PE20010220A1 - Uso de derivados de acido (-) (3-trihalometilfenoxi) (4-halofenil) acetico para el tratamiento de la resistencia a la insulina, de la diabetes tipo 2 y de la hiperlipidemia - Google Patents
Uso de derivados de acido (-) (3-trihalometilfenoxi) (4-halofenil) acetico para el tratamiento de la resistencia a la insulina, de la diabetes tipo 2 y de la hiperlipidemiaInfo
- Publication number
- PE20010220A1 PE20010220A1 PE2000000551A PE0005512000A PE20010220A1 PE 20010220 A1 PE20010220 A1 PE 20010220A1 PE 2000000551 A PE2000000551 A PE 2000000551A PE 0005512000 A PE0005512000 A PE 0005512000A PE 20010220 A1 PE20010220 A1 PE 20010220A1
- Authority
- PE
- Peru
- Prior art keywords
- disease
- collectional
- halophenyl
- diabetes
- acetic acid
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE AL USO DE DERIVADOS DE ACIDO (-)-(3-TRIHALOMETOXI)(4-HALOFENIL)ACETICO DE FORMULA I, DONDE: R ES OH, ARALCOXILO, DIALQUILAMINO, ALCOXILO, ALCANAMIDO, BENZAMIDO, UREIDO, N`-ALQUILO-UREIDO-ALCOXILO, CARBAMILO, ENTRE OTROS; X ES HALOGENO. UN COMPUESTO PREFERIDO ES ACETATO DE (-) 2-ACETAMIDOETIL 4-CLOROFENIL (3-TRIFLUOROMETILFENOXILO). TAMBIEN SE REFIERE AL USO COMBINADO CON UNA SULFONILUREA, DROGA GENERADORA DE SECRECION DE INSULINA, TIAZOLIDINDIONA, FIBRATO, INHIBIDOR DE HMGCoA REDUCTASA, BIGUANIDA, RESINA QUE UNE ACIDOS BILIARES, UN INHIBIDOR DE LA O-GLUCOSIDASA E INSULINA. EL COMPUESTO ES ADMINISTRADO POR VIA INTRAVENOSA, TRANSDERMICA, O POR VIA ORAL UTILIZANDO ALREDEDOR DE 100mg/DIA A 3000mg/DIA, Y ACTUA MODULANDO LA HIPERGLUCEMIA REDUCIENDO LOS NIVELES DE GLUCOSA, MODULA LA HEMOGLOBINA A1C, MODULA LA COMPLICACION MICROVASCULAR Y MACROVASCULAR ASOCIADA CON LA DIABETES, COMO RETINOPATIA, NEUROPATIA, NEFROPATIA, ENFERMEDAD CARDIOVASCULAR, ENFERMEDAD VASCULAR PERIFERICA, SINDROME DE OVARIOS POLICISTICOS, MODULA LA TOLERANCIA DISMINUIDA A LA GLUCOSA, OBESIDAD, DIABETES GESTACIONAL, SINDROME X, ARTERIOESCLEROSIS, DISMINUYE LOS NIVELES DE COLESTEROL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/325,997 US6262118B1 (en) | 1999-06-04 | 1999-06-04 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010220A1 true PE20010220A1 (es) | 2001-02-23 |
Family
ID=23270381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000551A PE20010220A1 (es) | 1999-06-04 | 2000-06-02 | Uso de derivados de acido (-) (3-trihalometilfenoxi) (4-halofenil) acetico para el tratamiento de la resistencia a la insulina, de la diabetes tipo 2 y de la hiperlipidemia |
Country Status (32)
Country | Link |
---|---|
US (6) | US6262118B1 (es) |
EP (2) | EP1614418B1 (es) |
JP (2) | JP4685300B2 (es) |
KR (2) | KR100721219B1 (es) |
CN (2) | CN1189168C (es) |
AR (1) | AR042574A1 (es) |
AT (2) | ATE336235T1 (es) |
AU (1) | AU775909C (es) |
BR (1) | BR0011342A (es) |
CA (2) | CA2751187C (es) |
CL (1) | CL2011001971A1 (es) |
CO (1) | CO5170453A1 (es) |
CY (1) | CY1112861T1 (es) |
CZ (1) | CZ20014341A3 (es) |
DE (1) | DE60030109T2 (es) |
DK (2) | DK1183020T3 (es) |
ES (2) | ES2269151T3 (es) |
HK (2) | HK1087616A1 (es) |
HU (1) | HUP0201611A3 (es) |
IL (3) | IL146914A0 (es) |
MX (1) | MXPA01012435A (es) |
NO (1) | NO20015909L (es) |
NZ (2) | NZ528266A (es) |
PE (1) | PE20010220A1 (es) |
PT (2) | PT1614418E (es) |
RU (2) | RU2281762C2 (es) |
SA (1) | SA00210535B1 (es) |
SK (1) | SK17562001A3 (es) |
TW (1) | TWI264303B (es) |
UA (1) | UA74147C2 (es) |
WO (1) | WO2000074666A2 (es) |
ZA (3) | ZA200300888B (es) |
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US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
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