DE602006005240D1 - Herstellungsverfahren für aztreonam - Google Patents

Herstellungsverfahren für aztreonam

Info

Publication number
DE602006005240D1
DE602006005240D1 DE602006005240T DE602006005240T DE602006005240D1 DE 602006005240 D1 DE602006005240 D1 DE 602006005240D1 DE 602006005240 T DE602006005240 T DE 602006005240T DE 602006005240 T DE602006005240 T DE 602006005240T DE 602006005240 D1 DE602006005240 D1 DE 602006005240D1
Authority
DE
Germany
Prior art keywords
aztreonam
manufacturing process
taem
azetidine
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006005240T
Other languages
English (en)
Inventor
Domenico Fimognari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sicor Inc
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of DE602006005240D1 publication Critical patent/DE602006005240D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DE602006005240T 2005-05-09 2006-05-09 Herstellungsverfahren für aztreonam Active DE602006005240D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67931305P 2005-05-09 2005-05-09
US68180805P 2005-05-17 2005-05-17
PCT/US2006/018261 WO2006122253A1 (en) 2005-05-09 2006-05-09 Process for making aztreonam

Publications (1)

Publication Number Publication Date
DE602006005240D1 true DE602006005240D1 (de) 2009-04-02

Family

ID=37012142

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006005240T Active DE602006005240D1 (de) 2005-05-09 2006-05-09 Herstellungsverfahren für aztreonam

Country Status (11)

Country Link
US (1) US7601832B2 (de)
EP (1) EP1888576B1 (de)
JP (1) JP2008505189A (de)
AT (1) ATE423115T1 (de)
CA (1) CA2606901A1 (de)
DE (1) DE602006005240D1 (de)
ES (1) ES2321336T3 (de)
IL (1) IL185030A0 (de)
MX (1) MX2007000526A (de)
PT (1) PT1888576E (de)
WO (1) WO2006122253A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103999A1 (en) * 2003-05-15 2004-12-02 TEVA Gyógyszergyár Részvénytársaság AZTREONAM β POLYMORPH WITH VERY LOW RESIDUAL SOLVENT CONTENT
US20090069286A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched aztreonam
CN102086196B (zh) 2011-01-28 2012-06-13 海南灵康制药有限公司 一种氨曲南的方法
CN102382026A (zh) * 2011-10-17 2012-03-21 重庆南松医药科技股份有限公司 氨曲南主环(3s-反式)-3-氨基-4-甲基-2-氧代-1-氮杂环丁烷基磺酸的环保合成工艺
CN103570707B (zh) * 2012-07-21 2016-03-09 重庆圣华曦药业股份有限公司 一种改进的氨曲南的合成方法
CN114437059A (zh) * 2020-11-04 2022-05-06 重庆圣华曦药业股份有限公司 一种氨曲南二聚体杂质的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923998A (en) 1977-03-14 1990-05-08 Fujisawa Pharmaceutical Company, Ltd. Cephem and cepham compounds and processes for preparation thereof
NZ196202A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Beta-lactam antibiotics (of azetidine-sulphonic acid type)
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4529698A (en) 1981-01-19 1985-07-16 E. R. Squibb & Sons, Inc. Process for preparing a 2-oxo-1-azetidinesulfonic acid salt
US4946838A (en) 1981-07-13 1990-08-07 E. R. Squibb & Sons, Inc. Crystalline anhydrous aztreonam
CA1181075A (en) 1981-07-13 1985-01-15 David M. Floyd CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
DE3372768D1 (de) * 1982-06-03 1987-09-03 Hoffmann La Roche 1-sulfo-2-oxoazetidine derivatives
US4652651A (en) 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
US4826973A (en) 1984-07-20 1989-05-02 E. R. Squibb & Sons, Inc. Delta form of aztreonam and preparation thereof
CA1339136C (en) 1987-07-01 1997-07-29 Sailesh Amilal Varia Amorphous form of aztreonam
US5254681A (en) * 1989-08-02 1993-10-19 Consiglio Nazionale Delle Ricerche Process for preparing monobactames and their intermediate product
IT1231770B (it) * 1989-08-02 1991-12-21 Consiglio Nazionale Ricerche Processo per la preparazione di monobattami ed intermedio di preparazione.
US5194604A (en) 1990-06-29 1993-03-16 E. R. Squibb & Sons, Inc. Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains
PL165700B1 (pl) 1991-10-15 1995-01-31 Pan Sposób wytwarzania kwasu 32/2-amtnotiazoiilo-4/-2/1 -t-butoksykarbonylo- 1 -metyloetoksylmino/octowego
EP2301524B1 (de) 2000-12-27 2013-04-24 Gilead Sciences, Inc. Inhalierbares Aztreonam ohne Arginine zur Behandlung und Vorbeugung von bakteriellen Lungeninfektionen
US7214364B2 (en) 2000-12-27 2007-05-08 Corus Pharma, Inc. Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
WO2003018578A1 (en) 2001-08-27 2003-03-06 Aurobindo Pharma Ltd. Method for producing beta form of crystalline anhydrous aztreonam
WO2004013133A1 (en) * 2002-08-05 2004-02-12 TEVA Gyógyszergyár Részvénytársaság Preparation of aztreonam
AU2002356646A1 (en) 2002-12-11 2004-06-30 Pari Gmbh Pharmaceutical compositions for the pulmonary delivery of aztreonam
WO2005005424A1 (en) 2003-07-02 2005-01-20 TEVA Gyógyszergyár Részvénytársaság Aztreonam l-lysine and methods for the preparation thereof
WO2007083187A2 (en) 2006-01-16 2007-07-26 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of monobactam antibiotic

Also Published As

Publication number Publication date
ATE423115T1 (de) 2009-03-15
EP1888576B1 (de) 2009-02-18
ES2321336T3 (es) 2009-06-04
WO2006122253A1 (en) 2006-11-16
MX2007000526A (es) 2007-03-28
CA2606901A1 (en) 2006-11-16
US7601832B2 (en) 2009-10-13
PT1888576E (pt) 2009-04-03
JP2008505189A (ja) 2008-02-21
IL185030A0 (en) 2007-12-03
US20060276640A1 (en) 2006-12-07
EP1888576A1 (de) 2008-02-20

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Legal Events

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