PE20010208A1 - Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos - Google Patents
Derivados de indolilpiperidina como agentes antihistaminicos y antialergicosInfo
- Publication number
- PE20010208A1 PE20010208A1 PE2000000524A PE0005242000A PE20010208A1 PE 20010208 A1 PE20010208 A1 PE 20010208A1 PE 2000000524 A PE2000000524 A PE 2000000524A PE 0005242000 A PE0005242000 A PE 0005242000A PE 20010208 A1 PE20010208 A1 PE 20010208A1
- Authority
- PE
- Peru
- Prior art keywords
- alkylene
- antihistamine
- allergic
- alcoxialkyl
- alcoxy
- Prior art date
Links
- HNQZRUDJRPSFAU-UHFFFAOYSA-N 2-piperidin-1-yl-1h-indole Chemical class C1CCCCN1C1=CC2=CC=CC=C2N1 HNQZRUDJRPSFAU-UHFFFAOYSA-N 0.000 title abstract 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001387 anti-histamine Effects 0.000 title abstract 2
- 239000000043 antiallergic agent Substances 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 3
- 239000005711 Benzoic acid Substances 0.000 abstract 2
- -1 CARBOXYL Chemical group 0.000 abstract 2
- 235000010233 benzoic acid Nutrition 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 206010048768 Dermatosis Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical class CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009901232A ES2165274B1 (es) | 1999-06-04 | 1999-06-04 | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010208A1 true PE20010208A1 (es) | 2001-03-19 |
Family
ID=8308707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000524A PE20010208A1 (es) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6683096B2 (https=) |
| EP (1) | EP1183251B1 (https=) |
| JP (1) | JP2003501424A (https=) |
| KR (1) | KR100683454B1 (https=) |
| CN (1) | CN1191246C (https=) |
| AR (1) | AR029640A1 (https=) |
| AT (1) | ATE259362T1 (https=) |
| AU (1) | AU773164B2 (https=) |
| BG (1) | BG106168A (https=) |
| BR (1) | BR0011340A (https=) |
| CA (1) | CA2375985A1 (https=) |
| CO (1) | CO5180556A1 (https=) |
| CZ (1) | CZ20014334A3 (https=) |
| DE (1) | DE60008239T2 (https=) |
| DK (1) | DK1183251T3 (https=) |
| EE (1) | EE04717B1 (https=) |
| ES (2) | ES2165274B1 (https=) |
| HK (1) | HK1040990A1 (https=) |
| HU (1) | HUP0203320A3 (https=) |
| IL (1) | IL146629A0 (https=) |
| MX (1) | MXPA01012425A (https=) |
| MY (1) | MY127033A (https=) |
| NO (1) | NO20015897L (https=) |
| NZ (1) | NZ515649A (https=) |
| PE (1) | PE20010208A1 (https=) |
| PL (1) | PL196774B1 (https=) |
| PT (1) | PT1183251E (https=) |
| RU (1) | RU2246493C2 (https=) |
| SI (1) | SI1183251T1 (https=) |
| SK (1) | SK17042001A3 (https=) |
| TR (1) | TR200103490T2 (https=) |
| TW (1) | TWI226889B (https=) |
| UA (1) | UA72517C2 (https=) |
| WO (1) | WO2000075130A1 (https=) |
| ZA (1) | ZA200109676B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6864219B2 (en) | 2000-01-17 | 2005-03-08 | Bayer Aktiengesellschaft | Substituted aryl ketones |
| ES2172436B1 (es) * | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| AU2002243394A1 (en) * | 2000-11-16 | 2002-06-24 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
| RU2382037C2 (ru) * | 2003-11-17 | 2010-02-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые пиперидинзамещенные индолы или их гетеропроизводные |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| EA015517B1 (ru) * | 2004-04-13 | 2011-08-30 | Инсайт Корпорейшн | Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора |
| WO2006002350A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| US8071624B2 (en) | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| AU2006239302B2 (en) * | 2005-04-26 | 2011-07-07 | Hypnion, Inc. | Benzisoxazole piperazine compounds and methods of use thereof |
| ATE531706T1 (de) | 2005-04-30 | 2011-11-15 | Boehringer Ingelheim Int | Neue piperidin-substituierte indole und ihre verwendung als ccr-3-modulatoren |
| US20060275516A1 (en) * | 2005-06-02 | 2006-12-07 | Ram A N S | Compositions and methods for the treatment of allergic rhinitis |
| WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
| EP2079725B1 (en) * | 2006-10-27 | 2011-12-14 | Boehringer Ingelheim International GmbH | Piperidyl-propane-thiol ccr3 modulators |
| CA2681162C (en) | 2007-03-15 | 2015-11-24 | Novartis Ag | Benzyl and pyridine derivatives as modulators of hedgehog pathway |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| CN101560179B (zh) * | 2009-05-25 | 2012-04-18 | 浙江大学 | 具有h3受体亲和能力的含氮吲哚衍生物和用途 |
| CN101747321B (zh) * | 2009-12-22 | 2013-01-02 | 浙江大学 | 吲哚-3-苄胺衍生物及制备方法和用途 |
| EP3040334A1 (en) * | 2014-12-29 | 2016-07-06 | Faes Farma, S.A. | New benzimidazole derivatives as antihistamine agents |
| PE20241304A1 (es) * | 2021-07-30 | 2024-06-24 | Confo Therapeutics N V | Compuestos para el tratamiento del dolor, en particular el dolor neuropatico, y/u otras enfermedades o trastornos que se asocian con at2r y/o senalizacion mediada por at2r |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
| JPS63301881A (ja) * | 1987-06-01 | 1988-12-08 | Fujisawa Pharmaceut Co Ltd | インドリルピペリジン誘導体 |
| DK733788A (da) * | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
| GB8800795D0 (en) * | 1988-01-14 | 1988-02-17 | Fujisawa Pharmaceutical Co | New indolylpiperidine compounds processes for preparations thereof & pharmaceutical composition comprising same |
| GB8900382D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| PH30434A (en) * | 1989-04-07 | 1997-05-09 | Janssen Pharmaceutica Nv | Hydroxyalkylfuranyl derivatives |
| NZ249286A (en) * | 1992-02-13 | 1996-02-27 | Merrell Dow Pharma | Piperidine-4-ylmethyl thiophene and thiazole derivatives and pharmaceutical compositions |
| IT1271417B (it) * | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
| DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
| DE19707628A1 (de) | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
| AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| AR028685A1 (es) * | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
-
1999
- 1999-06-04 ES ES009901232A patent/ES2165274B1/es not_active Expired - Fee Related
-
2000
- 2000-05-31 AT AT00940296T patent/ATE259362T1/de not_active IP Right Cessation
- 2000-05-31 EE EEP200100653A patent/EE04717B1/xx not_active IP Right Cessation
- 2000-05-31 IL IL14662900A patent/IL146629A0/xx unknown
- 2000-05-31 MY MYPI20002439A patent/MY127033A/en unknown
- 2000-05-31 SI SI200030323T patent/SI1183251T1/xx unknown
- 2000-05-31 KR KR1020017015570A patent/KR100683454B1/ko not_active Expired - Fee Related
- 2000-05-31 ES ES00940296T patent/ES2211559T3/es not_active Expired - Lifetime
- 2000-05-31 WO PCT/EP2000/005010 patent/WO2000075130A1/en not_active Ceased
- 2000-05-31 BR BR0011340-9A patent/BR0011340A/pt not_active Application Discontinuation
- 2000-05-31 DK DK00940296T patent/DK1183251T3/da active
- 2000-05-31 HK HK02102119.0A patent/HK1040990A1/zh unknown
- 2000-05-31 HU HU0203320A patent/HUP0203320A3/hu unknown
- 2000-05-31 TR TR2001/03490T patent/TR200103490T2/xx unknown
- 2000-05-31 SK SK1704-2001A patent/SK17042001A3/sk unknown
- 2000-05-31 MX MXPA01012425A patent/MXPA01012425A/es unknown
- 2000-05-31 UA UA2001118222A patent/UA72517C2/uk unknown
- 2000-05-31 JP JP2001502413A patent/JP2003501424A/ja not_active Ceased
- 2000-05-31 PL PL353164A patent/PL196774B1/pl not_active IP Right Cessation
- 2000-05-31 RU RU2002100073/04A patent/RU2246493C2/ru not_active IP Right Cessation
- 2000-05-31 CA CA002375985A patent/CA2375985A1/en not_active Abandoned
- 2000-05-31 CZ CZ20014334A patent/CZ20014334A3/cs unknown
- 2000-05-31 PE PE2000000524A patent/PE20010208A1/es not_active Application Discontinuation
- 2000-05-31 EP EP00940296A patent/EP1183251B1/en not_active Expired - Lifetime
- 2000-05-31 DE DE2000608239 patent/DE60008239T2/de not_active Expired - Lifetime
- 2000-05-31 PT PT00940296T patent/PT1183251E/pt unknown
- 2000-05-31 NZ NZ515649A patent/NZ515649A/en unknown
- 2000-05-31 AU AU55276/00A patent/AU773164B2/en not_active Ceased
- 2000-05-31 CN CNB008112819A patent/CN1191246C/zh not_active Expired - Fee Related
- 2000-06-02 TW TW089110816A patent/TWI226889B/zh not_active IP Right Cessation
- 2000-06-02 AR ARP000102755A patent/AR029640A1/es not_active Application Discontinuation
- 2000-06-02 CO CO00041546A patent/CO5180556A1/es not_active Application Discontinuation
-
2001
- 2001-11-23 ZA ZA200109676A patent/ZA200109676B/en unknown
- 2001-12-03 BG BG106168A patent/BG106168A/bg unknown
- 2001-12-03 NO NO20015897A patent/NO20015897L/no not_active Application Discontinuation
- 2001-12-04 US US10/006,416 patent/US6683096B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |