NZ205240A - Sulphonamide derivatives,being starting materials for producing beta-lactams - Google Patents

Sulphonamide derivatives,being starting materials for producing beta-lactams

Info

Publication number
NZ205240A
NZ205240A NZ205240A NZ20524081A NZ205240A NZ 205240 A NZ205240 A NZ 205240A NZ 205240 A NZ205240 A NZ 205240A NZ 20524081 A NZ20524081 A NZ 20524081A NZ 205240 A NZ205240 A NZ 205240A
Authority
NZ
New Zealand
Prior art keywords
amino
oxo
acid
salt
solution
Prior art date
Application number
NZ205240A
Other languages
English (en)
Inventor
Richard B Sykes
William L Parker
Christopher M Cimarusti
William H Koster
William A Slusarchyk
Alan W Fritz
David M Floyd
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of NZ205240A publication Critical patent/NZ205240A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ205240A 1980-02-07 1981-02-05 Sulphonamide derivatives,being starting materials for producing beta-lactams NZ205240A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11927680A 1980-02-07 1980-02-07
US18889380A 1980-09-29 1980-09-29

Publications (1)

Publication Number Publication Date
NZ205240A true NZ205240A (en) 1984-07-31

Family

ID=26817179

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ205240A NZ205240A (en) 1980-02-07 1981-02-05 Sulphonamide derivatives,being starting materials for producing beta-lactams
NZ196202A NZ196202A (en) 1980-02-07 1981-02-05 Beta-lactam antibiotics (of azetidine-sulphonic acid type)

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ196202A NZ196202A (en) 1980-02-07 1981-02-05 Beta-lactam antibiotics (of azetidine-sulphonic acid type)

Country Status (29)

Country Link
JP (3) JPS56125362A (en:Method)
KR (1) KR860001289B1 (en:Method)
AR (1) AR245932A1 (en:Method)
AU (1) AU569407B2 (en:Method)
CA (1) CA1338670C (en:Method)
CH (2) CH653993A5 (en:Method)
DD (1) DD156180A5 (en:Method)
DE (1) DE3104145C2 (en:Method)
DK (1) DK166280C (en:Method)
ES (1) ES499171A0 (en:Method)
FI (1) FI80271C (en:Method)
FR (1) FR2509299B1 (en:Method)
GB (2) GB2071650B (en:Method)
GR (1) GR74151B (en:Method)
HK (1) HK57785A (en:Method)
IE (2) IE51392B1 (en:Method)
IL (1) IL62082A (en:Method)
IT (1) IT1135360B (en:Method)
KE (1) KE3539A (en:Method)
LU (1) LU83117A1 (en:Method)
MY (1) MY8600179A (en:Method)
NL (1) NL192924C (en:Method)
NO (2) NO161065C (en:Method)
NZ (2) NZ205240A (en:Method)
PH (3) PH24729A (en:Method)
PT (1) PT72465B (en:Method)
SE (3) SE457954B (en:Method)
SG (1) SG39185G (en:Method)
YU (1) YU44829B (en:Method)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050965A1 (en) * 1980-10-23 1982-05-05 Takeda Chemical Industries, Ltd. Beta-lactamase inhibitory composition
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
MX7096E (es) * 1980-12-05 1987-06-19 Takeda Chemical Industries Ltd Metodo para preparacion de derivados de 2-oxoazetidina
WO1983000690A1 (en) * 1981-08-25 1983-03-03 Takeda Chemical Industries Ltd Azetidine derivatives and process for their preparation
US4673739A (en) * 1980-12-05 1987-06-16 Takeda Chemical Industries, Ltd. 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
US4675397A (en) * 1980-12-05 1987-06-23 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use
US4782147A (en) * 1980-12-05 1988-11-01 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
JPS58210061A (ja) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd １−スルホ−２−オキソアゼチジン誘導体、その製造法および用途
US4572801A (en) * 1981-04-30 1986-02-25 Takeda Chemical Industries, Ltd. 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
CA1181075A (en) * 1981-07-13 1985-01-15 David M. Floyd CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
FR2538389B2 (fr) * 1981-10-23 1986-05-16 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine-1-sulfamique, nouveau procede de preparation de produits optiquement actifs, application des nouveaux produits comme medicaments et produits necessaires a leur preparation
FR2515182B1 (fr) * 1981-10-23 1986-05-09 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation
US4421686A (en) 1981-11-30 1983-12-20 E. R. Squibb & Sons, Inc. 4-Norbornyl-sulfonyl azetidinone intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones
IL67451A (en) * 1981-12-25 1987-10-20 Takeda Chemical Industries Ltd 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them
EP0088488B1 (en) * 1982-01-22 1986-10-01 Beecham Group Plc Antibacterial agents, their preparation and use
EP0086563A1 (en) * 1982-01-22 1983-08-24 Beecham Group Plc Antibacterial agents, their preparation and use
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
WO1983002942A1 (en) * 1982-02-19 1983-09-01 Yoshioka, Kouichi Process for preparing 2-azetidinone-1-sulfonic acids, and starting materials therefor
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
EP0096297B1 (de) * 1982-06-03 1988-06-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten
DE3372768D1 (de) * 1982-06-03 1987-09-03 Hoffmann La Roche 1-sulfo-2-oxoazetidine derivatives
US4704457A (en) * 1982-06-21 1987-11-03 E. R. Squibb & Sons, Inc. Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs
US4681937A (en) * 1982-09-27 1987-07-21 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters
US4551276A (en) * 1982-10-06 1985-11-05 E. R. Squibb & Sons, Inc. 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs
US4533495A (en) * 1982-12-30 1985-08-06 Takeda Chemical Industries, Ltd. Method of producing 2-azetidinone-1-sulfonic acid compounds
US4548747A (en) * 1983-05-02 1985-10-22 E. R. Squibb & Sons, Inc. 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones
US4670554A (en) * 1983-05-31 1987-06-02 E. R. Squibb & Sons, Inc. ((3-Acylamino-2-oxo-1-azetidinyl)oxy)methyl)phosphinic acids
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
JPS601162A (ja) * 1983-06-17 1985-01-07 Dai Ichi Seiyaku Co Ltd ３―アジド―２―オキソアゼチジン―１―スルホン酸誘導体の製造法
US4501697A (en) * 1983-06-17 1985-02-26 E. R. Squibb & Sons, Inc. 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts
US4587051A (en) * 1983-07-18 1986-05-06 E. R. Squibb & Sons, Inc. Desulfonation process for preparing 2-azetidinones
US4596777A (en) * 1983-08-10 1986-06-24 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4551277A (en) * 1983-11-09 1985-11-05 E. R. Squibb & Sons, Inc. 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid
JPS60112789A (ja) * 1983-11-21 1985-06-19 Otsuka Chem Co Ltd ３−アシルアミノ−４−アルキル−２−アゼチジノン−１−スルホン酸誘導体、その製造方法および該誘導体を含有する薬剤
JPS60226855A (ja) * 1984-04-26 1985-11-12 Nippon Kayaku Co Ltd Ｎ−ベンジルオキシカルボニル−ｌ−スレオニンアミド・１／２水和物およびその製造法
US4918185A (en) * 1984-05-22 1990-04-17 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
US4771135A (en) * 1984-05-22 1988-09-13 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
US4680409A (en) * 1984-10-09 1987-07-14 E. R. Squibb & Sons, Inc. Hydrazide containing derivatives of 2-amino-4-thiazole-acetic acid
US4610824A (en) * 1984-10-09 1986-09-09 E. R. Squibb & Sons, Inc. Hydrazide derivatives of monocyclic beta-lactam antibiotics
US4647660A (en) * 1985-05-02 1987-03-03 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4632985A (en) * 1985-06-03 1986-12-30 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4638062A (en) * 1985-06-17 1987-01-20 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4754041A (en) * 1985-06-17 1988-06-28 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
FR2588867B1 (fr) * 1985-10-23 1988-12-09 Roussel Uclaf Nouveaux produits derives de la serie de la 3-amino 2-oxo azetidine, leur procede de preparation et leur application
PT1888576E (pt) * 2005-05-09 2009-04-03 Sicor Inc Processo de produção de aztreonam
JP5648250B2 (ja) * 2007-11-21 2015-01-07 国立大学法人東京工業大学 スルホン化含窒素複素環を有する高分子有機化合物および有機化合物、それらの製造方法、およびそれらを用いたイオン交換体、電解質膜、医薬品、触媒、膜電極接合体、燃料電池
EP2804589A1 (en) 2012-01-16 2014-11-26 Mahmut Bilgic Pharmaceutical formulations comprising aztreonam
CU24441B1 (es) 2014-03-24 2019-09-04 Novartis Ag Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas
EP3353175B1 (en) 2015-09-23 2020-08-12 Novartis AG Salts and solid forms of a monobactam antibiotic
AU2018311521B2 (en) 2017-08-02 2022-03-03 Novartis Ag Process for preparing 1 -(((Z)-(1 -(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-y l)methyl)-1 -sulfoazetidin-3- yl)amino)ethylidene)amino)oxy)cyclopropane carboxylic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6046955B2 (ja) * 1977-12-30 1985-10-18 武田薬品工業株式会社 抗生物質ｇ−６３０２
JPS55164672A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Azetidine derivative and its preparation
CA1338538C (en) * 1979-06-08 1996-08-20 Taisuke Matsuo 1-sulfo-2-oxoazetidine derivatives and their production
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use

Also Published As

Publication number Publication date
ES8205397A1 (es) 1982-06-01
IT1135360B (it) 1986-08-20
NO170015B (no) 1992-05-25
AU569407B2 (en) 1988-01-28
JPH0586023A (ja) 1993-04-06
NO860225L (no) 1981-08-10
JPH0623188B2 (ja) 1994-03-30
YU31981A (en) 1984-02-29
HK57785A (en) 1985-08-09
JPH02160764A (ja) 1990-06-20
NO161065B (no) 1989-03-20
DK166280C (da) 1993-08-30
NL192924C (nl) 1998-05-07
SE457954B (sv) 1989-02-13
PH23316A (en) 1989-07-14
FR2509299B1 (fr) 1985-08-30
NL8100571A (nl) 1981-09-01
FR2509299A1 (fr) 1983-01-14
KR860001289B1 (ko) 1986-09-10
DE3104145A1 (de) 1981-12-17
SE8602194L (sv) 1986-05-14
CA1338670C (en) 1996-10-22
AU6698581A (en) 1981-08-13
MY8600179A (en) 1986-12-31
IE810230L (en) 1981-08-07
NO161065C (no) 1989-06-28
NL192924B (nl) 1998-01-05
NO810410L (no) 1981-08-10
GB2139618A (en) 1984-11-14
SE8100861L (sv) 1981-08-08
GB8333191D0 (en) 1984-01-18
KR830005131A (ko) 1983-08-03
SG39185G (en) 1985-12-13
SE8602193L (sv) 1986-05-14
FI810352L (fi) 1981-08-08
DE3104145C2 (de) 1999-05-12
GB2071650B (en) 1984-12-05
KE3539A (en) 1985-07-12
SE8602194D0 (sv) 1986-05-14
IT8119587A0 (it) 1981-02-06
JPS56125362A (en) 1981-10-01
GR74151B (en:Method) 1984-06-06
PH24729A (en) 1990-10-01
IE51393B1 (en) 1986-12-24
SE8602193D0 (sv) 1986-05-14
DK52381A (da) 1981-08-08
AR245932A1 (es) 1994-03-30
PT72465B (en) 1982-02-04
CH653993A5 (de) 1986-01-31
IL62082A (en) 1986-08-31
NZ196202A (en) 1984-07-31
FI80271B (fi) 1990-01-31
NO170015C (no) 1992-09-02
LU83117A1 (fr) 1982-09-10
GB2139618B (en) 1985-05-01
DD156180A5 (de) 1982-08-04
IE862297L (en) 1981-08-07
FI80271C (fi) 1990-05-10
AU4574885A (en) 1985-11-07
PH23317A (en) 1989-07-14
YU44829B (en) 1991-04-30
ES499171A0 (es) 1982-06-01
GB2071650A (en) 1981-09-23
CH651020A5 (de) 1985-08-30
PT72465A (pt) 1981-03-01
DK166280B (da) 1993-03-29
IL62082A0 (en) 1981-03-31
JPH0670006B2 (ja) 1994-09-07
AU548896B2 (en) 1986-01-09
SE500216C2 (sv) 1994-05-09
IE51392B1 (en) 1986-12-24

Similar Documents

Publication Publication Date Title
NZ205240A (en) Sulphonamide derivatives,being starting materials for producing beta-lactams
US4775670A (en) 2-oxo-1-azetidinesulfonic acid salts
US4794108A (en) 1-carboxymethoxy acetidinones and their production
EP0048953B1 (en) Beta-lactam antibiotics
EP0014476B1 (en) Optically active acylated cephalosporin analogs, processes for their preparation and pharmaceutical compositions comprising them
US4529698A (en) Process for preparing a 2-oxo-1-azetidinesulfonic acid salt
CA1340253C (en) B-lactam antibiotics
US5635500A (en) Cephem compound and pharmaceutical composition containing the compound
EP0308416A1 (en) N-1 substituted sulfonylaminocarbonyl, c-4 substituted monobactams
EP0191989B1 (en) Antibiotic isoxazole derivatives, their production and use
EP0187500B1 (en) Monobactams
KR930001405B1 (ko) 2-(4-치환아미노-3-옥소-이속사졸리디닐)-5-옥소-2-테트라히드로푸란카르복실산 유도체의 제조방법
US4883869A (en) Novel beta-lactams containing amino acid substituents
JPH0240669B2 (en:Method)
EP0187355A1 (en) Process for preparing beta-lactam antibiotics
JPH08291124A (ja) 新規生理活性物質ヒドロスタチンａおよびその製造法と用途
WO1986003752A1 (en) Novel antibiotic derivatives, process for their preparation and use thereof
JPH0330595B2 (en:Method)