WO2009028575A1 - 血液凝固第vii因子プロモーターの活性化剤及びその利用 - Google Patents

血液凝固第vii因子プロモーターの活性化剤及びその利用 Download PDF

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Publication number
WO2009028575A1
WO2009028575A1 PCT/JP2008/065340 JP2008065340W WO2009028575A1 WO 2009028575 A1 WO2009028575 A1 WO 2009028575A1 JP 2008065340 W JP2008065340 W JP 2008065340W WO 2009028575 A1 WO2009028575 A1 WO 2009028575A1
Authority
WO
WIPO (PCT)
Prior art keywords
activator
blood coagulation
factor vii
coagulation factor
utilization
Prior art date
Application number
PCT/JP2008/065340
Other languages
English (en)
French (fr)
Inventor
Takashi Honda
Junki Takamatsu
Hidenori Toyoda
Koji Yamamoto
Hidemi Goto
Tetsuhito Kojima
Original Assignee
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Nagoya University filed Critical National University Corporation Nagoya University
Priority to JP2009530161A priority Critical patent/JPWO2009028575A1/ja
Priority to EP08828103A priority patent/EP2198870A4/en
Priority to US12/733,395 priority patent/US20110045535A1/en
Publication of WO2009028575A1 publication Critical patent/WO2009028575A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本発明は血液凝固第VII因子の活性化剤を提供することを目的とする。リバビリン又はその誘導体を血液凝固第VII因子のプロモーターの活性化剤として利用する。
PCT/JP2008/065340 2007-08-27 2008-08-27 血液凝固第vii因子プロモーターの活性化剤及びその利用 WO2009028575A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009530161A JPWO2009028575A1 (ja) 2007-08-27 2008-08-27 血液凝固第ｖｉｉ因子プロモーターの活性化剤及びその利用
EP08828103A EP2198870A4 (en) 2007-08-27 2008-08-27 ACTIVATOR FOR BLOOD COAGULATION FACTOR VII PROMOTER AND USE THEREOF
US12/733,395 US20110045535A1 (en) 2007-08-27 2008-08-27 Activator for Blood Coagulation Factor VII Promoter and Utilization of the Same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-220451 2007-08-27
JP2007220451 2007-08-27

Publications (1)

Publication Number Publication Date
WO2009028575A1 true WO2009028575A1 (ja) 2009-03-05

Family

ID=40387292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065340 WO2009028575A1 (ja) 2007-08-27 2008-08-27 血液凝固第vii因子プロモーターの活性化剤及びその利用

Country Status (4)

Country Link
US (1) US20110045535A1 (ja)
EP (1) EP2198870A4 (ja)
JP (1) JPWO2009028575A1 (ja)
WO (1) WO2009028575A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2201953A4 (en) * 2007-08-27 2011-08-03 Univ Nagoya Nat Univ Corp USE OF RIBAVIRIN IN BLOOD COAGULATION DISORDER

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5029720A (ja) 1973-03-12 1975-03-25
JPS50154253A (ja) 1974-03-18 1975-12-12
JPS53124271A (en) 1971-06-01 1978-10-30 Icn Pharmaceuticals Process for preparing 1*2*44triazolenucleoside
JPH09501306A (ja) * 1993-05-20 1997-02-10 ロイヤル フリー ホスピタル スクール オブ メディスン 血友病の遺伝子療法
JP2002527522A (ja) 1998-10-16 2002-08-27 シェリング・コーポレーション 慢性Ｃ型肝炎感染を有する患者における検出可能ＨＣＶ−ＲＮＡ根絶用リバビリン−インターフェロン−α併用療法
JP2003530093A (ja) * 2000-03-22 2003-10-14 オクタジーン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ヒト細胞株における組換え血液凝固因子の製造
JP2007522805A (ja) * 2004-02-03 2007-08-16 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 新規化合物
WO2007099652A1 (ja) * 2006-02-28 2007-09-07 National University Corporation Nagoya University 血液凝固障害治療用医薬組成物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53124271A (en) 1971-06-01 1978-10-30 Icn Pharmaceuticals Process for preparing 1*2*44triazolenucleoside
JPS5029720A (ja) 1973-03-12 1975-03-25
JPS50154253A (ja) 1974-03-18 1975-12-12
JPH09501306A (ja) * 1993-05-20 1997-02-10 ロイヤル フリー ホスピタル スクール オブ メディスン 血友病の遺伝子療法
JP2002527522A (ja) 1998-10-16 2002-08-27 シェリング・コーポレーション 慢性Ｃ型肝炎感染を有する患者における検出可能ＨＣＶ−ＲＮＡ根絶用リバビリン−インターフェロン−α併用療法
JP2003530093A (ja) * 2000-03-22 2003-10-14 オクタジーン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ヒト細胞株における組換え血液凝固因子の製造
JP2007522805A (ja) * 2004-02-03 2007-08-16 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 新規化合物
WO2007099652A1 (ja) * 2006-02-28 2007-09-07 National University Corporation Nagoya University 血液凝固障害治療用医薬組成物

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
A. GENNARO: "RemTngton's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2004 (2004-05-01), pages 1872 - 1875
HOMDA T. ET AL.: "Ribavirin and use of clotting factors in patients with hemophilia and chronic hepatitis C", JAMA, vol. 293, no. 10, 9 March 2005 (2005-03-09), pages 1190 - 1192, XP003017335 *
J. MED CHEM., vol. 20, 1977, pages 1684 - 1687
J. MED. CHEM., vol. 35, 1992, pages 3231 - 3238
J. SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRCSS
J. SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
JOURNAL OF THROMBOSIS AND HAEMOSTATIS, vol. 4, pages 469 - 487
KOKAME ET AL., LBC, vol. 276, 2001, pages 9166 - 9205
VIRUS RESEARCH, vol. 107, 2005, pages 165 - 171
YAMAMOTO K. ET AL.: "Ketsuyubyo kanja ni okeru C-gata Kan'en chiryoyaku ribavirin no shukketsu yobo koka to sono mechanism", JAPANESE JOURNAL OF THROMBOSIS AND HEMOSTASIS, vol. 16, no. 5, 1 October 2005 (2005-10-01), pages 519, XP003017334 *
YAMAMOTO, K. ET AL.: "Anti-HCV agent, ribavirin,elevates the activity of clotting factorVII in patients with hemophilia: a possible mechanism of decreased events of bleeding in patients with hemophilia by ribavirin", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 4, 31 January 2006 (2006-01-31), pages 469 - 470, XP003017333 *

Also Published As

Publication number Publication date
US20110045535A1 (en) 2011-02-24
EP2198870A1 (en) 2010-06-23
EP2198870A4 (en) 2011-08-03
JPWO2009028575A1 (ja) 2010-12-02

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WO2009028575A1 (ja) 血液凝固第vii因子プロモーターの活性化剤及びその利用

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