AR123674A2 - Composición farmacéutica en aerosol de formoterol y dipropionato de beclometasona - Google Patents
Composición farmacéutica en aerosol de formoterol y dipropionato de beclometasonaInfo
- Publication number
- AR123674A2 AR123674A2 ARP200101303A ARP200101303A AR123674A2 AR 123674 A2 AR123674 A2 AR 123674A2 AR P200101303 A ARP200101303 A AR P200101303A AR P200101303 A ARP200101303 A AR P200101303A AR 123674 A2 AR123674 A2 AR 123674A2
- Authority
- AR
- Argentina
- Prior art keywords
- formoterol
- beclomethasone dipropionate
- formoterol fumarate
- dihydrate
- aerosol
- Prior art date
Links
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title abstract 4
- 229950000210 beclometasone dipropionate Drugs 0.000 title abstract 4
- 239000000443 aerosol Substances 0.000 title abstract 2
- 229960002848 formoterol Drugs 0.000 title abstract 2
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 229960003610 formoterol fumarate dihydrate Drugs 0.000 abstract 3
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- -1 formoterol dihydrate Chemical class 0.000 abstract 1
- 229960000193 formoterol fumarate Drugs 0.000 abstract 1
- 239000008249 pharmaceutical aerosol Substances 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Una composición farmacéutica en aerosol para su uso en inhaladores presurizados de dosis medida (pMDI) que comprende: (a) entre 0,001 y 0,05% p/p de fumarato de formoterol dihidrato; (b) entre 0,05 y 0,16% p/p de dipropionato de beclometasona (BDP); (c) entre 2,0 y 4,8% p/p de etanol; (d) HFA 134a; caracterizada porque el único propelente es 1,1,1,2-tetrafluoroetano y el fumarato de formoterol dihidrato se suspende en forma micronizada en la composición mientras que el dipropionato de beclometasona se disuelve totalmente. Reivindicación 7: Un corticoesteroide caracterizado porque se usa en una composición en aerosol para inhalación de acuerdo con la reivindicación 1, que comprende fumarato de formoterol dihidrato como ingrediente activo y una mezcla de HFA134 y etanol como vehículo, para disminuir la solubilidad de dicho fumarato de formoterol dihidrato en dicho vehículo, que tiene una polaridad expresada como constante dieléctrica eₘ comprendida entre 9,5 y 11,0.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172083 | 2009-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123674A2 true AR123674A2 (es) | 2023-01-04 |
Family
ID=42035850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103583A AR078494A1 (es) | 2009-10-02 | 2010-10-01 | Formulaciones farmaceuticas en aerosol de formoterol y dipropionato de beclometasona |
| ARP200101303A AR123674A2 (es) | 2009-10-02 | 2020-05-07 | Composición farmacéutica en aerosol de formoterol y dipropionato de beclometasona |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103583A AR078494A1 (es) | 2009-10-02 | 2010-10-01 | Formulaciones farmaceuticas en aerosol de formoterol y dipropionato de beclometasona |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8420060B2 (es) |
| EP (2) | EP2482799B1 (es) |
| KR (1) | KR101778814B1 (es) |
| CN (2) | CN102548537B (es) |
| AR (2) | AR078494A1 (es) |
| BR (1) | BR112012007484A2 (es) |
| CA (1) | CA2776266C (es) |
| CY (2) | CY1115266T1 (es) |
| DK (2) | DK2482799T3 (es) |
| ES (2) | ES2568913T3 (es) |
| HK (2) | HK1199214A1 (es) |
| HR (2) | HRP20140818T1 (es) |
| HU (1) | HUE029159T2 (es) |
| JO (1) | JO3024B1 (es) |
| ME (1) | ME02398B (es) |
| PL (2) | PL2482799T3 (es) |
| PT (1) | PT2482799E (es) |
| RS (2) | RS54721B1 (es) |
| RU (1) | RU2650175C2 (es) |
| SI (2) | SI2727582T1 (es) |
| TW (1) | TWI449523B (es) |
| WO (1) | WO2011038872A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9119777B2 (en) * | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| ES2938466T3 (es) * | 2012-01-25 | 2023-04-11 | Chiesi Farm Spa | Formulación en polvo seco que comprende un corticoesteroide y un beta-adrenérgico para administración por inhalación |
| US11052202B2 (en) * | 2012-11-07 | 2021-07-06 | Chiesi Farmaceutici S.P.A. | Drug delivery device for the treatment of patients with respiratory diseases |
| EP3701940A1 (en) | 2015-12-04 | 2020-09-02 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition |
| CN112438966B (zh) * | 2019-08-30 | 2022-08-26 | 四川普锐特药业有限公司 | 一种医用定量吸入气雾剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290539A (en) | 1990-12-21 | 1994-03-01 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
| WO1995002651A1 (en) | 1993-07-15 | 1995-01-26 | Minnesota Mining And Manufacturing Company | Seals for use in an aerosol delivery device |
| GB9612297D0 (en) * | 1996-06-11 | 1996-08-14 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
| US6423298B2 (en) * | 1998-06-18 | 2002-07-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pharmaceutical formulations for aerosols with two or more active substances |
| SE9900833D0 (sv) * | 1999-03-09 | 1999-03-09 | Astra Ab | Novel combination |
| IT1317720B1 (it) | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
| ME00220B (me) * | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom |
| US6472563B1 (en) * | 2001-11-09 | 2002-10-29 | Sepracor Inc. | Formoterol tartrate process and polymorph |
| GB0205327D0 (en) * | 2002-03-06 | 2002-04-17 | Glaxo Group Ltd | compounds |
| GB0323685D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| EP1982709A1 (en) * | 2007-04-19 | 2008-10-22 | CHIESI FARMACEUTICI S.p.A. | Use of a composition comprising formoterol and beclomethasone dipropionate for the prevention or treatment of an acute condition of asthma |
| RU2356537C2 (ru) * | 2007-07-25 | 2009-05-27 | Закрытое Акционерное Общество (ЗАО) "Пульмомед" | Фармацевтический состав дозированных аэрозолей, содержащий противоастматические лекарственные средства в виде суспензий, растворов, эмульсий, растворов и эмульсий |
-
2010
- 2010-09-27 DK DK10763317.4T patent/DK2482799T3/da active
- 2010-09-27 PT PT107633174T patent/PT2482799E/pt unknown
- 2010-09-27 SI SI201031156A patent/SI2727582T1/sl unknown
- 2010-09-27 BR BR112012007484A patent/BR112012007484A2/pt not_active Application Discontinuation
- 2010-09-27 RU RU2012112454A patent/RU2650175C2/ru active
- 2010-09-27 PL PL10763317T patent/PL2482799T3/pl unknown
- 2010-09-27 ES ES14153337.2T patent/ES2568913T3/es active Active
- 2010-09-27 HU HUE14153337A patent/HUE029159T2/hu unknown
- 2010-09-27 EP EP10763317.4A patent/EP2482799B1/en active Active
- 2010-09-27 ME MEP-2016-85A patent/ME02398B/me unknown
- 2010-09-27 SI SI201030721T patent/SI2482799T1/sl unknown
- 2010-09-27 DK DK14153337.2T patent/DK2727582T3/en active
- 2010-09-27 CA CA2776266A patent/CA2776266C/en active Active
- 2010-09-27 ES ES10763317.4T patent/ES2487626T3/es active Active
- 2010-09-27 EP EP14153337.2A patent/EP2727582B1/en active Active
- 2010-09-27 PL PL14153337T patent/PL2727582T3/pl unknown
- 2010-09-27 RS RS20160274A patent/RS54721B1/en unknown
- 2010-09-27 CN CN201080044596.5A patent/CN102548537B/zh active Active
- 2010-09-27 RS RSP20140459 patent/RS53514B1/en unknown
- 2010-09-27 KR KR1020127008437A patent/KR101778814B1/ko active IP Right Grant
- 2010-09-27 CN CN201410156323.XA patent/CN103919785B/zh active Active
- 2010-09-27 WO PCT/EP2010/005879 patent/WO2011038872A1/en active Application Filing
- 2010-09-30 JO JOP/2010/0338A patent/JO3024B1/ar active
- 2010-10-01 AR ARP100103583A patent/AR078494A1/es not_active Application Discontinuation
- 2010-10-01 TW TW099133496A patent/TWI449523B/zh active
- 2010-10-04 US US12/897,117 patent/US8420060B2/en active Active
-
2012
- 2012-08-31 HK HK14112828.7A patent/HK1199214A1/xx unknown
- 2012-08-31 HK HK12108522.6A patent/HK1167817A1/xx unknown
-
2014
- 2014-07-10 CY CY20141100517T patent/CY1115266T1/el unknown
- 2014-09-01 HR HRP20140818AT patent/HRP20140818T1/hr unknown
-
2016
- 2016-04-26 CY CY20161100345T patent/CY1117596T1/el unknown
- 2016-06-08 HR HRP20160630TT patent/HRP20160630T1/hr unknown
-
2020
- 2020-05-07 AR ARP200101303A patent/AR123674A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |