ATE423115T1 - Herstellungsverfahren für aztreonam - Google Patents

Herstellungsverfahren für aztreonam

Info

Publication number
ATE423115T1
ATE423115T1 AT06759579T AT06759579T ATE423115T1 AT E423115 T1 ATE423115 T1 AT E423115T1 AT 06759579 T AT06759579 T AT 06759579T AT 06759579 T AT06759579 T AT 06759579T AT E423115 T1 ATE423115 T1 AT E423115T1
Authority
AT
Austria
Prior art keywords
aztreonam
production process
taem
azetidine
butyl
Prior art date
Application number
AT06759579T
Other languages
English (en)
Inventor
Domenico Fimognari
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE423115T1 publication Critical patent/ATE423115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Integrated Circuits (AREA)
  • Saccharide Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Bridges Or Land Bridges (AREA)
AT06759579T 2005-05-09 2006-05-09 Herstellungsverfahren für aztreonam ATE423115T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67931305P 2005-05-09 2005-05-09
US68180805P 2005-05-17 2005-05-17

Publications (1)

Publication Number Publication Date
ATE423115T1 true ATE423115T1 (de) 2009-03-15

Family

ID=37012142

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06759579T ATE423115T1 (de) 2005-05-09 2006-05-09 Herstellungsverfahren für aztreonam

Country Status (11)

Country Link
US (1) US7601832B2 (de)
EP (1) EP1888576B1 (de)
JP (1) JP2008505189A (de)
AT (1) ATE423115T1 (de)
CA (1) CA2606901A1 (de)
DE (1) DE602006005240D1 (de)
ES (1) ES2321336T3 (de)
IL (1) IL185030A0 (de)
MX (1) MX2007000526A (de)
PT (1) PT1888576E (de)
WO (1) WO2006122253A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452991B2 (en) * 2003-05-15 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Aztreonam β polymorph with very low residual solvent content
US20090069286A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched aztreonam
CN102086196B (zh) 2011-01-28 2012-06-13 海南灵康制药有限公司 一种氨曲南的方法
CN102382026A (zh) * 2011-10-17 2012-03-21 重庆南松医药科技股份有限公司 氨曲南主环(3s-反式)-3-氨基-4-甲基-2-氧代-1-氮杂环丁烷基磺酸的环保合成工艺
CN103570707B (zh) * 2012-07-21 2016-03-09 重庆圣华曦药业股份有限公司 一种改进的氨曲南的合成方法
CN114437059A (zh) * 2020-11-04 2022-05-06 重庆圣华曦药业股份有限公司 一种氨曲南二聚体杂质的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923998A (en) 1977-03-14 1990-05-08 Fujisawa Pharmaceutical Company, Ltd. Cephem and cepham compounds and processes for preparation thereof
NZ205240A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4529698A (en) 1981-01-19 1985-07-16 E. R. Squibb & Sons, Inc. Process for preparing a 2-oxo-1-azetidinesulfonic acid salt
US4946838A (en) 1981-07-13 1990-08-07 E. R. Squibb & Sons, Inc. Crystalline anhydrous aztreonam
CA1181075A (en) 1981-07-13 1985-01-15 David M. Floyd CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
EP0096296B1 (de) * 1982-06-03 1987-07-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 1-Sulfo-2-oxoazetidinderivate
US4652651A (en) 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
US4826973A (en) 1984-07-20 1989-05-02 E. R. Squibb & Sons, Inc. Delta form of aztreonam and preparation thereof
CA1339136C (en) 1987-07-01 1997-07-29 Sailesh Amilal Varia Amorphous form of aztreonam
IT1231770B (it) * 1989-08-02 1991-12-21 Consiglio Nazionale Ricerche Processo per la preparazione di monobattami ed intermedio di preparazione.
US5254681A (en) * 1989-08-02 1993-10-19 Consiglio Nazionale Delle Ricerche Process for preparing monobactames and their intermediate product
US5194604A (en) * 1990-06-29 1993-03-16 E. R. Squibb & Sons, Inc. Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains
PL165700B1 (pl) 1991-10-15 1995-01-31 Pan Sposób wytwarzania kwasu 32/2-amtnotiazoiilo-4/-2/1 -t-butoksykarbonylo- 1 -metyloetoksylmino/octowego
PT2301524E (pt) 2000-12-27 2013-07-10 Gilead Sciences Inc Aztreonam inalável sem arginina para tratamento e prevenção de infecções bacterianas pulmonares
US7214364B2 (en) 2000-12-27 2007-05-08 Corus Pharma, Inc. Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
WO2003018578A1 (en) 2001-08-27 2003-03-06 Aurobindo Pharma Ltd. Method for producing beta form of crystalline anhydrous aztreonam
EP1527072A1 (de) * 2002-08-05 2005-05-04 Teva Gyogyszergyar Reszvenytarsasag Herstellung von aztreonam
AU2002356646A1 (en) 2002-12-11 2004-06-30 Pari Gmbh Pharmaceutical compositions for the pulmonary delivery of aztreonam
CA2733145C (en) 2003-07-02 2012-06-19 Corus Pharma, Inc. Aztreonam l-lysine and method of determining impurities therein
WO2007083187A2 (en) 2006-01-16 2007-07-26 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of monobactam antibiotic

Also Published As

Publication number Publication date
US7601832B2 (en) 2009-10-13
CA2606901A1 (en) 2006-11-16
DE602006005240D1 (de) 2009-04-02
MX2007000526A (es) 2007-03-28
ES2321336T3 (es) 2009-06-04
JP2008505189A (ja) 2008-02-21
WO2006122253A1 (en) 2006-11-16
IL185030A0 (en) 2007-12-03
EP1888576A1 (de) 2008-02-20
US20060276640A1 (en) 2006-12-07
PT1888576E (pt) 2009-04-03
EP1888576B1 (de) 2009-02-18

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