GB2152508A - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
GB2152508A
GB2152508A GB08501742A GB8501742A GB2152508A GB 2152508 A GB2152508 A GB 2152508A GB 08501742 A GB08501742 A GB 08501742A GB 8501742 A GB8501742 A GB 8501742A GB 2152508 A GB2152508 A GB 2152508A
Authority
GB
United Kingdom
Prior art keywords
agents
group
hydrogen
carbon atoms
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08501742A
Other versions
GB8501742D0 (en
GB2152508B (en
Inventor
Edward A Bliss
Roger John Griffin
Malcolm Francis Graham Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aston University
Wellcome Foundation Ltd
Original Assignee
Aston University
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aston University, Wellcome Foundation Ltd filed Critical Aston University
Publication of GB8501742D0 publication Critical patent/GB8501742D0/en
Publication of GB2152508A publication Critical patent/GB2152508A/en
Application granted granted Critical
Publication of GB2152508B publication Critical patent/GB2152508B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2,4-Diamino-5-phenylpyrimidines in the form of the free base or an acid addition salt thereof are provided of general formula (I), wherein R<1> is hydrogen, halogen or an alkoxy group having a carbon chain of 1-4 carbon atoms while R<2> is hydrogen or an alkyl group of 1-4 carbon atoms. The compounds are useful for therapeutic treatment, for example as antitumour agents, antipsoriatic agents and antimalarial agents, and pharmaceutical preparations for administration to mammals are disclosed. Particularly useful compounds, especially for antitumour therapy, have the azido group in the 3'- or 4'-position and R<1> in the 4'- or 3'-position of the phenyl group.
GB08501742A 1983-05-26 1984-05-29 Pyrimidine derivatives Expired GB2152508B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838314643A GB8314643D0 (en) 1983-05-26 1983-05-26 Pyrimidine derivatives

Publications (3)

Publication Number Publication Date
GB8501742D0 GB8501742D0 (en) 1985-02-27
GB2152508A true GB2152508A (en) 1985-08-07
GB2152508B GB2152508B (en) 1986-10-15

Family

ID=10543429

Family Applications (2)

Application Number Title Priority Date Filing Date
GB838314643A Pending GB8314643D0 (en) 1983-05-26 1983-05-26 Pyrimidine derivatives
GB08501742A Expired GB2152508B (en) 1983-05-26 1984-05-29 Pyrimidine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB838314643A Pending GB8314643D0 (en) 1983-05-26 1983-05-26 Pyrimidine derivatives

Country Status (5)

Country Link
EP (1) EP0147443A1 (en)
JP (1) JPS60502255A (en)
AU (1) AU3016884A (en)
GB (2) GB8314643D0 (en)
WO (1) WO1984004746A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6244015B1 (en) * 1997-08-11 2001-06-12 Kabushiki Kaisha Toshiba Method of assembling plant

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3786256T2 (en) * 1986-12-02 1993-10-07 British Tech Group ANTIFOLATE AGENT.
GB9214994D0 (en) * 1992-07-15 1992-08-26 Shea Dennis M O Pyrimidine compounds
GB9700664D0 (en) * 1997-01-14 1997-03-05 British Tech Group Anti-cancer agents
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
PL424999A1 (en) * 2018-03-22 2019-09-23 Glg Pharma Spółka Akcyjna Pharmaceutically acceptable 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1032239A (en) * 1950-02-15 1953-06-30 Wellcome Found Pyrimidine derivatives and their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1032239A (en) * 1950-02-15 1953-06-30 Wellcome Found Pyrimidine derivatives and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6244015B1 (en) * 1997-08-11 2001-06-12 Kabushiki Kaisha Toshiba Method of assembling plant

Also Published As

Publication number Publication date
GB8314643D0 (en) 1983-06-29
GB8501742D0 (en) 1985-02-27
EP0147443A1 (en) 1985-07-10
AU3016884A (en) 1984-12-18
WO1984004746A1 (en) 1984-12-06
GB2152508B (en) 1986-10-15
JPS60502255A (en) 1985-12-26

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee