CY1115462T1 - ΣΥΝΔΥΑΣΜΟΣ ΑΝΑΣΤΟΛΕΩΝ ΗΜG-CoΑ ΑΝΑΓΩΓΑΣΗΣ ΑΤΟΡΒΑΣΤΑΤΙΝΗΣ Ή ΣYΜΒΑΣΤΑΤΙΝΗΣ ΜΕ ΑΝΑΣΤΟΛΕΑ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ 4 ΟΠΩΣ ΡΟΦΛΟΥΜΙΛΑΣΤΗ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΦΛΕΓΜΟΝΩΔΩΝ ΠΝΕΥΜΟΝΙΚΩΝ ΑΣΘΕΝΕΙΩΝ - Google Patents

ΣΥΝΔΥΑΣΜΟΣ ΑΝΑΣΤΟΛΕΩΝ ΗΜG-CoΑ ΑΝΑΓΩΓΑΣΗΣ ΑΤΟΡΒΑΣΤΑΤΙΝΗΣ Ή ΣYΜΒΑΣΤΑΤΙΝΗΣ ΜΕ ΑΝΑΣΤΟΛΕΑ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ 4 ΟΠΩΣ ΡΟΦΛΟΥΜΙΛΑΣΤΗ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΦΛΕΓΜΟΝΩΔΩΝ ΠΝΕΥΜΟΝΙΚΩΝ ΑΣΘΕΝΕΙΩΝ

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Publication number
CY1115462T1
CY1115462T1 CY20141100621T CY141100621T CY1115462T1 CY 1115462 T1 CY1115462 T1 CY 1115462T1 CY 20141100621 T CY20141100621 T CY 20141100621T CY 141100621 T CY141100621 T CY 141100621T CY 1115462 T1 CY1115462 T1 CY 1115462T1
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CY
Cyprus
Prior art keywords
coa
roflionimon
atomvastatin
anastoleis
hgg
Prior art date
Application number
CY20141100621T
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English (en)
Inventor
Stefan-Lutz Wollin
Andrea Wohlsen
Clemens Braun
Degenhard Marx
Original Assignee
Takeda Gmbh
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Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of CY1115462T1 publication Critical patent/CY1115462T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αφορά στην συνδυασμένη χρήση ενός αναστολέα ΡDΕ4 με έναν αναστολέα ΗΜG-CoΑ αναγωγάσης για την προληπτική και θεραπευτική αγωγή μιας φλεγμονώδους πνευμονικής ασθένειας.
CY20141100621T 2006-07-05 2014-08-07 ΣΥΝΔΥΑΣΜΟΣ ΑΝΑΣΤΟΛΕΩΝ ΗΜG-CoΑ ΑΝΑΓΩΓΑΣΗΣ ΑΤΟΡΒΑΣΤΑΤΙΝΗΣ Ή ΣYΜΒΑΣΤΑΤΙΝΗΣ ΜΕ ΑΝΑΣΤΟΛΕΑ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ 4 ΟΠΩΣ ΡΟΦΛΟΥΜΙΛΑΣΤΗ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΦΛΕΓΜΟΝΩΔΩΝ ΠΝΕΥΜΟΝΙΚΩΝ ΑΣΘΕΝΕΙΩΝ CY1115462T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116625 2006-07-05
EP11164518.0A EP2363130B1 (en) 2006-07-05 2007-07-03 Combination of HMG-CoA reductase inhibitors atorvastatin or simvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast for the treatment of inflammatory pulmonary diseases

Publications (1)

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CY1115462T1 true CY1115462T1 (el) 2017-01-04

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ID=37311957

Family Applications (2)

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CY20141100008T CY1114742T1 (el) 2006-07-05 2014-01-07 Συνδυασμος του αναστολεα αναγωγασης ημg-coa ροζουβαστατινης με αναστολεα φωσφοδιεστερασης 4, οπως η ροφλουμιλαστη, ν-οξειδιο ροφλουμιλαστης για τη θεραπεια φλεγμονωδων πνευμονικων νοσων
CY20141100621T CY1115462T1 (el) 2006-07-05 2014-08-07 ΣΥΝΔΥΑΣΜΟΣ ΑΝΑΣΤΟΛΕΩΝ ΗΜG-CoΑ ΑΝΑΓΩΓΑΣΗΣ ΑΤΟΡΒΑΣΤΑΤΙΝΗΣ Ή ΣYΜΒΑΣΤΑΤΙΝΗΣ ΜΕ ΑΝΑΣΤΟΛΕΑ ΦΩΣΦΟΔΙΕΣΤΕΡΑΣΗΣ 4 ΟΠΩΣ ΡΟΦΛΟΥΜΙΛΑΣΤΗ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΦΛΕΓΜΟΝΩΔΩΝ ΠΝΕΥΜΟΝΙΚΩΝ ΑΣΘΕΝΕΙΩΝ

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CY20141100008T CY1114742T1 (el) 2006-07-05 2014-01-07 Συνδυασμος του αναστολεα αναγωγασης ημg-coa ροζουβαστατινης με αναστολεα φωσφοδιεστερασης 4, οπως η ροφλουμιλαστη, ν-οξειδιο ροφλουμιλαστης για τη θεραπεια φλεγμονωδων πνευμονικων νοσων

Country Status (26)

Country Link
US (2) US20100069392A1 (el)
EP (3) EP2040707B1 (el)
JP (3) JP5349302B2 (el)
KR (1) KR101433394B1 (el)
CN (3) CN101484166B (el)
AT (1) ATE535244T1 (el)
AU (1) AU2007271186C1 (el)
BR (1) BRPI0713768A2 (el)
CA (1) CA2656366A1 (el)
CY (2) CY1114742T1 (el)
DK (2) DK2359826T3 (el)
EA (2) EA032476B1 (el)
ES (3) ES2378281T3 (el)
HR (2) HRP20140073T1 (el)
IL (3) IL195433A (el)
ME (2) ME01901B (el)
MX (1) MX2008016123A (el)
NO (1) NO342590B1 (el)
NZ (3) NZ594369A (el)
PL (2) PL2363130T3 (el)
PT (2) PT2363130E (el)
RS (2) RS53084B (el)
SI (2) SI2359826T1 (el)
UA (3) UA101556C2 (el)
WO (1) WO2008003701A2 (el)
ZA (1) ZA200809905B (el)

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CN102671198A (zh) * 2011-12-17 2012-09-19 东莞达信生物技术有限公司 一种降压降脂复方药及其制备方法
JP6755240B2 (ja) * 2014-06-05 2020-09-16 トランスゲニオン−インターナショナル インスティテュート フォー リジェネレイティヴ トランスレイショナル メディシン ゲーエムベーハー 新規分子バイオマーカーを使用して慢性閉塞性肺疾患（ｃｏｐｄ）を診断する方法
EP3152329A2 (en) 2014-06-05 2017-04-12 Transregion-International Institute For Translational Medicine Gmbh Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers
WO2015185656A1 (en) * 2014-06-05 2015-12-10 Medizinische Universität Wien Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers
US20210031012A1 (en) 2018-01-26 2021-02-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor
KR20210095165A (ko) 2018-11-19 2021-07-30 프로제너티, 인크. 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스
EP4309722A2 (en) 2019-12-13 2024-01-24 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2021218988A1 (zh) * 2020-04-30 2021-11-04 中国科学院上海药物研究所 Prdx1激动剂及其用途
US20240042147A1 (en) * 2022-08-03 2024-02-08 Chiesi Farmaceutici S.P.A. Dry powder inhaler

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