ME01648B - Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4,kao što je roflumilast, roflumilast-n-oksid za liječenje inflamatornih plućnih oboljenja - Google Patents

Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4,kao što je roflumilast, roflumilast-n-oksid za liječenje inflamatornih plućnih oboljenja

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Publication number
ME01648B
ME01648B MEP-2014-9A MEP914A ME01648B ME 01648 B ME01648 B ME 01648B ME P914 A MEP914 A ME P914A ME 01648 B ME01648 B ME 01648B
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ME
Montenegro
Prior art keywords
roflumilast
hmg
coa reductase
pharmaceutically acceptable
inhibitor
Prior art date
Application number
MEP-2014-9A
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English (en)
French (fr)
Inventor
Stefan-Lutz Wollin
Degenhard Marx
Andrea Wohlsen
Clemens Braun
Original Assignee
Nycomed Gmbh
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Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of ME01648B publication Critical patent/ME01648B/me

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Claims (34)

1.Farmaceutska kompozicija koja sadrži farmaceutsku formulaciju koja uključuje količinu PDE4 inhibitora, količinu inhibitora HMG-CoA reduktaze i bar jednu farmaceutsku prihvatljivu pomoćnu supstancu, gde je PDE4 inhibitor odabran iz grupe koja se sastoji od ROFLUMILASTA, farmaceutske prihvatljive soli ROFLUMILASTA, ROFLUMILAST-N-oksida i farmaceutske prihvatljive soli ROFLUMILAST-N-oksida, inhibitor HMG-CoA reduktaze je ROSUVASTATIN ili njegova farmaceutski prihvatljiva so, gde prva količina i druga količina zajedno obuhvataju efikasnu količinu za preventivni ili lekoviti tretman inflamatornog plućnog obolenja.
2.Kombinovani proizvod koji sadrži komponente: (A) količinu PDE4 inhibitora; (B) količinu inhibitora HMG-CoA reduktaze; pri čemu prva i druga količina zajedno obuhvataju efikasnu količinu za preventivno ili lekovito lečenje inflamatornog plućnog obolenja, pri čemu je svaka od komponenti (A) i (B) formulisana u smeši sa bar jednom farmaceutskom prihvatljivom pomoćnom supstancom, i gde je PDE4 inhibitor odabran iz grupe koja se sastoji od ROFLUMILASTA, farmaceutski prihvatljive soli ROFLUMILASTA, ROFLUMILAST-N-oksida i farmaceutske prihvatljive soli ROFLUMILAST-N-oksida, a inhibitor HMG-CoA reduktaze je ROSUVASTATIN ili njegova farmaceutski prihvatljiva so.
3.Oprema koja sadrži komponente: (A) farmaceutsku formulaciju koja obuhvata količinu PDE4 inhibitora, u smeši sa bar jednom farmaceutski prihvatljivom pomoćnom supstancom; (B) farmaceutsku formulaciju koja obuhvata količinu inhibitora HMG-CoA reduktaze, u smeši sa bar jednom farmaceutski prihvatljivom pomoćnom supstancom; gde prva i druga količina zajedno obuhvataju efikasnu količinu za preventivno ili lekovito lečenje inflamatornog plućnog obolenja, i gde je PDE4 inhibitor odabran iz grupe koja se sastoji od ROFLUMILASTA, farmaceutski prihvatljive soli ROFLUMILASTA, ROFLUMILAST-N-oksida i farmaceutske prihvatljive soli ROFLUMILAST-N-oksida, a inhibitor HMG-CoA reduktaze je ROSUVASTATIN ili njegova farmaceutski prihvatljiva so.
4.Farmaceutska kompozicija prema zahtevu 1, gde PDE 4 inhibitor je ROFLUMILAST.
5.Farmaceutska kompozicija prema zahtevu 1, gde PDE4 inhibitor je ROFLUMILAST- N- oksid.
6.Farmaceutska kompozicija prema bilo kom od zahteva 1, 4 ili 5, gde inhibitor HMG-CoA reduktazeje ROSUVASTATIN hemi-kalcijum.
7.Farmaceutska kompozicija prema bilo kom od zahteva 1, 4 ili 5, gde inhibitor HMG-CoA reduktazeje ROSUVASTATIN natrijum.
8.Farmaceutska kompozicija prema bilo kom od zahteva 1, 4 ili 5, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN.
9. Kombinovani proizvod prema zahtevu 2, gde PDE4 inhibitor je ROFLUMILAST.
10. Kombinovani proizvod prema zahtevu 2, gde PDE4 inhibitor je ROFLUMILAST-N-oksid.
11.Kombinovani proizvod prema bilo kom od zahteva 2, 9 ili 10, gde inhibitor HMG-CoA reduktazeje ROSUVASTATIN hemi-kalcijum.
12.Kombinovani proizvod prema bilo kom od zahteva 2, 9 ili 10, gde inhibitor HMG-CoA reduktazeje ROSUVASTATIN natrijum.
13.Kombinovani proizvod prema bilo kom od zahteva 2, 9 ili 10, gde inhibitor HMG-CoA reduktazeje ROSUVASTATIN.
14.Oprema prema zahtevu 3, gde PDE4 inhibitor je Roflumilast.
15.Oprema prema zahtevu 3, gde PDE4 inhibitor je ROFLUMILAST-N-oksid.
16.Oprema prema bilo kom od zahteva 3, 14 ili 15, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN hemi-kalcijum.
17.Oprema prema bilo kom od zahteva 3, 14 ili 15, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN natrijum.
18.Oprema prema bilo kom od zahteva 3, 14 ili 15, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN.
19.Farmaceutska kompozicija prema bilo kom od zahteva 1, 4, 5, 6, 7 ili 8, gde je inflamatorno plućno obolenje odabrano iz grupe koja se sastoji od astme, COPD, skleroze, alveolitisa, sarkoidoze, idiopatične pulmonarne fibroze i pulmonarne hipertenzije.
20.Farmaceutska kompozicija prema bilo kom od zahteva 1, 4, 5, 6, 7 ili 8, pri čemu je inflamatorno plućno obolenje COPD.
21.Kombinovani proizvod prema bilo kom od zahteva 2, 9, 10, 11, 12 ili 13, gde je inflamatorno plućno obolenje odabrano iz grupe koja se sastoji od astme, COPD, skleroze, alveolitisa, sarkoidoze, idiopatične pulmonarne fibroze i pulmonarne hipertenzije.
22.Kombinovani proizvod prema bilo kom od zahteva 2, 9, 10, 11, 12 ili 13, gde je inflamatorno plućno obolenje COPD.
23.Oprema prema bilo kom od zahteva 3, 14, 15, 16, 17 ili 18, gde je inflamatorno plućno obolenje odabrano iz grupe koja se sastoji od astme, COPD, skleroze, alveolitisa, sarkoidoze, idiopatične pulmonarne fibroze i pulmonarne hipertenzije.
24.Oprema prema bilo kom od zahteva 3, 14, 15, 16, 17 ili 18, gde je inflamatorno plućno obolenje COPD.
25.Primena PDE4 inhibitora i inhibitora HMG-CoA reduktaze za proizvodnju medikamenta, prvenstveno farmaceutske kompozicije prema pronalasku, za preventivnu ili lekovitu terapiju inflamatornog plućnog obolenja, pri čemu je PDE4 inhibitor odabran iz grupe koja se sastoji od ROFLUMILASTA, farmaceutski prihvatljive soli ROFLUMILASTA, ROFLUMILAST-N- oksida i farmaceutske prihvatljive soli ROFLUMILAST-N-oksida, a inhibitor HMG-CoA reduktaze je ROSUVASTATIN ili njegova farmaceutski prihvatljiva so.
26.Primena PDE4 inhibitora i inhibitora HMG-CoA reduktaze za proizvodnju uzastopnog ili odvojenog medikamenta za istovremenu primenu, prvenstveno kombinovanog proizvoda ili opreme prema pronalasku, za preventivnu ili lekovitu terapiju inflamatornog plućnog obolenja, pri čemu je PDE4 inhibitor odabran iz grupe koja se sastoji od ROFLUMILASTA, farmaceutski prihvatljive soli ROFLUMILASTA, ROFLUMILAST-N-oksida i farmaceutske prihvatljive soli ROFLUMILAST-N-oksida, a inhibitor HMG-CoA reduktaze je ROSUVASTATIN ili njegova farmaceutski prihvatljiva so.
27.Primena prema bilo kom od zahteva 25 ili 26, gde PDE4 inhibitor je ROFLUMILAST.
28.Primena prema bilo kom od zahteva 25 ili 26, gde PDE4 inhibitor je ROFLUMILAST-N- oksid.
29.Primena prema bilo kom od zahteva 25, 26, 27 ili 28, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN hemi-kalcijum.
30.Primena prema bilo kom od zahteva 25, 26, 27 ili 28, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN natrijum.
31.Primena prema bilo kom od zahteva 25, 26, 27 ili 28, gde inhibitor HMG-CoA reduktaze je ROSUVASTATIN.
32.Primena prema bilo kom od zahteva 25 do 31, gde je inflamatorno plućno obolenje odabrano iz grupe koja se sastoji od astme, COPD, skleroze, alveolitisa, sarkoidoze, idiopatične pulmonarne fibroze i pulmonarne hipertenzije.
33.Primena prema bilo kom od zahteva 25 do 31, gde je inflamatorno plućno obolenje COPD.
34.Postupak za pripremanje farmaceutske kompozicije kao što je definisano u bilo kom od zahteva 1, 4, 5, 6, 7, 8, 19 ili 20, koji obuhvata mešanje PDE4 inhibitora ili njegove farmaceutski prihvatljive soli sa inhibitorom HMG-CoA reduktaze ili njegovom farmaceutski prihvatljivom soli.
MEP-2014-9A 2006-07-05 2007-07-03 Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4,kao što je roflumilast, roflumilast-n-oksid za liječenje inflamatornih plućnih oboljenja ME01648B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06116625 2006-07-05
PCT/EP2007/056683 WO2008003701A2 (en) 2006-07-05 2007-07-03 Combination of hmg-coa reductase inhibitors with phosphodiesterase 4 inhibitors for the treatment of inflammatory pulmonary diseases
EP11164516.4A EP2359826B1 (en) 2006-07-05 2007-07-03 Combination of HMG-COA reductase inhibitor rosuvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast, roflumilast-N-oxide for the treatment of inflammatory pulmonary diseases

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ME01648B true ME01648B (me) 2014-09-20

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