NO313861B1 - Flytende oftalmisk avleveringssystem med langvarig frigjöring og fremgangsmÕte for fremstilling derav - Google Patents
Flytende oftalmisk avleveringssystem med langvarig frigjöring og fremgangsmÕte for fremstilling derav Download PDFInfo
- Publication number
- NO313861B1 NO313861B1 NO19963431A NO963431A NO313861B1 NO 313861 B1 NO313861 B1 NO 313861B1 NO 19963431 A NO19963431 A NO 19963431A NO 963431 A NO963431 A NO 963431A NO 313861 B1 NO313861 B1 NO 313861B1
- Authority
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- Norway
- Prior art keywords
- ophthalmic
- delivery system
- agent
- chitosan
- ocular
- Prior art date
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- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000008261 styrofoam Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940056501 technetium 99m Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000012443 tonicity enhancing agent Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/198,924 US5422116A (en) | 1994-02-18 | 1994-02-18 | Liquid ophthalmic sustained release delivery system |
PCT/IB1995/000082 WO1995022315A1 (en) | 1994-02-18 | 1995-02-09 | Liquid ophthalmic sustained release delivery system |
Publications (3)
Publication Number | Publication Date |
---|---|
NO963431D0 NO963431D0 (no) | 1996-08-16 |
NO963431L NO963431L (no) | 1996-10-09 |
NO313861B1 true NO313861B1 (no) | 2002-12-16 |
Family
ID=22735469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19963431A NO313861B1 (no) | 1994-02-18 | 1996-08-16 | Flytende oftalmisk avleveringssystem med langvarig frigjöring og fremgangsmÕte for fremstilling derav |
Country Status (21)
Country | Link |
---|---|
US (1) | US5422116A (ja) |
EP (1) | EP0744938B1 (ja) |
JP (1) | JP3720359B2 (ja) |
CN (1) | CN1138530C (ja) |
AT (1) | ATE205079T1 (ja) |
AU (1) | AU704353B2 (ja) |
CA (1) | CA2181715C (ja) |
CY (1) | CY2314B1 (ja) |
DE (1) | DE69522550T2 (ja) |
DK (1) | DK0744938T3 (ja) |
ES (1) | ES2163495T3 (ja) |
FI (1) | FI117851B (ja) |
GR (1) | GR3036884T3 (ja) |
IL (1) | IL112674A (ja) |
MX (1) | MX9603435A (ja) |
NO (1) | NO313861B1 (ja) |
NZ (1) | NZ278668A (ja) |
PT (1) | PT744938E (ja) |
TW (1) | TW317501B (ja) |
WO (1) | WO1995022315A1 (ja) |
ZA (1) | ZA951323B (ja) |
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US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
US6071904A (en) * | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
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US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
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WO1999058131A1 (en) * | 1998-05-08 | 1999-11-18 | University Of Miami | Use of tetracyclines for treating meibomian gland disease |
US7288532B1 (en) * | 1998-08-21 | 2007-10-30 | The University Of Maryland Biotechnology Institute | Modified chitosan polymers and enzymatic methods for the production thereof |
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DE69828451T2 (de) * | 1998-11-20 | 2006-01-12 | Laboratoire Medidom S.A. | Wässrige ophthalmische formulierungen mit chitosan |
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ATE243038T1 (de) | 1999-11-01 | 2003-07-15 | Alcon Inc | Pharmazeutische zusammensetzungen ein fluorchinolonantibiotikum und xanthangummi enthaltend |
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AU1848601A (en) * | 1999-12-09 | 2001-06-18 | Bio Syntech Canada Inc | Mineral-polymer hybrid composition |
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KR100371092B1 (ko) * | 1999-12-09 | 2003-02-05 | 주식회사대성미생물연구소 | 동물용 복합항균제 조성물 |
US6348508B1 (en) * | 2000-04-04 | 2002-02-19 | Bausch & Lomb Incorporated | Method for treating dry eye |
US6716970B2 (en) | 2000-04-21 | 2004-04-06 | Adjuvant Pharmaceuticals, Llc | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof |
EP1157688B1 (en) * | 2000-05-26 | 2003-05-02 | Laboratoire Medidom S.A. | Antibacterial aqueous ophthalmic formulations containing ofloxacin and chitosan |
MXPA03000203A (es) * | 2000-06-29 | 2004-09-13 | Biosyntech Canada Inc | Composicion y metodo para la reparacion y regeneracion del cartilago y otros tejidos. |
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CA2429168C (en) * | 2000-11-15 | 2010-06-08 | Bio Syntech Canada Inc. | Method for restoring a damaged or degenerated intervertebral disc |
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US7790010B2 (en) * | 2002-12-20 | 2010-09-07 | University Of Maryland, College Park | Spatially selective deposition of polysaccharide layer onto patterned template |
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US12042500B2 (en) * | 2018-04-03 | 2024-07-23 | Hyderabad Eye Research Foundation | Mucoadhesive drug delivery system for ocular administration of fluoroquinolone antibiotics |
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WO2020146353A1 (en) | 2019-01-08 | 2020-07-16 | Alumend, Llc | Topical compositions containing low molecular weight chitosan derivatives |
IT201900006104A1 (it) | 2019-04-18 | 2020-10-18 | S I I T S R L Servizio Int Imballaggi Termosaldanti | Metodo di preparazione di un prodotto a base di chitosano |
CN111848834B (zh) * | 2019-04-30 | 2023-01-24 | 苏州大学 | 含氟化合物修饰的阳离子聚合物在制备药物的跨黏膜给药中的应用 |
CN117771172A (zh) * | 2019-08-27 | 2024-03-29 | 参天制药株式会社 | 含有地夸磷索或其盐、及聚乙烯吡咯烷酮的水性眼科用组合物 |
CN114073670B (zh) * | 2020-08-11 | 2023-02-24 | 武汉科福新药有限责任公司 | 马来酸噻吗洛尔凝胶滴眼液及其制备方法 |
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US4136173A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
US4659700A (en) * | 1984-03-02 | 1987-04-21 | Johnson & Johnson Products, Inc. | Chitosan-glycerol-water gel |
EP0244178A3 (en) * | 1986-04-28 | 1989-02-08 | Iolab, Inc | Intraocular dosage compositions and method of use |
IT1190347B (it) * | 1986-06-16 | 1988-02-16 | Franco Conti | Processo per la preparazione dell'n-dimetilchitosano e suoi impieghi farmacologici |
JPS6471822A (en) * | 1987-09-12 | 1989-03-16 | Rohto Pharma | Ophthalmic sustained release preparation |
IE63392B1 (en) * | 1988-02-08 | 1995-04-19 | Insite Vision Inc | Ophthalmic suspensions |
FR2653021A1 (fr) * | 1989-10-17 | 1991-04-19 | Merck Sharp & Dohme | Composition ophtalmique aqueuse liquide a transition de phase liquide-gel. |
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US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
-
1994
- 1994-02-18 US US08/198,924 patent/US5422116A/en not_active Expired - Lifetime
- 1994-05-31 TW TW083104939A patent/TW317501B/zh active
-
1995
- 1995-02-09 CN CNB951916556A patent/CN1138530C/zh not_active Expired - Fee Related
- 1995-02-09 PT PT95906463T patent/PT744938E/pt unknown
- 1995-02-09 WO PCT/IB1995/000082 patent/WO1995022315A1/en active IP Right Grant
- 1995-02-09 EP EP95906463A patent/EP0744938B1/en not_active Expired - Lifetime
- 1995-02-09 NZ NZ278668A patent/NZ278668A/en not_active IP Right Cessation
- 1995-02-09 ES ES95906463T patent/ES2163495T3/es not_active Expired - Lifetime
- 1995-02-09 AT AT95906463T patent/ATE205079T1/de not_active IP Right Cessation
- 1995-02-09 DE DE69522550T patent/DE69522550T2/de not_active Expired - Fee Related
- 1995-02-09 MX MX9603435A patent/MX9603435A/es active IP Right Grant
- 1995-02-09 CA CA002181715A patent/CA2181715C/en not_active Expired - Fee Related
- 1995-02-09 AU AU14649/95A patent/AU704353B2/en not_active Ceased
- 1995-02-09 DK DK95906463T patent/DK0744938T3/da active
- 1995-02-09 JP JP52169695A patent/JP3720359B2/ja not_active Expired - Fee Related
- 1995-02-16 IL IL11267495A patent/IL112674A/xx not_active IP Right Cessation
- 1995-02-17 ZA ZA951323A patent/ZA951323B/xx unknown
-
1996
- 1996-08-16 FI FI963217A patent/FI117851B/fi active IP Right Grant
- 1996-08-16 NO NO19963431A patent/NO313861B1/no not_active IP Right Cessation
-
2001
- 2001-10-16 GR GR20010401754T patent/GR3036884T3/el not_active IP Right Cessation
-
2003
- 2003-02-03 CY CY0300008A patent/CY2314B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA951323B (en) | 1995-08-18 |
FI963217A0 (fi) | 1996-08-16 |
NZ278668A (en) | 1998-01-26 |
CA2181715C (en) | 2006-05-30 |
PT744938E (pt) | 2001-12-28 |
DK0744938T3 (da) | 2001-12-31 |
JP3720359B2 (ja) | 2005-11-24 |
NO963431D0 (no) | 1996-08-16 |
CN1138530C (zh) | 2004-02-18 |
CN1140988A (zh) | 1997-01-22 |
DE69522550D1 (de) | 2001-10-11 |
ATE205079T1 (de) | 2001-09-15 |
GR3036884T3 (en) | 2002-01-31 |
CA2181715A1 (en) | 1995-08-24 |
JPH09509166A (ja) | 1997-09-16 |
WO1995022315A1 (en) | 1995-08-24 |
CY2314B1 (en) | 2003-11-14 |
IL112674A (en) | 1999-12-22 |
AU704353B2 (en) | 1999-04-22 |
TW317501B (ja) | 1997-10-11 |
AU1464995A (en) | 1995-09-04 |
US5422116A (en) | 1995-06-06 |
IL112674A0 (en) | 1995-05-26 |
MX9603435A (es) | 1997-03-29 |
NO963431L (no) | 1996-10-09 |
FI117851B (fi) | 2007-03-30 |
EP0744938B1 (en) | 2001-09-05 |
ES2163495T3 (es) | 2002-02-01 |
DE69522550T2 (de) | 2002-05-02 |
EP0744938A1 (en) | 1996-12-04 |
FI963217A (fi) | 1996-08-16 |
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