NO310659B1 - Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer - Google Patents

Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer Download PDF

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Publication number
NO310659B1
NO310659B1 NO19982124A NO982124A NO310659B1 NO 310659 B1 NO310659 B1 NO 310659B1 NO 19982124 A NO19982124 A NO 19982124A NO 982124 A NO982124 A NO 982124A NO 310659 B1 NO310659 B1 NO 310659B1
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NO
Norway
Prior art keywords
formula
compound
hydrogen
alkyl
halo
Prior art date
Application number
NO19982124A
Other languages
English (en)
Norwegian (no)
Other versions
NO982124D0 (no
NO982124L (no
Inventor
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Francois Maria Sommen
Dominique Louis Nest Surleraux
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO982124D0 publication Critical patent/NO982124D0/no
Publication of NO982124L publication Critical patent/NO982124L/no
Publication of NO310659B1 publication Critical patent/NO310659B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19982124A 1996-03-19 1998-05-11 Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer NO310659B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200755 1996-03-19
PCT/EP1997/001264 WO1997034897A1 (en) 1996-03-19 1997-03-11 Fused imidazole derivatives as multidrug resistance modulators

Publications (3)

Publication Number Publication Date
NO982124D0 NO982124D0 (no) 1998-05-11
NO982124L NO982124L (no) 1998-09-18
NO310659B1 true NO310659B1 (no) 2001-08-06

Family

ID=8223797

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19982124A NO310659B1 (no) 1996-03-19 1998-05-11 Kondenserte imidazolderivater som multilegemiddel resistanse modulatorer

Country Status (30)

Country Link
US (3) US6218381B1 (tr)
EP (1) EP0888352B1 (tr)
JP (3) JP3630434B2 (tr)
KR (2) KR100349500B1 (tr)
CN (1) CN1083453C (tr)
AR (1) AR006271A1 (tr)
AT (1) ATE241626T1 (tr)
BG (1) BG62734B1 (tr)
BR (1) BR9708140A (tr)
CA (1) CA2237594C (tr)
CZ (1) CZ294060B6 (tr)
DE (1) DE69722389T2 (tr)
EA (1) EA001004B1 (tr)
EE (1) EE03773B1 (tr)
ES (1) ES2200159T3 (tr)
HK (1) HK1015769A1 (tr)
HR (1) HRP970161B1 (tr)
HU (1) HU224528B1 (tr)
ID (1) ID16375A (tr)
IL (1) IL124572A (tr)
MX (1) MX9804426A (tr)
MY (1) MY118282A (tr)
NO (1) NO310659B1 (tr)
NZ (1) NZ330466A (tr)
PL (1) PL193444B1 (tr)
SK (1) SK284434B6 (tr)
TR (1) TR199801191T2 (tr)
TW (1) TW527186B (tr)
WO (1) WO1997034897A1 (tr)
ZA (1) ZA972351B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1146099A (en) * 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
ATE327735T1 (de) * 1998-04-01 2006-06-15 Jagotec Ag Taxan-mikroemulsionen
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
DE60221891T2 (de) * 2001-11-23 2008-05-08 Janssen Pharmaceutica N.V. Verwendung von substituierten tetrazyclischen Imidazolderivaten als Antihistaminika
GB0301736D0 (en) * 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
US9682984B2 (en) * 2013-03-25 2017-06-20 Crystal Pharma S.A.U. Methods for the preparation of alcaftadine
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4153719A (en) * 1977-09-06 1979-05-08 Sterling Drug Inc. Aromatic diketones
JPS56125326A (en) * 1980-03-07 1981-10-01 Asahi Kagaku Kogyo Kk Preparation of chlorinated phenoxytoluenes in high selectivity
US4778931A (en) 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4794188A (en) 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4840971A (en) * 1986-04-07 1989-06-20 Sumitomo Chemical Company, Limited Novel ether compound, a process for manufacturing the same, a composition containing the same and a use thereof
JPS6475441A (en) * 1987-09-16 1989-03-22 Sumitomo Chemical Co Production of optically active ether compound
JPH01254680A (ja) * 1988-04-01 1989-10-11 Sumitomo Chem Co Ltd 複素環化合物、その製造法およびそれを有効成分とする殺菌剤
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
AU662602B2 (en) * 1992-02-06 1995-09-07 Merrell Dow Pharmaceuticals Inc. Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
CA2150805C (en) 1992-12-04 2006-08-15 Frans Eduard Janssens Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
DE69425882T2 (de) 1993-03-29 2001-01-11 Basf Ag 1-amino-3-phenoxy-propan-derivate als modulatoren bei multi-drug resistenz
US5674866A (en) 1993-07-13 1997-10-07 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
FR2731708B1 (fr) 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
JP4205319B2 (ja) 2009-01-07
HUP9900415A3 (en) 2001-11-28
DE69722389T2 (de) 2009-09-24
KR100330698B1 (ko) 2002-10-31
US6476018B1 (en) 2002-11-05
DE69722389D1 (de) 2003-07-03
ID16375A (id) 1997-09-25
HU224528B1 (hu) 2005-10-28
US6218381B1 (en) 2001-04-17
HRP970161B1 (en) 2002-06-30
HK1015769A1 (en) 1999-10-22
IL124572A (en) 2002-03-10
JP4251447B2 (ja) 2009-04-08
CA2237594A1 (en) 1997-09-25
KR20000064358A (ko) 2000-11-06
EA001004B1 (ru) 2000-08-28
AU709683B2 (en) 1999-09-02
AR006271A1 (es) 1999-08-11
NO982124D0 (no) 1998-05-11
CZ294060B6 (cs) 2004-09-15
ZA972351B (en) 1998-09-18
SK66298A3 (en) 1999-06-11
NZ330466A (en) 1999-03-29
BG62734B1 (bg) 2000-06-30
IL124572A0 (en) 1998-12-06
JP2000505477A (ja) 2000-05-09
JP2004067701A (ja) 2004-03-04
ATE241626T1 (de) 2003-06-15
PL193444B1 (pl) 2007-02-28
JP3630434B2 (ja) 2005-03-16
BG102459A (en) 1999-06-30
CZ152998A3 (cs) 1999-02-17
TR199801191T2 (tr) 1998-10-21
PL327985A1 (en) 1999-01-04
EP0888352B1 (en) 2003-05-28
HRP970161A2 (en) 1998-04-30
EA199800586A1 (ru) 1998-12-24
CN1211985A (zh) 1999-03-24
ES2200159T3 (es) 2004-03-01
CA2237594C (en) 2006-05-30
AU2026997A (en) 1997-10-10
KR100349500B1 (ko) 2002-08-21
EE9800281A (et) 1999-02-15
MX9804426A (es) 1998-09-30
EP0888352A1 (en) 1999-01-07
JP2002012594A (ja) 2002-01-15
MY118282A (en) 2004-09-30
EE03773B1 (et) 2002-06-17
US20030087895A1 (en) 2003-05-08
CN1083453C (zh) 2002-04-24
BR9708140A (pt) 1999-07-27
WO1997034897A1 (en) 1997-09-25
TW527186B (en) 2003-04-11
SK284434B6 (sk) 2005-04-01
HUP9900415A2 (hu) 1999-05-28
NO982124L (no) 1998-09-18

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