WO2008131047A3 - Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism - Google Patents
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism Download PDFInfo
- Publication number
- WO2008131047A3 WO2008131047A3 PCT/US2008/060542 US2008060542W WO2008131047A3 WO 2008131047 A3 WO2008131047 A3 WO 2008131047A3 US 2008060542 W US2008060542 W US 2008060542W WO 2008131047 A3 WO2008131047 A3 WO 2008131047A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plasminogen activator
- lipid metabolism
- inhibitors
- methods
- activator inhibitor
- Prior art date
Links
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 title abstract 3
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000037356 lipid metabolism Effects 0.000 title abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000013566 Plasminogen Human genes 0.000 abstract 1
- 108010051456 Plasminogen Proteins 0.000 abstract 1
- 102000018779 Replication Protein C Human genes 0.000 abstract 1
- 108010027647 Replication Protein C Proteins 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8132—Plasminogen activator inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to plasminogen activator- 1 (PAl-1I) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91207107P | 2007-04-16 | 2007-04-16 | |
US60/912,071 | 2007-04-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008131047A2 WO2008131047A2 (en) | 2008-10-30 |
WO2008131047A3 true WO2008131047A3 (en) | 2009-01-08 |
Family
ID=39580203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/060542 WO2008131047A2 (en) | 2007-04-16 | 2008-04-16 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
Country Status (2)
Country | Link |
---|---|
US (2) | US8759327B2 (en) |
WO (1) | WO2008131047A2 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9120744B2 (en) | 2007-04-16 | 2015-09-01 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
GB0819958D0 (en) * | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Therapeutic compositions |
GB0819959D0 (en) | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Fruit extracts |
JP6031355B2 (en) | 2009-10-11 | 2016-11-24 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | Biocompatible polymers for medical devices |
DE102011088982A1 (en) | 2011-12-19 | 2013-06-20 | Henkel Ag & Co. Kgaa | Detergents and cleaning agents with improved performance |
DE102011088984A1 (en) | 2011-12-19 | 2013-06-20 | Henkel Ag & Co. Kgaa | Detergents and cleaning agents with improved performance |
US20130164228A1 (en) * | 2011-12-21 | 2013-06-27 | Colgate-Palmolive Company | Compositions comprising gallates and gallamides |
EP3312155B1 (en) | 2012-02-03 | 2020-08-05 | Rutgers, The State University of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
US11472918B2 (en) | 2012-02-03 | 2022-10-18 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
AU2013252637B2 (en) | 2012-04-23 | 2016-12-22 | Provexis Natural Products Limited | Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract |
CN105008323B (en) | 2012-10-31 | 2018-11-06 | 密歇根大学董事会 | - 1 inhibitor of Plasminogen activator and its application method |
GB201223365D0 (en) | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
AR102361A1 (en) * | 2014-10-29 | 2017-02-22 | Lilly Co Eli | METHYL-QUINOLINE COMPOUNDS USEFUL TO INHIBIT THE MICROSOMAL PROSTAGLANDIN E2 SYNTHESA-1 |
US10774030B2 (en) | 2014-12-23 | 2020-09-15 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
KR20230048169A (en) | 2016-11-02 | 2023-04-10 | 프로벡시스 내추럴 프로덕츠 리미티드 | Water soluble tomato extract protects against adverse effects of air pollution |
AU2018307807B2 (en) | 2017-07-27 | 2024-05-02 | Eastern Michigan University | Plasminogen activator inhibitor-1 (PAI-1) inhibitor and method of use |
US10927138B2 (en) * | 2018-05-29 | 2021-02-23 | Syneurx International (Taiwan) Corp. | Inhibitors of D-amino acid oxidase (DAAO) and uses thereof |
US20200163850A1 (en) * | 2018-11-24 | 2020-05-28 | Momentive Performance Materials Gmbh | Use of polyhydroxyaromatic compounds for the treatment of fibrous amino acid based substrates |
CN110448563A (en) * | 2019-07-19 | 2019-11-15 | 南京中医药大学 | Application of 1,2,3,4, the 6- Penta-O-galloyl-D-glucopyranose in preparation prevention and treatment osteoporosis drug |
US11154531B2 (en) | 2020-02-08 | 2021-10-26 | Syneurx International (Taiwan) Corp. | Compounds and pharmaceutical uses thereof |
KR20230004765A (en) | 2020-04-23 | 2023-01-06 | 신유알엑스 인터내셔널 (타이완) 코포레이션 | COMPOUNDS AND PHARMACEUTICAL USES THEREOF |
US20230305023A1 (en) | 2020-06-25 | 2023-09-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment and diagnostic of pathological conditions associated with intense stress |
CN113679039B (en) * | 2021-05-12 | 2023-05-09 | 浙江大学 | Polyethylene glycol gallate protein carrier synergist and preparation method and application thereof |
CN115368278B (en) * | 2022-10-25 | 2023-04-11 | 北京鑫开元医药科技有限公司 | Method for preparing benzenesulfonic acid compound by hydrolyzing benzenesulfonamide compound |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6479198B2 (en) * | 2000-02-01 | 2002-11-12 | Fuji Photo Film Co., Ltd. | Silver halide light-sensitive material containing tanning developing agent |
CA2321348A1 (en) | 2000-09-27 | 2002-03-27 | Blaise Magloire N'zemba | Aromatic derivatives with hiv integrase inhibitory properties |
TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
WO2003055843A1 (en) | 2001-12-27 | 2003-07-10 | Bayer Healthcare Ag | Agaricoglycerides and analogs |
US20060058243A1 (en) * | 2002-07-24 | 2006-03-16 | Xiaozhuo Chen | Methods and compositions for treating diabetes mellitis |
CA2527052A1 (en) | 2003-05-28 | 2005-01-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Angiogenic agents from plant extracts, gallic acid, and derivatives |
US20090069302A1 (en) * | 2006-01-20 | 2009-03-12 | Smithkline Beecham Corporation | Chemical compounds |
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2008
- 2008-04-16 WO PCT/US2008/060542 patent/WO2008131047A2/en active Application Filing
- 2008-04-16 US US12/104,409 patent/US8759327B2/en active Active
-
2014
- 2014-05-21 US US14/284,021 patent/US9096501B2/en active Active
Non-Patent Citations (9)
Title |
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BONCORAGLIO G B ET AL: "An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke", CEREBROVASCULAR DISEASES 200607 CH, vol. 22, no. 2-3, July 2006 (2006-07-01), pages 191 - 195, XP008094227, ISSN: 1015-9770 * |
CHEN CHIH-HUNG ET AL: "4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke.", JOURNAL OF LABORATORY AND CLINICAL MEDICINE, vol. 142, no. 2, August 2003 (2003-08-01), pages 100 - 105, XP002489577, ISSN: 0022-2143 * |
DICHTL WOLFGANG ET AL: "In vivo stimulation by vascular plasminogen activator inhibitor-1 production by very low-density lipoprotein involves transcription factor binding to a VLDL-responsive element", THROMBOSIS AND HAEMOSTASIS, vol. 84, no. 4, October 2000 (2000-10-01), pages 706 - 711, XP008094149, ISSN: 0340-6245 * |
GORLATOVA NATALIA V ET AL: "Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 23 MAR 2007, vol. 282, no. 12, 23 March 2007 (2007-03-23), pages 9288 - 9296, XP002489583, ISSN: 0021-9258 * |
JENSEN JAN K ET AL: "Inhibition of plasminogen activator inhibitor-1 binding to endocytosis receptors of the low-density-lipoprotein receptor family by a peptide isolated from a phage display library", BIOCHEM. J.; BIOCHEMICAL JOURNAL NOV 1 2006, vol. 399, no. 3, 1 November 2006 (2006-11-01), pages 387 - 396, XP002489581 * |
LOPES C ET AL: "PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population.", DIABETOLOGIA SEP 2003, vol. 46, no. 9, September 2003 (2003-09-01), pages 1284 - 1290, XP002489579, ISSN: 0012-186X * |
NILSSON LENNART ET AL: "VLDL activation of plasminogen activator inhibitor-1 (PAI-1) expression: Involvement of the VLDL receptor", JOURNAL OF LIPID RESEARCH, vol. 40, no. 5, May 1999 (1999-05-01), pages 913 - 919, XP002489580, ISSN: 0022-2275 * |
RODENBURG K W ET AL: "Binding of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex to the endocytosis receptors alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor.", THE BIOCHEMICAL JOURNAL 1 JAN 1998, vol. 329 ( Pt 1), 1 January 1998 (1998-01-01), pages 55 - 63, XP002489582, ISSN: 0264-6021 * |
SCHÄFER K ET AL: "Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice.", THE FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY AUG 2001, vol. 15, no. 10, August 2001 (2001-08-01), pages 1840 - 1842, XP002489578, ISSN: 0892-6638 * |
Also Published As
Publication number | Publication date |
---|---|
US8759327B2 (en) | 2014-06-24 |
US20140343321A1 (en) | 2014-11-20 |
US9096501B2 (en) | 2015-08-04 |
WO2008131047A2 (en) | 2008-10-30 |
US20090011055A1 (en) | 2009-01-08 |
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