CA2257200A1 - Substituted imidazoles having cytokine inhibitory activity - Google Patents

Substituted imidazoles having cytokine inhibitory activity

Info

Publication number
CA2257200A1
CA2257200A1 CA002257200A CA2257200A CA2257200A1 CA 2257200 A1 CA2257200 A1 CA 2257200A1 CA 002257200 A CA002257200 A CA 002257200A CA 2257200 A CA2257200 A CA 2257200A CA 2257200 A1 CA2257200 A1 CA 2257200A1
Authority
CA
Canada
Prior art keywords
inhibitory activity
cytokine inhibitory
substituted imidazoles
atom
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002257200A
Other languages
French (fr)
Other versions
CA2257200C (en
Inventor
Nigel J. Liverton
John W. Butcher
David A. Claremon
Mark T. Bilodeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Nigel J. Liverton
John W. Butcher
David A. Claremon
Mark T. Bilodeau
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614190.8A external-priority patent/GB9614190D0/en
Priority claimed from GBGB9617897.5A external-priority patent/GB9617897D0/en
Application filed by Nigel J. Liverton, John W. Butcher, David A. Claremon, Mark T. Bilodeau, Merck & Co., Inc. filed Critical Nigel J. Liverton
Priority claimed from PCT/US1997/009888 external-priority patent/WO1997047618A1/en
Publication of CA2257200A1 publication Critical patent/CA2257200A1/en
Application granted granted Critical
Publication of CA2257200C publication Critical patent/CA2257200C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Compounds represented by formula (I) are disclosed. AR represents an aromatic group containing 6-10 atoms; and (a) represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O
or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.
CA002257200A 1996-06-10 1997-06-06 Substituted imidazoles having cytokine inhibitory activity Expired - Fee Related CA2257200C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US1948796P 1996-06-10 1996-06-10
US60/019,487 1996-06-10
GB9614190.8 1996-07-05
GBGB9614190.8A GB9614190D0 (en) 1996-07-05 1996-07-05 Substituted imidazoles having cytokine inhibitory activity
US2331296P 1996-07-31 1996-07-31
US60/023,312 1996-07-31
GB9617897.5 1996-08-28
GBGB9617897.5A GB9617897D0 (en) 1996-08-28 1996-08-28 Substituted imidazoles having cytokine inhibitory activity
PCT/US1997/009888 WO1997047618A1 (en) 1996-06-10 1997-06-06 Substituted imidazoles having cytokine inhibitory activity

Publications (2)

Publication Number Publication Date
CA2257200A1 true CA2257200A1 (en) 1997-12-18
CA2257200C CA2257200C (en) 2006-05-23

Family

ID=36481489

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002257200A Expired - Fee Related CA2257200C (en) 1996-06-10 1997-06-06 Substituted imidazoles having cytokine inhibitory activity

Country Status (1)

Country Link
CA (1) CA2257200C (en)

Also Published As

Publication number Publication date
CA2257200C (en) 2006-05-23

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed