FI893039A0 - Nya metylenbisfosfonsyraderivat. - Google Patents

Nya metylenbisfosfonsyraderivat.

Info

Publication number
FI893039A0
FI893039A0 FI893039A FI893039A FI893039A0 FI 893039 A0 FI893039 A0 FI 893039A0 FI 893039 A FI893039 A FI 893039A FI 893039 A FI893039 A FI 893039A FI 893039 A0 FI893039 A0 FI 893039A0
Authority
FI
Finland
Prior art keywords
pct
hydrogen
bromine
iodine
chlorine
Prior art date
Application number
FI893039A
Other languages
English (en)
Other versions
FI83421B (fi
FI893039A (fi
FI83421C (fi
Inventor
Esko Pohjala
Heikki Nupponen
Jouko Vepsaelaeinen
Original Assignee
Huhtamaeki Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huhtamaeki Oy filed Critical Huhtamaeki Oy
Publication of FI893039A0 publication Critical patent/FI893039A0/fi
Priority to FI893039A priority Critical patent/FI83421C/fi
Priority to ES90909051T priority patent/ES2078970T3/es
Priority to KR1019910701935A priority patent/KR920702684A/ko
Priority to JP2508624A priority patent/JP2929236B2/ja
Priority to US07/777,555 priority patent/US5376649A/en
Priority to EP90909051A priority patent/EP0479813B1/en
Priority to AU58272/90A priority patent/AU633459C/en
Priority to AT90909051T priority patent/ATE128139T1/de
Priority to HU904623A priority patent/HU208701B/hu
Priority to DE69022593T priority patent/DE69022593T2/de
Priority to SU905010886A priority patent/RU2074860C1/ru
Priority to PCT/FI1990/000163 priority patent/WO1990015806A1/en
Priority to CA002062735A priority patent/CA2062735C/en
Priority to NZ234179A priority patent/NZ234179A/en
Priority to ZA904828A priority patent/ZA904828B/xx
Publication of FI893039A publication Critical patent/FI893039A/fi
Publication of FI83421B publication Critical patent/FI83421B/fi
Application granted granted Critical
Publication of FI83421C publication Critical patent/FI83421C/fi
Priority to NO915021A priority patent/NO178030C/no
Priority to HU95P/P00212P priority patent/HU211204A9/hu
Priority to HK26096A priority patent/HK26096A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4037—Esters of poly(thio)phosphonic acids containing halogen or nitro(so) substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4081—Esters with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
FI893039A 1989-06-21 1989-06-21 Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. FI83421C (fi)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FI893039A FI83421C (fi) 1989-06-21 1989-06-21 Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
SU905010886A RU2074860C1 (ru) 1989-06-21 1990-06-19 Производные метиленбисфосфоновой кислоты
CA002062735A CA2062735C (en) 1989-06-21 1990-06-19 Novel methylenebisphosphonic acid derivatives
JP2508624A JP2929236B2 (ja) 1989-06-21 1990-06-19 カルシウム代謝異常による疾病用治療剤
US07/777,555 US5376649A (en) 1989-06-21 1990-06-19 Partial esters of (Di) chloromethanediphosphonic acid useful for treating disorders relating to the metabolism of calcium
EP90909051A EP0479813B1 (en) 1989-06-21 1990-06-19 Novel methylenebisphosphonic acid derivatives
AU58272/90A AU633459C (en) 1989-06-21 1990-06-19 Novel methylenebisphosphonic acid derivatives
AT90909051T ATE128139T1 (de) 1989-06-21 1990-06-19 Neue methylenbisphosphonsäurederivate.
HU904623A HU208701B (en) 1989-06-21 1990-06-19 Process for producing new methylene bisphosphonic acid derivatives and medical preparatives containing them as active agent
DE69022593T DE69022593T2 (de) 1989-06-21 1990-06-19 Neue methylenbisphosphonsäurederivate.
ES90909051T ES2078970T3 (es) 1989-06-21 1990-06-19 Nuevos derivados del acido metilenbisfosfonico.
PCT/FI1990/000163 WO1990015806A1 (en) 1989-06-21 1990-06-19 Novel methylenebisphosphonic acid derivatives
KR1019910701935A KR920702684A (ko) 1989-06-21 1990-06-19 신규의 메틸렌비스포스폰산 유도체
NZ234179A NZ234179A (en) 1989-06-21 1990-06-21 Halomethylene bisphosphonic acid derivatives and pharmaceutical compositions
ZA904828A ZA904828B (en) 1989-06-21 1990-06-21 Methylenebisphosphonic acid derivatives
NO915021A NO178030C (no) 1989-06-21 1991-12-19 Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater
HU95P/P00212P HU211204A9 (en) 1989-06-21 1995-06-15 Novel methylenebisphosphonic acid derivatives
HK26096A HK26096A (en) 1989-06-21 1996-02-08 Novel methylenebisphosphonic acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI893039 1989-06-21
FI893039A FI83421C (fi) 1989-06-21 1989-06-21 Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.

Publications (4)

Publication Number Publication Date
FI893039A0 true FI893039A0 (fi) 1989-06-21
FI893039A FI893039A (fi) 1990-12-22
FI83421B FI83421B (fi) 1991-03-28
FI83421C FI83421C (fi) 1991-07-10

Family

ID=8528656

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893039A FI83421C (fi) 1989-06-21 1989-06-21 Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.

Country Status (16)

Country Link
US (1) US5376649A (fi)
EP (1) EP0479813B1 (fi)
JP (1) JP2929236B2 (fi)
KR (1) KR920702684A (fi)
AT (1) ATE128139T1 (fi)
CA (1) CA2062735C (fi)
DE (1) DE69022593T2 (fi)
ES (1) ES2078970T3 (fi)
FI (1) FI83421C (fi)
HK (1) HK26096A (fi)
HU (2) HU208701B (fi)
NO (1) NO178030C (fi)
NZ (1) NZ234179A (fi)
RU (1) RU2074860C1 (fi)
WO (1) WO1990015806A1 (fi)
ZA (1) ZA904828B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5650168A (en) † 1993-05-15 1997-07-22 Boehringer Mannheim Gmbh Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
FR2721929B1 (fr) * 1994-06-30 1996-12-20 Centre Nat Rech Scient Analogues stables, non hydrolysables, de diphosphates et leurs procedes de preparation
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
CA2393410C (en) 1999-12-03 2011-10-11 Karl Y. Hostetler Phosphonate compounds
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US8168815B2 (en) * 2007-01-26 2012-05-01 Kaneq Pharma Inc. Fused aromatic PTP-1B inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303139A (en) * 1962-01-27 1967-02-07 Henkel & Cie Gmbh Aminophosphonic acids and their derivatives as complex formers for metal ions
SE350402B (fi) * 1965-12-08 1972-10-30 Procter & Gamble
DE1617118C3 (de) * 1966-08-26 1975-04-03 Henkel & Cie Gmbh, 4000 Duesseldorf Verfahren zur Reinigung von etikettierten starren Gegenständen
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3962318A (en) * 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2813121A1 (de) * 1977-03-29 1978-10-12 Procter & Gamble Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung
US4634691A (en) * 1980-10-07 1987-01-06 The Procter & Gamble Company Method for inhibiting tumor metastasis
US4478763A (en) 1982-10-20 1984-10-23 Univ. Of Southern California Process for preparing alpha-fluorinated alkanediphosphonates
GB8419489D0 (en) * 1984-07-31 1984-09-05 Leo Pharm Prod Ltd Chemical compounds
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method

Also Published As

Publication number Publication date
ZA904828B (en) 1991-03-27
FI83421B (fi) 1991-03-28
HUT62008A (en) 1993-03-29
DE69022593T2 (de) 1996-06-13
EP0479813A1 (en) 1992-04-15
HU211204A9 (en) 1995-11-28
ATE128139T1 (de) 1995-10-15
NO178030C (no) 1996-01-10
EP0479813B1 (en) 1995-09-20
DE69022593D1 (de) 1995-10-26
ES2078970T3 (es) 1996-01-01
HU208701B (en) 1993-12-28
AU5827290A (en) 1991-01-08
AU633459B2 (en) 1993-01-28
NO178030B (no) 1995-10-02
NO915021D0 (no) 1991-12-19
KR920702684A (ko) 1992-10-06
HU904623D0 (en) 1992-06-29
JPH05500208A (ja) 1993-01-21
CA2062735C (en) 2000-08-15
HK26096A (en) 1996-02-16
NZ234179A (en) 1991-12-23
FI893039A (fi) 1990-12-22
JP2929236B2 (ja) 1999-08-03
RU2074860C1 (ru) 1997-03-10
US5376649A (en) 1994-12-27
FI83421C (fi) 1991-07-10
CA2062735A1 (en) 1990-12-22
WO1990015806A1 (en) 1990-12-27
NO915021L (no) 1991-12-19

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Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: LEIRAS OY

FG Patent granted

Owner name: LEIRAS OY