SE8100861L - BETA-LACTAMANTIBIOTIC AGENTS - Google Patents

BETA-LACTAMANTIBIOTIC AGENTS

Info

Publication number
SE8100861L
SE8100861L SE8100861A SE8100861A SE8100861L SE 8100861 L SE8100861 L SE 8100861L SE 8100861 A SE8100861 A SE 8100861A SE 8100861 A SE8100861 A SE 8100861A SE 8100861 L SE8100861 L SE 8100861L
Authority
SE
Sweden
Prior art keywords
substd
beta
substit
opt
lactamantibiotic
Prior art date
Application number
SE8100861A
Other languages
Swedish (sv)
Other versions
SE457954B (en
Inventor
Richard B Sykes
William L Parker
Christopher M Cimarusti
William H Koster
William A Slusarchyk
Alan W Fritz
David M Floyd
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE8100861L publication Critical patent/SE8100861L/en
Priority to SE8602193A priority Critical patent/SE500216C2/en
Publication of SE457954B publication Critical patent/SE457954B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Beta lactams (I) having an SO3M substit. at 1-position and an opt. substd. or protected amino gp. or azido gp. at the 3-position are new. (M is hydrogen or a cation). They can also be substd. at the 4-position by alkyl, cycloalkyl, opt. substd. phenyl, alkoxycarbonyl, alken-1-yl, alkyn-1-yl, 2-phenylethenyl or 2-phenylethynyl. (I) having a 3-acylamino substit. are antibacterials effective against Gram negative and positive species, and useful therapeutically in human or veterinary medicine. The other new cpds. are intermediates.
SE8100861A 1980-02-07 1981-02-06 3-AMINO 1-AZETIDINE SULPHONIC ACID DERIVATIVES OR SALTS THEREOF, A B-LACTIC ANTIBIOTICS SE457954B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8602193A SE500216C2 (en) 1980-02-07 1986-05-14 1-Sulpho-3-amino-2-oxo-azetidine salt derivs. - useful as antibacterials for human or veterinary use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11927680A 1980-02-07 1980-02-07
US18889380A 1980-09-29 1980-09-29

Publications (2)

Publication Number Publication Date
SE8100861L true SE8100861L (en) 1981-08-08
SE457954B SE457954B (en) 1989-02-13

Family

ID=26817179

Family Applications (3)

Application Number Title Priority Date Filing Date
SE8100861A SE457954B (en) 1980-02-07 1981-02-06 3-AMINO 1-AZETIDINE SULPHONIC ACID DERIVATIVES OR SALTS THEREOF, A B-LACTIC ANTIBIOTICS
SE8602193A SE500216C2 (en) 1980-02-07 1986-05-14 1-Sulpho-3-amino-2-oxo-azetidine salt derivs. - useful as antibacterials for human or veterinary use
SE8602194A SE8602194L (en) 1980-02-07 1986-05-14 Beta-lactam antibiotics

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE8602193A SE500216C2 (en) 1980-02-07 1986-05-14 1-Sulpho-3-amino-2-oxo-azetidine salt derivs. - useful as antibacterials for human or veterinary use
SE8602194A SE8602194L (en) 1980-02-07 1986-05-14 Beta-lactam antibiotics

Country Status (29)

Country Link
JP (3) JPS56125362A (en)
KR (1) KR860001289B1 (en)
AR (1) AR245932A1 (en)
AU (1) AU569407B2 (en)
CA (1) CA1338670C (en)
CH (2) CH653993A5 (en)
DD (1) DD156180A5 (en)
DE (1) DE3104145C2 (en)
DK (1) DK166280C (en)
ES (1) ES8205397A1 (en)
FI (1) FI80271C (en)
FR (1) FR2509299B1 (en)
GB (2) GB2071650B (en)
GR (1) GR74151B (en)
HK (1) HK57785A (en)
IE (2) IE51392B1 (en)
IL (1) IL62082A (en)
IT (1) IT1135360B (en)
KE (1) KE3539A (en)
LU (1) LU83117A1 (en)
MY (1) MY8600179A (en)
NL (1) NL192924C (en)
NO (2) NO161065C (en)
NZ (2) NZ196202A (en)
PH (3) PH24729A (en)
PT (1) PT72465B (en)
SE (3) SE457954B (en)
SG (1) SG39185G (en)
YU (1) YU44829B (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050965A1 (en) * 1980-10-23 1982-05-05 Takeda Chemical Industries, Ltd. Beta-lactamase inhibitory composition
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
MX7096E (en) * 1980-12-05 1987-06-19 Takeda Chemical Industries Ltd METHOD FOR PREPARATION OF 2-OXOAZETIDINE DERIVATIVES
JPS58210061A (en) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use
US4675397A (en) * 1980-12-05 1987-06-23 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use
WO1983000690A1 (en) * 1981-08-25 1983-03-03 Takeda Chemical Industries Ltd Azetidine derivatives and process for their preparation
US4673739A (en) * 1980-12-05 1987-06-16 Takeda Chemical Industries, Ltd. 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
US4782147A (en) * 1980-12-05 1988-11-01 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
US4572801A (en) * 1981-04-30 1986-02-25 Takeda Chemical Industries, Ltd. 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
CA1181075A (en) * 1981-07-13 1985-01-15 David M. Floyd CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
FR2515182B1 (en) * 1981-10-23 1986-05-09 Roussel Uclaf NOVEL PRODUCTS DERIVED FROM 3-AMINO 2-OXO AZETIDINE 1-SULFAMIC ACID, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION
FR2538389B2 (en) * 1981-10-23 1986-05-16 Roussel Uclaf NEW PRODUCTS DERIVED FROM 3-AMINO 2-OXO AZETIDINE-1-SULFAMIC ACID, NEW PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE PRODUCTS, APPLICATION OF NEW PRODUCTS AS MEDICAMENTS AND PRODUCTS NECESSARY FOR THEIR PREPARATION
IL67451A (en) * 1981-12-25 1987-10-20 Takeda Chemical Industries Ltd 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them
EP0086563A1 (en) * 1982-01-22 1983-08-24 Beecham Group Plc Antibacterial agents, their preparation and use
EP0088488B1 (en) * 1982-01-22 1986-10-01 Beecham Group Plc Antibacterial agents, their preparation and use
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
WO1983002942A1 (en) * 1982-02-19 1983-09-01 Yoshioka, Kouichi Process for preparing 2-azetidinone-1-sulfonic acids, and starting materials therefor
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
DE3377061D1 (en) * 1982-06-03 1988-07-21 Hoffmann La Roche Process for the preparation of 1-sulfo-2-oxoazetidine derivatives
EP0096296B1 (en) * 1982-06-03 1987-07-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 1-sulfo-2-oxoazetidine derivatives
US4704457A (en) * 1982-06-21 1987-11-03 E. R. Squibb & Sons, Inc. Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs
US4681937A (en) * 1982-09-27 1987-07-21 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters
US4551276A (en) * 1982-10-06 1985-11-05 E. R. Squibb & Sons, Inc. 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs
US4533495A (en) * 1982-12-30 1985-08-06 Takeda Chemical Industries, Ltd. Method of producing 2-azetidinone-1-sulfonic acid compounds
US4548747A (en) * 1983-05-02 1985-10-22 E. R. Squibb & Sons, Inc. 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
US4670554A (en) * 1983-05-31 1987-06-02 E. R. Squibb & Sons, Inc. ((3-Acylamino-2-oxo-1-azetidinyl)oxy)methyl)phosphinic acids
US4501697A (en) * 1983-06-17 1985-02-26 E. R. Squibb & Sons, Inc. 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts
JPS601162A (en) * 1983-06-17 1985-01-07 Dai Ichi Seiyaku Co Ltd Azetidine-1-sulfonic acid derivative
US4587051A (en) * 1983-07-18 1986-05-06 E. R. Squibb & Sons, Inc. Desulfonation process for preparing 2-azetidinones
US4596777A (en) * 1983-08-10 1986-06-24 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
US4551277A (en) * 1983-11-09 1985-11-05 E. R. Squibb & Sons, Inc. 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid
JPS60112789A (en) * 1983-11-21 1985-06-19 Otsuka Chem Co Ltd 3-acylamino-4-alkyl-2-azetidinone-1-sulfonic acid derivative, tis preparation, and drug containing it
JPS60226855A (en) * 1984-04-26 1985-11-12 Nippon Kayaku Co Ltd N-benzyloxycarbonyl-l-threoninamide hemihydrate and preparation thereof
US4771135A (en) * 1984-05-22 1988-09-13 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
US4918185A (en) * 1984-05-22 1990-04-17 Eli Lilly And Company Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
US4680409A (en) * 1984-10-09 1987-07-14 E. R. Squibb & Sons, Inc. Hydrazide containing derivatives of 2-amino-4-thiazole-acetic acid
US4610824A (en) * 1984-10-09 1986-09-09 E. R. Squibb & Sons, Inc. Hydrazide derivatives of monocyclic beta-lactam antibiotics
US4647660A (en) * 1985-05-02 1987-03-03 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4632985A (en) * 1985-06-03 1986-12-30 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4754041A (en) * 1985-06-17 1988-06-28 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4638062A (en) * 1985-06-17 1987-01-20 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
FR2588867B1 (en) * 1985-10-23 1988-12-09 Roussel Uclaf NOVEL PRODUCTS DERIVED FROM THE 3-AMINO 2-OXO AZETIDINE SERIES, THEIR PREPARATION PROCESS AND THEIR APPLICATION
JP2008505189A (en) * 2005-05-09 2008-02-21 シコール インコーポレイティド Aztreonam manufacturing method
JP5648250B2 (en) * 2007-11-21 2015-01-07 国立大学法人東京工業大学 Polymer organic compounds and organic compounds having sulfonated nitrogen-containing heterocycles, methods for producing them, ion exchangers, electrolyte membranes, pharmaceuticals, catalysts, membrane electrode assemblies, fuel cells using them
WO2013109217A1 (en) 2012-01-16 2013-07-25 Mahmut Bilgic Pharmaceutical formulations comprising aztreonam
CN106164072B (en) 2014-03-24 2019-10-01 诺华股份有限公司 For treating the monobactam organic compound of bacterium infection
EA037569B1 (en) 2015-09-23 2021-04-15 Новартис Аг Salts of monobactam antibiotic and use thereof
CN111094281B (en) 2017-08-02 2023-08-29 诺华股份有限公司 Chemical process for preparing monolactam antibiotics and intermediates thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6046955B2 (en) * 1977-12-30 1985-10-18 武田薬品工業株式会社 Antibiotic G-6302
JPS55164672A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Azetidine derivative and its preparation
EP0021678B1 (en) * 1979-06-08 1984-11-07 Takeda Chemical Industries, Ltd. 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use

Also Published As

Publication number Publication date
GB2139618B (en) 1985-05-01
PT72465A (en) 1981-03-01
PT72465B (en) 1982-02-04
JPH02160764A (en) 1990-06-20
NO161065B (en) 1989-03-20
KR860001289B1 (en) 1986-09-10
FR2509299A1 (en) 1983-01-14
CH651020A5 (en) 1985-08-30
DE3104145C2 (en) 1999-05-12
FI80271B (en) 1990-01-31
AU4574885A (en) 1985-11-07
GB2071650B (en) 1984-12-05
NL192924B (en) 1998-01-05
NO810410L (en) 1981-08-10
DD156180A5 (en) 1982-08-04
SE8602193L (en) 1986-05-14
ES499171A0 (en) 1982-06-01
KR830005131A (en) 1983-08-03
IE862297L (en) 1981-08-07
NL8100571A (en) 1981-09-01
IT8119587A0 (en) 1981-02-06
CH653993A5 (en) 1986-01-31
NO170015B (en) 1992-05-25
GB2139618A (en) 1984-11-14
DE3104145A1 (en) 1981-12-17
SE8602194D0 (en) 1986-05-14
PH23316A (en) 1989-07-14
YU44829B (en) 1991-04-30
YU31981A (en) 1984-02-29
AU6698581A (en) 1981-08-13
GB8333191D0 (en) 1984-01-18
PH24729A (en) 1990-10-01
GB2071650A (en) 1981-09-23
NZ196202A (en) 1984-07-31
AR245932A1 (en) 1994-03-30
NZ205240A (en) 1984-07-31
IE810230L (en) 1981-08-07
NL192924C (en) 1998-05-07
KE3539A (en) 1985-07-12
IE51392B1 (en) 1986-12-24
JPH0586023A (en) 1993-04-06
DK52381A (en) 1981-08-08
NO860225L (en) 1981-08-10
MY8600179A (en) 1986-12-31
FI810352L (en) 1981-08-08
AU548896B2 (en) 1986-01-09
FI80271C (en) 1990-05-10
SG39185G (en) 1985-12-13
JPH0670006B2 (en) 1994-09-07
JPH0623188B2 (en) 1994-03-30
JPS56125362A (en) 1981-10-01
IL62082A (en) 1986-08-31
SE500216C2 (en) 1994-05-09
LU83117A1 (en) 1982-09-10
IT1135360B (en) 1986-08-20
SE8602193D0 (en) 1986-05-14
IE51393B1 (en) 1986-12-24
NO170015C (en) 1992-09-02
IL62082A0 (en) 1981-03-31
AU569407B2 (en) 1988-01-28
PH23317A (en) 1989-07-14
CA1338670C (en) 1996-10-22
SE457954B (en) 1989-02-13
FR2509299B1 (en) 1985-08-30
DK166280B (en) 1993-03-29
HK57785A (en) 1985-08-09
GR74151B (en) 1984-06-06
DK166280C (en) 1993-08-30
SE8602194L (en) 1986-05-14
ES8205397A1 (en) 1982-06-01
NO161065C (en) 1989-06-28

Similar Documents

Publication Publication Date Title
SE8100861L (en) BETA-LACTAMANTIBIOTIC AGENTS
LV11459A (en) Replaced azetidinone as an anti-inflammatory agent
ATE357509T1 (en) STIMULATION OF HEMATOPOIETIC CELLS IN VITRO
ES2032755T3 (en) MEDICINES CONTAINING HEXADECIL-PHOSPHOCOLINE WITH ANTITUMORAL EFFECT.
MY103388A (en) Azithromycin and derivatives as antiprotozoal agents
ES2023268T5 (en) IMPROVING GLASS TEMPERING.
IT1226424B (en) FRAME FOR GLASSES WITH ELASTIC DEFORMABLE NOSE.
DE3271532D1 (en) Salts of n-substituted-2-pyrrolidone-4-carboxylic acids as humectants
IT8119709A0 (en) POWER SUPPLY FOR TELEPHONE LINE.
SE8304408D0 (en) DESOXYURIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
DK0414019T3 (en) Substituted N- (quinolin-2-yl-methoxy) benzylsulfonylureas
HUP9901418A2 (en) Process for racemisation of levobupivacaine and analogous agents
ATE108993T1 (en) LIGHT PROTECTION.
DK0862454T3 (en) CTLA-8 in combination with G-CSF or with G-CSF and IL-6 and use of CTLA-8 to treat infections
DE3853085D1 (en) Discharge channel for cross-flow high-power lasers.
GB754197A (en) Improvements in or relating to suspension controllers for electric drives
CA623286A (en) Production of optically active 1-(3',4'-dihydroxyphenyl)-2-amino ethanols
IT8367587A0 (en) PHOTOTROPIC GLASS POSSIBLY FOR GLASS LENSES
SU1329101A1 (en) GLASS FOR LIGHTING
NL7904009A (en) N- (OXAZOLIDINOTHIO) IMIDES, WHICH PROVIDE SCREW RETARDANT NON-FLOWERING ELASTOMERIC PRODUCTS.
CA594960A (en) "wake up" or "morning call" system for automatically signaling private branch exchange extension stations
SU875717A1 (en) Dummy bar for semicontinuous casting plant
NO820958L (en) PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACID IN INSULIN.
NO841862L (en) LINE MANAGEMENT SYSTEM FOR LINE WITH LASABLE SUPPLY.
ES79266U (en) Frame profile of carpentry for the construction perfected (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8100861-7

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8100861-7

Format of ref document f/p: F