ES2044878T3 - Un proceso para la preparacion de derivados de benzimidazol. - Google Patents
Un proceso para la preparacion de derivados de benzimidazol.Info
- Publication number
- ES2044878T3 ES2044878T3 ES87110741T ES87110741T ES2044878T3 ES 2044878 T3 ES2044878 T3 ES 2044878T3 ES 87110741 T ES87110741 T ES 87110741T ES 87110741 T ES87110741 T ES 87110741T ES 2044878 T3 ES2044878 T3 ES 2044878T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl group
- substituted
- alkyl
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE DESCRIBEN COMPUESTOS DE FORMULA (I) DONDE R1 ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO, UN GRUPO ALCOXI, UN GRUPO DIALQUILAMINO O UN ATOMO HALOGENO; N ES DE 1 A 4; R2 ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO, UN GRUPO AMINOALQUILO SUSTITUIDO O NO SUSTITUIDO, UN GRUPO ACILO, UN GRUPO ARALQUILO SUSTITUIDO O NO SUSTITUIDO, UN GRUPO CARBOXIALQUILO, UN GRUPO ALCOXICARBONILALQUILO O (II) DONDE X ES UN GRUPO -FUROILO, -BENZOILO, -BENCILO O -FENILO, SUSTITUIDO O NO SUSTITUIDO; A ES -NR3- DONDE R3 ES HIDROGENO O ALQUILO, UN ALQUILENO O UN ALQUILIDENO; Y B ES UN GRUPO HETEROCICLICO SELECCIONADO DE ENTRE EL TRIAZOLILO, PIRIDILO, PIRIDAZINILO, PIRIMIDINILO, PIRAZINILO, BENCIMIDAZOLILO, BENZOTIAZOLILO, QUINOLILO E ISOQUINOLILO, DICHO GRUPO HETEROCICLICO ESTANDO SUSTITUIDO OPCIONALMENTE POR UNO O MAS, GRUPOS FENILO, NITRO, ALCOXI O ALQUILO, Y LAS SALES DE ADICION DE ACIDO ACEPTABLES FISIOLOGICAMENTE. EL COMPUESTO DE FORMULA (I) ES DE ACTIVIDAD CARDIOTONICA Y PUEDE UTILIZARSE PARA EL TRATAMIENTO DE ENFERMEDADES CIRCULATORIAS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17375986 | 1986-07-25 | ||
JP62171139A JPH0784462B2 (ja) | 1986-07-25 | 1987-07-10 | ベンゾイミダゾ−ル誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2044878T3 true ES2044878T3 (es) | 1994-01-16 |
Family
ID=26493951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87110741T Expired - Lifetime ES2044878T3 (es) | 1986-07-25 | 1987-07-24 | Un proceso para la preparacion de derivados de benzimidazol. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4886803A (es) |
EP (1) | EP0254322B1 (es) |
JP (1) | JPH0784462B2 (es) |
KR (1) | KR960011388B1 (es) |
AU (1) | AU597696B2 (es) |
CA (1) | CA1305481C (es) |
DE (1) | DE3781845T2 (es) |
ES (1) | ES2044878T3 (es) |
FI (1) | FI91152C (es) |
NO (1) | NO168770C (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0334809B1 (de) * | 1988-03-21 | 1994-06-15 | Ciba-Geigy Ag | Mittel zum Schutz von Pflanzen gegen Krankheiten |
US5089592A (en) * | 1988-06-09 | 1992-02-18 | The Dow Chemical Company | Biscyclobutarene monomer comprising two cyclobutarene moieties bridged by a divalent radical comprising at least one benzothiazole or benzimidazole linkage |
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
DE69311278T2 (de) * | 1992-12-16 | 1997-10-30 | Takeda Chemical Industries Ltd | Stabile pharmazeutische Zubereitung mit Fumagillolderivaten |
US5637724A (en) * | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
US5637725A (en) * | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
TW381092B (en) * | 1995-07-07 | 2000-02-01 | Otsuka Pharma Co Ltd | Novel benzimidazole derivatives for use in treating arteriosclerotic diseases |
WO2001058879A1 (en) * | 2000-02-09 | 2001-08-16 | The Procter & Gamble Company | 2-phenylcarbamoyl-benzimidazoles |
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
FR2833494B1 (fr) * | 2001-12-19 | 2006-12-15 | Univ Nantes | Utilisation de composes de la famille des benzamides comme agent immunosuppresseur |
JP2005289816A (ja) * | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
CA2503844A1 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity |
US7741341B2 (en) | 2003-05-19 | 2010-06-22 | Sanofi-Aventis Deutschland Gmbh | Benzimidazole-derivatives as factor Xa inhibitors |
EP1479676A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Benzimidazole-derivatives as factor xa inhibitors |
NZ551340A (en) * | 2004-04-22 | 2010-10-29 | Boehringer Ingelheim Int | Pharmaceutical composition comprising flibanserin and a melanocortin agonist for the treatment of premenstrual disorder or sexual aversion disorder |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
EP1742637A4 (en) * | 2004-04-23 | 2011-06-08 | Paratek Pharm Innc | TRANSCRIPTION FACTOR MODULATION COMPOUNDS AND METHODS OF USE |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
JP2008511569A (ja) * | 2004-09-03 | 2008-04-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 注意欠如活動過多障害の治療方法 |
WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
US20060211685A1 (en) * | 2005-03-04 | 2006-09-21 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of depression |
EP1858515A2 (en) * | 2005-03-04 | 2007-11-28 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
WO2006119884A2 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
CA2608713A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunctions due to medical conditions |
WO2006125042A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
CA2617546C (en) | 2005-08-03 | 2014-07-15 | Boehringer Ingelheim International Gmbh | Use of flibanserin in the treatment of obesity |
AU2006296004B2 (en) | 2005-09-27 | 2011-11-17 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
US7923449B2 (en) * | 2005-10-29 | 2011-04-12 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
EA200802208A1 (ru) * | 2006-05-09 | 2009-04-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Применение флибансерина для лечения расстройств полового влечения в постклимактерический период |
DE602007004615D1 (de) | 2006-06-30 | 2010-03-18 | Boehringer Ingelheim Pharma | Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen |
WO2008006838A1 (en) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Use of flibanserin for the treatment of sexual disorders in females |
AU2007286288A1 (en) * | 2006-08-14 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
CL2007002214A1 (es) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
BRPI0716436B8 (pt) * | 2006-08-25 | 2021-05-25 | Boehringer Ingelheim Int | sistema de liberação controlada e método para fabricação do mesmo |
ES2627221T3 (es) | 2006-12-28 | 2017-07-27 | Rigel Pharmaceuticals, Inc. | Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso |
UY31335A1 (es) | 2007-09-12 | 2009-04-30 | Tratamiento de sintomas vasomotores | |
KR20120049940A (ko) * | 2009-09-04 | 2012-05-17 | 노파르티스 아게 | 키나제 억제제로서의 헤테로아릴 화합물 |
CN102834380B (zh) | 2010-03-10 | 2015-04-01 | 阿斯利康公司 | 蛋白激酶的抑制剂 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
-
1987
- 1987-07-10 JP JP62171139A patent/JPH0784462B2/ja not_active Expired - Fee Related
- 1987-07-15 US US07/073,738 patent/US4886803A/en not_active Expired - Lifetime
- 1987-07-16 CA CA000542315A patent/CA1305481C/en not_active Expired - Fee Related
- 1987-07-21 FI FI873205A patent/FI91152C/fi not_active IP Right Cessation
- 1987-07-21 AU AU75965/87A patent/AU597696B2/en not_active Ceased
- 1987-07-23 NO NO873091A patent/NO168770C/no unknown
- 1987-07-24 DE DE8787110741T patent/DE3781845T2/de not_active Expired - Fee Related
- 1987-07-24 ES ES87110741T patent/ES2044878T3/es not_active Expired - Lifetime
- 1987-07-24 EP EP87110741A patent/EP0254322B1/en not_active Expired - Lifetime
- 1987-07-25 KR KR1019870008108A patent/KR960011388B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI873205A (fi) | 1988-01-26 |
NO873091D0 (no) | 1987-07-23 |
EP0254322A1 (en) | 1988-01-27 |
CA1305481C (en) | 1992-07-21 |
DE3781845D1 (de) | 1992-10-29 |
AU597696B2 (en) | 1990-06-07 |
NO873091L (no) | 1988-01-26 |
FI91152B (fi) | 1994-02-15 |
NO168770B (no) | 1991-12-23 |
EP0254322B1 (en) | 1992-09-23 |
KR960011388B1 (ko) | 1996-08-22 |
US4886803A (en) | 1989-12-12 |
AU7596587A (en) | 1988-01-28 |
JPS63146871A (ja) | 1988-06-18 |
NO168770C (no) | 1992-04-01 |
FI873205A0 (fi) | 1987-07-21 |
FI91152C (fi) | 1994-05-25 |
DE3781845T2 (de) | 1993-02-18 |
JPH0784462B2 (ja) | 1995-09-13 |
KR880001611A (ko) | 1988-04-25 |
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Legal Events
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