ES2135463T3 - Inversion de la resistencia multi-medicamento por medio de derivados de trifenil-piperidina. - Google Patents
Inversion de la resistencia multi-medicamento por medio de derivados de trifenil-piperidina.Info
- Publication number
- ES2135463T3 ES2135463T3 ES93903678T ES93903678T ES2135463T3 ES 2135463 T3 ES2135463 T3 ES 2135463T3 ES 93903678 T ES93903678 T ES 93903678T ES 93903678 T ES93903678 T ES 93903678T ES 2135463 T3 ES2135463 T3 ES 2135463T3
- Authority
- ES
- Spain
- Prior art keywords
- integer
- tumors
- triphenyl
- investment
- drug resistance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN COMPUESTO DE FORMULA (1) EN DONDE PH1, PH2, Y PH3 SON CADA UNO UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO CON UNA COMBINACION DE MAS DE TRES MIEMBROS DEL GRUPO CONSISTENTE EN FLUOR, CLORO, BROMO, HIDROXI, TRIFLUOROMETILO, NH2, N(CH3)2, ALQUILO (C1 TITUIDO CON UN GRUPO METILENODIOXILO; N ES UN NUMERO ENTERO DESDE 1 A 5; M ES 0 O UN NUMERO ENTERO DE 1 A 2; Y Q ES UN NUMERO ENTERO DE 1 A 2; O UNA SAL DEL MISMO DE ADICION ACIDA QUE INVIERTE LA RESISTENCIA A MULTIPLES MEDICAMENTOS EN CELULAS TUMOROSAS RESISTENTES A MULTIPLES MEDICAMENTOS Y POR ESO ES UTIL ADYUVANTE EN EL TRATAMIENTO DE TUMORES. ESTOS COMPUESTOS APARENTEMENTE FUNCIONAN INHIBIENDO UNA POMPA DE P-GLICOPROTEINA QUE SE VUELVE ACTIVA EN LA ULTIMA ETAPA DEL DESARROLLO DEL TUMOR Y QUE ESTA INHERENTEMENTE PRESENTE EN TUMORES DE CIERTOS ORIGENES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83254092A | 1992-02-06 | 1992-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2135463T3 true ES2135463T3 (es) | 1999-11-01 |
Family
ID=25261950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93903678T Expired - Lifetime ES2135463T3 (es) | 1992-02-06 | 1993-01-11 | Inversion de la resistencia multi-medicamento por medio de derivados de trifenil-piperidina. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0643693B1 (es) |
JP (1) | JPH07503957A (es) |
KR (1) | KR950700248A (es) |
AT (1) | ATE182582T1 (es) |
AU (1) | AU662602B2 (es) |
CA (1) | CA2129144C (es) |
DE (1) | DE69325805T2 (es) |
DK (1) | DK0643693T3 (es) |
ES (1) | ES2135463T3 (es) |
GR (1) | GR3031557T3 (es) |
HU (1) | HUT70564A (es) |
NO (1) | NO942920L (es) |
NZ (1) | NZ249040A (es) |
WO (1) | WO1993016044A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100377280B1 (ko) * | 1993-01-21 | 2003-07-18 | 메렐 파마슈티칼스 인크. | 디아릴알킬피페리딘을함유하는다중-약물내성종양치료효력증강용약제학적조성물 |
US5670521A (en) * | 1994-08-05 | 1997-09-23 | Merrell Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
EP1129707A3 (en) | 1994-08-31 | 2002-02-27 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Methods for identifying and treating resistant tumors |
TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
GB0003685D0 (en) * | 2000-02-17 | 2000-04-05 | Univ Cardiff | Sensitisation of cellular material |
CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
EP0235463A3 (en) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents |
CA2059127A1 (en) * | 1989-06-19 | 1990-12-20 | Oscar William Lever | Medicaments useful in cancer therapy and having antihistaminic properties |
GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
KR100377280B1 (ko) * | 1993-01-21 | 2003-07-18 | 메렐 파마슈티칼스 인크. | 디아릴알킬피페리딘을함유하는다중-약물내성종양치료효력증강용약제학적조성물 |
-
1993
- 1993-01-11 DE DE69325805T patent/DE69325805T2/de not_active Expired - Fee Related
- 1993-01-11 HU HU9402298A patent/HUT70564A/hu unknown
- 1993-01-11 NZ NZ249040A patent/NZ249040A/en unknown
- 1993-01-11 ES ES93903678T patent/ES2135463T3/es not_active Expired - Lifetime
- 1993-01-11 AU AU34842/93A patent/AU662602B2/en not_active Ceased
- 1993-01-11 JP JP5514096A patent/JPH07503957A/ja active Pending
- 1993-01-11 CA CA002129144A patent/CA2129144C/en not_active Expired - Fee Related
- 1993-01-11 WO PCT/US1993/000669 patent/WO1993016044A1/en active IP Right Grant
- 1993-01-11 EP EP93903678A patent/EP0643693B1/en not_active Expired - Lifetime
- 1993-01-11 DK DK93903678T patent/DK0643693T3/da active
- 1993-01-11 AT AT93903678T patent/ATE182582T1/de not_active IP Right Cessation
-
1994
- 1994-08-05 KR KR1019940702687A patent/KR950700248A/ko not_active Application Discontinuation
- 1994-08-05 NO NO942920A patent/NO942920L/no unknown
-
1999
- 1999-10-15 GR GR990402651T patent/GR3031557T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1993016044A1 (en) | 1993-08-19 |
KR950700248A (ko) | 1995-01-16 |
DK0643693T3 (da) | 1999-11-29 |
AU3484293A (en) | 1993-09-03 |
DE69325805D1 (de) | 1999-09-02 |
NO942920L (no) | 1994-08-05 |
ATE182582T1 (de) | 1999-08-15 |
HUT70564A (en) | 1995-10-30 |
HU9402298D0 (en) | 1994-10-28 |
EP0643693A1 (en) | 1995-03-22 |
CA2129144A1 (en) | 1993-08-19 |
GR3031557T3 (en) | 2000-01-31 |
NO942920D0 (es) | 1994-08-05 |
DE69325805T2 (de) | 2000-03-16 |
EP0643693B1 (en) | 1999-07-28 |
JPH07503957A (ja) | 1995-04-27 |
NZ249040A (en) | 1997-06-24 |
AU662602B2 (en) | 1995-09-07 |
CA2129144C (en) | 1999-07-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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