WO2003104270A3 - Dudulin genes, non-human animal model: uses in human hematological disease - Google Patents

Dudulin genes, non-human animal model: uses in human hematological disease Download PDF

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Publication number
WO2003104270A3
WO2003104270A3 PCT/EP2003/005920 EP0305920W WO03104270A3 WO 2003104270 A3 WO2003104270 A3 WO 2003104270A3 EP 0305920 W EP0305920 W EP 0305920W WO 03104270 A3 WO03104270 A3 WO 03104270A3
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WO
WIPO (PCT)
Prior art keywords
dudulin
human
animal model
modified
human animal
Prior art date
Application number
PCT/EP2003/005920
Other languages
French (fr)
Other versions
WO2003104270A2 (en
Inventor
Johannes Grosse
Juergen Laufs
Boris Schneider
Original Assignee
Molecular Engines Lab
Johannes Grosse
Juergen Laufs
Boris Schneider
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Engines Lab, Johannes Grosse, Juergen Laufs, Boris Schneider filed Critical Molecular Engines Lab
Priority to AU2003242633A priority Critical patent/AU2003242633A1/en
Publication of WO2003104270A2 publication Critical patent/WO2003104270A2/en
Publication of WO2003104270A3 publication Critical patent/WO2003104270A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides a non-human animal model, particularly a mouse model, for hematological disorders arising from expression of a modified dudulin 2. The modified dudulin 2 and nucleic acids coding therefor are also provided, as are the correspondingly modified recombinant mouse and human dudulin 2 proteins and nucleic acids. The invention further provides uses for the non-human animal model, the modified dudulin 2 and their dudulin 3 homologues; in particular for the modified human dudulin 2 in treating medical conditions associated with over-expression of dudulin 2.
PCT/EP2003/005920 2002-06-06 2003-06-05 Dudulin 2 genes, expression products, non-human animal model: uses in human hematological disease WO2003104270A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003242633A AU2003242633A1 (en) 2002-06-06 2003-06-05 Dudulin genes, non-human animal model: uses in human hematological disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38630202P 2002-06-06 2002-06-06
US60/386,302 2002-06-06

Publications (2)

Publication Number Publication Date
WO2003104270A2 WO2003104270A2 (en) 2003-12-18
WO2003104270A3 true WO2003104270A3 (en) 2004-12-29

Family

ID=29736147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/005920 WO2003104270A2 (en) 2002-06-06 2003-06-05 Dudulin 2 genes, expression products, non-human animal model: uses in human hematological disease

Country Status (2)

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AU (1) AU2003242633A1 (en)
WO (1) WO2003104270A2 (en)

Cited By (2)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002052274A2 (en) * 2000-12-26 2002-07-04 Molecular Engines Laboratories Screening method based on tsap6 binding partners

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002052274A2 (en) * 2000-12-26 2002-07-04 Molecular Engines Laboratories Screening method based on tsap6 binding partners

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RINALDY A R ET AL: "Role of pHyde novel gene product as an intrinsic factor for apoptotic pathway in prostate cancer", May 2000, GAN TO KAGAKU RYOHO - JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, GAN TO KAGAKU RYOHO, TOKYO, JP, PAGE(S) 215-222, ISSN: 0385-0684, XP009028708 *
ZHANG X ET AL: "APOPTOSIS INDUCTION IN PROSTATE CANCER CELLS BY A NOVEL GENE PRODUCT, PHYDE, INVOLVES CASPASE-3", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 20, no. 42, 20 September 2001 (2001-09-20), pages 5982 - 5990, XP008003138, ISSN: 0950-9232 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Also Published As

Publication number Publication date
WO2003104270A2 (en) 2003-12-18
AU2003242633A1 (en) 2003-12-22
AU2003242633A8 (en) 2003-12-22

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