PE20011323A1 - Formulaciones farmaceuticas en solucion estable para inhaladores presurizados con medicion de dosis - Google Patents
Formulaciones farmaceuticas en solucion estable para inhaladores presurizados con medicion de dosisInfo
- Publication number
- PE20011323A1 PE20011323A1 PE2001000439A PE2001000439A PE20011323A1 PE 20011323 A1 PE20011323 A1 PE 20011323A1 PE 2001000439 A PE2001000439 A PE 2001000439A PE 2001000439 A PE2001000439 A PE 2001000439A PE 20011323 A1 PE20011323 A1 PE 20011323A1
- Authority
- PE
- Peru
- Prior art keywords
- solution
- budene
- careensation
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- post
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION EN AEROSOL QUE COMPRENDE UNA DROGA DEL TIPO AMINO (SALBUTAMOL, FORMOTEROL, SALMETEROL) O EN COMBINACION CON ESTEROIDES COMO DIPROPIONATO DE BECLOMETASONA, PROPIONATO DE FLUTICASONA, BUDENOSINA Y EL EPIMERO 22R CARACTERIZADO PORQUE POSEE UNA FUNCION SENSIBLE A REACCIONES DE OXIDACION Y/O HIDROLISIS EN UNA SOLUCION DE UN PROPELENTEHIDROFLUOROALCANOS ( HFA) LICUADO, UN COSOLVENTE SELECCIONADO ENTRE ALCOHOL (ETANOL), DONDE EL pH DE LA SOLUCION SE HA AJUSTADO ENTRE 2,5 Y 5,0 POR ADICION DE PEQUENAS CANTIDADES DE ACIDO MINERAL COMO ACIDO CLORHIDRICO, NITRICO FOSFORICO, LA SOLUCION INCLUYE UN COMPONENTE DE BAJA VOLATILIDAD (GLICOL, ESTER, MIRISTATO DE ISOPROPILO) CON UNA PRESION DE VAPOR A 25°C DE NO MAS DE 0,1KPa PREFERIBLEMENTE NO MAS DE 0,05kPa. TAMBIEN SE REFIERE A UN METODO PARA LLENAR EL INHALADOR QUE COMPRENDE a)PREPARAR UNA SOLUCION DE UNO O MAS INGREDIENTES ACTIVOS EN UNO O MAS COSOLVENTES QUE OPCIONALMENTE CONTIENE UN COMPONENTE DE BAJA VOLATILIDAD; b)LLENAR EL DISPOSITIVO CON DICHA SOLUCION, c)AGREGAR UNA CANTIDAD DE ACIDO MINERAL, d)AGREGAR UN PROPELENTE QUE CONTIENE HIDROFLUOROALCANO, FIJAR CON VALVULAS Y LLENAR CON GAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2000/004635 WO2001089480A1 (en) | 2000-05-22 | 2000-05-22 | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20011323A1 true PE20011323A1 (es) | 2002-01-22 |
Family
ID=8163952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000439A PE20011323A1 (es) | 2000-05-22 | 2001-05-17 | Formulaciones farmaceuticas en solucion estable para inhaladores presurizados con medicion de dosis |
Country Status (41)
Country | Link |
---|---|
US (3) | US6716414B2 (es) |
EP (4) | EP1787639B1 (es) |
JP (1) | JP5392880B2 (es) |
CN (1) | CN1213732C (es) |
AR (1) | AR029523A1 (es) |
AT (4) | ATE415945T1 (es) |
AU (2) | AU5070100A (es) |
BE (1) | BE2011C032I2 (es) |
BG (1) | BG65883B1 (es) |
BR (1) | BR0015884A (es) |
CA (1) | CA2411047C (es) |
CY (6) | CY1108833T1 (es) |
CZ (1) | CZ303833B6 (es) |
DE (5) | DE122009000035I1 (es) |
DK (4) | DK1466594T3 (es) |
DZ (1) | DZ3358A1 (es) |
EA (1) | EA005179B1 (es) |
EE (1) | EE05167B1 (es) |
ES (4) | ES2380790T3 (es) |
FR (1) | FR11C0041I2 (es) |
HK (1) | HK1058900A1 (es) |
HR (1) | HRP20021025B1 (es) |
HU (2) | HU230804B1 (es) |
IL (2) | IL152955A0 (es) |
JO (1) | JO2310B1 (es) |
LT (1) | LTC1787639I2 (es) |
LU (1) | LU91875I2 (es) |
ME (2) | ME00220B (es) |
MX (1) | MXPA02011414A (es) |
MY (2) | MY143733A (es) |
NL (1) | NL300393I2 (es) |
NO (3) | NO342935B1 (es) |
PE (1) | PE20011323A1 (es) |
PT (4) | PT1157689E (es) |
SA (1) | SA01220126B1 (es) |
SI (4) | SI2223682T1 (es) |
SK (1) | SK286694B6 (es) |
TN (1) | TNSN01074A1 (es) |
TW (1) | TWI284047B (es) |
UA (1) | UA73986C2 (es) |
WO (1) | WO2001089480A1 (es) |
Families Citing this family (107)
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IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
ATE286716T1 (de) * | 1999-11-23 | 2005-01-15 | Glaxo Group Ltd | Pharmazeutische formulierungen enthaltend salmeterol |
IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
AU5070100A (en) * | 2000-05-22 | 2001-12-03 | Chiesi Farma Spa | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
AU5858501A (en) * | 2000-05-23 | 2001-12-03 | Glaxo Group Ltd | Aerosol container for formulations of salmeterol xinafoate |
FI20002177A0 (fi) * | 2000-10-02 | 2000-10-02 | Orion Yhtymae Oyj | Uusi yhdistelmä astman hoitoon |
EP1241113A1 (en) | 2001-03-12 | 2002-09-18 | CHIESI FARMACEUTICI S.p.A. | Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein |
US20040101483A1 (en) * | 2001-03-30 | 2004-05-27 | Rudi Muller-Walz | Medical aerosol formulations |
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
PT1273292E (pt) | 2001-07-02 | 2004-10-29 | Chiesi Farma Spa | Formulacao optimizada de tobramicina para aerossolizacao |
US7306925B2 (en) | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
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US20050003024A1 (en) * | 2003-03-04 | 2005-01-06 | The Procter & Gamble Company | Regulation of mammalian hair growth |
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