IL151857A0 - Production of recombinant blood clotting factors in human cell lines - Google Patents

Production of recombinant blood clotting factors in human cell lines

Info

Publication number
IL151857A0
IL151857A0 IL15185701A IL15185701A IL151857A0 IL 151857 A0 IL151857 A0 IL 151857A0 IL 15185701 A IL15185701 A IL 15185701A IL 15185701 A IL15185701 A IL 15185701A IL 151857 A0 IL151857 A0 IL 151857A0
Authority
IL
Israel
Prior art keywords
human cell
factor viii
production
factor
clotting factors
Prior art date
Application number
IL15185701A
Other languages
English (en)
Original Assignee
Octagene Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00106225A external-priority patent/EP1136553A1/en
Application filed by Octagene Gmbh filed Critical Octagene Gmbh
Publication of IL151857A0 publication Critical patent/IL151857A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL15185701A 2000-03-22 2001-03-21 Production of recombinant blood clotting factors in human cell lines IL151857A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00106225A EP1136553A1 (en) 2000-03-22 2000-03-22 Production of recombinant blood clotting factors in human cell lines
US20324900P 2000-05-08 2000-05-08
PCT/EP2001/003220 WO2001070968A2 (en) 2000-03-22 2001-03-21 Production of recombinant blood clotting factors in human cell lines

Publications (1)

Publication Number Publication Date
IL151857A0 true IL151857A0 (en) 2003-04-10

Family

ID=26070708

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15185701A IL151857A0 (en) 2000-03-22 2001-03-21 Production of recombinant blood clotting factors in human cell lines
IL151857A IL151857A (en) 2000-03-22 2002-09-19 Generation of recombinant blood clotting factors VIII in cell lines of human origin

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL151857A IL151857A (en) 2000-03-22 2002-09-19 Generation of recombinant blood clotting factors VIII in cell lines of human origin

Country Status (28)

Country Link
US (1) US7572619B2 (xx)
EP (2) EP1266006B1 (xx)
JP (1) JP3894795B2 (xx)
KR (1) KR100581574B1 (xx)
CN (1) CN1454257B (xx)
AT (1) ATE312176T1 (xx)
AU (3) AU2001254715B2 (xx)
BE (1) BE2014C077I2 (xx)
BG (1) BG65930B1 (xx)
BR (1) BRPI0109494B8 (xx)
CA (1) CA2404163C (xx)
CZ (1) CZ303929B6 (xx)
DE (1) DE60115613T2 (xx)
DK (1) DK1266006T3 (xx)
EA (1) EA004317B1 (xx)
EE (1) EE200200538A (xx)
ES (1) ES2254403T3 (xx)
FR (1) FR15C0003I2 (xx)
HR (1) HRP20020767B1 (xx)
HU (1) HU228091B1 (xx)
IL (2) IL151857A0 (xx)
MX (1) MXPA02009221A (xx)
NO (1) NO330910B1 (xx)
NZ (1) NZ521732A (xx)
RS (1) RS50743B (xx)
SI (1) SI1266006T1 (xx)
SK (1) SK287706B6 (xx)
WO (1) WO2001070968A2 (xx)

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Also Published As

Publication number Publication date
HRP20020767A2 (en) 2005-02-28
AU2006201848A1 (en) 2006-05-25
HUP0300588A2 (hu) 2003-06-28
SK15042002A3 (sk) 2003-09-11
JP2003530093A (ja) 2003-10-14
HRP20020767B1 (en) 2011-09-30
EP1460131A3 (en) 2005-06-01
NO330910B1 (no) 2011-08-15
CZ20023166A3 (cs) 2003-02-12
HUP0300588A3 (en) 2005-09-28
EP1266006B1 (en) 2005-12-07
ATE312176T1 (de) 2005-12-15
JP3894795B2 (ja) 2007-03-22
WO2001070968A3 (en) 2001-12-13
BE2014C077I2 (xx) 2020-01-30
NO20024475L (no) 2002-11-20
RS50743B (sr) 2010-08-31
YU71002A (sh) 2005-11-28
BG65930B1 (bg) 2010-05-31
SI1266006T1 (sl) 2006-06-30
EP1460131A2 (en) 2004-09-22
DK1266006T3 (da) 2006-01-16
EP1266006A2 (en) 2002-12-18
KR20030011079A (ko) 2003-02-06
DE60115613T2 (de) 2006-08-24
CN1454257A (zh) 2003-11-05
CA2404163C (en) 2009-09-29
CA2404163A1 (en) 2001-09-27
MXPA02009221A (es) 2005-07-25
AU2001254715B2 (en) 2006-02-02
DE60115613D1 (de) 2006-01-12
BG107152A (bg) 2003-06-30
EA200201008A1 (ru) 2003-02-27
FR15C0003I2 (fr) 2015-11-20
BR0109494A (pt) 2002-12-10
CZ303929B6 (cs) 2013-07-03
ES2254403T3 (es) 2006-06-16
HU228091B1 (en) 2012-10-29
IL151857A (en) 2010-05-31
SK287706B6 (en) 2011-07-06
FR15C0003I1 (fr) 2015-02-27
CN1454257B (zh) 2013-01-16
US20040023333A1 (en) 2004-02-05
BRPI0109494B8 (pt) 2021-05-25
BRPI0109494B1 (pt) 2021-05-11
US7572619B2 (en) 2009-08-11
NZ521732A (en) 2004-05-28
NO20024475D0 (no) 2002-09-19
EE200200538A (et) 2004-04-15
WO2001070968A2 (en) 2001-09-27
AU5471501A (en) 2001-10-03
EA004317B1 (ru) 2004-02-26
KR100581574B1 (ko) 2006-05-22

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