US5916891A
(en)
|
1992-01-13 |
1999-06-29 |
Smithkline Beecham Corporation |
Pyrimidinyl imidazoles
|
US6046208A
(en)
*
|
1996-01-11 |
2000-04-04 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
US5945418A
(en)
*
|
1996-12-18 |
1999-08-31 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
US6147080A
(en)
*
|
1996-12-18 |
2000-11-14 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
US6608060B1
(en)
|
1996-12-18 |
2003-08-19 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
US6087381A
(en)
|
1997-05-22 |
2000-07-11 |
G. D. Searle & Company |
Pyrazole derivatives as p38 kinase inhibitors
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
JP2002504909A
(ja)
|
1997-06-13 |
2002-02-12 |
スミスクライン・ビーチャム・コーポレイション |
新規な置換ピラゾールおよびピラゾリン化合物
|
US6610695B1
(en)
|
1997-06-19 |
2003-08-26 |
Smithkline Beecham Corporation |
Aryloxy substituted pyrimidine imidazole compounds
|
US7301021B2
(en)
|
1997-07-02 |
2007-11-27 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
US6562832B1
(en)
|
1997-07-02 |
2003-05-13 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
AU8381098A
(en)
|
1997-07-02 |
1999-01-25 |
Smithkline Beecham Corporation |
Novel cycloalkyl substituted imidazoles
|
JP2001518507A
(ja)
|
1997-10-08 |
2001-10-16 |
スミスクライン・ビーチャム・コーポレイション |
新規シクロアルケニル置換化合物
|
US6335340B1
(en)
|
1997-12-19 |
2002-01-01 |
Smithkline Beecham Corporation |
compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
|
GB9805655D0
(en)
|
1998-03-16 |
1998-05-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6521626B1
(en)
|
1998-03-24 |
2003-02-18 |
Celltech R&D Limited |
Thiocarboxamide derivatives
|
BR9910621A
(pt)
|
1998-05-22 |
2001-01-30 |
Smithkline Beecham Corp |
Novos compostos de imidazol 2-alquil substituìdos
|
US6858617B2
(en)
|
1998-05-26 |
2005-02-22 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
GB9814414D0
(en)
|
1998-07-03 |
1998-09-02 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6207687B1
(en)
*
|
1998-07-31 |
2001-03-27 |
Merck & Co., Inc. |
Substituted imidazoles having cytokine inhibitory activity
|
DE69933680T2
(de)
|
1998-08-29 |
2007-08-23 |
Astrazeneca Ab |
Pyrimidine verbindungen
|
ATE336484T1
(de)
|
1998-08-29 |
2006-09-15 |
Astrazeneca Ab |
Pyrimidine verbindungen
|
GB9821061D0
(en)
|
1998-09-28 |
1998-11-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
CA2346665A1
(en)
|
1998-10-07 |
2000-04-13 |
Smithkline Beecham Corporation |
Novel treatment for stroke management
|
WO2000026209A1
(en)
*
|
1998-11-03 |
2000-05-11 |
Novartis Ag |
Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles
|
ATE258055T1
(de)
|
1998-11-04 |
2004-02-15 |
Smithkline Beecham Corp |
Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
|
GB9828511D0
(en)
|
1998-12-24 |
1999-02-17 |
Zeneca Ltd |
Chemical compounds
|
EP1495758A3
(de)
*
|
1999-01-08 |
2005-04-13 |
3M Innovative Properties Company |
Zubereitungen, enthaltend Imiquimod oder andere Immunantwort modifizierende Verbindungen, zur Behandlung von mukosalen Erkrankungen
|
CA2361936C
(en)
*
|
1999-01-08 |
2009-06-16 |
3M Innovative Properties Company |
Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions
|
UA73492C2
(en)
*
|
1999-01-19 |
2005-08-15 |
|
Aromatic heterocyclic compounds as antiinflammatory agents
|
EP1157026A1
(de)
|
1999-02-22 |
2001-11-28 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Polyheterocyclische verbindungen mit entzündungshemmender wirkung
|
GB9905075D0
(en)
|
1999-03-06 |
1999-04-28 |
Zeneca Ltd |
Chemical compounds
|
EE04799B1
(et)
|
1999-03-12 |
2007-04-16 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Ühendid, mis on kasulikud põletikuvastaste vahenditena, nende ühendite valmistamise meetodid ja neid sisaldavad farmatseutilised kompositsioonid
|
ES2251360T3
(es)
|
1999-03-12 |
2006-05-01 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Compuestos heterociclicos aromaticos en calidad de agentes antiinflamatorios.
|
GB9907658D0
(en)
|
1999-04-06 |
1999-05-26 |
Zeneca Ltd |
Chemical compounds
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
ES2253233T3
(es)
|
1999-07-09 |
2006-06-01 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Procedimiento para sintesis de compuestos de urea heteroaril sustituidos.
|
GB9919778D0
(en)
|
1999-08-21 |
1999-10-27 |
Zeneca Ltd |
Chemical compounds
|
US6534513B1
(en)
|
1999-09-29 |
2003-03-18 |
Celltech R&D Limited |
Phenylalkanoic acid derivatives
|
HUP0203403A3
(en)
|
1999-11-22 |
2004-01-28 |
Smithkline Beecham Plc |
New imidazole derivatives, pharmaceutical compositions containing them and their use
|
US7053098B1
(en)
|
1999-11-23 |
2006-05-30 |
Smithkline Beecham Corporation |
3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
|
US6759410B1
(en)
|
1999-11-23 |
2004-07-06 |
Smithline Beecham Corporation |
3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
|
JP2003528043A
(ja)
|
1999-11-23 |
2003-09-24 |
スミスクライン・ビーチャム・コーポレイション |
CSBP/p38キナーゼ阻害剤としての3,4‐ジヒドロ−(1H)キナゾリン−2−オン化合物
|
US6455539B2
(en)
|
1999-12-23 |
2002-09-24 |
Celltech R&D Limited |
Squaric acid derivates
|
US6525046B1
(en)
|
2000-01-18 |
2003-02-25 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as antiinflammatory agents
|
US6608052B2
(en)
|
2000-02-16 |
2003-08-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compounds useful as anti-inflammatory agents
|
GB0004890D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
GB0004887D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
GB0004888D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
GB0004886D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
GB0005357D0
(en)
|
2000-03-06 |
2000-04-26 |
Smithkline Beecham Plc |
Compounds
|
AU2001235838A1
(en)
*
|
2000-03-06 |
2001-09-17 |
Smithkline Beecham Plc |
Imidazol derivatives as raf kinase inhibitors
|
GB0007371D0
(en)
|
2000-03-28 |
2000-05-17 |
Astrazeneca Uk Ltd |
Chemical compounds
|
WO2001079173A2
(en)
|
2000-04-17 |
2001-10-25 |
Celltech R & D Limited |
Enamine derivatives as cell adhesion molecules
|
US6403608B1
(en)
|
2000-05-30 |
2002-06-11 |
Celltech R&D, Ltd. |
3-Substituted isoquinolin-1-yl derivatives
|
US6545013B2
(en)
|
2000-05-30 |
2003-04-08 |
Celltech R&D Limited |
2,7-naphthyridine derivatives
|
WO2001091749A1
(en)
*
|
2000-06-01 |
2001-12-06 |
Merck & Co., Inc. |
Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors
|
WO2002004426A1
(en)
|
2000-07-07 |
2002-01-17 |
Celltech R & D Limited |
Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
|
GB0016877D0
(en)
|
2000-07-11 |
2000-08-30 |
Astrazeneca Ab |
Chemical compounds
|
EP1305291A1
(de)
|
2000-08-02 |
2003-05-02 |
Celltech R&D Limited |
3-substituierte isochinolin-1-yl-derivate
|
GB0021726D0
(en)
*
|
2000-09-05 |
2000-10-18 |
Astrazeneca Ab |
Chemical compounds
|
KR20030030027A
(ko)
*
|
2000-09-21 |
2003-04-16 |
스미스클라인비이참피이엘시이 |
Raf 키나제 저해제인 이미다졸 유도체
|
FR2818978B1
(fr)
*
|
2000-12-28 |
2003-02-28 |
Sod Conseils Rech Applic |
Modulateurs de canaux sodiques derives de 2-piperidylimidazoles
|
CA2437248A1
(en)
|
2001-02-02 |
2002-08-15 |
Takeda Chemical Industries, Ltd. |
Jnk inhibitor
|
GB0103926D0
(en)
|
2001-02-17 |
2001-04-04 |
Astrazeneca Ab |
Chemical compounds
|
US6727364B2
(en)
|
2001-04-30 |
2004-04-27 |
The Procter & Gamble Company |
Triazole compounds useful in treating diseases associated with unwanted cytokine activity
|
US6787555B2
(en)
|
2001-04-30 |
2004-09-07 |
The Procter & Gamble Company |
Triazole compounds useful in treating diseases associated with unwanted cytokine activity
|
GB0112348D0
(en)
*
|
2001-05-19 |
2001-07-11 |
Smithkline Beecham Plc |
Compounds
|
US6790846B2
(en)
|
2001-05-24 |
2004-09-14 |
The Procter & Gamble Company |
Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
|
GB0113041D0
(en)
|
2001-05-30 |
2001-07-18 |
Astrazeneca Ab |
Chemical compounds
|
EP1432703A1
(de)
*
|
2001-09-05 |
2004-06-30 |
Smithkline Beecham Plc |
Heterocycle-carboxamide derivate als raf kinase inhibitoren
|
US20030118575A1
(en)
*
|
2001-12-11 |
2003-06-26 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Method for administering BIRB 796 BS
|
WO2003072569A1
(en)
|
2002-02-25 |
2003-09-04 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases
|
GB0205690D0
(en)
|
2002-03-09 |
2002-04-24 |
Astrazeneca Ab |
Chemical compounds
|
WO2003076434A1
(en)
|
2002-03-09 |
2003-09-18 |
Astrazeneca Ab |
4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
|
GB0205688D0
(en)
|
2002-03-09 |
2002-04-24 |
Astrazeneca Ab |
Chemical compounds
|
GB0205693D0
(en)
|
2002-03-09 |
2002-04-24 |
Astrazeneca Ab |
Chemical compounds
|
AR039241A1
(es)
*
|
2002-04-04 |
2005-02-16 |
Biogen Inc |
Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
|
EP1534282B1
(de)
|
2002-07-09 |
2006-12-27 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
|
UA80295C2
(en)
*
|
2002-09-06 |
2007-09-10 |
Biogen Inc |
Pyrazolopyridines and using the same
|
CL2004000234A1
(es)
*
|
2003-02-12 |
2005-04-15 |
Biogen Idec Inc |
Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
|
GB0311274D0
(en)
|
2003-05-16 |
2003-06-18 |
Astrazeneca Ab |
Chemical compounds
|
GB0311276D0
(en)
|
2003-05-16 |
2003-06-18 |
Astrazeneca Ab |
Chemical compounds
|
TW200528101A
(en)
|
2004-02-03 |
2005-09-01 |
Astrazeneca Ab |
Chemical compounds
|
ATE432273T1
(de)
|
2004-03-09 |
2009-06-15 |
Boehringer Ingelheim Pharma |
3-ä4-heterocyclyl-1,2,3-triazol-1-ylü-n- arylbenzamide als inhibitoren der cytokinenproduktion für die behandlung von chronischen entzündlichen erkrankungen
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
NZ555474A
(en)
*
|
2004-12-17 |
2010-10-29 |
Astrazeneca Ab |
4-(4-(imidazol-4-yl) pyrimidin-2-ylamino) benzamides as CDK inhibitors
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
US7728013B2
(en)
|
2005-05-10 |
2010-06-01 |
Intermune, Inc. |
Method of modulating stress-activated protein kinase system
|
US20080280906A1
(en)
*
|
2005-07-30 |
2008-11-13 |
David Andrews |
Imidazolyl-Pyrimidine Compounds for Use in the Treatment of Proliferative Disorders
|
CA2623374A1
(en)
|
2005-09-30 |
2007-04-05 |
Astrazeneca Ab |
Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
|
JP2009517390A
(ja)
*
|
2005-11-23 |
2009-04-30 |
インターミューン インコーポレイテッド |
ストレス活性化プロテインキナーゼ系を調節する方法
|
WO2007082554A1
(en)
*
|
2006-01-23 |
2007-07-26 |
Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa |
Modulators of hcv replication
|
TW200811169A
(en)
*
|
2006-05-26 |
2008-03-01 |
Astrazeneca Ab |
Chemical compounds
|
TW200904437A
(en)
|
2007-02-14 |
2009-02-01 |
Janssen Pharmaceutica Nv |
2-aminopyrimidine modulators of the histamine H4 receptor
|
MX2009011754A
(es)
*
|
2007-04-30 |
2009-12-01 |
Abbott Lab |
Inhibidores de enzima de diacilglicerol o-aciltransferasa tipo 1.
|
AU2008247592A1
(en)
*
|
2007-05-02 |
2008-11-13 |
Vertex Pharmaceuticals Incorporated |
Thiazoles and pyrazoles useful as kinase inhibitors
|
EP1992344A1
(de)
|
2007-05-18 |
2008-11-19 |
Institut Curie |
P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
|
EP2296653B1
(de)
|
2008-06-03 |
2016-01-27 |
Intermune, Inc. |
Verbindungen und verfahren zur behandlung von entzündungserkrankungen und fibrotischen erkrankungen
|
RU2011151603A
(ru)
*
|
2009-05-19 |
2013-06-27 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭсСи |
Соединения и способы борьбы с грибами
|
AR092742A1
(es)
|
2012-10-02 |
2015-04-29 |
Intermune Inc |
Piridinonas antifibroticas
|
CA2943363A1
(en)
|
2014-04-02 |
2015-10-08 |
Intermune, Inc. |
Anti-fibrotic pyridinones
|