NO915021D0 - Nye metylenbisfosfonsyrederivater - Google Patents
Nye metylenbisfosfonsyrederivaterInfo
- Publication number
- NO915021D0 NO915021D0 NO1991915021A NO915021A NO915021D0 NO 915021 D0 NO915021 D0 NO 915021D0 NO 1991915021 A NO1991915021 A NO 1991915021A NO 915021 A NO915021 A NO 915021A NO 915021 D0 NO915021 D0 NO 915021D0
- Authority
- NO
- Norway
- Prior art keywords
- pct
- acid derivatives
- hydrogen
- bisphosphonic acid
- bromine
- Prior art date
Links
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4037—Esters of poly(thio)phosphonic acids containing halogen or nitro(so) substituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4081—Esters with cycloaliphatic alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paints Or Removers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI893039A FI83421C (fi) | 1989-06-21 | 1989-06-21 | Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. |
| PCT/FI1990/000163 WO1990015806A1 (en) | 1989-06-21 | 1990-06-19 | Novel methylenebisphosphonic acid derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO915021D0 true NO915021D0 (no) | 1991-12-19 |
| NO915021L NO915021L (no) | 1991-12-19 |
| NO178030B NO178030B (no) | 1995-10-02 |
| NO178030C NO178030C (no) | 1996-01-10 |
Family
ID=8528656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO915021A NO178030C (no) | 1989-06-21 | 1991-12-19 | Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5376649A (no) |
| EP (1) | EP0479813B1 (no) |
| JP (1) | JP2929236B2 (no) |
| KR (1) | KR920702684A (no) |
| AT (1) | ATE128139T1 (no) |
| CA (1) | CA2062735C (no) |
| DE (1) | DE69022593T2 (no) |
| ES (1) | ES2078970T3 (no) |
| FI (1) | FI83421C (no) |
| HK (1) | HK26096A (no) |
| HU (2) | HU208701B (no) |
| NO (1) | NO178030C (no) |
| NZ (1) | NZ234179A (no) |
| RU (1) | RU2074860C1 (no) |
| WO (1) | WO1990015806A1 (no) |
| ZA (1) | ZA904828B (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
| US5650168A (en) † | 1993-05-15 | 1997-07-22 | Boehringer Mannheim Gmbh | Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance |
| US5462932A (en) * | 1994-05-17 | 1995-10-31 | Merck & Co., Inc. | Oral liquid alendronate formulations |
| FR2721929B1 (fr) * | 1994-06-30 | 1996-12-20 | Centre Nat Rech Scient | Analogues stables, non hydrolysables, de diphosphates et leurs procedes de preparation |
| US5652227A (en) * | 1995-01-30 | 1997-07-29 | Teronen; Olli Pekka | Inhibition of the degradation of connective tissue matrix protein components in mammals |
| FI104901B (fi) | 1997-10-20 | 2000-04-28 | Leiras Oy | Uudet metyleenibisfosfonihappojohdannaiset |
| US20020128301A1 (en) * | 1998-02-13 | 2002-09-12 | Medivir AB | Non-nucleoside reverse transcriptase inhibitors |
| SE9903345D0 (sv) * | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
| CA2393410C (en) | 1999-12-03 | 2011-10-11 | Karl Y. Hostetler | Phosphonate compounds |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| US8168815B2 (en) * | 2007-01-26 | 2012-05-01 | Kaneq Pharma Inc. | Fused aromatic PTP-1B inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3303139A (en) * | 1962-01-27 | 1967-02-07 | Henkel & Cie Gmbh | Aminophosphonic acids and their derivatives as complex formers for metal ions |
| SE350402B (no) * | 1965-12-08 | 1972-10-30 | Procter & Gamble | |
| DE1617118C3 (de) * | 1966-08-26 | 1975-04-03 | Henkel & Cie Gmbh, 4000 Duesseldorf | Verfahren zur Reinigung von etikettierten starren Gegenständen |
| US3957858A (en) * | 1970-04-13 | 1976-05-18 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
| US3962318A (en) * | 1970-04-13 | 1976-06-08 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| DE2813121A1 (de) * | 1977-03-29 | 1978-10-12 | Procter & Gamble | Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung |
| US4634691A (en) * | 1980-10-07 | 1987-01-06 | The Procter & Gamble Company | Method for inhibiting tumor metastasis |
| US4478763A (en) | 1982-10-20 | 1984-10-23 | Univ. Of Southern California | Process for preparing alpha-fluorinated alkanediphosphonates |
| GB8419489D0 (en) * | 1984-07-31 | 1984-09-05 | Leo Pharm Prod Ltd | Chemical compounds |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| EP0356866A3 (en) * | 1988-08-29 | 1991-03-27 | E.R. SQUIBB & SONS, INC. | Phosphorus-containing squalene synthetase inhibitors and method |
-
1989
- 1989-06-21 FI FI893039A patent/FI83421C/fi active IP Right Grant
-
1990
- 1990-06-19 HU HU904623A patent/HU208701B/hu not_active IP Right Cessation
- 1990-06-19 RU SU905010886A patent/RU2074860C1/ru not_active IP Right Cessation
- 1990-06-19 KR KR1019910701935A patent/KR920702684A/ko not_active Application Discontinuation
- 1990-06-19 JP JP2508624A patent/JP2929236B2/ja not_active Expired - Fee Related
- 1990-06-19 CA CA002062735A patent/CA2062735C/en not_active Expired - Fee Related
- 1990-06-19 WO PCT/FI1990/000163 patent/WO1990015806A1/en active IP Right Grant
- 1990-06-19 AT AT90909051T patent/ATE128139T1/de not_active IP Right Cessation
- 1990-06-19 EP EP90909051A patent/EP0479813B1/en not_active Expired - Lifetime
- 1990-06-19 US US07/777,555 patent/US5376649A/en not_active Expired - Lifetime
- 1990-06-19 ES ES90909051T patent/ES2078970T3/es not_active Expired - Lifetime
- 1990-06-19 DE DE69022593T patent/DE69022593T2/de not_active Expired - Fee Related
- 1990-06-21 NZ NZ234179A patent/NZ234179A/en unknown
- 1990-06-21 ZA ZA904828A patent/ZA904828B/xx unknown
-
1991
- 1991-12-19 NO NO915021A patent/NO178030C/no not_active IP Right Cessation
-
1995
- 1995-06-15 HU HU95P/P00212P patent/HU211204A9/hu unknown
-
1996
- 1996-02-08 HK HK26096A patent/HK26096A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA904828B (en) | 1991-03-27 |
| FI83421B (fi) | 1991-03-28 |
| HUT62008A (en) | 1993-03-29 |
| DE69022593T2 (de) | 1996-06-13 |
| EP0479813A1 (en) | 1992-04-15 |
| HU211204A9 (en) | 1995-11-28 |
| ATE128139T1 (de) | 1995-10-15 |
| NO178030C (no) | 1996-01-10 |
| EP0479813B1 (en) | 1995-09-20 |
| DE69022593D1 (de) | 1995-10-26 |
| ES2078970T3 (es) | 1996-01-01 |
| HU208701B (en) | 1993-12-28 |
| AU5827290A (en) | 1991-01-08 |
| AU633459B2 (en) | 1993-01-28 |
| NO178030B (no) | 1995-10-02 |
| KR920702684A (ko) | 1992-10-06 |
| HU904623D0 (en) | 1992-06-29 |
| JPH05500208A (ja) | 1993-01-21 |
| CA2062735C (en) | 2000-08-15 |
| HK26096A (en) | 1996-02-16 |
| NZ234179A (en) | 1991-12-23 |
| FI893039A (fi) | 1990-12-22 |
| FI893039A0 (fi) | 1989-06-21 |
| JP2929236B2 (ja) | 1999-08-03 |
| RU2074860C1 (ru) | 1997-03-10 |
| US5376649A (en) | 1994-12-27 |
| FI83421C (fi) | 1991-07-10 |
| CA2062735A1 (en) | 1990-12-22 |
| WO1990015806A1 (en) | 1990-12-27 |
| NO915021L (no) | 1991-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |