PA8532401A1 - Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepina - Google Patents

Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepina

Info

Publication number
PA8532401A1
PA8532401A1 PA20018532401A PA8532401A PA8532401A1 PA 8532401 A1 PA8532401 A1 PA 8532401A1 PA 20018532401 A PA20018532401 A PA 20018532401A PA 8532401 A PA8532401 A PA 8532401A PA 8532401 A1 PA8532401 A1 PA 8532401A1
Authority
PA
Panama
Prior art keywords
benzodiazepina
triazolo
imidazo
ciclopropil
etil
Prior art date
Application number
PA20018532401A
Other languages
English (en)
Spanish (es)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8532401A1 publication Critical patent/PA8532401A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PA20018532401A 2000-11-16 2001-11-15 Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepina PA8532401A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16

Publications (1)

Publication Number Publication Date
PA8532401A1 true PA8532401A1 (es) 2002-08-26

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018532401A PA8532401A1 (es) 2000-11-16 2001-11-15 Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepina

Country Status (40)

Country Link
US (1) US6743789B2 (cg-RX-API-DMAC7.html)
EP (1) EP1337535B1 (cg-RX-API-DMAC7.html)
JP (1) JP4088151B2 (cg-RX-API-DMAC7.html)
KR (1) KR100504300B1 (cg-RX-API-DMAC7.html)
CN (1) CN1191255C (cg-RX-API-DMAC7.html)
AR (1) AR031345A1 (cg-RX-API-DMAC7.html)
AT (1) ATE268776T1 (cg-RX-API-DMAC7.html)
AU (2) AU2002217007B2 (cg-RX-API-DMAC7.html)
BG (1) BG107817A (cg-RX-API-DMAC7.html)
BR (1) BR0115393A (cg-RX-API-DMAC7.html)
CA (1) CA2427576C (cg-RX-API-DMAC7.html)
CZ (1) CZ295256B6 (cg-RX-API-DMAC7.html)
DE (1) DE60103776T2 (cg-RX-API-DMAC7.html)
DK (1) DK1337535T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP034607A (cg-RX-API-DMAC7.html)
ES (1) ES2220831T3 (cg-RX-API-DMAC7.html)
GC (1) GC0000375A (cg-RX-API-DMAC7.html)
GT (1) GT200100230A (cg-RX-API-DMAC7.html)
HR (1) HRP20030360A2 (cg-RX-API-DMAC7.html)
HU (1) HUP0303281A3 (cg-RX-API-DMAC7.html)
IL (1) IL155813A0 (cg-RX-API-DMAC7.html)
JO (1) JO2359B1 (cg-RX-API-DMAC7.html)
MA (1) MA26962A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA03004251A (cg-RX-API-DMAC7.html)
MY (1) MY141675A (cg-RX-API-DMAC7.html)
NO (1) NO324706B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ525413A (cg-RX-API-DMAC7.html)
PA (1) PA8532401A1 (cg-RX-API-DMAC7.html)
PE (1) PE20020583A1 (cg-RX-API-DMAC7.html)
PL (1) PL362925A1 (cg-RX-API-DMAC7.html)
PT (1) PT1337535E (cg-RX-API-DMAC7.html)
RU (1) RU2278865C2 (cg-RX-API-DMAC7.html)
SI (1) SI1337535T1 (cg-RX-API-DMAC7.html)
SK (1) SK7232003A3 (cg-RX-API-DMAC7.html)
TR (1) TR200402073T4 (cg-RX-API-DMAC7.html)
TW (1) TWI239333B (cg-RX-API-DMAC7.html)
UY (1) UY27026A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002040487A2 (cg-RX-API-DMAC7.html)
YU (1) YU35603A (cg-RX-API-DMAC7.html)
ZA (1) ZA200303435B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
WO2004113321A1 (ja) * 2003-06-19 2004-12-29 Daiichi Pharmaceutical Co., Ltd. 選択的なアミノ置換基導入法
US20050176680A1 (en) 2003-12-11 2005-08-11 Sepracor, Inc. Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
AU2005272627A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
AU2005293820B2 (en) 2004-10-12 2010-11-25 F. Hoffmann-La Roche Ag Imidazo [1, 5-a]triazolo[1, 5-d]benzodiazepine derivatives for the treatment of cognitive disorders
RU2007114763A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
CA2584259C (en) * 2004-10-20 2013-04-02 F. Hoffmann-La Roche Ag Imidazo-benzodiazepine derivatives
EP1828194B1 (en) 2004-12-14 2008-05-28 F. Hoffmann-Roche AG Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
BRPI0617204A2 (pt) * 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
CA2625210A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
CA2739900C (en) 2008-11-18 2016-11-08 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
SI2370441T1 (sl) * 2008-11-28 2013-12-31 F. Hoffmann-La Roche Ag Arilcikloheksiletri dihidrotetraazabenzoazulenov za uporabo kot antagonisti receptorja vazopresina V1A
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
CA2818025A1 (en) 2010-11-15 2012-05-24 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
EP2897963A4 (en) * 2012-09-21 2016-03-30 Uwm Res Foundation Inc Novel GABAA AGONISTS AND METHOD FOR USE TO COMBAT AIRWAY HYPER REAGIBILITY AND IGNITIONS IN ASTHMA
EP4032889A1 (en) * 2013-12-20 2022-07-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CA2990004C (en) 2015-06-19 2024-04-23 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio, Inc. derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
AU2019288382B2 (en) * 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
AU2023324882A1 (en) 2022-08-19 2025-03-20 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (cg-RX-API-DMAC7.html) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
WO2002040487A3 (en) 2002-09-26
ES2220831T3 (es) 2004-12-16
ATE268776T1 (de) 2004-06-15
AU2002217007B2 (en) 2006-11-30
IL155813A0 (en) 2003-12-23
KR100504300B1 (ko) 2005-07-28
RU2003116895A (ru) 2005-02-20
ZA200303435B (en) 2004-08-05
GC0000375A (en) 2007-03-31
AU1700702A (en) 2002-05-27
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
NO20032208D0 (no) 2003-05-15
MXPA03004251A (es) 2003-09-22
DE60103776T2 (de) 2005-07-14
BR0115393A (pt) 2004-07-06
PE20020583A1 (es) 2002-07-06
KR20030045192A (ko) 2003-06-09
EP1337535B1 (en) 2004-06-09
CN1474820A (zh) 2004-02-11
DK1337535T3 (da) 2004-10-25
SI1337535T1 (en) 2004-10-31
MY141675A (en) 2010-06-15
BG107817A (bg) 2004-07-30
GT200100230A (es) 2002-07-04
ECSP034607A (es) 2003-06-25
HUP0303281A2 (hu) 2004-01-28
HK1062442A1 (en) 2004-11-05
RU2278865C2 (ru) 2006-06-27
JO2359B1 (en) 2006-12-12
NO20032208L (no) 2003-05-15
PL362925A1 (en) 2004-11-02
YU35603A (sh) 2006-05-25
CZ20031597A3 (cs) 2003-11-12
CA2427576A1 (en) 2002-05-23
PT1337535E (pt) 2004-09-30
CA2427576C (en) 2007-11-06
CN1191255C (zh) 2005-03-02
DE60103776D1 (de) 2004-07-15
HUP0303281A3 (en) 2005-05-30
AR031345A1 (es) 2003-09-17
NO324706B1 (no) 2007-12-03
MA26962A1 (fr) 2004-12-20
JP4088151B2 (ja) 2008-05-21
CZ295256B6 (cs) 2005-06-15
US20020103371A1 (en) 2002-08-01
SK7232003A3 (en) 2004-03-02
US6743789B2 (en) 2004-06-01
UY27026A1 (es) 2002-06-20
HRP20030360A2 (en) 2005-04-30
TWI239333B (en) 2005-09-11
WO2002040487A2 (en) 2002-05-23
JP2004517070A (ja) 2004-06-10
EP1337535A2 (en) 2003-08-27

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