RS50743B - Proizvodnja rekombinantnih faktora koagulacije krvi u humanim ćelijama - Google Patents

Proizvodnja rekombinantnih faktora koagulacije krvi u humanim ćelijama

Info

Publication number
RS50743B
RS50743B YUP-710/02A YUP71002A RS50743B RS 50743 B RS50743 B RS 50743B YU P71002 A YUP71002 A YU P71002A RS 50743 B RS50743 B RS 50743B
Authority
RS
Serbia
Prior art keywords
production
cell lines
human cell
blood clotting
clotting factors
Prior art date
Application number
YUP-710/02A
Other languages
English (en)
Inventor
Charlotte Hauser
Andrea Hörster
Carola Schröder
Michael Lehnerer
Original Assignee
OCTAPHARMA BIOPHARMACEUTICALS GmbH.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00106225A external-priority patent/EP1136553A1/en
Application filed by OCTAPHARMA BIOPHARMACEUTICALS GmbH. filed Critical OCTAPHARMA BIOPHARMACEUTICALS GmbH.
Publication of YU71002A publication Critical patent/YU71002A/sh
Publication of RS50743B publication Critical patent/RS50743B/sr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Faktor VIII mutein, naznačen time, stoje u njemu B-domen između pozicija Arg740 i Glu1649 zamenjen Arg-bogatim linker peptidom koji ima bar 3 Arg ostatka i sadrži 10 do 25 ostataka amino kiselina, pri čemu je numeracija kod pomenutog faktora VIII u odnosu na sekvencu zrelog faktora VIII divljeg tipa dat u SEQ ID N0:2.Prijava sadrži još 6 zavisnih i 13 nezavisnih patentnih zahteva.
YUP-710/02A 2000-03-22 2001-03-21 Proizvodnja rekombinantnih faktora koagulacije krvi u humanim ćelijama RS50743B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00106225A EP1136553A1 (en) 2000-03-22 2000-03-22 Production of recombinant blood clotting factors in human cell lines
US20324900P 2000-05-08 2000-05-08

Publications (2)

Publication Number Publication Date
YU71002A YU71002A (sh) 2005-11-28
RS50743B true RS50743B (sr) 2010-08-31

Family

ID=26070708

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-710/02A RS50743B (sr) 2000-03-22 2001-03-21 Proizvodnja rekombinantnih faktora koagulacije krvi u humanim ćelijama

Country Status (28)

Country Link
US (1) US7572619B2 (sr)
EP (2) EP1460131A3 (sr)
JP (1) JP3894795B2 (sr)
KR (1) KR100581574B1 (sr)
CN (1) CN1454257B (sr)
AT (1) ATE312176T1 (sr)
AU (3) AU2001254715B2 (sr)
BE (1) BE2014C077I2 (sr)
BG (1) BG65930B1 (sr)
BR (1) BRPI0109494B8 (sr)
CA (1) CA2404163C (sr)
CZ (1) CZ303929B6 (sr)
DE (1) DE60115613T2 (sr)
DK (1) DK1266006T3 (sr)
EA (1) EA004317B1 (sr)
EE (1) EE200200538A (sr)
ES (1) ES2254403T3 (sr)
FR (1) FR15C0003I2 (sr)
HR (1) HRP20020767B1 (sr)
HU (1) HU228091B1 (sr)
IL (2) IL151857A0 (sr)
MX (1) MXPA02009221A (sr)
NO (1) NO330910B1 (sr)
NZ (1) NZ521732A (sr)
RS (1) RS50743B (sr)
SI (1) SI1266006T1 (sr)
SK (1) SK287706B6 (sr)
WO (1) WO2001070968A2 (sr)

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Also Published As

Publication number Publication date
US7572619B2 (en) 2009-08-11
FR15C0003I2 (fr) 2015-11-20
IL151857A0 (en) 2003-04-10
MXPA02009221A (es) 2005-07-25
AU2006201848A1 (en) 2006-05-25
IL151857A (en) 2010-05-31
HU228091B1 (en) 2012-10-29
US20040023333A1 (en) 2004-02-05
NO20024475D0 (no) 2002-09-19
CZ20023166A3 (cs) 2003-02-12
EP1460131A3 (en) 2005-06-01
ES2254403T3 (es) 2006-06-16
WO2001070968A3 (en) 2001-12-13
EE200200538A (et) 2004-04-15
DE60115613D1 (de) 2006-01-12
EA004317B1 (ru) 2004-02-26
SK15042002A3 (sk) 2003-09-11
DE60115613T2 (de) 2006-08-24
KR20030011079A (ko) 2003-02-06
BE2014C077I2 (sr) 2020-01-30
BG65930B1 (bg) 2010-05-31
ATE312176T1 (de) 2005-12-15
BRPI0109494B1 (pt) 2021-05-11
KR100581574B1 (ko) 2006-05-22
JP2003530093A (ja) 2003-10-14
NO330910B1 (no) 2011-08-15
HRP20020767A2 (en) 2005-02-28
JP3894795B2 (ja) 2007-03-22
CN1454257A (zh) 2003-11-05
CA2404163C (en) 2009-09-29
YU71002A (sh) 2005-11-28
NZ521732A (en) 2004-05-28
HUP0300588A3 (en) 2005-09-28
EP1266006A2 (en) 2002-12-18
AU2001254715B2 (en) 2006-02-02
HUP0300588A2 (hu) 2003-06-28
DK1266006T3 (da) 2006-01-16
HRP20020767B1 (en) 2011-09-30
SK287706B6 (en) 2011-07-06
CN1454257B (zh) 2013-01-16
FR15C0003I1 (fr) 2015-02-27
CZ303929B6 (cs) 2013-07-03
EA200201008A1 (ru) 2003-02-27
CA2404163A1 (en) 2001-09-27
WO2001070968A2 (en) 2001-09-27
EP1266006B1 (en) 2005-12-07
SI1266006T1 (sl) 2006-06-30
EP1460131A2 (en) 2004-09-22
BG107152A (bg) 2003-06-30
AU5471501A (en) 2001-10-03
BR0109494A (pt) 2002-12-10
BRPI0109494B8 (pt) 2021-05-25
NO20024475L (no) 2002-11-20

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