IE862297L - Sulfamic acid derivatives. - Google Patents
Sulfamic acid derivatives.Info
- Publication number
- IE862297L IE862297L IE862297A IE229786A IE862297L IE 862297 L IE862297 L IE 862297L IE 862297 A IE862297 A IE 862297A IE 229786 A IE229786 A IE 229786A IE 862297 L IE862297 L IE 862297L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen
- acid derivatives
- sulfamic acid
- group
- provides
- Prior art date
Links
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 2-phenylethenyl Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
This invention concerns intermediates for use in preparing beta -lactam antibiotics. More specifically the invention provides a compound of the formula <IMAGE> wherein R1 is hydrogen or acyl or the group R1-NH- is protected amino; R3 and R4 are the same or different and each is hydrogen, alkyl, cycloalkyl, phenyl or substituted phenyl, or one of R3 and R4 is hydrogen and the other is alkoxycarbonyl, alken-1-yl, alkyn-1-yl, 2-phenylethenyl or 2-phenylethynyl; V is a leaving group; and M<+> is hydrogen or a cation. It also provides similar compounds where R1 is a protecting group.
[GB2139618A]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11927680A | 1980-02-07 | 1980-02-07 | |
US18889380A | 1980-09-29 | 1980-09-29 | |
IE230/81A IE51392B1 (en) | 1980-02-07 | 1981-02-06 | Beta-lactam antibiotics |
Publications (2)
Publication Number | Publication Date |
---|---|
IE862297L true IE862297L (en) | 1981-08-07 |
IE51393B1 IE51393B1 (en) | 1986-12-24 |
Family
ID=26817179
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE2297/86A IE51393B1 (en) | 1980-02-07 | 1981-02-06 | Sulfamic acid derivatives |
IE230/81A IE51392B1 (en) | 1980-02-07 | 1981-02-06 | Beta-lactam antibiotics |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE230/81A IE51392B1 (en) | 1980-02-07 | 1981-02-06 | Beta-lactam antibiotics |
Country Status (29)
Country | Link |
---|---|
JP (3) | JPS56125362A (en) |
KR (1) | KR860001289B1 (en) |
AR (1) | AR245932A1 (en) |
AU (1) | AU569407B2 (en) |
CA (1) | CA1338670C (en) |
CH (2) | CH653993A5 (en) |
DD (1) | DD156180A5 (en) |
DE (1) | DE3104145C2 (en) |
DK (1) | DK166280C (en) |
ES (1) | ES8205397A1 (en) |
FI (1) | FI80271C (en) |
FR (1) | FR2509299B1 (en) |
GB (2) | GB2071650B (en) |
GR (1) | GR74151B (en) |
HK (1) | HK57785A (en) |
IE (2) | IE51393B1 (en) |
IL (1) | IL62082A (en) |
IT (1) | IT1135360B (en) |
KE (1) | KE3539A (en) |
LU (1) | LU83117A1 (en) |
MY (1) | MY8600179A (en) |
NL (1) | NL192924C (en) |
NO (2) | NO161065C (en) |
NZ (2) | NZ196202A (en) |
PH (3) | PH24729A (en) |
PT (1) | PT72465B (en) |
SE (3) | SE457954B (en) |
SG (1) | SG39185G (en) |
YU (1) | YU44829B (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0050965A1 (en) * | 1980-10-23 | 1982-05-05 | Takeda Chemical Industries, Ltd. | Beta-lactamase inhibitory composition |
WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
JPS57131758A (en) * | 1980-12-05 | 1982-08-14 | Takeda Chem Ind Ltd | 1-sulfo-2-oxoazetidine derivative, its preparation and use |
US4675397A (en) * | 1980-12-05 | 1987-06-23 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
JPS58210061A (en) * | 1982-05-31 | 1983-12-07 | Takeda Chem Ind Ltd | 1-sulfo-2-oxoazetidine derivative, its preparation and use |
US4782147A (en) * | 1980-12-05 | 1988-11-01 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
WO1983000690A1 (en) * | 1981-08-25 | 1983-03-03 | Takeda Chemical Industries Ltd | Azetidine derivatives and process for their preparation |
US4673739A (en) * | 1980-12-05 | 1987-06-16 | Takeda Chemical Industries, Ltd. | 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
MX7096E (en) * | 1980-12-05 | 1987-06-19 | Takeda Chemical Industries Ltd | METHOD FOR PREPARATION OF 2-OXOAZETIDINE DERIVATIVES |
US4572801A (en) * | 1981-04-30 | 1986-02-25 | Takeda Chemical Industries, Ltd. | 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
CA1181075A (en) * | 1981-07-13 | 1985-01-15 | David M. Floyd | CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID |
FR2538389B2 (en) * | 1981-10-23 | 1986-05-16 | Roussel Uclaf | NEW PRODUCTS DERIVED FROM 3-AMINO 2-OXO AZETIDINE-1-SULFAMIC ACID, NEW PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE PRODUCTS, APPLICATION OF NEW PRODUCTS AS MEDICAMENTS AND PRODUCTS NECESSARY FOR THEIR PREPARATION |
FR2515182B1 (en) * | 1981-10-23 | 1986-05-09 | Roussel Uclaf | NOVEL PRODUCTS DERIVED FROM 3-AMINO 2-OXO AZETIDINE 1-SULFAMIC ACID, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION |
IL67451A (en) * | 1981-12-25 | 1987-10-20 | Takeda Chemical Industries Ltd | 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them |
EP0086563A1 (en) * | 1982-01-22 | 1983-08-24 | Beecham Group Plc | Antibacterial agents, their preparation and use |
EP0088488B1 (en) * | 1982-01-22 | 1986-10-01 | Beecham Group Plc | Antibacterial agents, their preparation and use |
US4443374A (en) * | 1982-02-01 | 1984-04-17 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives |
WO1983002942A1 (en) * | 1982-02-19 | 1983-09-01 | Yoshioka, Kouichi | Process for preparing 2-azetidinone-1-sulfonic acids, and starting materials therefor |
AU564150B2 (en) * | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
EP0096297B1 (en) * | 1982-06-03 | 1988-06-15 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
EP0096296B1 (en) * | 1982-06-03 | 1987-07-29 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 1-sulfo-2-oxoazetidine derivatives |
US4704457A (en) * | 1982-06-21 | 1987-11-03 | E. R. Squibb & Sons, Inc. | Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof |
US4939253A (en) * | 1982-08-04 | 1990-07-03 | E. R. Squibb & Sons, Inc. | 2-oxoazetidin-1-yloxy acetic acids and analogs |
US4681937A (en) * | 1982-09-27 | 1987-07-21 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters |
US4551276A (en) * | 1982-10-06 | 1985-11-05 | E. R. Squibb & Sons, Inc. | 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs |
US4533495A (en) * | 1982-12-30 | 1985-08-06 | Takeda Chemical Industries, Ltd. | Method of producing 2-azetidinone-1-sulfonic acid compounds |
US4548747A (en) * | 1983-05-02 | 1985-10-22 | E. R. Squibb & Sons, Inc. | 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones |
US4670554A (en) * | 1983-05-31 | 1987-06-02 | E. R. Squibb & Sons, Inc. | ((3-Acylamino-2-oxo-1-azetidinyl)oxy)methyl)phosphinic acids |
US4652651A (en) * | 1983-05-31 | 1987-03-24 | Hoffmann-La Roche Inc. | Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage |
US4501697A (en) * | 1983-06-17 | 1985-02-26 | E. R. Squibb & Sons, Inc. | 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts |
JPS601162A (en) * | 1983-06-17 | 1985-01-07 | Dai Ichi Seiyaku Co Ltd | Azetidine-1-sulfonic acid derivative |
US4587051A (en) * | 1983-07-18 | 1986-05-06 | E. R. Squibb & Sons, Inc. | Desulfonation process for preparing 2-azetidinones |
US4596777A (en) * | 1983-08-10 | 1986-06-24 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof |
US4551277A (en) * | 1983-11-09 | 1985-11-05 | E. R. Squibb & Sons, Inc. | 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid |
JPS60112789A (en) * | 1983-11-21 | 1985-06-19 | Otsuka Chem Co Ltd | 3-acylamino-4-alkyl-2-azetidinone-1-sulfonic acid derivative, tis preparation, and drug containing it |
JPS60226855A (en) * | 1984-04-26 | 1985-11-12 | Nippon Kayaku Co Ltd | N-benzyloxycarbonyl-l-threoninamide hemihydrate and preparation thereof |
US4918185A (en) * | 1984-05-22 | 1990-04-17 | Eli Lilly And Company | Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor |
US4771135A (en) * | 1984-05-22 | 1988-09-13 | Eli Lilly And Company | Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor |
US4680409A (en) * | 1984-10-09 | 1987-07-14 | E. R. Squibb & Sons, Inc. | Hydrazide containing derivatives of 2-amino-4-thiazole-acetic acid |
US4610824A (en) * | 1984-10-09 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Hydrazide derivatives of monocyclic beta-lactam antibiotics |
US4647660A (en) * | 1985-05-02 | 1987-03-03 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinesulfonic acids |
US4632985A (en) * | 1985-06-03 | 1986-12-30 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinesulfonic acids |
US4754041A (en) * | 1985-06-17 | 1988-06-28 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinesulfonic acids |
US4638062A (en) * | 1985-06-17 | 1987-01-20 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinesulfonic acids |
FR2588867B1 (en) * | 1985-10-23 | 1988-12-09 | Roussel Uclaf | NOVEL PRODUCTS DERIVED FROM THE 3-AMINO 2-OXO AZETIDINE SERIES, THEIR PREPARATION PROCESS AND THEIR APPLICATION |
WO2006122253A1 (en) * | 2005-05-09 | 2006-11-16 | Sicor, Inc. | Process for making aztreonam |
JP5648250B2 (en) * | 2007-11-21 | 2015-01-07 | 国立大学法人東京工業大学 | Polymer organic compounds and organic compounds having sulfonated nitrogen-containing heterocycles, methods for producing them, ion exchangers, electrolyte membranes, pharmaceuticals, catalysts, membrane electrode assemblies, fuel cells using them |
WO2013109217A1 (en) | 2012-01-16 | 2013-07-25 | Mahmut Bilgic | Pharmaceutical formulations comprising aztreonam |
EP3511328B1 (en) | 2014-03-24 | 2021-03-03 | Novartis AG | Monobactam organic compounds for the treatment of bacterial infections |
PT3353175T (en) | 2015-09-23 | 2020-09-10 | Novartis Ag | Salts and solid forms of monobactam antibiotic |
CN111094281B (en) | 2017-08-02 | 2023-08-29 | 诺华股份有限公司 | Chemical process for preparing monolactam antibiotics and intermediates thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6046955B2 (en) * | 1977-12-30 | 1985-10-18 | 武田薬品工業株式会社 | Antibiotic G-6302 |
EP0021678B1 (en) * | 1979-06-08 | 1984-11-07 | Takeda Chemical Industries, Ltd. | 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof |
JPS55164672A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Azetidine derivative and its preparation |
WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
JPS57131758A (en) * | 1980-12-05 | 1982-08-14 | Takeda Chem Ind Ltd | 1-sulfo-2-oxoazetidine derivative, its preparation and use |
-
1981
- 1981-02-05 NZ NZ196202A patent/NZ196202A/en unknown
- 1981-02-05 NZ NZ205240A patent/NZ205240A/en unknown
- 1981-02-06 FR FR8102372A patent/FR2509299B1/en not_active Expired
- 1981-02-06 NO NO810410A patent/NO161065C/en unknown
- 1981-02-06 JP JP1737981A patent/JPS56125362A/en active Pending
- 1981-02-06 KR KR1019810000379A patent/KR860001289B1/en active
- 1981-02-06 DE DE3104145A patent/DE3104145C2/en not_active Expired - Lifetime
- 1981-02-06 IE IE2297/86A patent/IE51393B1/en not_active IP Right Cessation
- 1981-02-06 LU LU83117A patent/LU83117A1/en unknown
- 1981-02-06 GB GB8103655A patent/GB2071650B/en not_active Expired
- 1981-02-06 SE SE8100861A patent/SE457954B/en not_active IP Right Cessation
- 1981-02-06 FI FI810352A patent/FI80271C/en not_active IP Right Cessation
- 1981-02-06 CH CH5565/84A patent/CH653993A5/en not_active IP Right Cessation
- 1981-02-06 DK DK052381A patent/DK166280C/en active
- 1981-02-06 CH CH816/81A patent/CH651020A5/en not_active IP Right Cessation
- 1981-02-06 CA CA000370320A patent/CA1338670C/en not_active Expired - Fee Related
- 1981-02-06 PH PH25195A patent/PH24729A/en unknown
- 1981-02-06 IL IL62082A patent/IL62082A/en not_active IP Right Cessation
- 1981-02-06 PT PT72465A patent/PT72465B/en unknown
- 1981-02-06 DD DD81227473A patent/DD156180A5/en not_active IP Right Cessation
- 1981-02-06 GR GR64081A patent/GR74151B/el unknown
- 1981-02-06 IE IE230/81A patent/IE51392B1/en not_active IP Right Cessation
- 1981-02-06 NL NL8100571A patent/NL192924C/en not_active IP Right Cessation
- 1981-02-06 YU YU319/81A patent/YU44829B/en unknown
- 1981-02-06 ES ES499171A patent/ES8205397A1/en not_active Expired
- 1981-02-06 IT IT19587/81A patent/IT1135360B/en active Protection Beyond IP Right Term
- 1981-02-08 AR AR81284229A patent/AR245932A1/en active
-
1983
- 1983-12-13 GB GB08333191A patent/GB2139618B/en not_active Expired
-
1984
- 1984-06-15 PH PH30820A patent/PH23317A/en unknown
- 1984-06-15 PH PH30821A patent/PH23316A/en unknown
-
1985
- 1985-05-25 SG SG391/85A patent/SG39185G/en unknown
- 1985-05-29 KE KE3539A patent/KE3539A/en unknown
- 1985-08-01 HK HK577/85A patent/HK57785A/en not_active IP Right Cessation
- 1985-08-02 AU AU45748/85A patent/AU569407B2/en not_active Expired
-
1986
- 1986-01-22 NO NO86860225A patent/NO170015C/en unknown
- 1986-05-14 SE SE8602193A patent/SE500216C2/en unknown
- 1986-05-14 SE SE8602194A patent/SE8602194L/en not_active Application Discontinuation
- 1986-12-30 MY MY179/86A patent/MY8600179A/en unknown
-
1989
- 1989-11-22 JP JP1304538A patent/JPH0623188B2/en not_active Expired - Lifetime
-
1991
- 1991-05-27 JP JP3121251A patent/JPH0670006B2/en not_active Expired - Lifetime
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MK9A | Patent expired |