WO2009049648A3 - Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof - Google Patents

Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof Download PDF

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Publication number
WO2009049648A3
WO2009049648A3 PCT/EP2007/008998 EP2007008998W WO2009049648A3 WO 2009049648 A3 WO2009049648 A3 WO 2009049648A3 EP 2007008998 W EP2007008998 W EP 2007008998W WO 2009049648 A3 WO2009049648 A3 WO 2009049648A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
antiviral agent
pharmaceutical composition
composition containing
improved pharmaceutical
Prior art date
Application number
PCT/EP2007/008998
Other languages
French (fr)
Other versions
WO2009049648A2 (en
Inventor
Evangelos Karavas
Efthimios Koutris
Dimitrios Bikiaris
Vicky Samara
Anastasia Kalaskani
Eleni Stathaki
Original Assignee
Pharmathen S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathen S.A. filed Critical Pharmathen S.A.
Priority to EP07819066A priority Critical patent/EP2197424A2/en
Priority to PCT/EP2007/008998 priority patent/WO2009049648A2/en
Publication of WO2009049648A2 publication Critical patent/WO2009049648A2/en
Publication of WO2009049648A3 publication Critical patent/WO2009049648A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a pharmaceutical formulation of solid dosage forms comprising a therapeutically effective amount of an antiviral agent, and in particular Valaciclovir or a pharmaceutical acceptable salt or derivative thereof, in combination with an effective diluent, such as Dibasic Calcium Phosphate Dihydrate, and a process for the preparation thereof by wet granulation.
PCT/EP2007/008998 2007-10-17 2007-10-17 Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof WO2009049648A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07819066A EP2197424A2 (en) 2007-10-17 2007-10-17 Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof
PCT/EP2007/008998 WO2009049648A2 (en) 2007-10-17 2007-10-17 Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/008998 WO2009049648A2 (en) 2007-10-17 2007-10-17 Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof

Publications (2)

Publication Number Publication Date
WO2009049648A2 WO2009049648A2 (en) 2009-04-23
WO2009049648A3 true WO2009049648A3 (en) 2009-10-01

Family

ID=38699942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/008998 WO2009049648A2 (en) 2007-10-17 2007-10-17 Improved pharmaceutical composition containing antiviral agent and method for the preparation thereof

Country Status (2)

Country Link
EP (1) EP2197424A2 (en)
WO (1) WO2009049648A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2165706A1 (en) 2008-09-18 2010-03-24 BioAlliance Pharma Treating Inflammatory Pain in Mucosa of the Oral Cavity Using Mucosal Prolonged Release Bioadhesive Therapeutic Carriers.
EP2335690A1 (en) * 2009-12-09 2011-06-22 BioAlliance Pharma Mucoadhesive buccal tablets for the treatment of orofacial herpes
WO2011070125A1 (en) * 2009-12-09 2011-06-16 Bioalliance Pharma Mucoadhesive buccal tablets for the treatment of orofacial herpes
US8592434B2 (en) 2009-12-09 2013-11-26 Bioalliance Pharma Sa Mucoadhesive buccal tablets for the treatment of orofacial herpes
LT3169311T (en) * 2014-07-17 2023-10-25 Pharmathen S.A. Pediatric powder for oral suspension containing antiviral agent and method for the preparation thereof
US20170202844A1 (en) * 2014-07-31 2017-07-20 Pharmathen S.A. Pediatric chewable tablet containing antiviral agent and method for the preparation thereof

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001062229A1 (en) * 2000-02-24 2001-08-30 Advanced Pharma, Inc. Therapeutic product, use and formulation thereof
US20030099706A1 (en) * 2000-10-13 2003-05-29 Rudnic Edward M. Antiviral product, use and formulation thereof
US20030133982A1 (en) * 2001-12-20 2003-07-17 Heimlich John M. Zero-order sustained release dosage forms and method of making same
WO2004000265A2 (en) * 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
WO2004037263A1 (en) * 2002-10-22 2004-05-06 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
US20040234608A1 (en) * 2000-06-23 2004-11-25 Moshe Fleshner-Barak Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US20050192296A1 (en) * 2004-01-21 2005-09-01 Zvi Harel Process for the preparation of valacyclovir hydrochloride
US20050249799A1 (en) * 2004-03-03 2005-11-10 Spherics, Inc. Polymeric drug delivery system for hydrophobic drugs
WO2006011874A1 (en) * 2004-06-30 2006-02-02 Teva Pharmaceutical Industries, Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
WO2006039022A2 (en) * 2004-08-27 2006-04-13 Spherics, Inc. Controlled regional oral delivery
WO2006117803A2 (en) * 2005-03-14 2006-11-09 Devarajan, Padma, Venkitachalam Transmucosal drug delivery systems
WO2007079082A2 (en) * 2005-12-30 2007-07-12 Advancis Pharmaceutical Corporation Gastric release pulse system for drug delivery
WO2007090595A1 (en) * 2006-02-06 2007-08-16 Fidia Pharmaceutici S.P.A. Solid formulations of valacyclovir hydrochloride

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001062229A1 (en) * 2000-02-24 2001-08-30 Advanced Pharma, Inc. Therapeutic product, use and formulation thereof
US20040234608A1 (en) * 2000-06-23 2004-11-25 Moshe Fleshner-Barak Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US20030099706A1 (en) * 2000-10-13 2003-05-29 Rudnic Edward M. Antiviral product, use and formulation thereof
US20030133982A1 (en) * 2001-12-20 2003-07-17 Heimlich John M. Zero-order sustained release dosage forms and method of making same
WO2004000265A2 (en) * 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
WO2004037263A1 (en) * 2002-10-22 2004-05-06 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
US20050192296A1 (en) * 2004-01-21 2005-09-01 Zvi Harel Process for the preparation of valacyclovir hydrochloride
US20050249799A1 (en) * 2004-03-03 2005-11-10 Spherics, Inc. Polymeric drug delivery system for hydrophobic drugs
WO2006011874A1 (en) * 2004-06-30 2006-02-02 Teva Pharmaceutical Industries, Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
WO2006039022A2 (en) * 2004-08-27 2006-04-13 Spherics, Inc. Controlled regional oral delivery
WO2006117803A2 (en) * 2005-03-14 2006-11-09 Devarajan, Padma, Venkitachalam Transmucosal drug delivery systems
WO2007079082A2 (en) * 2005-12-30 2007-07-12 Advancis Pharmaceutical Corporation Gastric release pulse system for drug delivery
WO2007090595A1 (en) * 2006-02-06 2007-08-16 Fidia Pharmaceutici S.P.A. Solid formulations of valacyclovir hydrochloride

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LAUSIER, J.M. ET AL: "Aging of tablets made with Use of dibasic calcium phosphate dihydrate as matrix", J. PHARM. SCI., vol. 66, no. 11, 1997, XP002460262 *

Also Published As

Publication number Publication date
EP2197424A2 (en) 2010-06-23
WO2009049648A2 (en) 2009-04-23

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