KR100683454B1 - 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체 - Google Patents

항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체 Download PDF

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Publication number
KR100683454B1
KR100683454B1 KR1020017015570A KR20017015570A KR100683454B1 KR 100683454 B1 KR100683454 B1 KR 100683454B1 KR 1020017015570 A KR1020017015570 A KR 1020017015570A KR 20017015570 A KR20017015570 A KR 20017015570A KR 100683454 B1 KR100683454 B1 KR 100683454B1
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South Korea
Prior art keywords
ethoxy
piperidin
indol
ethyl
benzoic acid
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Expired - Fee Related
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KR1020017015570A
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English (en)
Korean (ko)
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KR20020020721A (ko
Inventor
페이지스산타카나루이스
폰퀘르나포우실비아
피그두란카를레스
페르난데즈포르너돌러스
Original Assignee
라보라토리오스 알미랄, 에스. 에이.
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Publication of KR20020020721A publication Critical patent/KR20020020721A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020017015570A 1999-06-04 2000-05-31 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체 Expired - Fee Related KR100683454B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009901232A ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
ES9901232 1999-06-04

Publications (2)

Publication Number Publication Date
KR20020020721A KR20020020721A (ko) 2002-03-15
KR100683454B1 true KR100683454B1 (ko) 2007-02-20

Family

ID=8308707

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017015570A Expired - Fee Related KR100683454B1 (ko) 1999-06-04 2000-05-31 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체

Country Status (35)

Country Link
US (1) US6683096B2 (https=)
EP (1) EP1183251B1 (https=)
JP (1) JP2003501424A (https=)
KR (1) KR100683454B1 (https=)
CN (1) CN1191246C (https=)
AR (1) AR029640A1 (https=)
AT (1) ATE259362T1 (https=)
AU (1) AU773164B2 (https=)
BG (1) BG106168A (https=)
BR (1) BR0011340A (https=)
CA (1) CA2375985A1 (https=)
CO (1) CO5180556A1 (https=)
CZ (1) CZ20014334A3 (https=)
DE (1) DE60008239T2 (https=)
DK (1) DK1183251T3 (https=)
EE (1) EE04717B1 (https=)
ES (2) ES2165274B1 (https=)
HK (1) HK1040990A1 (https=)
HU (1) HUP0203320A3 (https=)
IL (1) IL146629A0 (https=)
MX (1) MXPA01012425A (https=)
MY (1) MY127033A (https=)
NO (1) NO20015897L (https=)
NZ (1) NZ515649A (https=)
PE (1) PE20010208A1 (https=)
PL (1) PL196774B1 (https=)
PT (1) PT1183251E (https=)
RU (1) RU2246493C2 (https=)
SI (1) SI1183251T1 (https=)
SK (1) SK17042001A3 (https=)
TR (1) TR200103490T2 (https=)
TW (1) TWI226889B (https=)
UA (1) UA72517C2 (https=)
WO (1) WO2000075130A1 (https=)
ZA (1) ZA200109676B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864219B2 (en) 2000-01-17 2005-03-08 Bayer Aktiengesellschaft Substituted aryl ketones
ES2172436B1 (es) * 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU2002243394A1 (en) * 2000-11-16 2002-06-24 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
ES2201899B1 (es) * 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) * 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
RU2382037C2 (ru) * 2003-11-17 2010-02-20 Бёрингер Ингельхайм Интернациональ Гмбх Новые пиперидинзамещенные индолы или их гетеропроизводные
US20050245540A1 (en) * 2003-12-09 2005-11-03 Fujisawa Pharmaceutical Co., Ltd. New methods
EA015517B1 (ru) * 2004-04-13 2011-08-30 Инсайт Корпорейшн Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора
WO2006002350A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
US8071624B2 (en) 2004-06-24 2011-12-06 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
AU2006239302B2 (en) * 2005-04-26 2011-07-07 Hypnion, Inc. Benzisoxazole piperazine compounds and methods of use thereof
ATE531706T1 (de) 2005-04-30 2011-11-15 Boehringer Ingelheim Int Neue piperidin-substituierte indole und ihre verwendung als ccr-3-modulatoren
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
EP2079725B1 (en) * 2006-10-27 2011-12-14 Boehringer Ingelheim International GmbH Piperidyl-propane-thiol ccr3 modulators
CA2681162C (en) 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN101560179B (zh) * 2009-05-25 2012-04-18 浙江大学 具有h3受体亲和能力的含氮吲哚衍生物和用途
CN101747321B (zh) * 2009-12-22 2013-01-02 浙江大学 吲哚-3-苄胺衍生物及制备方法和用途
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
PE20241304A1 (es) * 2021-07-30 2024-06-24 Confo Therapeutics N V Compuestos para el tratamiento del dolor, en particular el dolor neuropatico, y/u otras enfermedades o trastornos que se asocian con at2r y/o senalizacion mediada por at2r

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
JPS63301881A (ja) * 1987-06-01 1988-12-08 Fujisawa Pharmaceut Co Ltd インドリルピペリジン誘導体
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8800795D0 (en) * 1988-01-14 1988-02-17 Fujisawa Pharmaceutical Co New indolylpiperidine compounds processes for preparations thereof & pharmaceutical composition comprising same
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
NZ249286A (en) * 1992-02-13 1996-02-27 Merrell Dow Pharma Piperidine-4-ylmethyl thiophene and thiazole derivatives and pharmaceutical compositions
IT1271417B (it) * 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
DE19707628A1 (de) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol

Also Published As

Publication number Publication date
PL196774B1 (pl) 2008-01-31
MY127033A (en) 2006-11-30
EE04717B1 (et) 2006-10-16
KR20020020721A (ko) 2002-03-15
HUP0203320A3 (en) 2004-01-28
TR200103490T2 (tr) 2002-04-22
PL353164A1 (en) 2003-10-20
ES2211559T3 (es) 2004-07-16
NO20015897D0 (no) 2001-12-03
ES2165274A1 (es) 2002-03-01
ZA200109676B (en) 2003-02-24
BR0011340A (pt) 2002-03-05
AU773164B2 (en) 2004-05-20
SI1183251T1 (en) 2004-06-30
ATE259362T1 (de) 2004-02-15
PT1183251E (pt) 2004-05-31
NZ515649A (en) 2003-08-29
ES2165274B1 (es) 2003-04-01
IL146629A0 (en) 2002-07-25
MXPA01012425A (es) 2002-06-04
RU2002100073A (ru) 2004-01-10
AU5527600A (en) 2000-12-28
EE200100653A (et) 2003-02-17
BG106168A (bg) 2002-07-31
CA2375985A1 (en) 2000-12-14
UA72517C2 (uk) 2005-03-15
JP2003501424A (ja) 2003-01-14
CZ20014334A3 (cs) 2002-03-13
HUP0203320A2 (hu) 2003-02-28
HK1040990A1 (zh) 2002-06-28
NO20015897L (no) 2001-12-03
EP1183251A1 (en) 2002-03-06
US20020147344A1 (en) 2002-10-10
AR029640A1 (es) 2003-07-10
DK1183251T3 (da) 2004-06-07
WO2000075130A1 (en) 2000-12-14
TWI226889B (en) 2005-01-21
DE60008239T2 (de) 2004-11-18
CN1368969A (zh) 2002-09-11
CN1191246C (zh) 2005-03-02
US6683096B2 (en) 2004-01-27
DE60008239D1 (de) 2004-03-18
PE20010208A1 (es) 2001-03-19
RU2246493C2 (ru) 2005-02-20
SK17042001A3 (sk) 2002-04-04
CO5180556A1 (es) 2002-07-30
EP1183251B1 (en) 2004-02-11

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