NO330910B1 - Faktor VIII mutein, DNA sekvens som koder derfor, fremgangsmate for fremstilling derav, farmasoytisk preparat omfattende faktor VIII mutein, dets anvendelse, samt vektor, vertscelle og immortalisert human cellelinje - Google Patents
Faktor VIII mutein, DNA sekvens som koder derfor, fremgangsmate for fremstilling derav, farmasoytisk preparat omfattende faktor VIII mutein, dets anvendelse, samt vektor, vertscelle og immortalisert human cellelinje Download PDFInfo
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- NO330910B1 NO330910B1 NO20024475A NO20024475A NO330910B1 NO 330910 B1 NO330910 B1 NO 330910B1 NO 20024475 A NO20024475 A NO 20024475A NO 20024475 A NO20024475 A NO 20024475A NO 330910 B1 NO330910 B1 NO 330910B1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/6424—Serine endopeptidases (3.4.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C—CHEMISTRY; METALLURGY
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- C12Y—ENZYMES
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00106225A EP1136553A1 (en) | 2000-03-22 | 2000-03-22 | Production of recombinant blood clotting factors in human cell lines |
| US20324900P | 2000-05-08 | 2000-05-08 | |
| PCT/EP2001/003220 WO2001070968A2 (en) | 2000-03-22 | 2001-03-21 | Production of recombinant blood clotting factors in human cell lines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20024475D0 NO20024475D0 (no) | 2002-09-19 |
| NO20024475L NO20024475L (no) | 2002-11-20 |
| NO330910B1 true NO330910B1 (no) | 2011-08-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20024475A NO330910B1 (no) | 2000-03-22 | 2002-09-19 | Faktor VIII mutein, DNA sekvens som koder derfor, fremgangsmate for fremstilling derav, farmasoytisk preparat omfattende faktor VIII mutein, dets anvendelse, samt vektor, vertscelle og immortalisert human cellelinje |
Country Status (28)
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| US (1) | US7572619B2 (xx) |
| EP (2) | EP1266006B1 (xx) |
| JP (1) | JP3894795B2 (xx) |
| KR (1) | KR100581574B1 (xx) |
| CN (1) | CN1454257B (xx) |
| AT (1) | ATE312176T1 (xx) |
| AU (3) | AU2001254715B2 (xx) |
| BE (1) | BE2014C077I2 (xx) |
| BG (1) | BG65930B1 (xx) |
| BR (1) | BRPI0109494B8 (xx) |
| CA (1) | CA2404163C (xx) |
| CZ (1) | CZ303929B6 (xx) |
| DE (1) | DE60115613T2 (xx) |
| DK (1) | DK1266006T3 (xx) |
| EA (1) | EA004317B1 (xx) |
| EE (1) | EE200200538A (xx) |
| ES (1) | ES2254403T3 (xx) |
| FR (1) | FR15C0003I2 (xx) |
| HR (1) | HRP20020767B1 (xx) |
| HU (1) | HU228091B1 (xx) |
| IL (2) | IL151857A0 (xx) |
| MX (1) | MXPA02009221A (xx) |
| NO (1) | NO330910B1 (xx) |
| NZ (1) | NZ521732A (xx) |
| RS (1) | RS50743B (xx) |
| SI (1) | SI1266006T1 (xx) |
| SK (1) | SK287706B6 (xx) |
| WO (1) | WO2001070968A2 (xx) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2404163C (en) * | 2000-03-22 | 2009-09-29 | Octagene Gmbh | Production of recombinant blood clotting factors in human cell lines |
| AU2001292861A1 (en) * | 2000-09-19 | 2002-04-02 | Emory University | Modified factor VIII |
| EP1469064A1 (en) | 2003-04-15 | 2004-10-20 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Expression of proteins in endothelial cells derived from precursor cells from cord blood |
| DE602005024955D1 (de) * | 2004-03-19 | 2011-01-05 | Baxter Healthcare Sa | Faktor ixa zur behandlung von blutungsstörungen |
| KR100624013B1 (ko) * | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
| EP2438931B1 (en) | 2004-09-22 | 2013-11-13 | St. Jude Children's Research Hospital | Improved expression of factor IX in gene therapy vectors |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| JP5523674B2 (ja) * | 2005-02-11 | 2014-06-18 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 植物タンパク質加水分解産物を含有する血清フリーの細胞培養液におけるポリペプチドの生産 |
| EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| KR101495549B1 (ko) | 2006-07-13 | 2015-02-25 | 와이어쓰 엘엘씨 | 당단백질의 생산 |
| JP6050927B2 (ja) * | 2007-04-26 | 2016-12-21 | シーエヌジェイ ホールディングス，インコーポレイテッド | 高シアル酸含量を有する組換えビタミンｋ依存性タンパク質およびその調製方法 |
| WO2009028575A1 (ja) * | 2007-08-27 | 2009-03-05 | National University Corporation Nagoya University | 血液凝固第vii因子プロモーターの活性化剤及びその利用 |
| JP2012500250A (ja) | 2008-08-21 | 2012-01-05 | オクタファルマ アクチェン ゲゼルシャフト | 組換えにより産生したヒト第ｖｉｉｉ及び第ｉｘ因子 |
| US9493545B2 (en) | 2009-02-11 | 2016-11-15 | Albumedix A/S | Albumin variants and conjugates |
| CA2776503C (en) | 2009-10-02 | 2020-07-28 | The Children's Hospital Of Philadelphia | Compositions and methods for enhancing coagulation factor viii function |
| EP3421491A3 (en) | 2009-10-30 | 2019-03-27 | Albumedix Ltd | Albumin variants |
| JP5969458B2 (ja) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | アルブミン誘導体及び変異体 |
| BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
| BR112013021526B1 (pt) | 2011-02-25 | 2021-09-21 | Chugai Seiyaku Kabushiki Kaisha | Polipeptídio variante, métodos para manter ou diminuir as atividades de ligação a fcgriia (tipo r) e fcgriia (tipo h) e aumentar a atividade de ligação a fcgriib de um polipeptídio e para a supressão da produção de um anticorpo contra um polipeptídio compreendendo a região fc do anticorpo, métodos para a produção do referido polipeptídio com atividades de ligação mantidas ou diminuídas e aumentada e para a produção suprimida de um anticorpo, composição farmacêutica e uso de um polipeptídio |
| CN102199607B (zh) * | 2011-03-30 | 2012-11-14 | 山西大学 | 重组人凝血因子ix小基因及其ptc突变体稳定细胞株 |
| DK3626737T3 (da) | 2011-05-13 | 2024-02-05 | Octapharma Ag | Fremgangsmåde til at forøge produktiviteten af eukaryote celler i produktionen af rekombinant fviii |
| TW201307563A (zh) * | 2011-05-19 | 2013-02-16 | Shire Human Genetic Therapies | 純化乙醯肝素－ｎ－硫酸酯酶之方法 |
| CN102321668A (zh) * | 2011-07-06 | 2012-01-18 | 中国人民解放军军事医学科学院野战输血研究所 | 一种表达重组人凝血因子ⅶ的方法及其专用载体 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| US9394353B2 (en) | 2011-10-18 | 2016-07-19 | Csl Limited | Method for improving the stability of purified factor VIII after reconstitution |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
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| MK1K | Patent expired |