NO320909B1 - Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat. - Google Patents
Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat. Download PDFInfo
- Publication number
- NO320909B1 NO320909B1 NO20014317A NO20014317A NO320909B1 NO 320909 B1 NO320909 B1 NO 320909B1 NO 20014317 A NO20014317 A NO 20014317A NO 20014317 A NO20014317 A NO 20014317A NO 320909 B1 NO320909 B1 NO 320909B1
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- Prior art keywords
- formula
- pyrimidine
- compounds
- compound
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- 150000003839 salts Chemical class 0.000 claims abstract description 30
- 238000001727 in vivo Methods 0.000 claims abstract description 29
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- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 230000008569 process Effects 0.000 claims abstract description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 3
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- 238000006243 chemical reaction Methods 0.000 claims description 46
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- 239000012038 nucleophile Substances 0.000 claims description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9905075.9A GB9905075D0 (en) | 1999-03-06 | 1999-03-06 | Chemical compounds |
| PCT/GB2000/000737 WO2000053595A1 (en) | 1999-03-06 | 2000-03-02 | Pyrimidine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20014317D0 NO20014317D0 (no) | 2001-09-05 |
| NO20014317L NO20014317L (no) | 2001-11-01 |
| NO320909B1 true NO320909B1 (no) | 2006-02-13 |
Family
ID=10849022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014317A NO320909B1 (no) | 1999-03-06 | 2001-09-05 | Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6716831B1 (zh) |
| EP (1) | EP1161428B1 (zh) |
| JP (1) | JP2002539120A (zh) |
| KR (1) | KR100683512B1 (zh) |
| CN (1) | CN1227249C (zh) |
| AT (1) | ATE241617T1 (zh) |
| AU (1) | AU754967B2 (zh) |
| BR (1) | BR0008770A (zh) |
| CA (1) | CA2366668A1 (zh) |
| DE (1) | DE60003001T2 (zh) |
| DK (1) | DK1161428T3 (zh) |
| ES (1) | ES2200824T3 (zh) |
| GB (1) | GB9905075D0 (zh) |
| IL (2) | IL145192A0 (zh) |
| MX (1) | MXPA01008960A (zh) |
| NO (1) | NO320909B1 (zh) |
| NZ (1) | NZ513893A (zh) |
| PT (1) | PT1161428E (zh) |
| WO (1) | WO2000053595A1 (zh) |
| ZA (1) | ZA200107252B (zh) |
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| WO2000012485A1 (en) | 1998-08-29 | 2000-03-09 | Astrazeneca Ab | Pyrimidine compounds |
| US6632820B1 (en) | 1998-08-29 | 2003-10-14 | Astrazeneca Ab | Pyrimidine compounds |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| ATE253915T1 (de) * | 1999-06-30 | 2003-11-15 | Merck & Co Inc | Src-kinase hemmende verbindungen |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| WO2001025220A1 (en) | 1999-10-07 | 2001-04-12 | Amgen Inc. | Triazine kinase inhibitors |
| EE200200275A (et) * | 1999-11-30 | 2003-10-15 | Pfizer Products Inc. | Immunosupressantidena kasutatavad 2,4-diaminopürimidiiniühendid |
| US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
| WO2001060816A1 (en) * | 2000-02-17 | 2001-08-23 | Amgen Inc. | Kinase inhibitors |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| GB0021726D0 (en) | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| US7105530B2 (en) | 2000-12-21 | 2006-09-12 | Smithkline Beecham Corporation | Pyrimidineamines as angiogenesis modulators |
| CN100480242C (zh) * | 2001-05-29 | 2009-04-22 | 舍林股份公司 | Cdk抑制性嘧啶化合物、其制备方法以及作为药物的应用 |
| DE10212098A1 (de) * | 2002-03-11 | 2003-10-23 | Schering Ag | CDK inhibitorische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| WO2003032994A2 (de) | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren |
| CA2463989C (en) | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof |
| EP1458687B1 (en) * | 2001-11-30 | 2012-01-11 | Synta Pharmaceuticals Corporation | Pyrimidine compounds as interleukin-12 (il-12) inhibitors |
| GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| WO2003076434A1 (en) * | 2002-03-09 | 2003-09-18 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
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1999
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- 2000-03-02 ES ES00906531T patent/ES2200824T3/es not_active Expired - Lifetime
- 2000-03-02 NZ NZ513893A patent/NZ513893A/xx unknown
- 2000-03-02 CN CNB008070679A patent/CN1227249C/zh not_active Expired - Fee Related
- 2000-03-02 DK DK00906531T patent/DK1161428T3/da active
- 2000-03-02 KR KR1020017011289A patent/KR100683512B1/ko not_active IP Right Cessation
- 2000-03-02 WO PCT/GB2000/000737 patent/WO2000053595A1/en active IP Right Grant
- 2000-03-02 IL IL14519200A patent/IL145192A0/xx active IP Right Grant
- 2000-03-02 BR BR0008770-0A patent/BR0008770A/pt not_active Application Discontinuation
- 2000-03-02 PT PT00906531T patent/PT1161428E/pt unknown
- 2000-03-02 AU AU28187/00A patent/AU754967B2/en not_active Ceased
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| WO2000053595A1 (en) | 2000-09-14 |
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| DK1161428T3 (da) | 2003-09-15 |
| KR100683512B1 (ko) | 2007-02-16 |
| ZA200107252B (en) | 2002-12-02 |
| CN1349528A (zh) | 2002-05-15 |
| DE60003001D1 (en) | 2003-07-03 |
| AU2818700A (en) | 2000-09-28 |
| DE60003001T2 (de) | 2004-05-06 |
| NZ513893A (en) | 2004-03-26 |
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| MXPA01008960A (es) | 2002-04-24 |
| KR20010102502A (ko) | 2001-11-15 |
| BR0008770A (pt) | 2002-01-08 |
| PT1161428E (pt) | 2003-10-31 |
| JP2002539120A (ja) | 2002-11-19 |
| US6716831B1 (en) | 2004-04-06 |
| EP1161428A1 (en) | 2001-12-12 |
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| AU754967B2 (en) | 2002-11-28 |
| ATE241617T1 (de) | 2003-06-15 |
| GB9905075D0 (en) | 1999-04-28 |
| IL145192A0 (en) | 2002-06-30 |
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| NO20014317L (no) | 2001-11-01 |
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