DK1109831T3 - Cytotoksiske peptider modificeret ved store eller lipofile dele - Google Patents

Cytotoksiske peptider modificeret ved store eller lipofile dele

Info

Publication number
DK1109831T3
DK1109831T3 DK99941773.6T DK99941773T DK1109831T3 DK 1109831 T3 DK1109831 T3 DK 1109831T3 DK 99941773 T DK99941773 T DK 99941773T DK 1109831 T3 DK1109831 T3 DK 1109831T3
Authority
DK
Denmark
Prior art keywords
lipophilic moieties
peptides modified
cytotoxic peptides
well
cytotoxic
Prior art date
Application number
DK99941773.6T
Other languages
English (en)
Inventor
John Sigurd Svendsen
Oeystein Rekdal
Baldur Sveinbjoernsson
Lars Vorland
Original Assignee
Lytix Biopharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lytix Biopharma As filed Critical Lytix Biopharma As
Application granted granted Critical
Publication of DK1109831T3 publication Critical patent/DK1109831T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK99941773.6T 1998-08-28 1999-08-31 Cytotoksiske peptider modificeret ved store eller lipofile dele DK1109831T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9818938.4A GB9818938D0 (en) 1998-08-28 1998-08-28 Bioactive peptides
PCT/GB1999/002850 WO2000012541A2 (en) 1998-08-28 1999-08-31 Cytotoxic peptides modified by bulky or lipophilic moieties

Publications (1)

Publication Number Publication Date
DK1109831T3 true DK1109831T3 (da) 2011-04-18

Family

ID=10838089

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99941773.6T DK1109831T3 (da) 1998-08-28 1999-08-31 Cytotoksiske peptider modificeret ved store eller lipofile dele

Country Status (12)

Country Link
US (3) US6890902B2 (da)
EP (2) EP1109827B1 (da)
JP (1) JP5475937B2 (da)
AT (2) ATE495192T1 (da)
AU (2) AU5526899A (da)
CA (2) CA2340326A1 (da)
DE (1) DE69943130D1 (da)
DK (1) DK1109831T3 (da)
ES (1) ES2359616T3 (da)
GB (1) GB9818938D0 (da)
NO (1) NO333073B1 (da)
WO (2) WO2000012541A2 (da)

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GB0605685D0 (en) * 2006-03-21 2006-05-03 Lytix Biopharma As Inhibition of tumour growth
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
GB0005702D0 (en) * 2000-03-09 2000-05-03 Alpharma As Method
GB0005703D0 (en) 2000-03-09 2000-05-03 Alpharma As Compounds
KR20020080731A (ko) * 2001-04-17 2002-10-26 주식회사 이지바이오 시스템 락토페리신 유전자 및 이를 도입한 락토페리신 발현용형질전환체
KR100454595B1 (ko) * 2001-11-30 2004-10-28 주식회사 이지바이오 시스템 락토페리신 유전자 및 이를 도입한 형질전환 대장균
SE0200598D0 (sv) * 2002-02-27 2002-02-27 A & Science Invest Ab Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences
PT1507554E (pt) 2002-05-10 2011-11-21 Agennix Inc Lactoferrina no tratamento de neoplasmas malignos e outras doenças hiperproliferativas
WO2004003195A1 (en) * 2002-06-28 2004-01-08 The Government Of The United States Of America,As Represented By The Secretary Of The Department Of Health And Human Services Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins
NO20031818D0 (no) * 2003-04-23 2003-04-23 Uni I Tromsoe Fremgangsmåte av bioaktiv peptid forberedelse
EP1635766A4 (en) * 2003-06-06 2009-09-30 Agennix Inc LACTOFERRIN AS ADJUVANS IN CANCER VACCINES
US7419667B2 (en) * 2004-03-19 2008-09-02 Morinaga Milk Industry Co. Ltd. Drug for cancer therapy
US8202841B2 (en) * 2004-06-17 2012-06-19 Mannkind Corporation SSX-2 peptide analogs
US8034762B2 (en) 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
CA2587727A1 (en) * 2004-11-19 2006-05-26 Jagat Rakesh Kanwar Methods of immune or haematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
WO2007055578A1 (en) * 2005-11-11 2007-05-18 Leids Universitair Medisch Centrum Cyclic antimicrobial peptides derived from lactoferrin
ATE501169T1 (de) 2005-12-30 2011-03-15 Evonik Roehm Gmbh Lactoferrin-peptide, geeignet als in die zelle eindringende peptide
ES2321358B1 (es) * 2006-04-05 2010-03-05 Consejo Susperior De Investigaciones Cientificas Uso de peptidos derivados de la lactoferrina para preparar formulaciones inhibidoras de la enzima conversora de angiotensina i.
EP2949663A1 (en) * 2006-04-27 2015-12-02 Singapore Health Services Pte Ltd Antimicrobial peptides
US7960339B2 (en) 2006-07-10 2011-06-14 Österreichische Akademie der Wissenschaften Antimicrobial peptides
GB0821616D0 (en) 2008-11-26 2008-12-31 Lytix Biopharma As Compounds
EP2754450A1 (en) 2013-01-11 2014-07-16 Österreichische Akademie der Wissenschaften Lactoferricin derived peptides
GB201401877D0 (en) * 2014-02-04 2014-03-19 Univ Tromsoe Peptides
WO2016056665A1 (ja) * 2014-10-08 2016-04-14 学校法人慶應義塾 白血球の細胞外トラップ形成の阻害剤
ITUB20153058A1 (it) * 2015-08-11 2017-02-11 Farmagens Health Care S R L Roma ?frammento di lattoferrina per uso come agente antibatterico ed antivirale?
WO2017223098A1 (en) * 2016-06-21 2017-12-28 The Curators Of The University Of Missouri Bis-amino acid based compound and use thereof
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
AU2018312110B2 (en) 2017-08-04 2023-03-16 Bioventures, Llc Linear lipopeptide paenipeptins and methods of using the same
US11236138B2 (en) * 2020-01-14 2022-02-01 Renorigin Innovation Institute Co., Ltd. Peptide, method and composition for melanin polymerization and hair darkening
CN115073352A (zh) * 2022-06-28 2022-09-20 吉尔多肽生物制药(大连市)有限公司 一种2,5,7-三叔丁基色氨酸的合成方法

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US5141581A (en) * 1972-10-08 1992-08-25 Markham Harold A Implants with a cover which resists formation of firm spherical encapsulation
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
US5073542A (en) 1989-06-07 1991-12-17 Magainin Sciences Inc. CPF peptide compositions and their use in inhibiting growth of target cells or a virus
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
NZ241936A (en) * 1991-03-13 1994-03-25 Morinaga Milk Industry Co Ltd Antimicrobial peptide and its use in an antimicrobial composition
JPH06511234A (ja) * 1991-06-12 1994-12-15 マゲイニン　ファーマス−ティカルズ，インコーポレーテッド Ｃ末端置換を有する生物活性ペプチド組成物および治療法
US5547939A (en) * 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5646119A (en) * 1991-11-01 1997-07-08 Periodontix, Inc. D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
US5631228A (en) * 1991-11-01 1997-05-20 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
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JPH08500818A (ja) * 1992-06-01 1996-01-30 マガイニン ファーマシューティカルズ，インコーポレーテッド Ｎ末端置換を有する生物活性ペプチド
DE69332377T2 (de) * 1992-07-13 2003-07-03 Bionebraska, Inc. Verfahren zur modifizierung rekombinanter polypeptide
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
CA2150946A1 (en) 1992-12-03 1994-06-09 Leonard S. Jacob Treatment of dermatological malignancies with biologically active peptides
JP3312946B2 (ja) * 1993-03-04 2002-08-12 雪印乳業株式会社 ウイルス感染・増殖抑制剤
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
WO1998006425A1 (en) * 1996-08-12 1998-02-19 A+ Science Invest Ab Treatment and prevention of infections, inflammations and/or tumours with lactoferrin and/or lactoferricin
CA2262429A1 (en) * 1996-08-14 1998-02-19 Novartis Ag Peptide with inhibitory activity towards plant pathogenic fungi
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
WO1998040091A1 (en) * 1997-03-13 1998-09-17 The Research Foundation Of State University Of New York Microbicidal peptides and methods of use
GB9818938D0 (en) * 1998-08-28 1998-10-21 Alpharma As Bioactive peptides

Also Published As

Publication number Publication date
WO2000012541A3 (en) 2000-06-08
CA2341037A1 (en) 2000-03-09
EP1109831A2 (en) 2001-06-27
EP1109831B1 (en) 2011-01-12
JP2002523517A (ja) 2002-07-30
JP5475937B2 (ja) 2014-04-16
ES2359616T3 (es) 2011-05-25
WO2000012541A2 (en) 2000-03-09
US6890902B2 (en) 2005-05-10
US7439228B2 (en) 2008-10-21
WO2000012542A3 (en) 2000-06-29
NO20010995D0 (no) 2001-02-27
GB9818938D0 (en) 1998-10-21
AU5526899A (en) 2000-03-21
AU772176B2 (en) 2004-04-08
AU5526799A (en) 2000-03-21
WO2000012542A2 (en) 2000-03-09
US20030022821A1 (en) 2003-01-30
NO333073B1 (no) 2013-02-25
NO20010995L (no) 2001-04-27
US20080287346A1 (en) 2008-11-20
CA2341037C (en) 2013-11-05
CA2340326A1 (en) 2000-03-09
ATE513847T1 (de) 2011-07-15
US20030148936A1 (en) 2003-08-07
EP1109827A2 (en) 2001-06-27
US8143211B2 (en) 2012-03-27
DE69943130D1 (de) 2011-02-24
ATE495192T1 (de) 2011-01-15
EP1109827B1 (en) 2011-06-22

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