OA11146A - Process for preparing eprosartan - Google Patents

Process for preparing eprosartan Download PDF

Info

Publication number
OA11146A
OA11146A OA9900179A OA9900179A OA11146A OA 11146 A OA11146 A OA 11146A OA 9900179 A OA9900179 A OA 9900179A OA 9900179 A OA9900179 A OA 9900179A OA 11146 A OA11146 A OA 11146A
Authority
OA
OAPI
Prior art keywords
compound
formula
alkyl
reacting
pharmaceutically acceptable
Prior art date
Application number
OA9900179A
Other languages
English (en)
Inventor
Clifford S Labaw
Joseph Robert Flisak
Li Liu
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of OA11146A publication Critical patent/OA11146A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
OA9900179A 1997-02-14 1999-08-13 Process for preparing eprosartan OA11146A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3819597P 1997-02-14 1997-02-14

Publications (1)

Publication Number Publication Date
OA11146A true OA11146A (en) 2003-04-16

Family

ID=21898583

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900179A OA11146A (en) 1997-02-14 1999-08-13 Process for preparing eprosartan

Country Status (41)

Country Link
US (1) US6172237B1 (sk)
EP (1) EP0970073B1 (sk)
JP (1) JP4537499B2 (sk)
KR (1) KR100573638B1 (sk)
CN (1) CN1085208C (sk)
AP (1) AP1128A (sk)
AR (1) AR011125A1 (sk)
AT (1) ATE280765T1 (sk)
AU (1) AU730383B2 (sk)
BG (1) BG63804B1 (sk)
BR (1) BR9808664A (sk)
CA (1) CA2281708C (sk)
CO (1) CO4950550A1 (sk)
CY (1) CY2555B1 (sk)
CZ (1) CZ296349B6 (sk)
DE (1) DE69827240T2 (sk)
DK (1) DK0970073T3 (sk)
EA (1) EA001659B1 (sk)
EG (1) EG23935A (sk)
ES (1) ES2231963T3 (sk)
HU (1) HU228781B1 (sk)
ID (1) ID23181A (sk)
IL (1) IL131309A (sk)
IN (2) IN187999B (sk)
MA (1) MA24470A1 (sk)
MY (1) MY118704A (sk)
NO (1) NO317194B1 (sk)
NZ (1) NZ337180A (sk)
OA (1) OA11146A (sk)
PE (1) PE59299A1 (sk)
PL (1) PL192838B1 (sk)
PT (1) PT970073E (sk)
RO (1) RO119719B1 (sk)
SA (1) SA98190082B1 (sk)
SI (1) SI0970073T1 (sk)
SK (1) SK285036B6 (sk)
TR (1) TR199901936T2 (sk)
TW (1) TW399050B (sk)
UA (1) UA54487C2 (sk)
WO (1) WO1998035963A1 (sk)
ZA (1) ZA981207B (sk)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2097408A4 (en) * 2006-12-27 2010-08-25 Hetero Drugs Ltd IMPROVED PROCESS FOR THE PREPARATION OF EPROSARTAN
WO2009013760A2 (en) * 2007-07-25 2009-01-29 Hetero Drugs Limited Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan
EP2295430A3 (en) * 2007-07-25 2011-08-03 Hetero Drugs Limited Crystalline solid of eprosartan acetate
WO2009084028A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate
CN101215284B (zh) * 2007-12-31 2010-10-13 浙江华海药业股份有限公司 一种改进的依普罗沙坦的制备方法
WO2009122421A2 (en) * 2008-03-31 2009-10-08 Hetero Research Foundation Improved process for eprosartan intermediate
WO2010023688A2 (en) * 2008-08-25 2010-03-04 Matrix Laboratories Limited An improved process for the preparation of eprosartan
WO2011004384A2 (en) 2009-06-05 2011-01-13 Glochem Industries Limited Process for the preparation of eprosartan
WO2011051975A1 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
PL185858B1 (pl) * 1994-05-20 2003-08-29 Smithkline Beecham Corp Związek addycyjny kwasu 4-[(2-n-butylo-5-formylo-1Związek addycyjny kwasu 4-[(2-n-butylo-5-formylo-1H-imidazol-1-ilo)metylo]benzoesowego z wodorosiarcH-imidazol-1-ilo)metylo]benzoesowego z wodorosiarczynem i sposób jego wytwarzaniazynem i sposób jego wytwarzania

Also Published As

Publication number Publication date
IN187999B (sk) 2002-08-03
IL131309A (en) 2002-09-12
NZ337180A (en) 2000-11-24
EA001659B1 (ru) 2001-06-25
AU730383B2 (en) 2001-03-08
US6172237B1 (en) 2001-01-09
RO119719B1 (ro) 2005-02-28
SI0970073T1 (en) 2005-02-28
HUP0001994A3 (en) 2001-07-30
BG63804B1 (bg) 2003-01-31
NO993913D0 (no) 1999-08-13
TR199901936T2 (xx) 2000-04-21
CA2281708A1 (en) 1998-08-20
EP0970073B1 (en) 2004-10-27
AR011125A1 (es) 2000-08-02
CA2281708C (en) 2007-08-14
ATE280765T1 (de) 2004-11-15
AP9901620A0 (en) 1999-09-30
JP4537499B2 (ja) 2010-09-01
NO317194B1 (no) 2004-09-13
SK285036B6 (sk) 2006-05-04
JP2001510466A (ja) 2001-07-31
MA24470A1 (fr) 1998-10-01
PL335075A1 (en) 2000-04-10
EP0970073A1 (en) 2000-01-12
TW399050B (en) 2000-07-21
CZ285299A3 (cs) 2000-02-16
PT970073E (pt) 2005-02-28
HUP0001994A2 (hu) 2001-06-28
WO1998035963A1 (en) 1998-08-20
KR100573638B1 (ko) 2006-04-26
EP0970073A4 (en) 2001-01-24
DK0970073T3 (da) 2005-02-21
CY2555B1 (en) 2008-07-02
CZ296349B6 (cs) 2006-02-15
ID23181A (id) 2000-03-23
IL131309A0 (en) 2001-01-28
KR20000071007A (ko) 2000-11-25
PE59299A1 (es) 1999-09-09
NO993913L (no) 1999-08-13
CO4950550A1 (es) 2000-09-01
EG23935A (en) 2008-01-14
SK108799A3 (en) 2000-05-16
IN192743B (sk) 2004-05-15
EA199900740A1 (ru) 2000-02-28
SA98190082B1 (ar) 2006-08-20
BG103650A (en) 2000-06-30
MY118704A (en) 2005-01-31
CN1085208C (zh) 2002-05-22
AP1128A (en) 2002-12-06
AU6150898A (en) 1998-09-08
BR9808664A (pt) 2000-07-11
PL192838B1 (pl) 2006-12-29
DE69827240D1 (de) 2004-12-02
DE69827240T2 (de) 2005-10-13
HU228781B1 (en) 2013-05-28
UA54487C2 (uk) 2003-03-17
ES2231963T3 (es) 2005-05-16
CN1247539A (zh) 2000-03-15
ZA981207B (en) 1998-11-12

Similar Documents

Publication Publication Date Title
CN103282350B (zh) 制备雷米普利的方法
JP4048119B2 (ja) ２−（４−クロロベンゾイルアミノ）−３−［２（１ｈ）−キノールリノン−４−イル］プロピオン酸の製造方法
OA11146A (en) Process for preparing eprosartan
US6458963B1 (en) Process for preparing eprosartan using regioselective protection of 2,4-disubstituted-imidazole intermediates
FR2731219A1 (fr) Procede de synthese d'acides acryliques alpha-substitues et leur application
WO1997032874A1 (fr) Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
CA1313883C (en) Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
US6610855B2 (en) Synthesis of 3-amino-3-aryl propanoates
JP2893893B2 (ja) 環状ケトン類の製造方法
US4559178A (en) Resolution of 3-benzoylthio-2-methyl-propanoic acid with (+)-dehydroabietylamine
MXPA99007536A (en) Process for preparing eprosartan
HUT58734A (en) Optical separating process for producing 3r/3-carboxy-benzyl/-6-/5-fluoro-2-benzothiazolyl/-methoxy-4r-chromanol
FR2574792A1 (fr) Procede pour la preparation de derives de pyrrolidine
JPH1059947A (ja) キラルで、非ラセミの（４−アリール−２，５−ジオキソイミダゾリジン−１−イル）酢酸の製造方法
BE858897A (fr) Esters phtalidyliques d'acides aryl-alcanoiques therapeutiquement actifs et procede pour leur preparation
JPH08259519A (ja) α−アミノグリコールの製造法及びその中間体
JPH10291980A (ja) 光学活性な４，５−ジフェニル−２−イミダゾリジノン誘導体及びこれを用いた光学活性なα−アミノリン酸の製造方法
JPH03215451A (ja) 光学活性２―ヒドロキシ―４―フェニル酪酸のラセミ化法
JP2002544190A (ja) 新規方法