ES2163495T3 - Sistema de suministro oftalmico de liquido de liberacion sostenida. - Google Patents
Sistema de suministro oftalmico de liquido de liberacion sostenida.Info
- Publication number
- ES2163495T3 ES2163495T3 ES95906463T ES95906463T ES2163495T3 ES 2163495 T3 ES2163495 T3 ES 2163495T3 ES 95906463 T ES95906463 T ES 95906463T ES 95906463 T ES95906463 T ES 95906463T ES 2163495 T3 ES2163495 T3 ES 2163495T3
- Authority
- ES
- Spain
- Prior art keywords
- sustained release
- ophthalmic
- polymer
- mammal
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
SE DESCRIBE UN SISTEMA DE ADMINISTRACION DE UN LIQUIDO ACUOSO OFTALMICO POR LIBERACION CONTINUA Y UN METODO PARA PROPORCIONAR UNA LIBERACION LENTA Y CONTINUA DE AGENTES DE TRATAMIENTO OFTALMICO AL OJO DE UN MAMIFERO, QUE CONSISTE EN ADMINISTRAR AL OJO DE DICHO MAMIFERO UNA CANTIDAD EFICAZ DE UNA COMPOSICION FARMACEUTICA OFTALMICA ACUOSA HOMOGENEA, DE PH ENTRE APROXIMADAMENTE 3,0 Y 6,2, EN FORMA DE GOTAS, Y QUE CONTIENE UNA CONCENTRACION OFTALMICAMENTE EFICAZ DEL AGENTE DE TRATAMIENTO OFTALMICO MENCIONADO Y ENTRE APROXIMADAMENTE 0,05% Y 10%, POR PESO, DEL POLIMERO QUITOSAN. ESTE POLIMERO CONSTA BASICAMENTE DE (A) UNIDADES ENLAZADAS DE {BE}(1-4)-D-GLUCOSAMINA MONOMERICA Y (B) UNIDADES ENLAZADAS DE {BE}(1-4)-N-ACETIL-D-G LUCOSAMINA MONOMERICA, DISTRIBUIDAS ALEATORIAMENTE EN LA MOLECULA DEL POLIMERO. LAS PROPORCIONES NUMERICAS DE A Y B SON ENTRE 60 Y 99%, APROXIMADAMENTE, DE A Y ENTRE 1 Y 40%, APROXIMADAMENTE, DE B. LA VISCOSIDAD ES DE ENTRE APROXIMADAMENTE 3 Y 3000 CPS. EN ESTE METODO, AL CONTACTO CON EL PH MAS ALTO DEL LIQUIDO OCULAR, LA FORMULACION LIQUIDA SE CONVIERTE EN UN GEL DEL QUE SE LIBERA LENTAMENTE EL AGENTE DE TRATAMIENTO OFTALMICO DURANTE UN PERIODO PROLONGADO DE TIEMPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/198,924 US5422116A (en) | 1994-02-18 | 1994-02-18 | Liquid ophthalmic sustained release delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2163495T3 true ES2163495T3 (es) | 2002-02-01 |
Family
ID=22735469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95906463T Expired - Lifetime ES2163495T3 (es) | 1994-02-18 | 1995-02-09 | Sistema de suministro oftalmico de liquido de liberacion sostenida. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5422116A (es) |
EP (1) | EP0744938B1 (es) |
JP (1) | JP3720359B2 (es) |
CN (1) | CN1138530C (es) |
AT (1) | ATE205079T1 (es) |
AU (1) | AU704353B2 (es) |
CA (1) | CA2181715C (es) |
CY (1) | CY2314B1 (es) |
DE (1) | DE69522550T2 (es) |
DK (1) | DK0744938T3 (es) |
ES (1) | ES2163495T3 (es) |
FI (1) | FI117851B (es) |
GR (1) | GR3036884T3 (es) |
IL (1) | IL112674A (es) |
MX (1) | MX9603435A (es) |
NO (1) | NO313861B1 (es) |
NZ (1) | NZ278668A (es) |
PT (1) | PT744938E (es) |
TW (1) | TW317501B (es) |
WO (1) | WO1995022315A1 (es) |
ZA (1) | ZA951323B (es) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5762903A (en) * | 1995-03-10 | 1998-06-09 | Korea Atomic Energy Research Institute | Radioactive chitosan complex for radiation therapy |
US5843930A (en) * | 1995-06-06 | 1998-12-01 | Bayer Corporation | Method of treating otitis with ciprofloxacin-hydrocortisone suspension |
ES2173287T3 (es) * | 1995-06-06 | 2002-10-16 | Bayer Ag | Composiciones oticas antibacterianas no irritantes, no sensibilizantes y no ototoxicas. |
AU6742696A (en) * | 1995-08-17 | 1997-03-12 | Ciba-Geigy Ag | Stabilized chitin derivative compounds |
TW389694B (en) * | 1995-08-17 | 2000-05-11 | Novartis Ag | Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics |
US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
US6071904A (en) * | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
CA2212300A1 (en) | 1997-08-04 | 1999-02-04 | Abdellatif Chenite | In vitro or in vivo gelfying chitosan and therapeutic uses thereof |
US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
US6174524B1 (en) | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
DK1075265T3 (da) * | 1998-05-08 | 2006-06-26 | Univ Miami | Anvendelse af tetracycliner til behandling af sygdom i de Meibomske kirtler |
US7288532B1 (en) * | 1998-08-21 | 2007-10-30 | The University Of Maryland Biotechnology Institute | Modified chitosan polymers and enzymatic methods for the production thereof |
US20040152664A1 (en) * | 1998-09-02 | 2004-08-05 | Allergan, Inc. | Prednisolone compositions |
US6214381B1 (en) | 1998-09-08 | 2001-04-10 | Effcon, Inc. | Methazolamide composition and method of use |
SI1128809T1 (en) * | 1998-11-20 | 2005-06-30 | Laboratoire Medidom S.A. | Aqueous ophthalmic formulations comprising chitosan |
PL201130B1 (pl) * | 1999-09-24 | 2009-03-31 | Alcon Inc | Kompozycje zawiesinowe zawierające ciprofloksacynę i deksametazon do podawania miejscowego do oczu, uszu lub nosa |
JP2003513046A (ja) | 1999-11-01 | 2003-04-08 | アルコン,インコーポレイテッド | フルオロキノロン抗生薬およびキサンタンガムを含有する薬学的組成物 |
CA2685349C (en) * | 1999-11-15 | 2013-09-17 | Bio Syntech Canada Inc. | Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution |
US20030158302A1 (en) * | 1999-12-09 | 2003-08-21 | Cyric Chaput | Mineral-polymer hybrid composition |
WO2001041821A1 (en) * | 1999-12-09 | 2001-06-14 | Biosyntech Canada Inc. | Mineral-polymer hybrid composition |
KR100371092B1 (ko) * | 1999-12-09 | 2003-02-05 | 주식회사대성미생물연구소 | 동물용 복합항균제 조성물 |
US6348508B1 (en) * | 2000-04-04 | 2002-02-19 | Bausch & Lomb Incorporated | Method for treating dry eye |
US6716970B2 (en) | 2000-04-21 | 2004-04-06 | Adjuvant Pharmaceuticals, Llc | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof |
ATE238767T1 (de) * | 2000-05-26 | 2003-05-15 | Medidom Lab | Antibakterielle wässerige ophtalmische formulierungen mit ofloxacin und chitosan |
EP1294414B1 (en) * | 2000-06-29 | 2006-03-15 | Biosyntech Canada Inc. | Composition and method for the repair and regeneration of cartilage and other tissues |
CN1218689C (zh) | 2000-07-28 | 2005-09-14 | 爱尔康公司 | 包含妥布霉素和黄原胶的药物组合物 |
CA2429168C (en) * | 2000-11-15 | 2010-06-08 | Bio Syntech Canada Inc. | Method for restoring a damaged or degenerated intervertebral disc |
US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
AR034372A1 (es) * | 2001-06-08 | 2004-02-18 | Novartis Ag | Composiciones farmaceuticas |
US20030124679A1 (en) * | 2001-06-27 | 2003-07-03 | Short Jay M. | Glycosylated kinamycins and methods of making and using them |
ATA13842001A (de) | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung |
JP5614913B2 (ja) * | 2002-07-16 | 2014-10-29 | ピラマル ヘルスケア (カナダ) リミテッド | 生細胞又は生物学的活性因子を封入し送達するための、細胞適合性、注射可能、かつ自己ゲル化性のキトサン溶液の組成物 |
WO2004018741A1 (en) * | 2002-08-23 | 2004-03-04 | University Of Maryland Biotechnology Institute | Assembly of chitosan onto an electrode surface |
US7138373B2 (en) * | 2002-09-26 | 2006-11-21 | University Of Maryland, Baltimore County | Polysaccharide-based polymers and methods of making the same |
US7790010B2 (en) * | 2002-12-20 | 2010-09-07 | University Of Maryland, College Park | Spatially selective deposition of polysaccharide layer onto patterned template |
TW200416046A (en) * | 2002-12-23 | 2004-09-01 | Alcon Inc | Contact lens care compositions containing chitin derivatives |
GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
AU2004207507B2 (en) * | 2003-01-24 | 2009-11-19 | Eyepoint Pharmaceuticals Us, Inc. | Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors |
US7883615B2 (en) * | 2003-02-12 | 2011-02-08 | University Of Maryland, College Park | Controlled electrochemical deposition of polysaccharide films and hydrogels, and materials formed therefrom |
WO2004087043A2 (en) * | 2003-02-21 | 2004-10-14 | Sun Pharmaceutical Industries Limited | Stable ophthalmic formulation containing an antibiotic and a corticosteroid |
US20040202687A1 (en) * | 2003-04-14 | 2004-10-14 | Babu M.K. Manoj | Ciprofloxacin formulations and methods of making and using the same |
US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
US7125967B2 (en) * | 2003-10-08 | 2006-10-24 | Adjuvant Pharmaceuticals, Llc | Water-soluble chitosan having low endotoxin concentration and methods for making and using the same |
US20050101582A1 (en) * | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
US7375404B2 (en) * | 2003-12-05 | 2008-05-20 | University Of Maryland Biotechnology Institute | Fabrication and integration of polymeric bioMEMS |
GB0403938D0 (en) * | 2004-02-21 | 2004-03-24 | West Pharm Serv Drug Res Ltd | Chitosan containing solution |
KR101080056B1 (ko) * | 2004-12-01 | 2011-11-04 | 한국원자력연구원 | 체내 주사시 겔화 안정성이 개선된 방사성물질-키토산복합체용액 조성물 및 그 제조 방법 |
DE602005007319D1 (de) * | 2005-02-17 | 2008-07-17 | Jordanian Pharmaceutical Mfg | Zubereitung zur kontinuierlichen Arzneimittelfreisetzung Chitosan enthaltend |
US8088773B2 (en) | 2005-05-12 | 2012-01-03 | The Texas A&M University System | Therapeutic compositions and methods |
EP1945712A4 (en) * | 2005-11-04 | 2013-05-01 | Piramal Healthcare Canada Ltd | BINDING OF AQUEOUS POLYELECTROLYTE SOLUTIONS BY THERMALLY INDUCED CHANGES IN THE IONIZATION CONDITION |
CN101355876B (zh) | 2005-11-09 | 2012-09-05 | 康宾纳特克斯公司 | 一种适用于眼部给药的组合物 |
US20070154523A1 (en) * | 2005-12-30 | 2007-07-05 | Rick Lewis | Controlled pupil dilation for diagnostic and treatment of visual anomalies |
US7785624B2 (en) * | 2006-03-02 | 2010-08-31 | Inspire Pharmaceuticals, Inc. | Pharmaceutical latrunculin formulations |
PT1938839E (pt) * | 2006-12-18 | 2009-09-30 | Jorge Luis Benozzi | Composições oftálmicas de estimulantes parassimpáticos e anti-inflamatórios para utilização no tratamento de presbiopia |
US8252771B2 (en) * | 2007-01-31 | 2012-08-28 | Allergan, Inc. | Biomaterials and a method for making and using same |
EP2134355A4 (en) * | 2007-03-02 | 2012-01-11 | Saint Simeon Lda | NOVEL OPHTHALMIC COMPOSITIONS CONTAINING RECOMBINANT HUMAN LYSOZYME AND USE THEREOF FOR TREATING DISORDERS THEREOF AND SOLUTION FOR CONTACT LENSES |
CA2698812A1 (en) | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
CN101780105B (zh) * | 2009-01-20 | 2011-09-28 | 沈阳兴齐制药有限公司 | 小牛血去蛋白提取物的滴眼液 |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
WO2011018800A2 (en) | 2009-08-13 | 2011-02-17 | Fdc Limited | A novel in-situ gel forming solution for ocular drug delivery |
DE102010009475B4 (de) | 2010-02-26 | 2011-11-24 | F. Holzer Gmbh | Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates |
US20120231072A1 (en) * | 2011-03-11 | 2012-09-13 | Chemisches Institut Schaefer Ag | Thermo-responsive hydrogel compositions |
WO2013041967A2 (en) | 2011-09-20 | 2013-03-28 | Altavista Instituto De Investigation Medica S.A.S | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
CN104768533A (zh) * | 2012-06-11 | 2015-07-08 | 马库克利尔公司 | 治疗性制剂和治疗方法 |
WO2015055301A1 (en) * | 2013-10-15 | 2015-04-23 | Pharmathen S.A. | Preservative free pharmaceutical compositions for ophthalmic administration |
TWI609701B (zh) * | 2016-01-05 | 2018-01-01 | 國立交通大學 | 滴點式複合藥物凝膠及其製備方法 |
AU2017311636B2 (en) | 2016-08-19 | 2023-08-10 | Orasis Pharmaceuticals Ltd. | Ophthalmic pharmaceutical compositions and uses relating thereto |
CN106511268A (zh) * | 2017-01-22 | 2017-03-22 | 吉林省始祖生物波医学研究院有限公司 | 治疗眼病的溶液及其应用、眼贴及其制作方法 |
US9980946B1 (en) | 2017-01-25 | 2018-05-29 | Effcon Laboratories, Inc. | Extended release methazolamide formulation |
KR20220163519A (ko) * | 2018-02-28 | 2022-12-09 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 |
US20210038612A1 (en) * | 2018-04-03 | 2021-02-11 | Hyderabad Eye Research Foundation | Mucoadhesive drug delivery system for ocular administration of fluoroquinolone antibiotics |
KR20230079489A (ko) | 2018-04-24 | 2023-06-07 | 알러간, 인코포레이티드 | 안구 증상의 치료를 위한 필로카르핀 염산염의 용도 |
WO2020146353A1 (en) | 2019-01-08 | 2020-07-16 | Alumend, Llc | Topical compositions containing low molecular weight chitosan derivatives |
IT201900006104A1 (it) * | 2019-04-18 | 2020-10-18 | S I I T S R L Servizio Int Imballaggi Termosaldanti | Metodo di preparazione di un prodotto a base di chitosano |
CN111848832B (zh) * | 2019-04-30 | 2024-02-20 | 苏州大学 | 含氟化合物修饰的阳离子聚合物作为药物载体的应用及制备方法 |
KR20240049646A (ko) * | 2019-08-27 | 2024-04-16 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물 |
CN114073670B (zh) * | 2020-08-11 | 2023-02-24 | 武汉科福新药有限责任公司 | 马来酸噻吗洛尔凝胶滴眼液及其制备方法 |
US11872213B2 (en) * | 2021-01-28 | 2024-01-16 | Glaukos Corporation | Formulations |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4136173A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
US4659700A (en) * | 1984-03-02 | 1987-04-21 | Johnson & Johnson Products, Inc. | Chitosan-glycerol-water gel |
EP0244178A3 (en) * | 1986-04-28 | 1989-02-08 | Iolab, Inc | Intraocular dosage compositions and method of use |
IT1190347B (it) * | 1986-06-16 | 1988-02-16 | Franco Conti | Processo per la preparazione dell'n-dimetilchitosano e suoi impieghi farmacologici |
JPS6471822A (en) * | 1987-09-12 | 1989-03-16 | Rohto Pharma | Ophthalmic sustained release preparation |
IE63392B1 (en) * | 1988-02-08 | 1995-04-19 | Insite Vision Inc | Ophthalmic suspensions |
FR2653021A1 (fr) * | 1989-10-17 | 1991-04-19 | Merck Sharp & Dohme | Composition ophtalmique aqueuse liquide a transition de phase liquide-gel. |
JPH0418022A (ja) * | 1990-05-10 | 1992-01-22 | Fujikawa Kk | ピロキシカムの安定水溶液ならびにその製造法 |
JP2536806B2 (ja) * | 1991-03-27 | 1996-09-25 | アルコン ラボラトリーズ インコーポレイテッド | ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物 |
US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
-
1994
- 1994-02-18 US US08/198,924 patent/US5422116A/en not_active Expired - Lifetime
- 1994-05-31 TW TW083104939A patent/TW317501B/zh active
-
1995
- 1995-02-09 NZ NZ278668A patent/NZ278668A/en not_active IP Right Cessation
- 1995-02-09 JP JP52169695A patent/JP3720359B2/ja not_active Expired - Fee Related
- 1995-02-09 DE DE69522550T patent/DE69522550T2/de not_active Expired - Fee Related
- 1995-02-09 AU AU14649/95A patent/AU704353B2/en not_active Ceased
- 1995-02-09 DK DK95906463T patent/DK0744938T3/da active
- 1995-02-09 MX MX9603435A patent/MX9603435A/es active IP Right Grant
- 1995-02-09 AT AT95906463T patent/ATE205079T1/de not_active IP Right Cessation
- 1995-02-09 WO PCT/IB1995/000082 patent/WO1995022315A1/en active IP Right Grant
- 1995-02-09 CN CNB951916556A patent/CN1138530C/zh not_active Expired - Fee Related
- 1995-02-09 CA CA002181715A patent/CA2181715C/en not_active Expired - Fee Related
- 1995-02-09 ES ES95906463T patent/ES2163495T3/es not_active Expired - Lifetime
- 1995-02-09 PT PT95906463T patent/PT744938E/pt unknown
- 1995-02-09 EP EP95906463A patent/EP0744938B1/en not_active Expired - Lifetime
- 1995-02-16 IL IL11267495A patent/IL112674A/xx not_active IP Right Cessation
- 1995-02-17 ZA ZA951323A patent/ZA951323B/xx unknown
-
1996
- 1996-08-16 FI FI963217A patent/FI117851B/fi active IP Right Grant
- 1996-08-16 NO NO19963431A patent/NO313861B1/no not_active IP Right Cessation
-
2001
- 2001-10-16 GR GR20010401754T patent/GR3036884T3/el not_active IP Right Cessation
-
2003
- 2003-02-03 CY CY0300008A patent/CY2314B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69522550D1 (de) | 2001-10-11 |
NO963431D0 (no) | 1996-08-16 |
MX9603435A (es) | 1997-03-29 |
AU704353B2 (en) | 1999-04-22 |
WO1995022315A1 (en) | 1995-08-24 |
US5422116A (en) | 1995-06-06 |
DK0744938T3 (da) | 2001-12-31 |
IL112674A0 (en) | 1995-05-26 |
AU1464995A (en) | 1995-09-04 |
CY2314B1 (en) | 2003-11-14 |
IL112674A (en) | 1999-12-22 |
ATE205079T1 (de) | 2001-09-15 |
EP0744938B1 (en) | 2001-09-05 |
CN1140988A (zh) | 1997-01-22 |
NO963431L (no) | 1996-10-09 |
EP0744938A1 (en) | 1996-12-04 |
FI117851B (fi) | 2007-03-30 |
TW317501B (es) | 1997-10-11 |
CN1138530C (zh) | 2004-02-18 |
JP3720359B2 (ja) | 2005-11-24 |
FI963217A (fi) | 1996-08-16 |
JPH09509166A (ja) | 1997-09-16 |
NO313861B1 (no) | 2002-12-16 |
CA2181715A1 (en) | 1995-08-24 |
DE69522550T2 (de) | 2002-05-02 |
FI963217A0 (fi) | 1996-08-16 |
GR3036884T3 (en) | 2002-01-31 |
PT744938E (pt) | 2001-12-28 |
NZ278668A (en) | 1998-01-26 |
ZA951323B (en) | 1995-08-18 |
CA2181715C (en) | 2006-05-30 |
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