NO315903B1 - Immunokonjugater, fremgangsmåte for fremstilling derav, farmasöytiske preparater, samt anvendelse av immunokonjugatene for fremstilling avlegemidler mot tumorer - Google Patents
Immunokonjugater, fremgangsmåte for fremstilling derav, farmasöytiske preparater, samt anvendelse av immunokonjugatene for fremstilling avlegemidler mot tumorer Download PDFInfo
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- NO315903B1 NO315903B1 NO19944980A NO944980A NO315903B1 NO 315903 B1 NO315903 B1 NO 315903B1 NO 19944980 A NO19944980 A NO 19944980A NO 944980 A NO944980 A NO 944980A NO 315903 B1 NO315903 B1 NO 315903B1
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- antibody
- mab
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- tumor
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A61P35/00—Antineoplastic agents
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
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- Zoology (AREA)
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- Toxicology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93120865 | 1993-12-24 |
Publications (3)
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| NO944980D0 NO944980D0 (no) | 1994-12-22 |
| NO944980L NO944980L (no) | 1995-06-26 |
| NO315903B1 true NO315903B1 (no) | 2003-11-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| NO19944980A NO315903B1 (no) | 1993-12-24 | 1994-12-22 | Immunokonjugater, fremgangsmåte for fremstilling derav, farmasöytiske preparater, samt anvendelse av immunokonjugatene for fremstilling avlegemidler mot tumorer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6979726B1 (ja) |
| EP (1) | EP0659439B1 (ja) |
| JP (2) | JPH07223968A (ja) |
| KR (1) | KR950016781A (ja) |
| AT (1) | ATE207366T1 (ja) |
| AU (1) | AU688817B2 (ja) |
| CA (1) | CA2138928C (ja) |
| CZ (1) | CZ289099B6 (ja) |
| DE (1) | DE69428764T2 (ja) |
| DK (1) | DK0659439T3 (ja) |
| ES (1) | ES2166368T3 (ja) |
| HU (1) | HU219680B (ja) |
| NO (1) | NO315903B1 (ja) |
| PL (1) | PL178793B1 (ja) |
| PT (1) | PT659439E (ja) |
| RU (1) | RU2129018C1 (ja) |
| SK (1) | SK283494B6 (ja) |
| UA (1) | UA41888C2 (ja) |
| ZA (1) | ZA9410282B (ja) |
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| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| WO1998011241A1 (en) * | 1996-09-16 | 1998-03-19 | Merck Patent Gmbh | Oligocistronic expression system for the production of heteromeric proteins |
| WO2001000245A2 (en) | 1999-06-25 | 2001-01-04 | Genentech, Inc. | HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| DK1585966T3 (da) | 2002-07-15 | 2012-02-20 | Hoffmann La Roche | Behandling af cancer med anti-ErbB2-antistoffet rhuMab 2C4 |
| KR101438983B1 (ko) | 2003-11-06 | 2014-09-05 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| WO2005063820A2 (en) | 2003-12-30 | 2005-07-14 | Merck Patent Gmbh | Il-7 fusion proteins |
| WO2005070020A2 (en) | 2004-01-23 | 2005-08-04 | The Regents Of The University Of Colorado | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| US20060034840A1 (en) | 2004-04-08 | 2006-02-16 | Agus David B | ErbB antagonists for pain therapy |
| WO2005117553A2 (en) | 2004-05-27 | 2005-12-15 | The Regents Of The University Of Colorado | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients |
| EP1753463A2 (en) | 2004-06-01 | 2007-02-21 | Genentech, Inc. | Antibody drug conjugates and methods |
| RU2412947C2 (ru) | 2004-09-23 | 2011-02-27 | Дженентек, Инк. | Антитела, сконструированные на основе цистеинов, и их конъюгаты |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| UA94899C2 (ru) | 2005-01-21 | 2011-06-25 | Дженентек, Инк. | Фиксированное дозирование антител к her |
| RS53128B (en) | 2005-02-23 | 2014-06-30 | Genentech Inc. | Extending the time of disease progression or survival in patients with ovarian cancers using PERTUZUMAB |
| AR053272A1 (es) | 2005-05-11 | 2007-04-25 | Hoffmann La Roche | Determinacion de responsivos a la quimioterapia |
| WO2007076933A1 (en) | 2005-12-30 | 2007-07-12 | Merck Patent Gmbh | Interleukin-12p40 variants with improved stability |
| ES2426468T3 (es) | 2005-12-30 | 2013-10-23 | Merck Patent Gmbh | Anticuerpos anti-CD19 con inmunogenicidad reducida |
| CA2655361C (en) * | 2006-06-16 | 2014-10-07 | Kumamoto University | Sparc-derived tumor rejection antigenic peptides and medicaments comprising the same |
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| DK2171090T3 (da) | 2007-06-08 | 2013-06-10 | Genentech Inc | Genekspressionsmarkører for tumorresistens over for HER2-inhibitorbehandling |
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| SG10201402742YA (en) | 2009-03-20 | 2014-08-28 | Genentech Inc | Bispecific anti-her antibodies |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
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| ES2573336T3 (es) | 2011-08-12 | 2016-06-07 | F. Hoffmann-La Roche Ag | Compuestos de indazol, composiciones y métodos de uso |
| BR112014003431A2 (pt) | 2011-08-17 | 2017-06-13 | Genentech Inc | anticorpo, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, agente farmacêutico, uso do anticorpo, método de tratamento de um indivíduo que tem câncer e método de aumento de tempo para recorrência de tumor |
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- 1994-12-22 ZA ZA9410282A patent/ZA9410282B/xx unknown
- 1994-12-22 JP JP6320978A patent/JPH07223968A/ja active Pending
- 1994-12-22 CA CA002138928A patent/CA2138928C/en not_active Expired - Fee Related
- 1994-12-22 PL PL94306474A patent/PL178793B1/pl not_active IP Right Cessation
- 1994-12-23 RU RU94045281A patent/RU2129018C1/ru not_active IP Right Cessation
- 1994-12-23 HU HU9403784A patent/HU219680B/hu not_active IP Right Cessation
- 1994-12-23 KR KR1019940036168A patent/KR950016781A/ko not_active Application Discontinuation
- 1994-12-23 US US08/362,951 patent/US6979726B1/en not_active Expired - Fee Related
- 1994-12-27 CZ CZ19943306A patent/CZ289099B6/cs not_active IP Right Cessation
-
2006
- 2006-06-28 JP JP2006178409A patent/JP2006298936A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07223968A (ja) | 1995-08-22 |
| AU8159394A (en) | 1995-06-29 |
| RU2129018C1 (ru) | 1999-04-20 |
| KR950016781A (ko) | 1995-07-20 |
| RU94045281A (ru) | 1996-11-10 |
| CZ330694A3 (en) | 1995-10-18 |
| SK283494B6 (sk) | 2003-08-05 |
| AU688817B2 (en) | 1998-03-19 |
| EP0659439B1 (en) | 2001-10-24 |
| DE69428764D1 (de) | 2001-11-29 |
| HU9403784D0 (en) | 1995-02-28 |
| US6979726B1 (en) | 2005-12-27 |
| CA2138928C (en) | 2009-02-17 |
| PL306474A1 (en) | 1995-06-26 |
| ATE207366T1 (de) | 2001-11-15 |
| UA41888C2 (uk) | 2001-10-15 |
| CZ289099B6 (cs) | 2001-11-14 |
| EP0659439A3 (en) | 1996-12-04 |
| NO944980D0 (no) | 1994-12-22 |
| DK0659439T3 (da) | 2002-01-14 |
| PL178793B1 (pl) | 2000-06-30 |
| JP2006298936A (ja) | 2006-11-02 |
| CA2138928A1 (en) | 1995-06-25 |
| PT659439E (pt) | 2002-04-29 |
| SK156294A3 (en) | 1995-07-11 |
| ES2166368T3 (es) | 2002-04-16 |
| EP0659439A2 (en) | 1995-06-28 |
| ZA9410282B (en) | 1995-08-29 |
| HU219680B (hu) | 2001-06-28 |
| DE69428764T2 (de) | 2002-06-20 |
| NO944980L (no) | 1995-06-26 |
| HUT70471A (en) | 1995-10-30 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |