TW200806285A - Therapeutic agent for keratoconjunctive problem - Google Patents

Therapeutic agent for keratoconjunctive problem

Info

Publication number
TW200806285A
TW200806285A TW096111148A TW96111148A TW200806285A TW 200806285 A TW200806285 A TW 200806285A TW 096111148 A TW096111148 A TW 096111148A TW 96111148 A TW96111148 A TW 96111148A TW 200806285 A TW200806285 A TW 200806285A
Authority
TW
Taiwan
Prior art keywords
corneal
group
keratoconjunctive
therapeutic agent
keratoconjunctivits
Prior art date
Application number
TW096111148A
Other languages
Chinese (zh)
Inventor
Shinichiro Hirai
Keiichi Shibagaki
Masatsugu Nakamura
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of TW200806285A publication Critical patent/TW200806285A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Abstract

A compound of the following formula (I) or the salt thereof has an exellent improving effect in the model with corneal problem, and can be used as the therapeutic agent for keratoconjunctive problem, such as dry eye, corneal ulcer, corneitis, conjunctivitis, punctate cortex corneal disease, corneal epithelium deficiency, conjunctive epithelium deficiency, xerotic keratoconjunctivits, upper limb keratoconjunctivits, filamentous corneitis etc. (wherein, R1 represents a hydrogen atom, a lower alkyl group, an aryl group or a group of formula:A-NR2(R3);R2 and R3 may be the same or different, each represents a hydrogen atom or an acyl group; A represents a lower alkylen group).
TW096111148A 2006-03-30 2007-03-30 Therapeutic agent for keratoconjunctive problem TW200806285A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006094167 2006-03-30

Publications (1)

Publication Number Publication Date
TW200806285A true TW200806285A (en) 2008-02-01

Family

ID=38563582

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096111148A TW200806285A (en) 2006-03-30 2007-03-30 Therapeutic agent for keratoconjunctive problem

Country Status (2)

Country Link
TW (1) TW200806285A (en)
WO (1) WO2007114315A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
AU2002210839A1 (en) * 2000-11-28 2002-06-11 Pfizer Products Inc. Preparation of sodium-hydrogen exchanger type-1 inhibitors
JP2005008570A (en) * 2003-06-19 2005-01-13 Santen Pharmaceut Co Ltd Agent for treating corneal disease
KR20070053283A (en) * 2004-09-13 2007-05-23 산텐 세이야꾸 가부시키가이샤 Therapeutic agent for keratoconjunctiva disorder
KR20080038412A (en) * 2005-08-29 2008-05-06 깃세이 야쿠힌 고교 가부시키가이샤 Preventive or therapeutic agent for disease caused by decrease in lacrimal fluid
CN101336113B (en) * 2005-11-28 2015-07-29 千寿制药株式会社 Comprise the medicine of PPAR agonist

Also Published As

Publication number Publication date
WO2007114315A1 (en) 2007-10-11

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