CO5261589A1 - Compuestos heterociclicos, su produccion y su utilizacion - Google Patents

Compuestos heterociclicos, su produccion y su utilizacion

Info

Publication number
CO5261589A1
CO5261589A1 CO01027571A CO01027571A CO5261589A1 CO 5261589 A1 CO5261589 A1 CO 5261589A1 CO 01027571 A CO01027571 A CO 01027571A CO 01027571 A CO01027571 A CO 01027571A CO 5261589 A1 CO5261589 A1 CO 5261589A1
Authority
CO
Colombia
Prior art keywords
production
jpeg
formula
alkyl group
represented
Prior art date
Application number
CO01027571A
Other languages
English (en)
Inventor
Akihiro Tasaka
Hitaka Takenori
Matsutani Etsuya
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CO5261589A1 publication Critical patent/CO5261589A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

Un compuesto caracterizado por que está representado por la fórmula:<EMI FILE="01027571_1" ID="1" IMF=JPEG >en donde n es de valor 1 ó 2;R1 es un átomo halógeno o un grupo alquilo C1-2 opcionalmente halogenado;uno de R2 y R3 es un átomo de hidrógeno y el otro es un grupo representado por la fórmula:<EMI FILE="01027571_2" ID="2" IMF=JPEG >en donde n es 3 ó 4; R4 es un grupo alquilo C1-4 sustituido por 1 o 2 grupos hidroxilo, o una sal del mismo.
CO01027571A 2000-04-07 2001-04-06 Compuestos heterociclicos, su produccion y su utilizacion CO5261589A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000106836 2000-04-07

Publications (1)

Publication Number Publication Date
CO5261589A1 true CO5261589A1 (es) 2003-03-31

Family

ID=18619943

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01027571A CO5261589A1 (es) 2000-04-07 2001-04-06 Compuestos heterociclicos, su produccion y su utilizacion

Country Status (19)

Country Link
US (2) US6716863B2 (es)
EP (1) EP1268473A1 (es)
KR (1) KR20020028865A (es)
CN (1) CN1444582A (es)
AU (1) AU2001244726A1 (es)
BR (1) BR0109851A (es)
CA (1) CA2404760A1 (es)
CO (1) CO5261589A1 (es)
CZ (1) CZ20023264A3 (es)
EE (1) EE200200576A (es)
HU (1) HUP0300434A3 (es)
IL (1) IL152115A0 (es)
MX (1) MXPA02009621A (es)
NO (1) NO20024742L (es)
OA (1) OA12244A (es)
PE (1) PE20011178A1 (es)
PL (1) PL365787A1 (es)
SK (1) SK14132002A3 (es)
WO (1) WO2001077107A1 (es)

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KR20010080007A (ko) * 1998-10-08 2001-08-22 다케다 야쿠힌 고교 가부시키가이샤 호르몬 의존성 암의 호르몬 비의존성 암으로의 변화 지연제
KR20030013360A (ko) * 2000-07-19 2003-02-14 다케다 야쿠힌 고교 가부시키가이샤 1-치환-1,2,3-트리아졸 유도체의 제조 방법
WO2002087616A1 (fr) * 2001-04-25 2002-11-07 Takeda Chemical Industries, Ltd. Remedes contre la recurrence postoperative du cancer du sein chez les femmes en premenopause
WO2002087618A1 (fr) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Methode de prevention et de traitement du cancer
US20040138160A1 (en) * 2001-04-27 2004-07-15 Kenichiro Naito Preventive/therapeutic method for cancer
WO2003015820A1 (fr) * 2001-08-10 2003-02-27 Takeda Chemical Industries, Ltd. Medicaments combines d'agoniste de la gnrh
WO2003031442A1 (fr) * 2001-10-05 2003-04-17 Takeda Chemical Industries, Ltd. Composes heterocycliques, derives oxazole, procede permettant de les presenter et leur utilisation
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
US7622479B2 (en) * 2001-11-26 2009-11-24 Takeda Pharmaceutical Company Limited Bicyclic derivative, its production and use
WO2003059907A1 (fr) * 2002-01-17 2003-07-24 Takeda Chemical Industries, Ltd. Composes heterocycliques azotes : procede de preparation et d'utilisation
RU2376029C2 (ru) 2002-04-25 2009-12-20 Юниверсити Оф Коннектикут Хелт Сентер Применение белков теплового шока для улучшения терапевтического эффекта невакцинного лечебного воздействия
JP4633469B2 (ja) * 2002-12-16 2011-02-16 キッセイ薬品工業株式会社 経口固形医薬
TW200505913A (en) * 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
TW200423931A (en) * 2003-04-30 2004-11-16 Hoffmann La Roche Novel aniline derivatives, their manufacture and use as pharmaceutical agents
US7247649B2 (en) * 2003-08-13 2007-07-24 Hoffmann-La Roche Inc. Oxazoles, their manufacture and use as pharmaceutical agents
US7259262B2 (en) 2003-10-24 2007-08-21 Hoffmann-La Roche Inc. Arylazole derivatives, their manufacture and use as pharmaceutical agents
US20050186275A1 (en) * 2004-02-23 2005-08-25 Standard Chem. & Pharm. Co. Ltd. Sustained release tamsulosin formulations
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
TW200612914A (en) * 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents
TW200533346A (en) * 2004-03-18 2005-10-16 Hoffmann La Roche Novel ether derivatives, their manufacture and use as pharmaceutical agents
AU2005231936A1 (en) 2004-04-02 2005-10-20 F. Hoffmann-La-Roche Ag New process for the preparation of diazine derivatives
US7005526B2 (en) * 2004-05-25 2006-02-28 Hoffmann-La Roche Inc. Thioether derivatives
US7163953B2 (en) 2004-05-25 2007-01-16 Hoffmann-La Roche Inc. Benzylether derivatives
US7618769B2 (en) * 2004-06-07 2009-11-17 Applied Materials, Inc. Textured chamber surface
US7288557B2 (en) 2004-09-21 2007-10-30 Hoffmann-La Roche Inc. Triazole derivatives
TW200616951A (en) 2004-09-22 2006-06-01 Hoffmann La Roche Indole derivatives, their manufacture and use as pharmaceutial agents
US20060069095A1 (en) * 2004-09-24 2006-03-30 Thomas Hofmeister Azole derivatives
US20060116407A1 (en) * 2004-11-22 2006-06-01 Birgit Bossenmaier Amide derivatives
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
US7429605B2 (en) * 2005-08-04 2008-09-30 Hoffmann-La Roche Inc. Phenylpyridine derivatives
CA2616075A1 (en) * 2005-08-08 2007-02-15 Hans-Willi Krell Pyrazole derivatives, their manufacture and their use as pharmaceutical agents
CN101233130A (zh) * 2005-09-30 2008-07-30 霍夫曼-拉罗奇有限公司 二嗪唑衍生物，它们的制备和作为药剂的应用
WO2008034579A1 (en) * 2006-09-20 2008-03-27 F. Hoffmann-La Roche Ag 2-heterocyclyl-5-phenoxymethylpyridine derivatives as anticancer agents
JPWO2008072634A1 (ja) 2006-12-12 2010-04-02 武田薬品工業株式会社 縮合複素環化合物
US9101617B2 (en) 2007-04-20 2015-08-11 Daido Chemical Corporation Base for dry solid dispersion, solid dispersion containing the base, and composition containing the dispersion
WO2009113560A1 (ja) 2008-03-12 2009-09-17 武田薬品工業株式会社 縮合複素環化合物
WO2010036917A1 (en) * 2008-09-26 2010-04-01 Takeda Pharmaceutical Company Limited Prevention and treatment of cancer with ras gene mutation
AR073679A1 (es) * 2008-09-26 2010-11-24 Takeda Pharmaceutical Prevencion y tratamiento de cancer con la no expresion de lkb1 supresion o mutacion, composicion farmaceutica. usos
EP2484383B1 (en) 2009-09-30 2021-04-28 Kabushiki Kaisha Sangi Method for improving the aqueous solubility of poorly-soluble substances
EP2540286A4 (en) 2010-02-26 2015-05-27 Nisshin Kasei Co Ltd HARD CAPSULE AND METHOD OF PRODUCING THE SAME
US8993634B2 (en) 2010-06-02 2015-03-31 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to Her2/neu receptor complex
WO2011153050A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
WO2014050910A1 (ja) 2012-09-26 2014-04-03 武田薬品工業株式会社 固体粒子の製造方法
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
WO2017003668A1 (en) 2015-07-01 2017-01-05 California Institute Of Technology Cationic mucic acid polymer-based delivery systems
EP3238711B1 (en) 2016-04-26 2023-07-12 Mitsubishi Chemical Corporation Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
CA2995617A1 (en) * 2017-11-03 2019-05-03 Universite De Montreal Heterocyclic mitochondrial activity inhibitors and uses thereof
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
CN114217025B (zh) * 2021-12-17 2024-01-23 哈尔滨工业大学 评估空气质量浓度预测中气象数据对其影响的分析方法

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EP0525109A4 (en) * 1990-04-16 1993-06-30 Rhone-Poulenc Rorer International (Holdings) Inc. Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase
CA2260999C (en) * 1996-07-19 2006-07-11 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use in tyrosine kinase inhibition

Also Published As

Publication number Publication date
KR20020028865A (ko) 2002-04-17
CA2404760A1 (en) 2001-10-18
US20040024035A1 (en) 2004-02-05
HUP0300434A2 (hu) 2003-06-28
CN1444582A (zh) 2003-09-24
IL152115A0 (en) 2003-05-29
MXPA02009621A (es) 2003-05-14
EE200200576A (et) 2004-06-15
HUP0300434A3 (en) 2004-11-29
US6716863B2 (en) 2004-04-06
EP1268473A1 (en) 2003-01-02
CZ20023264A3 (cs) 2003-02-12
WO2001077107A1 (en) 2001-10-18
WO2001077107B1 (en) 2001-12-20
OA12244A (en) 2006-05-10
WO2001077107A8 (en) 2003-02-13
SK14132002A3 (sk) 2003-04-01
PE20011178A1 (es) 2001-11-19
PL365787A1 (en) 2005-01-10
NO20024742L (no) 2002-11-25
BR0109851A (pt) 2003-06-03
NO20024742D0 (no) 2002-10-02
US20020173526A1 (en) 2002-11-21
AU2001244726A1 (en) 2001-10-23

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