NO332941B1 - Bionedbrytbare triblokk-kopolymerer av polyester-polyetylenglykol med lav molekylvekt og med reversible termiske gelingsegenskaper - Google Patents
Bionedbrytbare triblokk-kopolymerer av polyester-polyetylenglykol med lav molekylvekt og med reversible termiske gelingsegenskaperInfo
- Publication number
- NO332941B1 NO332941B1 NO20011639A NO20011639A NO332941B1 NO 332941 B1 NO332941 B1 NO 332941B1 NO 20011639 A NO20011639 A NO 20011639A NO 20011639 A NO20011639 A NO 20011639A NO 332941 B1 NO332941 B1 NO 332941B1
- Authority
- NO
- Norway
- Prior art keywords
- polymer
- drug
- triblock
- lactide
- acid
- Prior art date
Links
- 239000002202 Polyethylene glycol Substances 0.000 title claims abstract description 41
- 229920001223 polyethylene glycol Polymers 0.000 title claims abstract description 41
- 230000002441 reversible effect Effects 0.000 title claims abstract description 36
- 229920000428 triblock copolymer Polymers 0.000 title claims description 44
- 229920000642 polymer Polymers 0.000 claims abstract description 116
- 239000003814 drug Substances 0.000 claims abstract description 102
- 229940079593 drug Drugs 0.000 claims abstract description 99
- 239000000203 mixture Substances 0.000 claims abstract description 39
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 38
- 229920000229 biodegradable polyester Polymers 0.000 claims abstract description 16
- 239000004622 biodegradable polyester Substances 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000007787 solid Substances 0.000 claims abstract description 14
- 229920001577 copolymer Polymers 0.000 claims description 46
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- 108090000623 proteins and genes Proteins 0.000 claims description 38
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 37
- 238000001879 gelation Methods 0.000 claims description 37
- 102000004169 proteins and genes Human genes 0.000 claims description 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 238000001248 thermal gelation Methods 0.000 claims description 28
- -1 D-lactide Chemical compound 0.000 claims description 25
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- 229920001184 polypeptide Polymers 0.000 claims description 23
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 22
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims description 21
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyesters Or Polycarbonates (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/164,865 US6117949A (en) | 1998-10-01 | 1998-10-01 | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US09/396,589 US6201072B1 (en) | 1997-10-03 | 1999-09-15 | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| PCT/US1999/022755 WO2000018821A1 (fr) | 1998-10-01 | 1999-09-30 | Copolymeres trisequences de polyester polyethyleneglycol, de faible poids moleculaire, biodegradables et dotes de caracteristiques inverses de gelification thermique |
Publications (3)
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| NO20011639D0 NO20011639D0 (no) | 2001-03-30 |
| NO20011639L NO20011639L (no) | 2001-03-30 |
| NO332941B1 true NO332941B1 (no) | 2013-02-04 |
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| NO20011639A NO332941B1 (no) | 1998-10-01 | 2001-03-30 | Bionedbrytbare triblokk-kopolymerer av polyester-polyetylenglykol med lav molekylvekt og med reversible termiske gelingsegenskaper |
Country Status (19)
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| US (1) | US6201072B1 (fr) |
| EP (1) | EP1141079B1 (fr) |
| JP (1) | JP4628545B2 (fr) |
| KR (1) | KR100558025B1 (fr) |
| CN (1) | CN1161396C (fr) |
| AT (1) | ATE378365T1 (fr) |
| AU (1) | AU758475B2 (fr) |
| BR (1) | BR9914258B1 (fr) |
| CA (1) | CA2345659C (fr) |
| CY (1) | CY1107888T1 (fr) |
| DK (1) | DK1141079T3 (fr) |
| ES (1) | ES2301250T3 (fr) |
| IL (1) | IL142313A0 (fr) |
| NO (1) | NO332941B1 (fr) |
| NZ (1) | NZ510832A (fr) |
| PL (1) | PL205127B1 (fr) |
| RU (1) | RU2232779C2 (fr) |
| TR (1) | TR200100900T2 (fr) |
| WO (1) | WO2000018821A1 (fr) |
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| KR20010083880A (ko) | 2001-09-03 |
| ES2301250T3 (es) | 2008-06-16 |
| IL142313A0 (en) | 2002-03-10 |
| CA2345659C (fr) | 2010-09-21 |
| CN1324374A (zh) | 2001-11-28 |
| JP4628545B2 (ja) | 2011-02-09 |
| AU1098300A (en) | 2000-04-17 |
| PL346963A1 (en) | 2002-03-11 |
| CA2345659A1 (fr) | 2000-04-06 |
| RU2232779C2 (ru) | 2004-07-20 |
| ATE378365T1 (de) | 2007-11-15 |
| WO2000018821A1 (fr) | 2000-04-06 |
| EP1141079A4 (fr) | 2004-03-24 |
| EP1141079A1 (fr) | 2001-10-10 |
| CN1161396C (zh) | 2004-08-11 |
| JP2002525404A (ja) | 2002-08-13 |
| US6201072B1 (en) | 2001-03-13 |
| BR9914258B1 (pt) | 2014-07-15 |
| TR200100900T2 (tr) | 2001-10-22 |
| KR100558025B1 (ko) | 2006-03-07 |
| EP1141079B1 (fr) | 2007-11-14 |
| NZ510832A (en) | 2002-10-25 |
| NO20011639L (no) | 2001-03-30 |
| CY1107888T1 (el) | 2013-06-19 |
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