ES2078970T3 - Nuevos derivados del acido metilenbisfosfonico. - Google Patents

Nuevos derivados del acido metilenbisfosfonico.

Info

Publication number
ES2078970T3
ES2078970T3 ES90909051T ES90909051T ES2078970T3 ES 2078970 T3 ES2078970 T3 ES 2078970T3 ES 90909051 T ES90909051 T ES 90909051T ES 90909051 T ES90909051 T ES 90909051T ES 2078970 T3 ES2078970 T3 ES 2078970T3
Authority
ES
Spain
Prior art keywords
pct
hydrogen
methylenbisphosphonic
acid
bromine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909051T
Other languages
English (en)
Inventor
Esko Pohjala
Heikki Nupponen
Jouko Vepsalainen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Oy
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Application granted granted Critical
Publication of ES2078970T3 publication Critical patent/ES2078970T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4037—Esters of poly(thio)phosphonic acids containing halogen or nitro(so) substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4081—Esters with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

NUEVOS DERIVADOS DE ACIDO BIFOSFONICO FARMACEUTICAMENTE ACTIVOS DE LA FORMULA (I), EN LA QUE R ELEVADO 1, R (AL CUADRADO) , R ELEVADO 3 Y R ELEVADO 4 SON INDEPENDIENTEMENTE ALQUILO C SUB 1-C SUB 2, ALQUENILO C SUB 2-C SUB 22, ALQUINILO C SUB 2-C SUB 22, CICLOALQUILO C SUB 3-C SUB 10, CICLOALQUENILO C SUB 3-C SUB 10, ARILO, ARALQUILO, SILILO O HIDROGENO, POR LO QUE EN LA FORMULA (I) POR LO MENOS UNO DE LOS GRUPOS R ELEVADO 1, R (AL CUADRADO) , R ELEVADO 3 Y R ELEVADO 4 ES HIDROGENO, Y POR LO MENOS UNO DE LOS GRUPOS R ELEVADO 1, R (AL CUADRADO) , R ELEVADO 3 Y R ELEVADO 4 ES DIFERENTE DE HIDROGENO, Q ELEVADO 1 ES HIDROGENO, FLUOR, CLORO BROMO O YODO, Y Q (AL CUADRADO) ES CLORO, BROMO O YODO, INCLUYENDO LOS ESTEROISOMEROS, TALES COMO LOS ISOMEROS GEOMETRICOS Y ISOMEROS OPTICAMENTE ACTIVOS, DE LOS COMPUESTOS, ASI COMO LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS.
ES90909051T 1989-06-21 1990-06-19 Nuevos derivados del acido metilenbisfosfonico. Expired - Lifetime ES2078970T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI893039A FI83421C (fi) 1989-06-21 1989-06-21 Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.

Publications (1)

Publication Number Publication Date
ES2078970T3 true ES2078970T3 (es) 1996-01-01

Family

ID=8528656

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909051T Expired - Lifetime ES2078970T3 (es) 1989-06-21 1990-06-19 Nuevos derivados del acido metilenbisfosfonico.

Country Status (16)

Country Link
US (1) US5376649A (es)
EP (1) EP0479813B1 (es)
JP (1) JP2929236B2 (es)
KR (1) KR920702684A (es)
AT (1) ATE128139T1 (es)
CA (1) CA2062735C (es)
DE (1) DE69022593T2 (es)
ES (1) ES2078970T3 (es)
FI (1) FI83421C (es)
HK (1) HK26096A (es)
HU (2) HU208701B (es)
NO (1) NO178030C (es)
NZ (1) NZ234179A (es)
RU (1) RU2074860C1 (es)
WO (1) WO1990015806A1 (es)
ZA (1) ZA904828B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) * 1909-10-07 2002-10-01 Medivir Ab Prodrugs
CZ287984B6 (cs) † 1993-05-15 2001-03-14 Roche Diagnostics Gmbh Tableta se zlepšenou biodostupností účinné látky, kyseliny klodronové, a způsob její výroby
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
FR2721929B1 (fr) * 1994-06-30 1996-12-20 Centre Nat Rech Scient Analogues stables, non hydrolysables, de diphosphates et leurs procedes de preparation
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
WO2001039724A2 (en) 1999-12-03 2001-06-07 The Regents Of The University Of California, San Diego Phosphonate compounds
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
DK2114971T3 (en) * 2007-01-26 2015-08-31 Kaneq Pharma Inc Fused aromatic PTB-1B inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303139A (en) * 1962-01-27 1967-02-07 Henkel & Cie Gmbh Aminophosphonic acids and their derivatives as complex formers for metal ions
SE350402B (es) * 1965-12-08 1972-10-30 Procter & Gamble
DE1617118C3 (de) * 1966-08-26 1975-04-03 Henkel & Cie Gmbh, 4000 Duesseldorf Verfahren zur Reinigung von etikettierten starren Gegenständen
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3962318A (en) * 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2813121A1 (de) * 1977-03-29 1978-10-12 Procter & Gamble Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung
US4634691A (en) * 1980-10-07 1987-01-06 The Procter & Gamble Company Method for inhibiting tumor metastasis
US4478763A (en) 1982-10-20 1984-10-23 Univ. Of Southern California Process for preparing alpha-fluorinated alkanediphosphonates
GB8419489D0 (en) * 1984-07-31 1984-09-05 Leo Pharm Prod Ltd Chemical compounds
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method

Also Published As

Publication number Publication date
ZA904828B (en) 1991-03-27
EP0479813B1 (en) 1995-09-20
HUT62008A (en) 1993-03-29
NZ234179A (en) 1991-12-23
NO915021D0 (no) 1991-12-19
NO178030B (no) 1995-10-02
AU633459B2 (en) 1993-01-28
NO178030C (no) 1996-01-10
FI83421C (fi) 1991-07-10
WO1990015806A1 (en) 1990-12-27
ATE128139T1 (de) 1995-10-15
HU208701B (en) 1993-12-28
AU5827290A (en) 1991-01-08
HU211204A9 (en) 1995-11-28
FI83421B (fi) 1991-03-28
EP0479813A1 (en) 1992-04-15
RU2074860C1 (ru) 1997-03-10
US5376649A (en) 1994-12-27
CA2062735C (en) 2000-08-15
DE69022593T2 (de) 1996-06-13
FI893039A0 (fi) 1989-06-21
KR920702684A (ko) 1992-10-06
HK26096A (en) 1996-02-16
CA2062735A1 (en) 1990-12-22
JP2929236B2 (ja) 1999-08-03
HU904623D0 (en) 1992-06-29
DE69022593D1 (de) 1995-10-26
JPH05500208A (ja) 1993-01-21
NO915021L (no) 1991-12-19
FI893039A (fi) 1990-12-22

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