AR245932A1 - Un proceso para la preparacion de derivados del acido 3-acilamino-2-oxo-azetidin-1-sulfonico y sus sales. - Google Patents

Un proceso para la preparacion de derivados del acido 3-acilamino-2-oxo-azetidin-1-sulfonico y sus sales.

Info

Publication number
AR245932A1
AR245932A1 AR81284229A AR28422981A AR245932A1 AR 245932 A1 AR245932 A1 AR 245932A1 AR 81284229 A AR81284229 A AR 81284229A AR 28422981 A AR28422981 A AR 28422981A AR 245932 A1 AR245932 A1 AR 245932A1
Authority
AR
Argentina
Prior art keywords
alcanoilo
alcanoyl
oxo
amino
tiazolil
Prior art date
Application number
AR81284229A
Other languages
English (en)
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of AR245932A1 publication Critical patent/AR245932A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN PROCESO PARA PREPARAR DERIVADOS DEL ACIDO 3-ACILAMINO-2-OXO-AZETIDIN-1- SULFONICO DE FORMULA (I),EN LA CUAL R2 ES H O ALCOXI,R3 ES H O ALQUILO;R4 ES H,ALQUILO,CICLOALQUILO,FENILO,ALCOXI-CO,ALQUEN-1-ILO,ALQUIN-1-ILO O 2- FENILETENILO M(+) HIDROGENO O UN CATION,Y ACILO SIGNIFICA ENTRE OTROS,DEFINICION NRO.1:(2-AMINO-4-TIAZOLIL)-ALCANOILO;4:(2-AMINO-4- TIAZOLIL)¡(HIDROXI(FENILMETOX I)FOSFINIL)METOXIIMINO¿ALCANOILO(C1-C4);(2H- TETRAZOL-2-IL)ALCANOILO;(3-(2-FURAN ILMETILENAMINO)-2-OXO-1-IMIDAZOLIDINIL- CARBONILAMINO)(FENIL)ALCANOILO;(2-OXO-1- IMIDAZOLIDINILCARBONILAMINO)- (FENIL)ALCANOILO;¡(4-ETIL-2,3-DIOXO-1-PIPERAZINIL) -CARBONILAMINO¿-(2- TIENIL)ALCANOILO;¡(2,3-DIOXO-4-)-FENILMETILENAMINO-1-PIPERAZ INIL- CARBONILAMINO¿-(FENIL)ALCANOILO (C1-C4);¡(3-(4-CLOROFENIL)METILENAMINO)-2- OXO-1-IMIDAZOLIDINILCARBONILAMINO¿-(F ENIL)ALCANOILO;(2-FURANILMETILENAMINO 2-OXO-1-IMIDAZOLIDINILCARBONILAMINO)-(4-H IDROXIFENIL)ALCANOILO;(2-FURANIL) (METOXIIMINO)ALCANOILO (C1-C4);(2-AMINO-4-TIAZOLIL)-(OXO)ALCAN OILO;(AMINOACETILAMINO)-(FENIL)ALCANOILO ;(2,6-DICLORO-4-PIRIDINILTIO ALCANOILO;¡(5-HIDROXI-2-(4-FORMIL-1-PIPERAZINIL)PIRIDO)(2,3-D)PIRIMIDIN-6- IL-CA RBONILAMINO¿-(FENIL)ALCANOILO;(2-AMINO-4-TIAZOLIL)¡(4-HIDROXI-4- OXOBUTOXI)IMINO ¿-ALCANOILO;¡(2-AMINOMETIL)-(FENIL)ALCANOILO; QUE COMPRENDE HACER REACCIONAR UN COMPUESTO DE LA FORMULA (IA) CON UN ACIDO DE FORMULA ACILO - OH DONDEEL GRUPO ACILO TIENE LOS VALORES SENALADOS, O LOS ANHIDRIDOS DE DICHOS ACIDOS, PREFERENTEMENTE EN PRESENCIA DE UN SOLVENTE ORGANICO INERTE.
AR81284229A 1980-02-07 1981-02-08 Un proceso para la preparacion de derivados del acido 3-acilamino-2-oxo-azetidin-1-sulfonico y sus sales. AR245932A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11927680A 1980-02-07 1980-02-07
US18889380A 1980-09-29 1980-09-29

Publications (1)

Publication Number Publication Date
AR245932A1 true AR245932A1 (es) 1994-03-30

Family

ID=26817179

Family Applications (1)

Application Number Title Priority Date Filing Date
AR81284229A AR245932A1 (es) 1980-02-07 1981-02-08 Un proceso para la preparacion de derivados del acido 3-acilamino-2-oxo-azetidin-1-sulfonico y sus sales.

Country Status (29)

Country Link
JP (3) JPS56125362A (es)
KR (1) KR860001289B1 (es)
AR (1) AR245932A1 (es)
AU (1) AU569407B2 (es)
CA (1) CA1338670C (es)
CH (2) CH653993A5 (es)
DD (1) DD156180A5 (es)
DE (1) DE3104145C2 (es)
DK (1) DK166280C (es)
ES (1) ES8205397A1 (es)
FI (1) FI80271C (es)
FR (1) FR2509299B1 (es)
GB (2) GB2071650B (es)
GR (1) GR74151B (es)
HK (1) HK57785A (es)
IE (2) IE51392B1 (es)
IL (1) IL62082A (es)
IT (1) IT1135360B (es)
KE (1) KE3539A (es)
LU (1) LU83117A1 (es)
MY (1) MY8600179A (es)
NL (1) NL192924C (es)
NO (2) NO161065C (es)
NZ (2) NZ205240A (es)
PH (3) PH24729A (es)
PT (1) PT72465B (es)
SE (3) SE457954B (es)
SG (1) SG39185G (es)
YU (1) YU44829B (es)

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DE602006005240D1 (de) * 2005-05-09 2009-04-02 Sicor Inc Herstellungsverfahren für aztreonam
JP5648250B2 (ja) * 2007-11-21 2015-01-07 国立大学法人東京工業大学 スルホン化含窒素複素環を有する高分子有機化合物および有機化合物、それらの製造方法、およびそれらを用いたイオン交換体、電解質膜、医薬品、触媒、膜電極接合体、燃料電池
WO2013109217A1 (en) 2012-01-16 2013-07-25 Mahmut Bilgic Pharmaceutical formulations comprising aztreonam
ES2719136T3 (es) 2014-03-24 2019-07-08 Novartis Ag Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas
KR20180054816A (ko) 2015-09-23 2018-05-24 노파르티스 아게 모노박탐 항생제의 염 및 고체 형태
WO2019026004A2 (en) 2017-08-02 2019-02-07 Novartis Ag CHEMICAL PROCESS FOR THE PREPARATION OF ANTIBIOTIC MONOBACTAM AND ITS INTERMEDIATES

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Publication number Priority date Publication date Assignee Title
JPS6046955B2 (ja) * 1977-12-30 1985-10-18 武田薬品工業株式会社 抗生物質ｇ−６３０２
CA1338538C (en) * 1979-06-08 1996-08-20 Taisuke Matsuo 1-sulfo-2-oxoazetidine derivatives and their production
JPS55164672A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Azetidine derivative and its preparation
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use

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GB8333191D0 (en) 1984-01-18
IL62082A0 (en) 1981-03-31
GB2139618B (en) 1985-05-01
IL62082A (en) 1986-08-31
DK166280C (da) 1993-08-30
KE3539A (en) 1985-07-12
SE8602194D0 (sv) 1986-05-14
AU548896B2 (en) 1986-01-09
LU83117A1 (fr) 1982-09-10
NO161065C (no) 1989-06-28
CH651020A5 (de) 1985-08-30
NO170015C (no) 1992-09-02
SE8602194L (sv) 1986-05-14
PH24729A (en) 1990-10-01
JPH0623188B2 (ja) 1994-03-30
PH23317A (en) 1989-07-14
FI80271B (fi) 1990-01-31
JPH0586023A (ja) 1993-04-06
NL8100571A (nl) 1981-09-01
PH23316A (en) 1989-07-14
ES499171A0 (es) 1982-06-01
FI810352L (fi) 1981-08-08
IT8119587A0 (it) 1981-02-06
NO170015B (no) 1992-05-25
YU31981A (en) 1984-02-29
IT1135360B (it) 1986-08-20
IE51393B1 (en) 1986-12-24
DE3104145A1 (de) 1981-12-17
AU4574885A (en) 1985-11-07
IE862297L (en) 1981-08-07
SE457954B (sv) 1989-02-13
IE810230L (en) 1981-08-07
JPH0670006B2 (ja) 1994-09-07
DE3104145C2 (de) 1999-05-12
SE8602193D0 (sv) 1986-05-14
NO860225L (no) 1981-08-10
NL192924B (nl) 1998-01-05
NO810410L (no) 1981-08-10
SE500216C2 (sv) 1994-05-09
HK57785A (en) 1985-08-09
IE51392B1 (en) 1986-12-24
CA1338670C (en) 1996-10-22
NL192924C (nl) 1998-05-07
JPH02160764A (ja) 1990-06-20
NO161065B (no) 1989-03-20
JPS56125362A (en) 1981-10-01
MY8600179A (en) 1986-12-31
PT72465A (pt) 1981-03-01
GB2139618A (en) 1984-11-14
AU6698581A (en) 1981-08-13
KR860001289B1 (ko) 1986-09-10
AU569407B2 (en) 1988-01-28
DK52381A (da) 1981-08-08
SG39185G (en) 1985-12-13
GR74151B (es) 1984-06-06
FR2509299B1 (fr) 1985-08-30
CH653993A5 (de) 1986-01-31
DK166280B (da) 1993-03-29
KR830005131A (ko) 1983-08-03
ES8205397A1 (es) 1982-06-01
FR2509299A1 (fr) 1983-01-14
GB2071650A (en) 1981-09-23
NZ196202A (en) 1984-07-31
SE8100861L (sv) 1981-08-08
NZ205240A (en) 1984-07-31
SE8602193L (sv) 1986-05-14
YU44829B (en) 1991-04-30
FI80271C (fi) 1990-05-10
GB2071650B (en) 1984-12-05
PT72465B (en) 1982-02-04
DD156180A5 (de) 1982-08-04

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