DE3786256D1 - Antifolat-mittel. - Google Patents
Antifolat-mittel.Info
- Publication number
- DE3786256D1 DE3786256D1 DE8787907792T DE3786256T DE3786256D1 DE 3786256 D1 DE3786256 D1 DE 3786256D1 DE 8787907792 T DE8787907792 T DE 8787907792T DE 3786256 T DE3786256 T DE 3786256T DE 3786256 D1 DE3786256 D1 DE 3786256D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- agents
- group
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868628731A GB8628731D0 (en) | 1986-12-02 | 1986-12-02 | Antifolate agents |
GB878721283A GB8721283D0 (en) | 1987-09-10 | 1987-09-10 | Antifolate agents |
GB878721284A GB8721284D0 (en) | 1987-09-10 | 1987-09-10 | Antifolate agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3786256D1 true DE3786256D1 (de) | 1993-07-22 |
DE3786256T2 DE3786256T2 (de) | 1993-10-07 |
Family
ID=27263226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE87907792T Expired - Fee Related DE3786256T2 (de) | 1986-12-02 | 1987-11-30 | Antifolat-mittel. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4992444A (de) |
EP (1) | EP0290558B1 (de) |
JP (1) | JP2704747B2 (de) |
AT (1) | ATE90673T1 (de) |
DE (1) | DE3786256T2 (de) |
GB (1) | GB2204867B (de) |
WO (1) | WO1988004293A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08504798A (ja) * | 1992-12-18 | 1996-05-21 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬としての,ピリミジン,ピリジン,プテリジノンおよびインダゾール誘導体 |
GB9226377D0 (en) * | 1992-12-18 | 1993-02-10 | Babbedge Rachel C | Pharmaceutical compositions |
US5747476A (en) * | 1996-07-17 | 1998-05-05 | Mortar & Pestle Veterinary Pharmacy, Inc. | Treatment of equine protozoal myeloencephalitis |
GB9700664D0 (en) * | 1997-01-14 | 1997-03-05 | British Tech Group | Anti-cancer agents |
US7371758B2 (en) * | 2003-03-13 | 2008-05-13 | National Science & Technology Development Agency | Antimalarial pyrimidine derivatives and methods of making and using them |
US20050171132A1 (en) * | 2003-09-26 | 2005-08-04 | Zhili Xin | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists |
WO2014145386A2 (en) * | 2013-03-15 | 2014-09-18 | University Of Florida Research Foundation Incorporated | Novel allosteric inhibitors of thymidylate synthase |
US10835524B2 (en) | 2015-06-24 | 2020-11-17 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of pancreatic cancer and uses thereof |
WO2023081141A1 (en) * | 2021-11-02 | 2023-05-11 | University Of Florida Research Foundation, Incorporated | Thymidylate synthase inhibitors and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2903850A1 (de) * | 1979-02-01 | 1980-08-07 | Bayer Ag | 2-amino-8-cyclopropyl-5-oxo-5,8- dihydro-pyrido eckige klammer auf 2,3-d eckige klammer zu -pyrimidin-6-carnonsaeuren, verfahren zu ihrer herstellung sowie ihrer verwendung als antibakterielle mittel |
GB8314643D0 (en) * | 1983-05-26 | 1983-06-29 | Wellcome Found | Pyrimidine derivatives |
GB8410636D0 (en) * | 1984-04-26 | 1984-05-31 | Stevens M F G | Pharmaceutical substances/compositions |
-
1987
- 1987-11-30 GB GB8728018A patent/GB2204867B/en not_active Expired - Lifetime
- 1987-11-30 WO PCT/GB1987/000859 patent/WO1988004293A1/en active IP Right Grant
- 1987-11-30 AT AT87907792T patent/ATE90673T1/de active
- 1987-11-30 JP JP63500078A patent/JP2704747B2/ja not_active Expired - Lifetime
- 1987-11-30 EP EP87907792A patent/EP0290558B1/de not_active Expired - Lifetime
- 1987-11-30 DE DE87907792T patent/DE3786256T2/de not_active Expired - Fee Related
- 1987-12-02 US US07/127,452 patent/US4992444A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB8728018D0 (en) | 1988-01-06 |
ATE90673T1 (de) | 1993-07-15 |
JPH01501477A (ja) | 1989-05-25 |
JP2704747B2 (ja) | 1998-01-26 |
EP0290558A1 (de) | 1988-11-17 |
WO1988004293A1 (en) | 1988-06-16 |
GB2204867A (en) | 1988-11-23 |
GB2204867B (en) | 1991-05-29 |
EP0290558B1 (de) | 1993-06-16 |
US4992444A (en) | 1991-02-12 |
DE3786256T2 (de) | 1993-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |