EE9800281A - Kondenseeritud imidasoolderivaadid multiravimiresistentsi moduleerijatena - Google Patents

Kondenseeritud imidasoolderivaadid multiravimiresistentsi moduleerijatena

Info

Publication number
EE9800281A
EE9800281A EE9800281A EE9800281A EE9800281A EE 9800281 A EE9800281 A EE 9800281A EE 9800281 A EE9800281 A EE 9800281A EE 9800281 A EE9800281 A EE 9800281A EE 9800281 A EE9800281 A EE 9800281A
Authority
EE
Estonia
Prior art keywords
modulators
multidrug resistance
imidazole derivatives
condensed imidazole
condensed
Prior art date
Application number
EE9800281A
Other languages
English (en)
Other versions
EE03773B1 (et
Inventor
Eduard Janssens Frans
Elisabeth Leenaerts Joseph
Maria Sommen Fran�ois
Louis Nestor Ghislaine Surleraux Dominique
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9800281A publication Critical patent/EE9800281A/et
Publication of EE03773B1 publication Critical patent/EE03773B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
EE9800281A 1996-03-19 1997-03-11 Kondenseeritud imidasoolderivaadid, nende kasutamine ravimina, neid sisaldav farmatseutiline kompositsioon, meetod selle valmistamiseks ning seda sisaldav kombineeritud preparaat EE03773B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200755 1996-03-19
PCT/EP1997/001264 WO1997034897A1 (en) 1996-03-19 1997-03-11 Fused imidazole derivatives as multidrug resistance modulators

Publications (2)

Publication Number Publication Date
EE9800281A true EE9800281A (et) 1999-02-15
EE03773B1 EE03773B1 (et) 2002-06-17

Family

ID=8223797

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800281A EE03773B1 (et) 1996-03-19 1997-03-11 Kondenseeritud imidasoolderivaadid, nende kasutamine ravimina, neid sisaldav farmatseutiline kompositsioon, meetod selle valmistamiseks ning seda sisaldav kombineeritud preparaat

Country Status (30)

Country Link
US (3) US6218381B1 (et)
EP (1) EP0888352B1 (et)
JP (3) JP3630434B2 (et)
KR (2) KR100330698B1 (et)
CN (1) CN1083453C (et)
AR (1) AR006271A1 (et)
AT (1) ATE241626T1 (et)
BG (1) BG62734B1 (et)
BR (1) BR9708140A (et)
CA (1) CA2237594C (et)
CZ (1) CZ294060B6 (et)
DE (1) DE69722389T2 (et)
EA (1) EA001004B1 (et)
EE (1) EE03773B1 (et)
ES (1) ES2200159T3 (et)
HK (1) HK1015769A1 (et)
HR (1) HRP970161B1 (et)
HU (1) HU224528B1 (et)
ID (1) ID16375A (et)
IL (1) IL124572A (et)
MX (1) MX9804426A (et)
MY (1) MY118282A (et)
NO (1) NO310659B1 (et)
NZ (1) NZ330466A (et)
PL (1) PL193444B1 (et)
SK (1) SK284434B6 (et)
TR (1) TR199801191T2 (et)
TW (1) TW527186B (et)
WO (1) WO1997034897A1 (et)
ZA (1) ZA972351B (et)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999013871A2 (en) * 1997-09-18 1999-03-25 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
CA2326485C (en) * 1998-04-01 2008-12-09 Rtp Pharma Inc. Anticancer compositions
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
NZ532718A (en) * 2001-11-23 2007-01-26 Janssen Pharmaceutica Nv The use of anti-histaminics for acute reduction of elevated intracranial pressure
GB0301736D0 (en) * 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
EP2978765B1 (en) * 2013-03-25 2018-05-02 Crystal Pharma S.A.U Methods for the preparation of alcaftadine
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4153719A (en) * 1977-09-06 1979-05-08 Sterling Drug Inc. Aromatic diketones
JPS56125326A (en) * 1980-03-07 1981-10-01 Asahi Kagaku Kogyo Kk Preparation of chlorinated phenoxytoluenes in high selectivity
US4778931A (en) 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4794188A (en) 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
AU7100887A (en) * 1986-04-07 1987-10-08 Sumitomo Chemical Company, Limited Halogenated aromatic ethers and alcohol and aldehyde intermediates
JPS6475441A (en) * 1987-09-16 1989-03-22 Sumitomo Chemical Co Production of optically active ether compound
JPH01254680A (ja) * 1988-04-01 1989-10-11 Sumitomo Chem Co Ltd 複素環化合物、その製造法およびそれを有効成分とする殺菌剤
DE69110685T2 (de) * 1990-10-10 1995-11-09 Schering Corp Substituierte imidazobenzazepine und imidazopyridoazepine.
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
WO1993016044A1 (en) * 1992-02-06 1993-08-19 Merrell Dow Pharmaceuticals Inc. Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
AU676702B2 (en) 1992-12-04 1997-03-20 Janssen Pharmaceutica N.V. Antiallergic imidazo{1,2-a}(pyrrolo, thieno or furano){2,3-d}azepine derivatives
WO1994022842A1 (en) 1993-03-29 1994-10-13 Basf Aktiengesellschaft 1-amino-3-phenoxy propane derivatives as modulators of multi-drug resistance
AU679102B2 (en) 1993-07-13 1997-06-19 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
FR2731708B1 (fr) 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
JP3630434B2 (ja) 2005-03-16
SK284434B6 (sk) 2005-04-01
ZA972351B (en) 1998-09-18
CA2237594C (en) 2006-05-30
WO1997034897A1 (en) 1997-09-25
EP0888352A1 (en) 1999-01-07
EA199800586A1 (ru) 1998-12-24
MX9804426A (es) 1998-09-30
PL327985A1 (en) 1999-01-04
JP4205319B2 (ja) 2009-01-07
BG62734B1 (bg) 2000-06-30
CN1083453C (zh) 2002-04-24
JP2000505477A (ja) 2000-05-09
DE69722389D1 (de) 2003-07-03
KR100330698B1 (ko) 2002-10-31
BG102459A (en) 1999-06-30
JP2002012594A (ja) 2002-01-15
HUP9900415A3 (en) 2001-11-28
TW527186B (en) 2003-04-11
DE69722389T2 (de) 2009-09-24
HU224528B1 (hu) 2005-10-28
SK66298A3 (en) 1999-06-11
EE03773B1 (et) 2002-06-17
BR9708140A (pt) 1999-07-27
US6476018B1 (en) 2002-11-05
ID16375A (id) 1997-09-25
AR006271A1 (es) 1999-08-11
MY118282A (en) 2004-09-30
AU709683B2 (en) 1999-09-02
KR100349500B1 (ko) 2002-08-21
CZ294060B6 (cs) 2004-09-15
JP2004067701A (ja) 2004-03-04
HRP970161B1 (en) 2002-06-30
US6218381B1 (en) 2001-04-17
CZ152998A3 (cs) 1999-02-17
HK1015769A1 (en) 1999-10-22
IL124572A (en) 2002-03-10
ES2200159T3 (es) 2004-03-01
HUP9900415A2 (hu) 1999-05-28
NZ330466A (en) 1999-03-29
CN1211985A (zh) 1999-03-24
KR20000064358A (ko) 2000-11-06
NO982124D0 (no) 1998-05-11
CA2237594A1 (en) 1997-09-25
AU2026997A (en) 1997-10-10
JP4251447B2 (ja) 2009-04-08
ATE241626T1 (de) 2003-06-15
EP0888352B1 (en) 2003-05-28
NO982124L (no) 1998-09-18
NO310659B1 (no) 2001-08-06
EA001004B1 (ru) 2000-08-28
HRP970161A2 (en) 1998-04-30
PL193444B1 (pl) 2007-02-28
US20030087895A1 (en) 2003-05-08
TR199801191T2 (xx) 1998-10-21
IL124572A0 (en) 1998-12-06

Similar Documents

Publication Publication Date Title
DE69712331D1 (de) Pyrimidin-4-on derivate als pestizidesmittel
DE69706292D1 (de) Chinazoline derivate
BR9700850A (pt) Derivados de quinazolina substituídos
DE69728685D1 (de) Neue substituierte imidazolverbindungen
PT934320E (pt) Derivados de naftiridina
PT891332E (pt) Derivados de 6-fenilpiridil-2-amina
NO20001628D0 (no) Polymerderivater av kamptoteciner
ATE290001T1 (de) Neue substituierte imidazolverbindungen
ID24638A (id) Senyawa-senyawa anti aritmia bispidina
DE69738426D1 (de) Klebstoffzusammensetzung
ID18685A (id) Senyawa trisiklik tersubstitusi
ATE277917T1 (de) Alkylaminobenzothiazole und -benzoxazole derivate
EE9800281A (et) Kondenseeritud imidasoolderivaadid multiravimiresistentsi moduleerijatena
PT923594E (pt) Compostos de bromotiacumicina
PT931087E (pt) Novos derivados de piranosido
PT906279E (pt) Derivados de pirrol
ATE211884T1 (de) Halopropargyl-einschlussverbindungen
DE69709869T2 (de) BENZO[g]CHINOLIN DERIVATE
BR9706980A (pt) Derivados de isooxacefem
BR9708310A (pt) Derivados de 2-tioxotetrahidropirimidin-4-ona
DE69635901D1 (de) Polycyclische derivate
FI991343A0 (fi) Dihydropolyprenolien öljykoostumus
DE69730098D1 (de) Klebstoffzusammensetzung
BR9708484A (pt) Aplicação de arilimidazóis substituídos
FI974228A0 (fi) Foerfarande foer elimination av momentsvaengningen hos en frekvensomformarstyrd vaexelstroemmotor

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

MM4A Lapsed by not paying the annual fees

Effective date: 20100311