FI906296A0 - Nya metylenbisfosfonsyrederivat. - Google Patents

Nya metylenbisfosfonsyrederivat.

Info

Publication number
FI906296A0
FI906296A0 FI906296A FI906296A FI906296A0 FI 906296 A0 FI906296 A0 FI 906296A0 FI 906296 A FI906296 A FI 906296A FI 906296 A FI906296 A FI 906296A FI 906296 A0 FI906296 A0 FI 906296A0
Authority
FI
Finland
Prior art keywords
pct
groups
group
independently
formula
Prior art date
Application number
FI906296A
Other languages
English (en)
Other versions
FI89365B (fi
FI906296A (fi
FI89365C (fi
Inventor
Hannu Hanhijaervi
Heikki Nupponen
Jouko Vepsaelaeinen
Esko Pohjala
Original Assignee
Huhtamaeki Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huhtamaeki Oy filed Critical Huhtamaeki Oy
Publication of FI906296A0 publication Critical patent/FI906296A0/fi
Priority to FI906296A priority Critical patent/FI89365C/fi
Priority to IL10033691A priority patent/IL100336A/en
Priority to IE439091A priority patent/IE914390A1/en
Priority to CA002098734A priority patent/CA2098734A1/en
Priority to AU90800/91A priority patent/AU663268B2/en
Priority to PL91299980A priority patent/PL169728B1/pl
Priority to DE69130231T priority patent/DE69130231T2/de
Priority to HU9301780A priority patent/HUT64547A/hu
Priority to AT92901217T priority patent/ATE171182T1/de
Priority to JP4502098A priority patent/JPH06504770A/ja
Priority to PCT/FI1991/000396 priority patent/WO1992011268A1/en
Priority to SK630-93A priority patent/SK63093A3/sk
Priority to ES92901217T priority patent/ES2121003T3/es
Priority to KR1019930701879A priority patent/KR930703336A/ko
Priority to NZ241039A priority patent/NZ241039A/en
Priority to US08/078,155 priority patent/US5442101A/en
Priority to CS931195A priority patent/CZ119593A3/cs
Priority to RU9393050805A priority patent/RU2100364C1/ru
Priority to EP92901217A priority patent/EP0570380B1/en
Priority to DK92901217T priority patent/DK0570380T3/da
Priority to ZA9110007A priority patent/ZA9110007B/xx
Priority to CN91111881A priority patent/CN1028866C/zh
Priority to TW081100320A priority patent/TW203053B/zh
Publication of FI906296A publication Critical patent/FI906296A/fi
Publication of FI89365B publication Critical patent/FI89365B/fi
Priority to NO932256A priority patent/NO303121B1/no
Application granted granted Critical
Publication of FI89365C publication Critical patent/FI89365C/fi
Priority to EE9400299A priority patent/EE02950B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4423—Amides of poly (thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Detergent Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
FI906296A 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat FI89365C (fi)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FI906296A FI89365C (fi) 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
IL10033691A IL100336A (en) 1990-12-20 1991-12-11 History of methylenbysphosphonic acid preparation and pharmaceutical preparations containing them
IE439091A IE914390A1 (en) 1990-12-20 1991-12-17 Novel methylenebisphosphonic acid derivatives
ES92901217T ES2121003T3 (es) 1990-12-20 1991-12-18 Nuevos derivados del acido metilenbisfosfonico.
CS931195A CZ119593A3 (en) 1990-12-20 1991-12-18 Novel derivatives of methylene-bisphosphonic acid
PL91299980A PL169728B1 (pl) 1990-12-20 1991-12-18 Sposób wytwarzania nowych pochodnych kwasu metylenobisfosfonowego PL PL
DE69130231T DE69130231T2 (de) 1990-12-20 1991-12-18 Neue methylenbisphosphonsaürederivate
HU9301780A HUT64547A (en) 1990-12-20 1991-12-18 Method for producing new methylene-biphosphonic acid derivatives and pharmaceutical preparatives containing them
AT92901217T ATE171182T1 (de) 1990-12-20 1991-12-18 Neue methylenbisphosphonsaürederivate
JP4502098A JPH06504770A (ja) 1990-12-20 1991-12-18 新規なメチレンビスホスホン酸誘導体
PCT/FI1991/000396 WO1992011268A1 (en) 1990-12-20 1991-12-18 Novel methylenebisphosphonic acid derivatives
SK630-93A SK63093A3 (en) 1990-12-20 1991-12-18 Novel methylenbisphosphonic acid derivatives
CA002098734A CA2098734A1 (en) 1990-12-20 1991-12-18 Novel mrthylenebisphosphonic acid derivatives
KR1019930701879A KR930703336A (ko) 1990-12-20 1991-12-18 신규한 메틸렌비스포스폰산 유도체
NZ241039A NZ241039A (en) 1990-12-20 1991-12-18 Methylenebisphosphonic acid ester amide derivatives and pharmaceutical compositions
US08/078,155 US5442101A (en) 1990-12-20 1991-12-18 Methylenebisphosphonic acid derivatives
AU90800/91A AU663268B2 (en) 1990-12-20 1991-12-18 Novel methylenebisphosphonic acid derivatives
RU9393050805A RU2100364C1 (ru) 1990-12-20 1991-12-18 Производные амидов метиленбисфосфоновых кислот и способы их получения
EP92901217A EP0570380B1 (en) 1990-12-20 1991-12-18 Novel methylenebisphosphonic acid derivatives
DK92901217T DK0570380T3 (da) 1990-12-20 1991-12-18 Nye methylenbisphosphonsyrederivater
ZA9110007A ZA9110007B (en) 1990-12-20 1991-12-19 Methylenebisphosphonic acid derivatives
CN91111881A CN1028866C (zh) 1990-12-20 1991-12-20 新型的亚甲基双膦酸衍生物的制备方法
TW081100320A TW203053B (fi) 1990-12-20 1991-12-31
NO932256A NO303121B1 (no) 1990-12-20 1993-06-18 AnalogifremgangsmÕte ved fremstilling av terapeutisk aktive metylenbisfosfonsyreamid- og esteramidderivater
EE9400299A EE02950B1 (et) 1990-12-20 1994-11-14 Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI906296 1990-12-20
FI906296A FI89365C (fi) 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Publications (4)

Publication Number Publication Date
FI906296A0 true FI906296A0 (fi) 1990-12-20
FI906296A FI906296A (fi) 1992-06-21
FI89365B FI89365B (fi) 1993-06-15
FI89365C FI89365C (fi) 1993-09-27

Family

ID=8531621

Family Applications (1)

Application Number Title Priority Date Filing Date
FI906296A FI89365C (fi) 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Country Status (25)

Country Link
US (1) US5442101A (fi)
EP (1) EP0570380B1 (fi)
JP (1) JPH06504770A (fi)
KR (1) KR930703336A (fi)
CN (1) CN1028866C (fi)
AT (1) ATE171182T1 (fi)
AU (1) AU663268B2 (fi)
CA (1) CA2098734A1 (fi)
CZ (1) CZ119593A3 (fi)
DE (1) DE69130231T2 (fi)
DK (1) DK0570380T3 (fi)
EE (1) EE02950B1 (fi)
ES (1) ES2121003T3 (fi)
FI (1) FI89365C (fi)
HU (1) HUT64547A (fi)
IE (1) IE914390A1 (fi)
IL (1) IL100336A (fi)
NO (1) NO303121B1 (fi)
NZ (1) NZ241039A (fi)
PL (1) PL169728B1 (fi)
RU (1) RU2100364C1 (fi)
SK (1) SK63093A3 (fi)
TW (1) TW203053B (fi)
WO (1) WO1992011268A1 (fi)
ZA (1) ZA9110007B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4815197A (en) 1996-10-09 1998-05-05 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
EP1469003A3 (en) * 1996-10-09 2004-11-24 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
US20040181078A1 (en) * 1997-10-10 2004-09-16 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
EP1868628B1 (en) 2005-04-08 2014-06-11 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2254582B1 (en) * 2008-01-25 2016-01-20 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
BR112012002551A2 (pt) 2009-08-03 2017-06-13 Chimerix Inc composição e métodos de tratamento de infecções virais e tumores induzidos por vírus
CA2789443C (en) 2010-02-12 2016-09-13 Chimerix, Inc. Nucleoside phosphonate salts
CN102190684A (zh) * 2010-03-15 2011-09-21 南通波锐生物医药有限公司 一种具有药物应用的含磷化合物及其制备和用途
WO2011139709A2 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
CN102453050B (zh) * 2010-11-03 2015-01-07 成都云克药业有限责任公司 一种二膦酸化合物及其制备方法
WO2018005659A1 (en) * 2016-06-28 2018-01-04 Aequor, Inc. Antimicrobial compounds and methods of use
RU2630226C1 (ru) * 2016-12-20 2017-09-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет" Новая ионная жидкость производная бис-(N,N-диметиламида) метилфосфоновой кислоты с высокими термическими свойствами

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293505A (en) * 1967-04-06 1981-10-06 Randall David I Preparation of β-haloethylphosphonic acids and half esters thereof
US3524846A (en) * 1967-06-02 1970-08-18 Syntex Corp Process for the didealkylation of phosphonate esters
US3808265A (en) * 1971-03-26 1974-04-30 Gaf Corp Preparation of 2-haloethylphosphonic acid
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US5273969A (en) * 1988-08-29 1993-12-28 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors and method
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method
US5212164A (en) * 1988-08-29 1993-05-18 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Also Published As

Publication number Publication date
WO1992011268A1 (en) 1992-07-09
NO932256D0 (no) 1993-06-18
SK63093A3 (en) 1993-12-08
FI89365B (fi) 1993-06-15
ES2121003T3 (es) 1998-11-16
NO303121B1 (no) 1998-06-02
AU9080091A (en) 1992-07-22
CN1028866C (zh) 1995-06-14
IE914390A1 (en) 1992-07-01
NO932256L (no) 1993-08-20
ATE171182T1 (de) 1998-10-15
CN1062533A (zh) 1992-07-08
TW203053B (fi) 1993-04-01
KR930703336A (ko) 1993-11-29
IL100336A0 (en) 1992-09-06
DE69130231D1 (de) 1998-10-22
FI906296A (fi) 1992-06-21
DE69130231T2 (de) 1999-03-25
PL169728B1 (pl) 1996-08-30
HU9301780D0 (en) 1993-09-28
EP0570380B1 (en) 1998-09-16
CZ119593A3 (en) 1994-02-16
CA2098734A1 (en) 1992-06-21
ZA9110007B (en) 1992-09-30
EP0570380A1 (en) 1993-11-24
RU2100364C1 (ru) 1997-12-27
FI89365C (fi) 1993-09-27
DK0570380T3 (da) 1999-02-08
US5442101A (en) 1995-08-15
AU663268B2 (en) 1995-09-28
EE02950B1 (et) 1996-12-16
HUT64547A (en) 1994-01-28
IL100336A (en) 1998-07-15
NZ241039A (en) 1993-05-26
JPH06504770A (ja) 1994-06-02

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: LEIRAS OY

BB Publication of examined application
MM Patent lapsed

Owner name: LEIRAS OY