29 FI FI956333A patent/FI112864B/fi not_active IP Right Cessation
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1998
- 1998-12-08 HK HK98112932A patent/HK1011690A1/xx not_active IP Right Cessation
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2003
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2010
- 2010-07-21 LU LU91709C patent/LU91709I2/fr unknown
- 2010-09-29 CY CY2010015C patent/CY2010015I2/el unknown
- 2010-09-30 NO NO2010018C patent/NO2010018I1/no unknown
- 2010-12-06 FR FR10C0052C patent/FR10C0052I2/fr active Active
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8431154B2 (en) | 2002-02-20 | 2013-04-30 | Takeda Gmbh | Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidone as excipient |
US9468598B2 (en) | 2002-02-20 | 2016-10-18 | Astrazeneca Ab | Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidon as excipient |
US8536206B2 (en) | 2003-03-08 | 2013-09-17 | Takeda Gmbh | Process for the preparation of roflumilast |
US8604064B2 (en) | 2003-03-10 | 2013-12-10 | Takeda Gmbh | Process for the preparation of roflumilast |
US8618142B2 (en) | 2003-03-10 | 2013-12-31 | Takeda Gmbh | Process for the preparation of roflumilast |
US8663694B2 (en) | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
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