NO860225L - Mellomprodukt for fremstilling av antibakterielle beta-laktamer. - Google Patents

Mellomprodukt for fremstilling av antibakterielle beta-laktamer.

Info

Publication number
NO860225L
NO860225L NO860225A NO860225A NO860225L NO 860225 L NO860225 L NO 860225L NO 860225 A NO860225 A NO 860225A NO 860225 A NO860225 A NO 860225A NO 860225 L NO860225 L NO 860225L
Authority
NO
Norway
Prior art keywords
manufacture
lactames
antibacterial
antibacterial beta
beta lactames
Prior art date
Application number
NO860225A
Other languages
English (en)
Other versions
NO170015C (no
NO170015B (no
Inventor
Richard Brook Sykes
William Lawrence Parker
Christopher Michael Cimarusti
William Henry Koster
William Allen Slusarchyk
Alan William Fritz
David Mack Floyd
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO860225L publication Critical patent/NO860225L/no
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of NO170015B publication Critical patent/NO170015B/no
Publication of NO170015C publication Critical patent/NO170015C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO86860225A 1980-02-07 1986-01-22 Mellomprodukter for fremstilling av antibakterielle beta-laktamer. NO170015C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11927680A 1980-02-07 1980-02-07
US18889380A 1980-09-29 1980-09-29
NO810410A NO161065C (no) 1980-02-07 1981-02-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-azetidinoner.

Publications (3)

Publication Number Publication Date
NO860225L true NO860225L (no) 1981-08-10
NO170015B NO170015B (no) 1992-05-25
NO170015C NO170015C (no) 1992-09-02

Family

ID=26817179

Family Applications (2)

Application Number Title Priority Date Filing Date
NO810410A NO161065C (no) 1980-02-07 1981-02-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-azetidinoner.
NO86860225A NO170015C (no) 1980-02-07 1986-01-22 Mellomprodukter for fremstilling av antibakterielle beta-laktamer.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO810410A NO161065C (no) 1980-02-07 1981-02-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-azetidinoner.

Country Status (29)

Country Link
JP (3) JPS56125362A (no)
KR (1) KR860001289B1 (no)
AR (1) AR245932A1 (no)
AU (1) AU569407B2 (no)
CA (1) CA1338670C (no)
CH (2) CH651020A5 (no)
DD (1) DD156180A5 (no)
DE (1) DE3104145C2 (no)
DK (1) DK166280C (no)
ES (1) ES8205397A1 (no)
FI (1) FI80271C (no)
FR (1) FR2509299B1 (no)
GB (2) GB2071650B (no)
GR (1) GR74151B (no)
HK (1) HK57785A (no)
IE (2) IE51393B1 (no)
IL (1) IL62082A (no)
IT (1) IT1135360B (no)
KE (1) KE3539A (no)
LU (1) LU83117A1 (no)
MY (1) MY8600179A (no)
NL (1) NL192924C (no)
NO (2) NO161065C (no)
NZ (2) NZ205240A (no)
PH (3) PH24729A (no)
PT (1) PT72465B (no)
SE (3) SE457954B (no)
SG (1) SG39185G (no)
YU (1) YU44829B (no)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050965A1 (en) * 1980-10-23 1982-05-05 Takeda Chemical Industries, Ltd. Beta-lactamase inhibitory composition
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
US4782147A (en) * 1980-12-05 1988-11-01 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use
US4675397A (en) * 1980-12-05 1987-06-23 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
WO1983000690A1 (en) * 1981-08-25 1983-03-03 Takeda Chemical Industries Ltd Azetidine derivatives and process for their preparation
MX7096E (es) * 1980-12-05 1987-06-19 Takeda Chemical Industries Ltd Metodo para preparacion de derivados de 2-oxoazetidina
US4673739A (en) * 1980-12-05 1987-06-16 Takeda Chemical Industries, Ltd. 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
JPS58210061A (ja) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd １−スルホ−２−オキソアゼチジン誘導体、その製造法および用途
US4572801A (en) * 1981-04-30 1986-02-25 Takeda Chemical Industries, Ltd. 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
CA1181075A (en) * 1981-07-13 1985-01-15 David M. Floyd CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
FR2515182B1 (fr) * 1981-10-23 1986-05-09 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation
FR2538389B2 (fr) * 1981-10-23 1986-05-16 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine-1-sulfamique, nouveau procede de preparation de produits optiquement actifs, application des nouveaux produits comme medicaments et produits necessaires a leur preparation
IL67451A (en) * 1981-12-25 1987-10-20 Takeda Chemical Industries Ltd 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them
EP0086563A1 (en) * 1982-01-22 1983-08-24 Beecham Group Plc Antibacterial agents, their preparation and use
EP0088488B1 (en) * 1982-01-22 1986-10-01 Beecham Group Plc Antibacterial agents, their preparation and use
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
WO1983002942A1 (en) * 1982-02-19 1983-09-01 Yoshioka, Kouichi Process for preparing 2-azetidinone-1-sulfonic acids, and starting materials therefor
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
DE3377061D1 (en) * 1982-06-03 1988-07-21 Hoffmann La Roche Process for the preparation of 1-sulfo-2-oxoazetidine derivatives
DE3372768D1 (de) * 1982-06-03 1987-09-03 Hoffmann La Roche 1-sulfo-2-oxoazetidine derivatives
US4704457A (en) * 1982-06-21 1987-11-03 E. R. Squibb & Sons, Inc. Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs
US4681937A (en) * 1982-09-27 1987-07-21 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters
US4551276A (en) * 1982-10-06 1985-11-05 E. R. Squibb & Sons, Inc. 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs
US4533495A (en) * 1982-12-30 1985-08-06 Takeda Chemical Industries, Ltd. Method of producing 2-azetidinone-1-sulfonic acid compounds
US4548747A (en) * 1983-05-02 1985-10-22 E. R. Squibb & Sons, Inc. 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones
US4670554A (en) * 1983-05-31 1987-06-02 E. R. Squibb & Sons, Inc. ((3-Acylamino-2-oxo-1-azetidinyl)oxy)methyl)phosphinic acids
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
US4501697A (en) * 1983-06-17 1985-02-26 E. R. Squibb & Sons, Inc. 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts
JPS601162A (ja) * 1983-06-17 1985-01-07 Dai Ichi Seiyaku Co Ltd ３―アジド―２―オキソアゼチジン―１―スルホン酸誘導体の製造法
US4587051A (en) * 1983-07-18 1986-05-06 E. R. Squibb & Sons, Inc. Desulfonation process for preparing 2-azetidinones
US4596777A (en) * 1983-08-10 1986-06-24 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4551277A (en) * 1983-11-09 1985-11-05 E. R. Squibb & Sons, Inc. 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid
JPS60112789A (ja) * 1983-11-21 1985-06-19 Otsuka Chem Co Ltd ３−アシルアミノ−４−アルキル−２−アゼチジノン−１−スルホン酸誘導体、その製造方法および該誘導体を含有する薬剤
JPS60226855A (ja) * 1984-04-26 1985-11-12 Nippon Kayaku Co Ltd Ｎ−ベンジルオキシカルボニル−ｌ−スレオニンアミド・１／２水和物およびその製造法
US4918185A (en) * 1984-05-22 1990-04-17 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
US4771135A (en) * 1984-05-22 1988-09-13 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
US4680409A (en) * 1984-10-09 1987-07-14 E. R. Squibb & Sons, Inc. Hydrazide containing derivatives of 2-amino-4-thiazole-acetic acid
US4610824A (en) * 1984-10-09 1986-09-09 E. R. Squibb & Sons, Inc. Hydrazide derivatives of monocyclic beta-lactam antibiotics
US4647660A (en) * 1985-05-02 1987-03-03 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4632985A (en) * 1985-06-03 1986-12-30 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4638062A (en) * 1985-06-17 1987-01-20 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4754041A (en) * 1985-06-17 1988-06-28 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
FR2588867B1 (fr) * 1985-10-23 1988-12-09 Roussel Uclaf Nouveaux produits derives de la serie de la 3-amino 2-oxo azetidine, leur procede de preparation et leur application
ATE423115T1 (de) * 2005-05-09 2009-03-15 Sicor Inc Herstellungsverfahren für aztreonam
JP5648250B2 (ja) * 2007-11-21 2015-01-07 国立大学法人東京工業大学 スルホン化含窒素複素環を有する高分子有機化合物および有機化合物、それらの製造方法、およびそれらを用いたイオン交換体、電解質膜、医薬品、触媒、膜電極接合体、燃料電池
WO2013109217A1 (en) 2012-01-16 2013-07-25 Mahmut Bilgic Pharmaceutical formulations comprising aztreonam
EP3122745B1 (en) 2014-03-24 2019-02-27 Novartis AG Monobactam organic compounds for the treatment of bacterial infections
CN108137573B (zh) 2015-09-23 2021-06-11 诺华股份有限公司 单环内酰胺抗生素的盐和固体形式
JP7235718B2 (ja) 2017-08-02 2023-03-08 ノバルティス アーゲー モノバクタム系抗生物質およびその中間体を製造するための化学的方法

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Publication number Priority date Publication date Assignee Title
JPS6046955B2 (ja) * 1977-12-30 1985-10-18 武田薬品工業株式会社 抗生物質ｇ−６３０２
JPS55164672A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Azetidine derivative and its preparation
EP0021678B1 (en) * 1979-06-08 1984-11-07 Takeda Chemical Industries, Ltd. 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use

Also Published As

Publication number Publication date
DE3104145A1 (de) 1981-12-17
KR830005131A (ko) 1983-08-03
KE3539A (en) 1985-07-12
CA1338670C (en) 1996-10-22
JPH02160764A (ja) 1990-06-20
NO161065B (no) 1989-03-20
AR245932A1 (es) 1994-03-30
NZ205240A (en) 1984-07-31
FI80271B (fi) 1990-01-31
GB2071650A (en) 1981-09-23
PH24729A (en) 1990-10-01
NO161065C (no) 1989-06-28
CH653993A5 (de) 1986-01-31
DK52381A (da) 1981-08-08
IT1135360B (it) 1986-08-20
IE51393B1 (en) 1986-12-24
CH651020A5 (de) 1985-08-30
FI80271C (fi) 1990-05-10
GB2139618B (en) 1985-05-01
AU6698581A (en) 1981-08-13
NL8100571A (nl) 1981-09-01
LU83117A1 (fr) 1982-09-10
PH23316A (en) 1989-07-14
JPS56125362A (en) 1981-10-01
SE8100861L (sv) 1981-08-08
GR74151B (no) 1984-06-06
HK57785A (en) 1985-08-09
ES499171A0 (es) 1982-06-01
AU548896B2 (en) 1986-01-09
AU569407B2 (en) 1988-01-28
NL192924B (nl) 1998-01-05
NO810410L (no) 1981-08-10
JPH0670006B2 (ja) 1994-09-07
DK166280C (da) 1993-08-30
DE3104145C2 (de) 1999-05-12
SE8602193D0 (sv) 1986-05-14
GB2071650B (en) 1984-12-05
IT8119587A0 (it) 1981-02-06
DD156180A5 (de) 1982-08-04
SE457954B (sv) 1989-02-13
ES8205397A1 (es) 1982-06-01
FI810352L (fi) 1981-08-08
IL62082A (en) 1986-08-31
IE51392B1 (en) 1986-12-24
GB2139618A (en) 1984-11-14
SE8602193L (sv) 1986-05-14
IL62082A0 (en) 1981-03-31
SE500216C2 (sv) 1994-05-09
PT72465A (pt) 1981-03-01
SE8602194D0 (sv) 1986-05-14
JPH0586023A (ja) 1993-04-06
AU4574885A (en) 1985-11-07
PT72465B (en) 1982-02-04
FR2509299B1 (fr) 1985-08-30
SG39185G (en) 1985-12-13
NO170015C (no) 1992-09-02
MY8600179A (en) 1986-12-31
YU31981A (en) 1984-02-29
IE810230L (en) 1981-08-07
NZ196202A (en) 1984-07-31
IE862297L (en) 1981-08-07
PH23317A (en) 1989-07-14
SE8602194L (sv) 1986-05-14
KR860001289B1 (ko) 1986-09-10
GB8333191D0 (en) 1984-01-18
YU44829B (en) 1991-04-30
NL192924C (nl) 1998-05-07
NO170015B (no) 1992-05-25
DK166280B (da) 1993-03-29
FR2509299A1 (fr) 1983-01-14
JPH0623188B2 (ja) 1994-03-30

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