NO178030C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater - Google Patents

Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater

Info

Publication number
NO178030C
NO178030C NO915021A NO915021A NO178030C NO 178030 C NO178030 C NO 178030C NO 915021 A NO915021 A NO 915021A NO 915021 A NO915021 A NO 915021A NO 178030 C NO178030 C NO 178030C
Authority
NO
Norway
Prior art keywords
pct
acid derivatives
bisphosphonic acid
hydrogen
therapeutically active
Prior art date
Application number
NO915021A
Other languages
English (en)
Norwegian (no)
Other versions
NO178030B (no
NO915021D0 (no
NO915021L (no
Inventor
Esko Pohjala
Heikki Nupponen
Jouko Vepsalainen
Original Assignee
Leiras Oy
Huhtamaeki Yhthymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy, Huhtamaeki Yhthymae Oy filed Critical Leiras Oy
Publication of NO915021D0 publication Critical patent/NO915021D0/no
Publication of NO915021L publication Critical patent/NO915021L/no
Publication of NO178030B publication Critical patent/NO178030B/no
Publication of NO178030C publication Critical patent/NO178030C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025Esters of poly(thio)phosphonic acids
    • C07F9/4037Esters of poly(thio)phosphonic acids containing halogen or nitro(so) substituents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4081Esters with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
NO915021A 1989-06-21 1991-12-19 Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater NO178030C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI893039A FI83421C (fi) 1989-06-21 1989-06-21 Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
PCT/FI1990/000163 WO1990015806A1 (en) 1989-06-21 1990-06-19 Novel methylenebisphosphonic acid derivatives

Publications (4)

Publication Number Publication Date
NO915021D0 NO915021D0 (no) 1991-12-19
NO915021L NO915021L (no) 1991-12-19
NO178030B NO178030B (no) 1995-10-02
NO178030C true NO178030C (no) 1996-01-10

Family

ID=8528656

Family Applications (1)

Application Number Title Priority Date Filing Date
NO915021A NO178030C (no) 1989-06-21 1991-12-19 Analogifremgangsmåte ved fremstilling av terapeutisk aktive metylenbisfosfonsyrederivater

Country Status (16)

Country Link
US (1) US5376649A (fi)
EP (1) EP0479813B1 (fi)
JP (1) JP2929236B2 (fi)
KR (1) KR920702684A (fi)
AT (1) ATE128139T1 (fi)
CA (1) CA2062735C (fi)
DE (1) DE69022593T2 (fi)
ES (1) ES2078970T3 (fi)
FI (1) FI83421C (fi)
HK (1) HK26096A (fi)
HU (2) HU208701B (fi)
NO (1) NO178030C (fi)
NZ (1) NZ234179A (fi)
RU (1) RU2074860C1 (fi)
WO (1) WO1990015806A1 (fi)
ZA (1) ZA904828B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
SK281193B6 (sk) 1993-05-15 2001-01-18 Roche Diagnostics Gmbh Tableta so zlepšenou biodostupnosťou účinnej látky, kyseliny klodrónovej, spôsob jej výroby a použitie mikrokryštalickej celulózy
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
FR2721929B1 (fr) * 1994-06-30 1996-12-20 Centre Nat Rech Scient Analogues stables, non hydrolysables, de diphosphates et leurs procedes de preparation
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
FI104901B (fi) * 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
SE9903345D0 (sv) * 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
ES2498046T3 (es) 1999-12-03 2014-09-24 The Regents Of The University Of California Compuestos antivirales de éster de fosfonato
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
CN102317296B (zh) * 2007-01-26 2015-05-27 卡内克制药公司 稠合芳烃ptp-1b抑制剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303139A (en) * 1962-01-27 1967-02-07 Henkel & Cie Gmbh Aminophosphonic acids and their derivatives as complex formers for metal ions
DK122031B (da) * 1965-12-08 1972-01-10 Procter & Gamble Tand- eller mundplejemiddel til forhindring af dannelsen af tandsten.
DE1617118C3 (de) * 1966-08-26 1975-04-03 Henkel & Cie Gmbh, 4000 Duesseldorf Verfahren zur Reinigung von etikettierten starren Gegenständen
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3962318A (en) * 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2813121A1 (de) * 1977-03-29 1978-10-12 Procter & Gamble Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung
US4634691A (en) * 1980-10-07 1987-01-06 The Procter & Gamble Company Method for inhibiting tumor metastasis
US4478763A (en) 1982-10-20 1984-10-23 Univ. Of Southern California Process for preparing alpha-fluorinated alkanediphosphonates
GB8419489D0 (en) * 1984-07-31 1984-09-05 Leo Pharm Prod Ltd Chemical compounds
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method

Also Published As

Publication number Publication date
EP0479813A1 (en) 1992-04-15
JPH05500208A (ja) 1993-01-21
ATE128139T1 (de) 1995-10-15
CA2062735C (en) 2000-08-15
KR920702684A (ko) 1992-10-06
FI893039A0 (fi) 1989-06-21
JP2929236B2 (ja) 1999-08-03
US5376649A (en) 1994-12-27
HU904623D0 (en) 1992-06-29
NO178030B (no) 1995-10-02
NZ234179A (en) 1991-12-23
AU633459B2 (en) 1993-01-28
WO1990015806A1 (en) 1990-12-27
AU5827290A (en) 1991-01-08
EP0479813B1 (en) 1995-09-20
HU211204A9 (en) 1995-11-28
HU208701B (en) 1993-12-28
NO915021D0 (no) 1991-12-19
NO915021L (no) 1991-12-19
FI83421C (fi) 1991-07-10
ZA904828B (en) 1991-03-27
HK26096A (en) 1996-02-16
DE69022593D1 (de) 1995-10-26
RU2074860C1 (ru) 1997-03-10
CA2062735A1 (en) 1990-12-22
ES2078970T3 (es) 1996-01-01
FI83421B (fi) 1991-03-28
FI893039A (fi) 1990-12-22
DE69022593T2 (de) 1996-06-13
HUT62008A (en) 1993-03-29

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