CO5261527A1 - Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina - Google Patents
Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazinaInfo
- Publication number
- CO5261527A1 CO5261527A1 CO00094338A CO00094338A CO5261527A1 CO 5261527 A1 CO5261527 A1 CO 5261527A1 CO 00094338 A CO00094338 A CO 00094338A CO 00094338 A CO00094338 A CO 00094338A CO 5261527 A1 CO5261527 A1 CO 5261527A1
- Authority
- CO
- Colombia
- Prior art keywords
- 4alkyl
- hydroxyacetilepiperazine
- eteres
- oxazolidinones
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula I:<EMI FILE="00094338_1" ID="1" IMF=JPEG >o una sal farmacéuticamente aceptable del mismo, en donde:A es una estructura i, ii o iii<EMI FILE="00094338_2" ID="2" IMF=JPEG >X es O o S;R1 es(a) H,(b) NH2,(c) NHC1-4alquilo,(d) C1-4alquilo, opcionaImente substituido con uno o más F, Cl o CN,(e) C2-4 alquenilo,(f) OC1-4 alquilo,(g) SC1-4alquilo, o(h) (CH2)nC3-6cicloalquilo;R2 y R3 son independientemente H, F, CI o C1-2 alquilo;R4 está ubicado en C-3 ó en C-4 y es:<EMI FILE="00094338_3" ID="3" IMF=JPEG >R5 es H O CH3;R6 es H O C1-4alquilo, opcionalmente substituido con OH, SH, SCH3, NH2 o NHC(=NH)NH2;R7 y R8 son independientemente(a) H,(b) C1-4 alquilo, o(c) R7 y R8 conjuntamente con el nitrógeno al cual están adjuntos forman un anillo heterocíclico saturado de 5,6 ó 7 miembros que puede tener heteroátomos adicionales seleccionados del grupo constituido de O, S(O)n o N-R5;n es 0, 1 ó 2; ycon la condición de que cuando X es O, R4 no está en la subsección (a).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17067599P | 1999-12-14 | 1999-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261527A1 true CO5261527A1 (es) | 2003-03-31 |
Family
ID=22620832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00094338A CO5261527A1 (es) | 1999-12-14 | 2000-12-12 | Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6281210B1 (es) |
| EP (1) | EP1242395B1 (es) |
| JP (1) | JP2003516977A (es) |
| KR (1) | KR20020062332A (es) |
| CN (1) | CN1390211A (es) |
| AR (1) | AR026547A1 (es) |
| AT (1) | ATE288423T1 (es) |
| AU (1) | AU1805801A (es) |
| BR (1) | BR0015177A (es) |
| CA (1) | CA2387047A1 (es) |
| CO (1) | CO5261527A1 (es) |
| CZ (1) | CZ20022389A3 (es) |
| DE (1) | DE60017941T2 (es) |
| EA (1) | EA200200673A1 (es) |
| ES (1) | ES2236006T3 (es) |
| HU (1) | HUP0203787A3 (es) |
| IL (1) | IL150031A0 (es) |
| MX (1) | MXPA02005909A (es) |
| NO (1) | NO20022811L (es) |
| PE (1) | PE20010851A1 (es) |
| PL (1) | PL355369A1 (es) |
| PT (1) | PT1242395E (es) |
| SK (1) | SK5972002A3 (es) |
| TW (1) | TW544449B (es) |
| WO (1) | WO2001044212A1 (es) |
| ZA (1) | ZA200202953B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| ES2256318T3 (es) * | 2000-10-17 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Metodos de produccion de compuestos de oxazolidinona. |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| WO2004045616A1 (en) * | 2002-11-21 | 2004-06-03 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) * | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| JP5416408B2 (ja) | 2005-10-04 | 2014-02-12 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ５−クロロ−ｎ−（｛（５ｓ）−２−オキソ−３−［４−（３−オキソ−４−モルホリニル）−フェニル］−１，３−オキサゾリジン−５−イル｝−メチル）−２−チオフェンカルボキサミドの新規多形および無定形 |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| US20100210602A1 (en) * | 2006-12-12 | 2010-08-19 | The Johns Hopkins University | PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA |
| CA2692255A1 (en) * | 2007-06-22 | 2008-12-31 | Orchid Research Laboratories Limited | Novel compounds and their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1046276C (zh) * | 1993-11-22 | 1999-11-10 | 法玛西雅厄普约翰美国公司 | 取代羟基乙酰基哌嗪苯基唑烷酮酯及其用途 |
| MY116093A (en) * | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
| CN1138765C (zh) * | 1997-05-30 | 2004-02-18 | 法玛西雅厄普约翰美国公司 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
| GB9812019D0 (en) * | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-11-15 PE PE2000001220A patent/PE20010851A1/es not_active Application Discontinuation
- 2000-11-20 AR ARP000106119A patent/AR026547A1/es unknown
- 2000-11-24 TW TW089125030A patent/TW544449B/zh not_active IP Right Cessation
- 2000-12-06 HU HU0203787A patent/HUP0203787A3/hu unknown
- 2000-12-06 BR BR0015177-7A patent/BR0015177A/pt not_active IP Right Cessation
- 2000-12-06 MX MXPA02005909A patent/MXPA02005909A/es not_active Application Discontinuation
- 2000-12-06 KR KR1020027007514A patent/KR20020062332A/ko not_active Application Discontinuation
- 2000-12-06 PT PT00980849T patent/PT1242395E/pt unknown
- 2000-12-06 IL IL15003100A patent/IL150031A0/xx unknown
- 2000-12-06 AT AT00980849T patent/ATE288423T1/de not_active IP Right Cessation
- 2000-12-06 AU AU18058/01A patent/AU1805801A/en not_active Abandoned
- 2000-12-06 JP JP2001544702A patent/JP2003516977A/ja active Pending
- 2000-12-06 EA EA200200673A patent/EA200200673A1/ru unknown
- 2000-12-06 WO PCT/US2000/032432 patent/WO2001044212A1/en active IP Right Grant
- 2000-12-06 ES ES00980849T patent/ES2236006T3/es not_active Expired - Lifetime
- 2000-12-06 CA CA002387047A patent/CA2387047A1/en not_active Abandoned
- 2000-12-06 DE DE60017941T patent/DE60017941T2/de not_active Expired - Fee Related
- 2000-12-06 US US09/732,088 patent/US6281210B1/en not_active Expired - Fee Related
- 2000-12-06 PL PL00355369A patent/PL355369A1/xx not_active Application Discontinuation
- 2000-12-06 CN CN00815710A patent/CN1390211A/zh active Pending
- 2000-12-06 EP EP00980849A patent/EP1242395B1/en not_active Expired - Lifetime
- 2000-12-06 SK SK597-2002A patent/SK5972002A3/sk unknown
- 2000-12-06 CZ CZ20022389A patent/CZ20022389A3/cs unknown
- 2000-12-12 CO CO00094338A patent/CO5261527A1/es not_active Application Discontinuation
-
2002
- 2002-04-15 ZA ZA200202953A patent/ZA200202953B/xx unknown
- 2002-06-13 NO NO20022811A patent/NO20022811L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6281210B1 (en) | 2001-08-28 |
| PL355369A1 (en) | 2004-04-19 |
| HUP0203787A2 (hu) | 2003-07-28 |
| ES2236006T3 (es) | 2005-07-16 |
| DE60017941D1 (de) | 2005-03-10 |
| NO20022811D0 (no) | 2002-06-13 |
| KR20020062332A (ko) | 2002-07-25 |
| CN1390211A (zh) | 2003-01-08 |
| DE60017941T2 (de) | 2006-03-30 |
| HUP0203787A3 (en) | 2005-06-28 |
| IL150031A0 (en) | 2002-12-01 |
| EP1242395B1 (en) | 2005-02-02 |
| MXPA02005909A (es) | 2002-10-23 |
| NO20022811L (no) | 2002-06-13 |
| AR026547A1 (es) | 2003-02-19 |
| TW544449B (en) | 2003-08-01 |
| SK5972002A3 (en) | 2003-01-09 |
| PT1242395E (pt) | 2005-05-31 |
| JP2003516977A (ja) | 2003-05-20 |
| ZA200202953B (en) | 2003-09-23 |
| EA200200673A1 (ru) | 2002-12-26 |
| ATE288423T1 (de) | 2005-02-15 |
| BR0015177A (pt) | 2002-06-18 |
| WO2001044212A1 (en) | 2001-06-21 |
| CA2387047A1 (en) | 2001-06-21 |
| AU1805801A (en) | 2001-06-25 |
| EP1242395A1 (en) | 2002-09-25 |
| PE20010851A1 (es) | 2001-08-17 |
| CZ20022389A3 (cs) | 2002-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |