NZ212541A - 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1- hydroxybutyl)-3- (hydroxymethyl)-benzonitrile - Google Patents

4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1- hydroxybutyl)-3- (hydroxymethyl)-benzonitrile

Info

Publication number
NZ212541A
NZ212541A NZ212541A NZ21254185A NZ212541A NZ 212541 A NZ212541 A NZ 212541A NZ 212541 A NZ212541 A NZ 212541A NZ 21254185 A NZ21254185 A NZ 21254185A NZ 212541 A NZ212541 A NZ 212541A
Authority
NZ
New Zealand
Prior art keywords
filtered
mixture
crystals
fluorophenyl
compound
Prior art date
Application number
NZ212541A
Other languages
English (en)
Inventor
K P Bogeso
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ212541(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NZ212541A publication Critical patent/NZ212541A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Furan Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
NZ212541A 1984-08-06 1985-06-25 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1- hydroxybutyl)-3- (hydroxymethyl)-benzonitrile NZ212541A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419963A GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method

Publications (1)

Publication Number Publication Date
NZ212541A true NZ212541A (en) 1988-05-30

Family

ID=10564974

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ212541A NZ212541A (en) 1984-08-06 1985-06-25 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1- hydroxybutyl)-3- (hydroxymethyl)-benzonitrile

Country Status (18)

Country Link
US (1) US4650884A (cg-RX-API-DMAC7.html)
EP (1) EP0171943B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0625099B2 (cg-RX-API-DMAC7.html)
AT (1) ATE38661T1 (cg-RX-API-DMAC7.html)
AU (1) AU574819B2 (cg-RX-API-DMAC7.html)
CA (1) CA1237147A (cg-RX-API-DMAC7.html)
DE (1) DE3566251D1 (cg-RX-API-DMAC7.html)
DK (2) DK172450B1 (cg-RX-API-DMAC7.html)
ES (1) ES8606257A1 (cg-RX-API-DMAC7.html)
FI (2) FI81338C (cg-RX-API-DMAC7.html)
GB (1) GB8419963D0 (cg-RX-API-DMAC7.html)
GR (1) GR851894B (cg-RX-API-DMAC7.html)
IE (1) IE57817B1 (cg-RX-API-DMAC7.html)
IL (1) IL75690A (cg-RX-API-DMAC7.html)
NO (1) NO160364C (cg-RX-API-DMAC7.html)
NZ (1) NZ212541A (cg-RX-API-DMAC7.html)
PT (1) PT80913B (cg-RX-API-DMAC7.html)
ZA (1) ZA855026B (cg-RX-API-DMAC7.html)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH0675987U (ja) * 1993-04-09 1994-10-25 日立造船株式会社 貨物輸送船におけるバラストタンクへのアクセス用トランク構造
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
SK283309B6 (sk) * 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ATE221522T1 (de) * 1997-11-11 2002-08-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
UA70979C2 (uk) 1998-12-23 2004-11-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HK1048122B (zh) 1999-04-14 2005-01-14 H‧隆德贝克有限公司 製備西酞普蘭的方法
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
PT1298124E (pt) 1999-10-25 2007-05-31 Lundbeck & Co As H Método para a preparação de citalopram
CH692421A5 (de) * 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
KR20020073489A (ko) 1999-12-28 2002-09-26 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
ATE253568T1 (de) * 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AU2006201612B2 (en) * 2000-01-14 2008-03-13 H Lundbeck A/S Method for the preparation of 5-cyanophthalide
PT1254129E (pt) 2000-01-14 2004-03-31 Lundbeck & Co As H Metodo para a preparacao da 5-cionaftalida
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
WO2001068631A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1418205A (zh) 2000-03-14 2003-05-14 H·隆德贝克有限公司 制备西酞普兰的方法
NZ521059A (en) * 2000-03-16 2004-04-30 H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
US6494503B1 (en) * 2000-03-25 2002-12-17 Non Metallic Resources, Inc. Pipe joint assembly and method for using same
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BG64901B1 (bg) * 2000-05-29 2006-08-31 H. Lundbeck A/S Метод за получаване на циталопрам
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
IS6021A (is) * 2000-08-10 2001-10-20 H. Lundbeck A/S Lyfjasamsetningar sem innihalda sítalópram
CA2354880C (en) * 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
PT1181713E (pt) 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
HRP20020005A2 (en) * 2000-12-28 2003-04-30 Lundbeck & Co As H Process for the preparation of pure citalopram
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20050066373A1 (en) * 2001-02-02 2005-03-24 Matthew Rabinowitz Position location using broadcast digital television signals
CZ20033267A3 (en) * 2001-05-01 2004-06-16 H. Lundbeck A/S The use of enantiomeric pure escitalopram
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
WO2003011278A1 (en) * 2001-07-31 2003-02-13 H. Lundbeck A/S Crystalline composition containing escitalopram
DK1281707T3 (da) * 2001-08-02 2005-05-02 Infosint Sa Fremgangsmåde til fremstilling af 5-substituerede isobenzenfuraner
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
AU2003207774A1 (en) * 2002-01-30 2003-09-02 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
BG65516B1 (bg) * 2002-07-31 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
MXPA05005772A (es) 2002-12-23 2005-08-16 Lundbeck & Co As H Bromhidrato de escitalopram y un metodo para su preparacion.
US7390913B2 (en) 2002-12-23 2008-06-24 H. Lundbeck A/S Process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
WO2004083197A2 (en) * 2003-03-21 2004-09-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
CA2537402C (en) 2003-09-12 2009-05-05 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
SI1506963T1 (en) * 2003-10-28 2005-10-31 Adorkem Technology Spa Method for the preparation of citalopram
BR0318581A (pt) * 2003-10-28 2006-10-10 Wockhardt Ltd processo melhorando para fabriacação de bromidrato de citalopram
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2005070914A1 (en) * 2004-01-23 2005-08-04 Jubilant Organosys Limited A method for the preparation of citalopram acid addition salts
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
JP2005263741A (ja) * 2004-03-19 2005-09-29 Sumitomo Chemical Co Ltd シタロプラムの製造方法ならびにその中間体およびその製造方法
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
EP2141156A1 (en) * 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ITMI20041872A1 (it) * 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
CN101265215B (zh) * 2008-04-18 2011-03-16 浙江奥托康制药集团股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
US20110092719A1 (en) * 2008-06-16 2011-04-21 Shodhana Laboratories Limited Preparation of Escitalopram, Its Salts and Intermediates
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
CN102190600B (zh) * 2010-03-13 2015-04-15 浙江华海药业股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
EP3309142B1 (en) 2015-06-09 2020-08-05 Zhejiang Huahai Pharmaceutical Co., Ltd Method for preparing citalopram diol intermediate
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
KR102134179B1 (ko) * 2018-09-17 2020-07-16 (주)유케이케미팜 카보네이트를 이용한 시탈로프람 및 에스시탈로프람의 새로운 제조 방법
CN112409212B (zh) * 2020-11-30 2023-03-14 四川新迪医药化工有限公司 西酞普兰二醇中间体氢溴酸盐的制备方法及西酞普兰二醇中间体氢溴酸盐、西酞普兰

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (cg-RX-API-DMAC7.html) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.

Also Published As

Publication number Publication date
US4650884A (en) 1987-03-17
FI852902L (fi) 1986-02-07
NO160364C (no) 1989-04-12
FI81338B (fi) 1990-06-29
EP0171943B1 (en) 1988-11-17
DE3566251D1 (en) 1988-12-22
DK172450B1 (da) 1998-08-10
EP0171943A1 (en) 1986-02-19
IL75690A (en) 1988-10-31
PT80913B (pt) 1987-09-30
DK172713B1 (da) 1999-06-14
AU4577685A (en) 1986-02-13
DK356285A (da) 1986-02-07
JPS6187654A (ja) 1986-05-06
IE851603L (en) 1986-02-06
FI115300B (fi) 2005-04-15
ZA855026B (en) 1986-06-25
PT80913A (en) 1985-09-01
NO160364B (no) 1989-01-02
GB8419963D0 (en) 1984-09-12
FI852902A0 (fi) 1985-07-25
NO853091L (no) 1986-02-07
ES545885A0 (es) 1986-04-01
FI81338C (fi) 1990-10-10
GR851894B (cg-RX-API-DMAC7.html) 1985-12-03
CA1237147A (en) 1988-05-24
JPH0625099B2 (ja) 1994-04-06
ES8606257A1 (es) 1986-04-01
AU574819B2 (en) 1988-07-14
IE57817B1 (en) 1993-04-21
ATE38661T1 (de) 1988-12-15
FI20031369A7 (fi) 2003-09-23
DK356285D0 (da) 1985-08-05
DK89595A (da) 1995-08-10

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