AR006271A1 - Derivados de imidazol [2,1-b][3] benzacepina, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimientopara preparar dicha composicion farmaceutica - Google Patents
Derivados de imidazol [2,1-b][3] benzacepina, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimientopara preparar dicha composicion farmaceuticaInfo
- Publication number
- AR006271A1 AR006271A1 ARP970101072A ARP970101072A AR006271A1 AR 006271 A1 AR006271 A1 AR 006271A1 AR P970101072 A ARP970101072 A AR P970101072A AR P970101072 A ARP970101072 A AR P970101072A AR 006271 A1 AR006271 A1 AR 006271A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- pharmaceutical composition
- alkyloxy
- procedure
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- YGLDQFWPUCURIP-UHFFFAOYSA-N 3h-3-benzazepine Chemical class C1=CNC=CC2=CC=CC=C21 YGLDQFWPUCURIP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000036457 multidrug resistance Effects 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se relaciona con derivados de imidazol[2,1-b][3]benzacepina de la fórmula (I). Las formas de N-óxido, las sales de adición farmacéuticamente aceptablesy las formas estereoquímicamente isoméricas de los mismos, en los cuales la línea de puntose s un enlace optativo; n es 1 o 2; R1 es hidrógeno, halo,formilo, alquilo C1-4, alquilo C1-4 sustituido con hidroxi alquiloxi C1-4, alquilcarboniloxi C1-4, imidazolilo, tiazolilo u oxazolilo, o un radical dela fórmula: -X-CO-OR5, -X-CO-NR6R7,o - X-COR10, en la cual -X- es un enlace directo, alcandiilo C1-4,o alquendiilo C2-6; R5 es hidrógeno, alquilo C1-12;Ar, Het, alquilo C1-C6 sustituido con alquiloxi C1-4 arilo o heteroarilo; cada uno de R6 y R7 independientemente eshidrógeno o alquilo C1-C4; R2 eshidrógeno, halo, alquilo C1-C4, hidroxialquilo C1-4, alquiloxicarboniloC1-4, carboxilo, formilo o fenilo; R3 es hidrógeno, alquilo C1-C4 o alquiloxiC1-4; R4 es hidrógeno, halo, alquilo C1-C4, alquiloxi C1-4 o haloc1-4alquilo; Z es -CH2, CH2-CH2- o -CH=CH-, -CHOH-CH2-,-O-CH2-,-C(=O)-CH2, o -C(=NOH-CH2;-A-B- es un radical bivalente; -A1- es un enlace directo, alcandiilo C1-6, optativamente sustituido, C1-6alcandiil-oxi C1-6 acandiilo, alcandiiloxiC1-6,carbonil, alca ndiilcarbonilo C1-6, alcandiiloxi C1-6 optativamente sustituido, -A2- es un enlace directo o alcandiilo C1-6; y Q es arilo. Se describenprocesos para preparar dichos productos, una composición farmacéutica que comprendelos mismos, un procedim iento para preparar dicha composiciónfarmacéutica, un producto y el uso de dichos compuestos como medicamento para inhibir o revertir los efectos de la resistencia a los fármacos múltiples.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200755 | 1996-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006271A1 true AR006271A1 (es) | 1999-08-11 |
Family
ID=8223797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101072A AR006271A1 (es) | 1996-03-19 | 1997-03-18 | Derivados de imidazol [2,1-b][3] benzacepina, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, un procedimientopara preparar dicha composicion farmaceutica |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6218381B1 (es) |
| EP (1) | EP0888352B1 (es) |
| JP (3) | JP3630434B2 (es) |
| KR (2) | KR100349500B1 (es) |
| CN (1) | CN1083453C (es) |
| AR (1) | AR006271A1 (es) |
| AT (1) | ATE241626T1 (es) |
| BG (1) | BG62734B1 (es) |
| BR (1) | BR9708140A (es) |
| CA (1) | CA2237594C (es) |
| CZ (1) | CZ294060B6 (es) |
| DE (1) | DE69722389T2 (es) |
| EA (1) | EA001004B1 (es) |
| EE (1) | EE03773B1 (es) |
| ES (1) | ES2200159T3 (es) |
| HK (1) | HK1015769A1 (es) |
| HR (1) | HRP970161B1 (es) |
| HU (1) | HU224528B1 (es) |
| ID (1) | ID16375A (es) |
| IL (1) | IL124572A (es) |
| MX (1) | MX9804426A (es) |
| MY (1) | MY118282A (es) |
| NO (1) | NO310659B1 (es) |
| NZ (1) | NZ330466A (es) |
| PL (1) | PL193444B1 (es) |
| SK (1) | SK284434B6 (es) |
| TR (1) | TR199801191T2 (es) |
| TW (1) | TW527186B (es) |
| WO (1) | WO1997034897A1 (es) |
| ZA (1) | ZA972351B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544979B1 (en) * | 1997-09-18 | 2003-04-08 | Janssen Pharmaceuticals, N.V. | Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents |
| CA2326485C (en) * | 1998-04-01 | 2008-12-09 | Rtp Pharma Inc. | Anticancer compositions |
| US6743794B2 (en) | 1999-12-22 | 2004-06-01 | Eli Lilly And Company | Methods and compounds for inhibiting MRP1 |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| CN100491378C (zh) | 2001-06-12 | 2009-05-27 | 詹森药业有限公司 | 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途 |
| ES2290364T3 (es) * | 2001-11-23 | 2008-02-16 | Janssen Pharmaceutica N.V. | Uso de derivados de imidazol tetraciclicos sustituidos como antihistaminicos. |
| GB0301736D0 (en) * | 2003-01-24 | 2003-02-26 | Xenova Ltd | Pharmaceutical compounds |
| US9682984B2 (en) * | 2013-03-25 | 2017-06-20 | Crystal Pharma S.A.U. | Methods for the preparation of alcaftadine |
| CN103408549B (zh) * | 2013-06-14 | 2016-01-20 | 苏州汇和药业有限公司 | 一种阿卡他定中间体的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2418502C3 (de) * | 1974-04-11 | 1980-04-24 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4153719A (en) * | 1977-09-06 | 1979-05-08 | Sterling Drug Inc. | Aromatic diketones |
| JPS56125326A (en) * | 1980-03-07 | 1981-10-01 | Asahi Kagaku Kogyo Kk | Preparation of chlorinated phenoxytoluenes in high selectivity |
| US4778931A (en) | 1982-12-01 | 1988-10-18 | Usv Pharmaceutical Corporation | Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity |
| US4567184A (en) | 1982-12-01 | 1986-01-28 | Usv Pharmaceutical Corporation | Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies |
| US4794188A (en) | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
| US4588722A (en) | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| JPS61151176A (ja) * | 1984-12-24 | 1986-07-09 | Sumitomo Chem Co Ltd | ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤 |
| US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| AU7100887A (en) * | 1986-04-07 | 1987-10-08 | Sumitomo Chemical Company, Limited | Halogenated aromatic ethers and alcohol and aldehyde intermediates |
| JPS6475441A (en) * | 1987-09-16 | 1989-03-22 | Sumitomo Chemical Co | Production of optically active ether compound |
| JPH01254680A (ja) * | 1988-04-01 | 1989-10-11 | Sumitomo Chem Co Ltd | 複素環化合物、その製造法およびそれを有効成分とする殺菌剤 |
| AU8902591A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Substituted imidazobenzazepines and imidazopyridoazepines |
| IL101850A (en) | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| IL101851A (en) | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
| GB9122590D0 (en) * | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| NZ249040A (en) * | 1992-02-06 | 1997-06-24 | Merrell Dow Pharma | Triphenyl azacycloalkane derivatives; treatment of drug resistance |
| HU223466B1 (hu) | 1992-12-04 | 2004-07-28 | Janssen Pharmaceutica N.V. | Allergia elleni imidazo[1,2a]tieno[2,3-d]azepin-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
| JPH08508270A (ja) | 1993-03-29 | 1996-09-03 | ビーエーエスエフ アクチエンゲゼルシャフト | マルチ・ドラッグ耐性のモジュレーターとしての１−アミノ−３−フェノキシ−プロパン誘導体 |
| DE69426528T2 (de) | 1993-07-13 | 2001-08-23 | Janssen Pharmaceutica Nv | Antiallergische imidazoazepine |
| US5486612A (en) * | 1993-12-14 | 1996-01-23 | Eli Lilly And Company | N-benzyl dihydroindole LTD4 antagonists |
| US5596008A (en) * | 1995-02-10 | 1997-01-21 | G. D. Searle & Co. | 3,4-Diaryl substituted pyridines for the treatment of inflammation |
| FR2731708B1 (fr) | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de piperidine, leur procede de preparation et leur application en therapeutique |
| TW382017B (en) | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
-
1997
- 1997-03-05 TW TW086102623A patent/TW527186B/zh not_active IP Right Cessation
- 1997-03-11 WO PCT/EP1997/001264 patent/WO1997034897A1/en active IP Right Grant
- 1997-03-11 EE EE9800281A patent/EE03773B1/xx not_active IP Right Cessation
- 1997-03-11 US US09/142,932 patent/US6218381B1/en not_active Expired - Fee Related
- 1997-03-11 TR TR1998/01191T patent/TR199801191T2/xx unknown
- 1997-03-11 KR KR1020017008287A patent/KR100349500B1/ko not_active IP Right Cessation
- 1997-03-11 CZ CZ19981529A patent/CZ294060B6/cs not_active IP Right Cessation
- 1997-03-11 PL PL97327985A patent/PL193444B1/pl not_active IP Right Cessation
- 1997-03-11 HU HU9900415A patent/HU224528B1/hu not_active IP Right Cessation
- 1997-03-11 EA EA199800586A patent/EA001004B1/ru unknown
- 1997-03-11 BR BR9708140A patent/BR9708140A/pt not_active IP Right Cessation
- 1997-03-11 AT AT97908226T patent/ATE241626T1/de not_active IP Right Cessation
- 1997-03-11 CN CN97192399A patent/CN1083453C/zh not_active Expired - Fee Related
- 1997-03-11 SK SK662-98A patent/SK284434B6/sk not_active IP Right Cessation
- 1997-03-11 CA CA002237594A patent/CA2237594C/en not_active Expired - Fee Related
- 1997-03-11 KR KR1019980703754A patent/KR100330698B1/ko not_active IP Right Cessation
- 1997-03-11 ES ES97908226T patent/ES2200159T3/es not_active Expired - Lifetime
- 1997-03-11 NZ NZ330466A patent/NZ330466A/xx unknown
- 1997-03-11 IL IL12457297A patent/IL124572A/en not_active IP Right Cessation
- 1997-03-11 DE DE69722389T patent/DE69722389T2/de not_active Expired - Fee Related
- 1997-03-11 JP JP53312197A patent/JP3630434B2/ja not_active Expired - Fee Related
- 1997-03-11 EP EP97908226A patent/EP0888352B1/en not_active Expired - Lifetime
- 1997-03-17 MY MYPI97001123A patent/MY118282A/en unknown
- 1997-03-18 ZA ZA972351A patent/ZA972351B/xx unknown
- 1997-03-18 AR ARP970101072A patent/AR006271A1/es unknown
- 1997-03-19 HR HR970161A patent/HRP970161B1/xx not_active IP Right Cessation
- 1997-03-19 ID IDP970888A patent/ID16375A/id unknown
-
1998
- 1998-05-11 NO NO19982124A patent/NO310659B1/no not_active IP Right Cessation
- 1998-05-18 BG BG102459A patent/BG62734B1/bg active Active
- 1998-06-03 MX MX9804426A patent/MX9804426A/es not_active IP Right Cessation
-
1999
- 1999-02-20 HK HK99100695A patent/HK1015769A1/xx not_active IP Right Cessation
-
2001
- 2001-02-02 US US09/775,524 patent/US6476018B1/en not_active Expired - Fee Related
- 2001-06-01 JP JP2001167003A patent/JP4205319B2/ja not_active Expired - Fee Related
-
2002
- 2002-07-02 US US10/187,665 patent/US20030087895A1/en not_active Abandoned
-
2003
- 2003-10-08 JP JP2003349802A patent/JP4251447B2/ja not_active Expired - Fee Related
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